BR0308113A - Compostos macrocìclicos úteis como substâncias farmacêuticas - Google Patents

Compostos macrocìclicos úteis como substâncias farmacêuticas

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Publication number
BR0308113A
BR0308113A BR0308113-3A BR0308113A BR0308113A BR 0308113 A BR0308113 A BR 0308113A BR 0308113 A BR0308113 A BR 0308113A BR 0308113 A BR0308113 A BR 0308113A
Authority
BR
Brazil
Prior art keywords
pharmaceutical substances
macrocyclic compounds
compounds useful
present
disorders
Prior art date
Application number
BR0308113-3A
Other languages
English (en)
Other versions
BRPI0308113B8 (pt
BRPI0308113B1 (pt
Inventor
Roch Boivin
Kenichi Chiba
Jesse Chow
Hong Du
Yoshihito Eguchi
Masanori Fujita
Masaki Goto
Fabian Gusovsky
Jean-Christophe Harmange
Atsushi Inoue
Yimin Jiang
Megumi Kawada
Takatoshi Kawai
Yoshiyuki Kawakami
Akifumi Kimura
Makoto Kotake
Yoshikazu Kuboi
Charles-Andre Lemelin
Xiang-Yi Li
Tomohiro Matsushima
Yoshiharu Mizui
Kenzo Muramoto
Hideki Sakurai
Yong-Chun Shen
Hiroshi Shirota
Mark Spyvee
Isao Tanaka
John Wang
Satoshi Yamamoto
Naoki Yoneda
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of BR0308113A publication Critical patent/BR0308113A/pt
Publication of BRPI0308113B1 publication Critical patent/BRPI0308113B1/pt
Publication of BRPI0308113B8 publication Critical patent/BRPI0308113B8/pt

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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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  • Ophthalmology & Optometry (AREA)

Abstract

"COMPOSTOS MACROCìCLICOS úTEIS COMO SUBSTâNCIAS FARMACêUTICAS". A presente invenção provê compostos possuindo a fórmula (I) e, adicionalmente, provê, processos para síntese dos mesmos e para uso dos mesmos no tratamento de vários distúrbios incluindo distúrbios inflamatórios e autoimunes e distúrbios envolvendo malignidade ou angiogenese aumentada, onde R~ 1~-R~ 11~, X, Y, Z, e n são conforme definido aqui.
BRPI0308113A 2002-03-08 2003-03-07 compostos macrocíclicos úteis como substâncias farmacêuticas BRPI0308113B8 (pt)

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Families Citing this family (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003076424A1 (en) 2002-03-08 2003-09-18 Eisai Co. Ltd. Macrocyclic compounds useful as pharmaceuticals
US7915306B2 (en) * 2002-03-08 2011-03-29 Eisai Co., Ltd. Macrocyclic compounds useful as pharmaceuticals
EP1633774B1 (en) 2003-06-18 2010-02-17 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor
US20060037617A1 (en) * 2004-04-19 2006-02-23 Walke Amrish J Airway implant devices and methods of use
AU2005244988C1 (en) 2004-05-21 2012-06-28 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
US7329495B2 (en) 2004-06-09 2008-02-12 Board Of Regents, The University Of Texas System Mutations in KIT confer imatinib resistance in gastrointestinal stromal tumors
EP1937845B1 (en) 2005-08-01 2015-06-10 The Ohio State University Research Foundation Micro-rna-based methods and compositions for the diagnosis, prognosis and treatment of breast cancer
ES2523989T3 (es) 2005-09-12 2014-12-03 The Ohio State University Research Foundation Composiciones para la terapia de cánceres asociados con BCL2
CN104211655B (zh) * 2005-12-14 2016-08-17 云南维和药业股份有限公司 具有抗菌和抗肿瘤活性的大环内酯化合物
EP2586455B1 (en) 2006-01-05 2014-06-25 The Ohio State University Research Foundation MicroRNA expressions abnormalities in pancreatic endocrine and acinar tumors
EP2479285B1 (en) 2006-01-05 2014-05-14 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers
AU2007205234B2 (en) 2006-01-05 2012-07-12 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer
EP1996731A2 (en) 2006-03-20 2008-12-03 The Ohio State University Research Foundation Microrna fingerprints during human megakaryocytopoiesis
