ATE478852T1 - Neue 4-cyano-, 4-amino-, und 4- aminomethylderivative von pyrazoloä1,5- aüpyridinen, pyrazoloä1,5-cüpyrimidinen und 2h- indazolverbindungen und 5-cyano-, 5-amino- und 5- aminomethylderivative von imidazoä1,2-aüpyridinen,und imidazoä1,5-aüpyrazinverbindungen als inhibitoren der cyclinabhänggen kinase - Google Patents
Neue 4-cyano-, 4-amino-, und 4- aminomethylderivative von pyrazoloä1,5- aüpyridinen, pyrazoloä1,5-cüpyrimidinen und 2h- indazolverbindungen und 5-cyano-, 5-amino- und 5- aminomethylderivative von imidazoä1,2-aüpyridinen,und imidazoä1,5-aüpyrazinverbindungen als inhibitoren der cyclinabhänggen kinaseInfo
- Publication number
- ATE478852T1 ATE478852T1 AT06802808T AT06802808T ATE478852T1 AT E478852 T1 ATE478852 T1 AT E478852T1 AT 06802808 T AT06802808 T AT 06802808T AT 06802808 T AT06802808 T AT 06802808T AT E478852 T1 ATE478852 T1 AT E478852T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- cyano
- amino
- imidazoä1
- aüpyridines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71562105P | 2005-09-09 | 2005-09-09 | |
PCT/US2006/034233 WO2007032936A2 (en) | 2005-09-09 | 2006-08-31 | Azafused cyclin dependent kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE478852T1 true ATE478852T1 (de) | 2010-09-15 |
Family
ID=37487994
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06802808T ATE478852T1 (de) | 2005-09-09 | 2006-08-31 | Neue 4-cyano-, 4-amino-, und 4- aminomethylderivative von pyrazoloä1,5- aüpyridinen, pyrazoloä1,5-cüpyrimidinen und 2h- indazolverbindungen und 5-cyano-, 5-amino- und 5- aminomethylderivative von imidazoä1,2-aüpyridinen,und imidazoä1,5-aüpyrazinverbindungen als inhibitoren der cyclinabhänggen kinase |
Country Status (10)
Country | Link |
---|---|
US (3) | US7700773B2 (de) |
EP (1) | EP1931641B1 (de) |
JP (1) | JP2009507843A (de) |
CN (1) | CN101300233A (de) |
AT (1) | ATE478852T1 (de) |
CA (1) | CA2621983A1 (de) |
DE (1) | DE602006016455D1 (de) |
ES (1) | ES2349476T3 (de) |
HK (1) | HK1112229A1 (de) |
WO (1) | WO2007032936A2 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2603457A1 (en) * | 2005-04-07 | 2006-10-19 | Teijin Pharma Limited | Pyrazolo[1,5-a]pyridine derivatives or pharmaceutically acceptable salts thereof |
EP1931641B1 (de) * | 2005-09-09 | 2010-08-25 | Schering Corporation | Neue 4-cyano-, 4-amino-, und 4-aminomethylderivative von pyrazolo[1,5-a]pyridinen, pyrazolo[1,5-c]pyrimidinen und 2h-indazolverbindungen und 5-cyano-, 5-amino- und 5-aminomethylderivative von imidazo[1,2-a]pyridinen, und imidazo[1,5-a]pyrazinverbindungen als inhibitoren der cyclinabhänggen kinase |
JP2009532356A (ja) * | 2006-03-31 | 2009-09-10 | シェーリング コーポレイション | キナーゼ阻害物質 |
AU2010238361B2 (en) * | 2009-04-16 | 2015-08-06 | Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii | Imidazopyrazines for use as kinase inhibitors |
CA2787714C (en) | 2010-01-22 | 2019-04-09 | Joaquin Pastor Fernandez | Inhibitors of pi3 kinase |
WO2011141713A1 (en) | 2010-05-13 | 2011-11-17 | Centro Nacional De Investigaciones Oncologicas (Cnio) | New bicyclic compounds as pi3-k and mtor inhibitors |
EP2651944B1 (de) * | 2010-12-17 | 2015-09-23 | Bayer Intellectual Property GmbH | Substituierte 6-imidazopyrazines zur verwendung als mps-1 und tkk-inhibitoren zur behandlung von hyperproliferativen erkrankungen |