US8486921B2 (en) 2006-04-07 2013-07-16 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
US7601852B2 (en) * 2006-05-11 2009-10-13 Kosan Biosciences Incorporated Macrocyclic kinase inhibitors
EP2455493B1 (en) 2006-07-13 2014-01-08 The Ohio State University Research Foundation Micro-RNA-based methods and compositions for the diagnosis and treatment of colon related diseases
US8067412B2 (en) 2006-08-11 2011-11-29 Universite De Strasbourg Macrocyclic compounds useful as inhibitors of kinases and HSP90
WO2008097277A2 (en) 2006-09-19 2008-08-14 The Ohio State University Research Foundation Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181
AU2007304880B9 (en) * 2006-10-04 2012-11-08 Bionomics Limited Novel benzofuran potassium channel blockers and uses thereof
EP3056487B1 (en) 2006-10-11 2018-02-21 President and Fellows of Harvard College Synthesis of enone intermediate
JP5501766B2 (ja) 2006-11-01 2014-05-28 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 肝細胞癌における生存および転移を予測するためのマイクロｒｎａ発現サイン
ES2379696T3 (es) * 2006-12-18 2012-04-30 F. Hoffmann-La Roche Ag Procedimiento para la preparación de la 3,5-di-omicron-acil-2-fluoro-2-C-metil-D-ribono-gamma-lactona
CA2674895A1 (en) 2007-01-31 2008-08-07 The Ohio State University Research Foundation Microrna-based methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (aml)
US8513440B2 (en) * 2007-06-05 2013-08-20 Universite De Strasbourg Compositions and methods comprising analogues of radicicol A
CN101711287B (zh) 2007-06-08 2016-04-27 由卫生与公众服务部代表的美利坚合众国政府 确定肝细胞癌亚型和检测肝癌干细胞的方法
CN101918424A (zh) 2007-06-15 2010-12-15 俄亥俄州立大学研究基金会 用于靶向由Drosha介导的微小RNA加工的致癌ALL-1融合蛋白
ES2670423T3 (es) * 2007-07-25 2018-05-30 Eisai R&D Management Co., Ltd. Inhibidores de multicinasas para uso en el tratamiento de cáncer
TW200924749A (en) * 2007-07-25 2009-06-16 Eisai R & Amp D Man Co Ltd Zearalenone macrolide derivatives and uses of the same
CN101809169B (zh) 2007-07-31 2013-07-17 俄亥俄州立大学研究基金会 通过靶向dnmt3a和dnmt3b恢复甲基化的方法
EP2653561B1 (en) 2007-08-03 2016-03-02 The Ohio State University Research Foundation Ultraconserved regions encoding ncRNAs
JP5770472B2 (ja) 2007-08-22 2015-08-26 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイションＴｈｅ Ｏｈｉｏ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ ヒト急性白血病におけるｅｐｈａ７及びｅｒｋリン酸化の調節解除を誘発するための方法及び組成物
EP2197832A4 (en) 2007-10-04 2013-10-30 Bionomics Ltd NOVEL ARYL GROUP POTASSIUM CHANNEL INHIBITORS AND USES THEREOF
WO2009055773A2 (en) 2007-10-26 2009-04-30 The Ohio State University Research Foundation Methods for identifying fragile histidine triad (fhit) interaction and uses thereof
AU2013203117B2 (en) * 2007-10-29 2015-09-03 Eisai R & D Management Co., Ltd. Methods for prognosing the ability of a zearalenone analog compound to treat cancer
JP5564431B2 (ja) * 2007-10-29 2014-07-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 ゼアラレノンアナログ化合物ががんを処置する能力を予測する方法
EP2231635B1 (en) * 2007-12-07 2014-03-19 Eisai R&D Management Co., Ltd. Intermediates and methods for making zearalenone macrolide analogs
US20110190237A1 (en) * 2008-01-15 2011-08-04 Nexgenix Pharmaceuticals Macrocyclic Prodrug Compounds Useful as Therapeutics
KR101640951B1 (ko) 2008-02-21 2016-07-29 온코시너지, 인코포레이티드 치료제로서 유용한 거대고리 프로드러그
CN102112440A (zh) 2008-05-30 2011-06-29 武田药品工业株式会社 杂环化合物
EP2307028B1 (en) 2008-06-11 2013-10-02 The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services Use of mir-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy
WO2009149508A1 (en) 2008-06-13 2009-12-17 Bionomics Limited Novel potassium channel blockers and uses thereof
MX2011002470A (es) 2008-09-08 2011-04-05 Merck Patent Gmbh Pirimidinas macrociclicas como inhibidores de aurora cinasa.
CN102271706A (zh) * 2008-11-21 2011-12-07 俄亥俄州立大学研究基金会 作为转录调节剂的Tcl1
JP2012512224A (ja) * 2008-12-17 2012-05-31 サノフイ マクロラクトン誘導体、その製造方法、及びがんの処置のためのその使用
WO2010126607A2 (en) 2009-04-30 2010-11-04 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
AU2010299835A1 (en) 2009-09-28 2012-04-05 Centre National De La Recherche Scientifique Irreversible inhibitors useful for the treatment of kinase-related pathologies
CN102803511A (zh) 2009-11-23 2012-11-28 俄亥俄州立大学 用于影响肿瘤细胞生长、迁移和侵袭的材料和方法
JP5931897B2 (ja) 2010-11-12 2016-06-08 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイションＴｈｅ Ｏｈｉｏ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ マイクロｒｎａ−２１、ミスマッチ修復および結腸直腸癌に関連する物質および方法
US10758619B2 (en) 2010-11-15 2020-09-01 The Ohio State University Controlled release mucoadhesive systems
US8664192B2 (en) 2011-03-07 2014-03-04 The Ohio State University Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer
WO2013013188A1 (en) 2011-07-21 2013-01-24 Tolero Pharmaceuticals, Inc. Heterocyclic protein kinase inhibitors
US9963481B2 (en) 2011-09-07 2018-05-08 The Scripps Research Institute Chiral oligomeric pentenoate amides as bio-oligomer mimetics
AU2012323924A1 (en) 2011-10-14 2014-05-29 The Ohio State University Methods and materials related to ovarian cancer
WO2013090556A1 (en) 2011-12-13 2013-06-20 The Ohio State University Methods and compositions related to mir-21 and mir-29a, exosome inhibition, and cancer metastasis
KR101983421B1 (ko) * 2011-12-27 2019-05-29 디에스엠 아이피 어셋츠 비.브이. 비타민 a 중간체의 촉매 합성법
CA2860676A1 (en) 2012-01-09 2013-07-18 Novartis Ag Organic compositions to treat beta-catenin-related diseases
WO2013110053A1 (en) 2012-01-20 2013-07-25 The Ohio State University Breast cancer biomarker signatures for invasiveness and prognosis
WO2013133343A1 (ja) * 2012-03-08 2013-09-12 国立大学法人豊橋技術科学大学 含フッ素α，β－不飽和アルデヒド及びその製造方法、並びに含フッ素α，β－不飽和アルデヒドを用いた光学活性含フッ素化合物及びその製造方法
ES2649905T3 (es) * 2012-03-30 2018-01-16 Daiichi Sankyo Company, Limited Derivado de ácido (2-heteroarilamino)succínico
JP6243918B2 (ja) 2012-10-16 2017-12-06 トレロ ファーマシューティカルズ， インコーポレイテッド Ｐｋｍ２調節因子およびそれらの使用方法
US9498532B2 (en) 2013-03-13 2016-11-22 Novartis Ag Antibody drug conjugates
TR201911151T4 (tr) 2013-03-14 2019-08-21 Tolero Pharmaceuticals Inc Jak2 ve alk2 inhibitörleri ve bunların kullanım yöntemleri.