JP2013545779A (ja) * | 2010-12-17 | 2013-12-26 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 過剰増殖性障害の治療におけるmps−1およびtkk阻害剤として使用するための6置換イミダゾピラジン |
EP2694500B1 (de) | 2011-04-06 | 2015-05-27 | Bayer Pharma Aktiengesellschaft | Substituierte imidazopyridine und deren zwischenprodukte |
UY34305A (es) | 2011-09-01 | 2013-04-30 | Novartis Ag | Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar |
SG10201805807PA (en) | 2012-06-26 | 2018-08-30 | Del Mar Pharmaceuticals | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof |
CA2885392A1 (en) * | 2012-12-10 | 2014-06-19 | Zhanling CHENG | Novel bi-ring phenyl-pyridines/pyrazines for the treatment of cancer |
CN104837842A (zh) * | 2012-12-10 | 2015-08-12 | 霍夫曼-拉罗奇有限公司 | 新型二环苯基-吡啶/吡嗪用于治疗癌症 |
US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
KR20160061911A (ko) | 2013-04-08 | 2016-06-01 | 데니스 엠. 브라운 | 최적하 투여된 화학 화합물의 치료 효과 |
HUE045725T2 (hu) | 2014-02-13 | 2020-01-28 | Incyte Corp | Ciklopropilaminok mint LSD1 inhibitorok |
ES2760261T3 (es) | 2014-02-13 | 2020-05-13 | Incyte Corp | Ciclopropilaminas como inhibidores de LSD1 |
WO2015157955A1 (en) | 2014-04-17 | 2015-10-22 | Abbvie Inc. | Heterocyclic btk inhibit ors |
WO2016007722A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines and triazolopyrazines as lsd1 inhibitors |
MX2017012699A (es) | 2015-04-03 | 2018-02-09 | Incyte Corp | Compuestos heterociclicos como inhibidores de demetilasa 1 especifica de lisina (lsd1). |
KR20180051523A (ko) | 2015-08-12 | 2018-05-16 | 인사이트 코포레이션 | Lsd1 저해제의 염 |
WO2020047198A1 (en) | 2018-08-31 | 2020-03-05 | Incyte Corporation | Salts of an lsd1 inhibitor and processes for preparing the same |
EP3849537A4 (de) | 2018-09-10 | 2022-06-29 | Mirati Therapeutics, Inc. | Kombinationstherapien |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69130683T2 (de) | 1991-04-22 | 1999-05-06 | Otsuka Pharma Co Ltd | PYRAZOLO[1,5-a]PYRIMIDINDERIVATE UND SIE ENTHALTENDE ANTIINFLAMMATORISCHE MITTEL |
US5571813A (en) * | 1993-06-10 | 1996-11-05 | Beiersdorf-Lilly Gmbh | Fused pyrimidine compounds and their use as pharmaceuticals |
EP0628559B1 (de) | 1993-06-10 | 2002-04-03 | Beiersdorf-Lilly GmbH | Pyrimidinverbindungen und ihre Verwendung als Pharmazeutika |
KR100315837B1 (ko) * | 1994-06-21 | 2002-02-28 | 고리 히데아끼 | 피라졸로[1,5-a]피리미딘유도체 |
CA2314355A1 (en) * | 1997-12-13 | 1999-06-24 | Bristol-Myers Squibb Company | Use of pyrazolo ¢3,4-b! pyridine as cyclin dependent kinase inhibitors |
US6413974B1 (en) * | 1998-02-26 | 2002-07-02 | Aventis Pharmaceuticals Inc. | 6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines |
EP1140938B1 (de) * | 1999-01-11 | 2003-08-27 | Princeton University | Kinase-inhibitoren mit hoher affinität zur ziel detektion und ihre verwendung |
MXPA02012605A (es) * | 2000-06-28 | 2003-05-14 | Squibb Bristol Myers Co | Moduladores selectivos del receptor androgeno y metodo para su identificacion, dise°o y uso. |
YU4903A (sh) | 2000-07-26 | 2006-03-03 | Bristol-Myers Squibb Company | N-/5-///5-alkil-2-oksazolil/metil/tio/-2-tiazolil/ karboksamidni inhibitori ciklin zavisnih kinaza |
US7067520B2 (en) * | 2000-11-17 | 2006-06-27 | Ishihara Sangyo Kaisha, Ltd. | Preventive or therapeutic medicines for diabetes containing fused-heterocyclic compounds or their salts |