NZ710929A (en) 2013-03-15 2018-02-23 Novartis Ag Antibody drug conjugates
WO2015181628A1 (en) * 2014-05-27 2015-12-03 Eisai R&D Management Co., Ltd. Treatment of acute myeloid leukemia with an hck inhibitor
US10786578B2 (en) 2014-08-05 2020-09-29 Novartis Ag CKIT antibody drug conjugates
CN106659790A (zh) 2014-08-12 2017-05-10 诺华股份有限公司 抗cdh6抗体药物缀合物
JP6681905B2 (ja) 2014-09-13 2020-04-15 ノバルティス アーゲー Ａｌｋ阻害剤の併用療法
AU2015327868A1 (en) 2014-10-03 2017-04-20 Novartis Ag Combination therapies
KR20170084202A (ko) 2014-11-14 2017-07-19 노파르티스 아게 항체 약물 접합체
WO2016100882A1 (en) 2014-12-19 2016-06-23 Novartis Ag Combination therapies
SI3237418T1 (sl) 2014-12-23 2019-06-28 Novartis Ag Spojine triazolopirimidina in njihove uporabe
MX2017012295A (es) 2015-03-25 2018-01-09 Novartis Ag Derivados formilados n-heterociclicos como inhibidores de fgfr4.
WO2016196256A2 (en) 2015-06-04 2016-12-08 University Of North Carolina At Greensboro Non-aromatic difluoro analogues of resorcylic acid lactones
EP3310813A1 (en) 2015-06-17 2018-04-25 Novartis AG Antibody drug conjugates
MA44334A (fr) 2015-10-29 2018-09-05 Novartis Ag Conjugués d'anticorps comprenant un agoniste du récepteur de type toll
EP3415008A4 (en) 2016-02-08 2019-09-11 SDS Biotech K. K. GERMIC COMPOSITION
EP3472161B1 (en) 2016-06-20 2020-03-25 Novartis AG Triazolopyridine compounds and uses thereof
CN109790166A (zh) 2016-06-20 2019-05-21 诺华股份有限公司 咪唑并吡啶化合物用于治疗癌症
MX2018016331A (es) 2016-06-20 2019-05-20 Novartis Ag Formas cristalinas de compuesto de triazolopirimidina.
WO2018163051A1 (en) 2017-03-06 2018-09-13 Novartis Ag Methods of treatment of cancer with reduced ubb expression
WO2018185618A1 (en) 2017-04-03 2018-10-11 Novartis Ag Anti-cdh6 antibody drug conjugates and anti-gitr antibody combinations and methods of treatment
AR111651A1 (es) 2017-04-28 2019-08-07 Novartis Ag Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación
AU2018274216A1 (en) 2017-05-24 2019-12-12 Novartis Ag Antibody-cytokine engrafted proteins and methods of use in the treatment of cancer
EP3630162A1 (en) 2017-05-24 2020-04-08 Novartis AG Antibody-cytokine engrafted proteins and methods of use
WO2018215937A1 (en) 2017-05-24 2018-11-29 Novartis Ag Interleukin-7 antibody cytokine engrafted proteins and methods of use in the treatment of cancer
CN111655288A (zh) 2017-11-16 2020-09-11 诺华股份有限公司 组合疗法
CN112533602A (zh) 2018-04-05 2021-03-19 大日本住友制药肿瘤公司 Axl激酶抑制剂及其用途
AR116109A1 (es) 2018-07-10 2021-03-31 Novartis Ag Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
JOP20210001A1 (ar) 2018-07-10 2021-01-05 Novartis Ag مشتقات 3-(5- هيدروكسي -1- أوكسو أيزو إندولين -2- يل) بيبريدين -2، 6- دايون واستخدامها لمعالجة أمراض مرتبطة ببروتين ذات أصبع الزنك من عائلة (ikaros 2 (ikzf2
KR102643582B1 (ko) 2018-07-25 2024-03-05 어드밴스드 엑셀러레이터 어플리케이션즈 안정한 농축 방사성 핵종 복합체 용액
WO2020021465A1 (en) 2018-07-25 2020-01-30 Advanced Accelerator Applications (Italy) S.R.L. Method of treatment of neuroendocrine tumors
CA3103995A1 (en) 2018-07-26 2020-01-30 Sumitomo Dainippon Pharma Oncology, Inc. Methods for treating diseases associated with abnormal acvr1 expression and acvr1 inhibitors for use in the same
JP7328323B2 (ja) 2018-08-17 2023-08-16 ノバルティス アーゲー ＳＭＡＲＣＡ２／ＢＲＭ ＡＴＰａｓｅ阻害剤としての尿素化合物及び組成物
US20210346527A1 (en) 2018-09-25 2021-11-11 Advanced Accelerator Applications (Italy) Srl Combination Therapy
JP7518533B2 (ja) * 2018-10-29 2024-07-18 公立大学法人大阪 新規イノン化合物及びその用途
EP3873532A1 (en) 2018-10-31 2021-09-08 Novartis AG Dc-sign antibody drug conjugates
KR20210106437A (ko) 2018-12-20 2021-08-30 노파르티스 아게 3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체를 포함하는 투약 요법 및 약학적 조합물
MX2021009371A (es) 2019-02-12 2021-09-10 Sumitomo Pharma Oncology Inc Formulaciones que comprenden inhibidores de proteina cinasa heterociclicos.
CN113490528A (zh) 2019-02-15 2021-10-08 诺华股份有限公司 3-(1-氧代-5-(哌啶-4-基)异吲哚啉-2-基)哌啶-2,6-二酮衍生物及其用途
EP3924055B1 (en) 2019-02-15 2024-04-03 Novartis AG Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
MX2021011289A (es) 2019-03-22 2021-11-03 Sumitomo Pharma Oncology Inc Composiciones que comprenden moduladores de isoenzima m2 muscular de piruvato cinasa pkm2 y metodos de tratamiento que usan las mismas.
CA3145864A1 (en) 2019-07-03 2021-01-07 Sumitomo Dainippon Pharma Oncology, Inc. Tyrosine kinase non-receptor 1 (tnk1) inhibitors and uses thereof
JP2022550353A (ja) 2019-09-26 2022-12-01 ノバルティス アーゲー アザキノリン化合物およびその使用
WO2021110968A1 (en) 2019-12-04 2021-06-10 Aarhus Universitet Macrocylces comprising a 4-amido-2,4-pentadienoate moiety for the treatment of hypoxic cancers
MX2022007759A (es) 2019-12-20 2022-07-19 Novartis Ag Combinacion del anticuerpo anti tim-3 mbg453 y anticuerpo anti tgf-beta nis793, con o sin decitabina o el anticuerpo anti pd-1 spartalizumab, para el tratamiento de mielofibrosis y sindrome mielodisplasico.
AU2021288224A1 (en) 2020-06-11 2023-01-05 Novartis Ag ZBTB32 inhibitors and uses thereof
CN115916199A (zh) 2020-06-23 2023-04-04 诺华股份有限公司 包含3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物的给药方案
EP4188549A1 (en) 2020-08-03 2023-06-07 Novartis AG Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
AR123185A1 (es) 2020-08-10 2022-11-09 Novartis Ag Compuestos y composiciones para inhibir ezh2
CN111875470B (zh) * 2020-08-17 2023-02-03 苏州正济药业有限公司 一种用于制备艾日布林的中间体(r)-2-甲基-1-溴-3-碘-3-丁烯的制备方法
WO2022043557A1 (en) 2020-08-31 2022-03-03 Advanced Accelerator Applications International Sa Method of treating psma-expressing cancers
WO2022043558A1 (en) 2020-08-31 2022-03-03 Advanced Accelerator Applications International Sa Method of treating psma-expressing cancers
WO2022043556A1 (en) 2020-08-31 2022-03-03 Novartis Ag Stable radiopharmaceutical composition
TW202237119A (zh) 2020-12-10 2022-10-01 美商住友製藥腫瘤公司 Ａｌｋ﹘５抑制劑和彼之用途
CN117794929A (zh) 2021-02-02 2024-03-29 法国施维雅药厂 选择性bcl-xl protac化合物及使用方法
WO2022195551A1 (en) 2021-03-18 2022-09-22 Novartis Ag Biomarkers for cancer and methods of use thereof
TW202304979A (zh) 2021-04-07 2023-02-01 瑞士商諾華公司 抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途
PE20240327A1 (es) 2021-04-13 2024-02-22 Nuvalent Inc Heterociclos con sustitucion amino para tratar canceres con mutaciones de egfr
AR125874A1 (es) 2021-05-18 2023-08-23 Novartis Ag Terapias de combinación
CN113583036B (zh) * 2021-08-02 2024-09-06 上海兆维科技发展有限公司 一种化合物的制备方法