WO2002050079A1 (fr) | 2000-12-20 | 2002-06-27 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Inhibiteurs de kinases dependantes des cylines (cdk) et de la glycogene synthase kinase-3 (gsk-3) |
US6897208B2 (en) * | 2001-10-26 | 2005-05-24 | Aventis Pharmaceuticals Inc. | Benzimidazoles |
TWI263640B (en) * | 2001-12-19 | 2006-10-11 | Bristol Myers Squibb Co | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
FR2836915B1 (fr) * | 2002-03-11 | 2008-01-11 | Aventis Pharma Sa | Derives d'aminoindazoles, procede de preparation et intermediaires de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant |
GB0218625D0 (en) * | 2002-08-10 | 2002-09-18 | Astex Technology Ltd | Pharmaceutical compounds |
DE60313872T2 (de) | 2002-09-04 | 2008-01-17 | Schering Corp. | Pyrazoloä1,5-aüpyrimidine als hemmstoffe cyclin-abhängiger kinasen |
ATE376548T1 (de) | 2002-09-04 | 2007-11-15 | Schering Corp | Pyrazolopyrimidine als hemmstoffe cyclin- abhängiger kinasen |
JP2006500391A (ja) | 2002-09-04 | 2006-01-05 | シェーリング コーポレイション | サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン |
ES2285164T3 (es) | 2002-09-04 | 2007-11-16 | Schering Corporation | Pirazolopirimidinas como inhibidores de quinasas dependientes de ciclina. |
KR101088922B1 (ko) | 2002-09-04 | 2011-12-01 | 파마코페이아, 엘엘씨. | 사이클린 의존성 키나제 억제제로서의 피라졸로피리미딘 |
WO2004022562A1 (en) * | 2002-09-09 | 2004-03-18 | Cellular Genomics, Inc. | 6-ARYL-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINES, METHOD OF MAKING, AND METHOD OF USE THEREOF |
CN100549011C (zh) * | 2002-09-19 | 2009-10-14 | 先灵公司 | 用作细胞周期蛋白依赖性激酶抑制剂的新颖咪唑并吡啶 |
AR041292A1 (es) | 2002-09-19 | 2005-05-11 | Schering Corp | Pirazolopiridinas como inhibidores de quinasa dependientes de ciclina |
KR20060010709A (ko) * | 2002-09-23 | 2006-02-02 | 쉐링 코포레이션 | 사이클린 의존성 키나제 억제제로서의 신규한 이미다조피라진 |
EP1543008B1 (de) * | 2002-09-23 | 2007-11-07 | Schering Corporation | Imidazopyrazine als cdk-inhibitoren |
US7417053B2 (en) * | 2005-04-07 | 2008-08-26 | Teijin Pharma Limited | Pyrazolo[1,5-a]pyridine derivatives or pharmaceutically acceptable salts thereof |
EP1931641B1 (de) * | 2005-09-09 | 2010-08-25 | Schering Corporation | Neue 4-cyano-, 4-amino-, und 4-aminomethylderivative von pyrazolo[1,5-a]pyridinen, pyrazolo[1,5-c]pyrimidinen und 2h-indazolverbindungen und 5-cyano-, 5-amino- und 5-aminomethylderivative von imidazo[1,2-a]pyridinen, und imidazo[1,5-a]pyrazinverbindungen als inhibitoren der cyclinabhänggen kinase |
-
2006
- 2006-08-31 EP EP06802808A patent/EP1931641B1/de active Active
- 2006-08-31 WO PCT/US2006/034233 patent/WO2007032936A2/en active Application Filing
- 2006-08-31 US US11/514,548 patent/US7700773B2/en not_active Expired - Fee Related
- 2006-08-31 ES ES06802808T patent/ES2349476T3/es active Active
- 2006-08-31 DE DE602006016455T patent/DE602006016455D1/de active Active
- 2006-08-31 JP JP2008530115A patent/JP2009507843A/ja active Pending
- 2006-08-31 CN CNA2006800412880A patent/CN101300233A/zh active Pending
- 2006-08-31 AT AT06802808T patent/ATE478852T1/de not_active IP Right Cessation
- 2006-08-31 CA CA002621983A patent/CA2621983A1/en not_active Abandoned
-
2008