WO2023214325A1 (en) 2022-05-05 2023-11-09 Novartis Ag Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors
WO2023225320A1 (en) 2022-05-20 2023-11-23 Novartis Ag Epha2 bcl-xl inhibitor antibody-drug conjugates and methods of use thereof
CN115304967B (zh) * 2022-07-22 2023-08-15 大连奥首科技有限公司 一种晶圆切割保护液、制备方法、用途及切割方法
WO2024023666A1 (en) 2022-07-26 2024-02-01 Novartis Ag Crystalline forms of an akr1c3 dependent kars inhibitor
CN115154460A (zh) * 2022-08-10 2022-10-11 浙江大学 大环类化合物在制备治疗血液瘤药物中的应用
WO2024189481A1 (en) 2023-03-10 2024-09-19 Novartis Ag Panras inhibitor antibody-drug conjugates and methods of use thereof

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB323845A (en) 1928-10-30 1930-01-16 John Thomas Hay Corrosion resistant ferrous alloy
US4336243A (en) 1980-08-11 1982-06-22 G. D. Searle & Co. Transdermal nitroglycerin pad
US4768523A (en) 1981-04-29 1988-09-06 Lifecore Biomedical, Inc. Hydrogel adhesive
US4751087A (en) 1985-04-19 1988-06-14 Riker Laboratories, Inc. Transdermal nitroglycerin delivery system
US4615699A (en) 1985-05-03 1986-10-07 Alza Corporation Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US5041126A (en) 1987-03-13 1991-08-20 Cook Incorporated Endovascular stent and delivery system
US5213580A (en) 1988-08-24 1993-05-25 Endoluminal Therapeutics, Inc. Biodegradable polymeric endoluminal sealing process
US5328471A (en) 1990-02-26 1994-07-12 Endoluminal Therapeutics, Inc. Method and apparatus for treatment of focal disease in hollow tubular organs and other tissue lumens
US5089606A (en) 1989-01-24 1992-02-18 Minnesota Mining And Manufacturing Company Water-insoluble polysaccharide hydrogel foam for medical applications
US5052998A (en) 1990-04-04 1991-10-01 Zimmon David S Indwelling stent and method of use
US5064435A (en) 1990-06-28 1991-11-12 Schneider (Usa) Inc. Self-expanding prosthesis having stable axial length
US5147370A (en) 1991-06-12 1992-09-15 Mcnamara Thomas O Nitinol stent for hollow body conduits
US5176626A (en) 1992-01-15 1993-01-05 Wilson-Cook Medical, Inc. Indwelling stent
US5224166A (en) * 1992-08-11 1993-06-29 International Business Machines Corporation System for seamless processing of encrypted and non-encrypted data and instructions
GB9225396D0 (en) 1992-12-04 1993-01-27 Sandoz Ltd Improvements in or relating to organic compounds
JPH0840893A (ja) * 1993-08-31 1996-02-13 Takeda Chem Ind Ltd インターロイキン−１産生抑制剤
US5795910A (en) * 1994-10-28 1998-08-18 Cor Therapeutics, Inc. Method and compositions for inhibiting protein kinases
US6231600B1 (en) 1995-02-22 2001-05-15 Scimed Life Systems, Inc. Stents with hybrid coating for medical devices
US5837313A (en) 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
US5837224A (en) 1996-01-19 1998-11-17 The Regents Of The University Of Michigan Method of inhibiting photoaging of skin
US5892826A (en) * 1996-01-30 1999-04-06 Motorola, Inc. Data processor with flexible data encryption
US5727726A (en) * 1996-06-14 1998-03-17 Newco Pneumatic Corp. Cassette assembly for a stapling mechanism
ZA9710342B (en) 1996-11-25 1998-06-10 Alza Corp Directional drug delivery stent and method of use.
US6515016B2 (en) 1996-12-02 2003-02-04 Angiotech Pharmaceuticals, Inc. Composition and methods of paclitaxel for treating psoriasis
US6265603B1 (en) * 1997-02-27 2001-07-24 Eisai Co., Ltd. Inhibitors of isoprenyl transferase
GB2323845A (en) 1997-03-31 1998-10-07 Merck & Co Inc MEK inhibiting lactones
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
TWI234467B (en) 1997-06-04 2005-06-21 Univ Michigan Composition for inhibiting photoaging of skin
US5891507A (en) 1997-07-28 1999-04-06 Iowa-India Investments Company Limited Process for coating a surface of a metallic stent
US6153252A (en) 1998-06-30 2000-11-28 Ethicon, Inc. Process for coating stents
US6248127B1 (en) 1998-08-21 2001-06-19 Medtronic Ave, Inc. Thromboresistant coated medical device
JP2002533389A (ja) * 1998-12-24 2002-10-08 ノーベーション ファーマシューティカルズ インコーポレーテッド ｍＲＮＡ安定性に影響する化合物およびそのための使用
GB9828709D0 (en) 1998-12-24 1999-02-17 Novartis Ag Assay
US6258121B1 (en) 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
US6203551B1 (en) 1999-10-04 2001-03-20 Advanced Cardiovascular Systems, Inc. Chamber for applying therapeutic substances to an implant device
AU1607501A (en) 1999-11-15 2001-05-30 Drug Innovation & Design, Inc. Selective cellular targeting: multifunctional delivery vehicles
US6251136B1 (en) 1999-12-08 2001-06-26 Advanced Cardiovascular Systems, Inc. Method of layering a three-coated stent using pharmacological and polymeric agents
JP2001294527A (ja) 2000-04-14 2001-10-23 Ajinomoto Co Inc Ｔｈ２反応に特異的な免疫寛容誘導剤
JP2004292315A (ja) 2000-12-14 2004-10-21 Chugai Pharmaceut Co Ltd Ｔａｋ１阻害剤
JP2004292314A (ja) 2000-12-14 2004-10-21 Chugai Pharmaceut Co Ltd ケラチノサイト増殖抑制剤
US6517889B1 (en) 2001-11-26 2003-02-11 Swaminathan Jayaraman Process for coating a surface of a stent
US7915306B2 (en) * 2002-03-08 2011-03-29 Eisai Co., Ltd. Macrocyclic compounds useful as pharmaceuticals
WO2003076424A1 (en) * 2002-03-08 2003-09-18 Eisai Co. Ltd. Macrocyclic compounds useful as pharmaceuticals
ES2670423T3 (es) * 2007-07-25 2018-05-30 Eisai R&D Management Co., Ltd. Inhibidores de multicinasas para uso en el tratamiento de cáncer
EP2231635B1 (en) * 2007-12-07 2014-03-19 Eisai R&D Management Co., Ltd. Intermediates and methods for making zearalenone macrolide analogs
US8578879B2 (en) * 2009-07-29 2013-11-12 Applied Materials, Inc. Apparatus for VHF impedance match tuning

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NZ535101A (en) 2007-07-27
KR101210018B1 (ko) 2012-12-07
AU2003224672A1 (en) 2003-09-22
EP2308861A1 (en) 2011-04-13
CN104876904A (zh) 2015-09-02
ZA200407156B (en) 2006-12-27
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TWI343916B (en) 2011-06-21
JP2005519954A (ja) 2005-07-07
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CA2478065A1 (en) 2003-09-18
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CN1653059A (zh) 2005-08-10

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