- 2008-06-27 HK HK08107150.3A patent/HK1112229A1/xx not_active IP Right Cessation
-
2010
- 2010-02-16 US US12/706,551 patent/US20100143384A1/en not_active Abandoned
- 2010-02-17 US US12/706,814 patent/US20100137326A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2007032936A2 (en) | 2007-03-22 |
DE602006016455D1 (de) | 2010-10-07 |
US7700773B2 (en) | 2010-04-20 |
CN101300233A (zh) | 2008-11-05 |
US20100137326A1 (en) | 2010-06-03 |
HK1112229A1 (en) | 2008-08-29 |
ES2349476T3 (es) | 2011-01-03 |
JP2009507843A (ja) | 2009-02-26 |
US20100143384A1 (en) | 2010-06-10 |
EP1931641A2 (de) | 2008-06-18 |
CA2621983A1 (en) | 2007-03-22 |
EP1931641B1 (de) | 2010-08-25 |
WO2007032936A3 (en) | 2007-05-03 |
US20070066621A1 (en) | 2007-03-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE478852T1 (de) | Neue 4-cyano-, 4-amino-, und 4- aminomethylderivative von pyrazoloä1,5- aüpyridinen, pyrazoloä1,5-cüpyrimidinen und 2h- indazolverbindungen und 5-cyano-, 5-amino- und 5- aminomethylderivative von imidazoä1,2-aüpyridinen,und imidazoä1,5-aüpyrazinverbindungen als inhibitoren der cyclinabhänggen kinase | |
ATE470668T1 (de) | Pyrazolopyrimidine als inhibitoren von cyclinabhängiger kinase zur behandlung von krebs | |
BRPI0314001B8 (pt) | pirazolopirimidinas como inibidores de cinase dependente de ciclina e composição farmacêutica compreendendo as mesmas | |
TW200745123A (en) | Pyrazolopyrimidines as protein kinase inhibitors | |
TW200745128A (en) | Pyrazolopyrimidines as protein kinase inhibitors | |
MY149044A (en) | Pyrazolopyrimidines - derivatives as cyclin dependent kinase inhibitors | |
MX2009011355A (es) | Nuevas pirazolopirimidinas como inhibidores de quinasas dependientes de ciclinas. | |
TW200745127A (en) | Pyrazolopyrimidines as protein kinase inhibitors | |
WO2007044449A3 (en) | Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors | |
MY133311A (en) | Novel imidazopyridines as cyclin dependent kinase inhibitors | |
WO2007044401A3 (en) | Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors | |
WO2007058873A3 (en) | Imidazopyrazines as cyclin depentend kinase inhibitors | |
MY139336A (en) | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | |
MY137843A (en) | Pyrazolopyrimidines as cyclin dependent kinase inhibitors | |
MX2009003733A (es) | Pirazolopirimidinas como inhibidores de quinasas dependientes de ciclina. | |
MY134589A (en) | Imidazopyrazines as cyclin dependent kinase inhibitors | |
MY137888A (en) | Pyrazolopyrimidines as cyclin dependent kinase inhibitors | |
WO2008045267A3 (en) | Pyrazolopyrimidines as cyclin dependent kinase inhibitors | |
UA95230C2 (ru) | ЗАМЕЩЕННЫЕ ТЕТРАГИДРОПИРИМИДО[4,5-d]ПИРИМИДИНЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ИХ, И ИХ ПРИМЕНЕНИЕ | |
MY188338A (en) | Imidazotriazines and imidazopyrimidines as kinase inhibitors | |
WO2004026310A8 (en) | Novel imidazopyrazines as cyclin dependent kinase inhibitors | |
MX2009003734A (es) | Pirazolopirimidinas como inhibidor de cinasas dependientes de ciclina. | |
MY136840A (en) | Pyrazolopyridines as cyclin dependent kinase inhibitors | |
NO20080418L (no) | Pyrido[2,3-D]pyrimidiriderivater, fremgangsmate for fremstilling derav og terapeutisk anvendelse av samme | |
MY138201A (en) | Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |