TR200103016T2 - CDK2 önleyicileri olarak pirazolobenzodiazepinler - Google Patents

CDK2 önleyicileri olarak pirazolobenzodiazepinler

Info

Publication number
TR200103016T2
TR200103016T2 TR2001/03016T TR200103016T TR200103016T2 TR 200103016 T2 TR200103016 T2 TR 200103016T2 TR 2001/03016 T TR2001/03016 T TR 2001/03016T TR 200103016 T TR200103016 T TR 200103016T TR 200103016 T2 TR200103016 T2 TR 200103016T2
Authority
TR
Turkey
Prior art keywords
pirazolobenzodiazepines
formula
cdk2 inhibitors
cdk2
pyrazolobenzodiazepines
Prior art date
Application number
TR2001/03016T
Other languages
English (en)
Inventor
Ding Qingjie
Liu Jin-Jun
Stewart Madison Vincent
Pizzolato Giacomo
Chen Wei Chung
Michael Wovkulich Peter
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of TR200103016T2 publication Critical patent/TR200103016T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/22—Sulfur atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

R1, R2, R3 ve R4'ün burada tanimlandigi gibi oldugu formül (I)'e ait yeni pirazolobenzodiazepinler ve bunlarin farmasötik açidan kabul gören tuzlari, sikline bagli kinazlari (CDKler), özellikle de CDK2'yi önler; bunlar, hücre artisi olan bozukluklarin özellikle gögüs, kolon, akciger ve prostat tümörlerinin tedavisinde ya da kontrolünde faydali anti-proliferatif maddelerdir. (FORMÜL VAR)
TR2001/03016T 1999-04-21 2000-04-14 CDK2 önleyicileri olarak pirazolobenzodiazepinler TR200103016T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13037099P 1999-04-21 1999-04-21

Publications (1)

Publication Number Publication Date
TR200103016T2 true TR200103016T2 (tr) 2002-04-22

Family

ID=22444382

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/03016T TR200103016T2 (tr) 1999-04-21 2000-04-14 CDK2 önleyicileri olarak pirazolobenzodiazepinler

Country Status (33)

Country Link
US (3) US6440959B1 (tr)
EP (1) EP1185529B1 (tr)
JP (1) JP3746680B2 (tr)
KR (1) KR100481757B1 (tr)
CN (2) CN1279029C (tr)
AR (1) AR023542A1 (tr)
AT (1) ATE279413T1 (tr)
AU (1) AU768667B2 (tr)
BR (1) BR0009887A (tr)
CA (1) CA2367704C (tr)
CO (1) CO5170444A1 (tr)
CZ (1) CZ20013738A3 (tr)
DE (1) DE60014893T2 (tr)
DK (1) DK1185529T3 (tr)
ES (1) ES2228522T3 (tr)
HK (1) HK1046278B (tr)
HR (1) HRP20010742A2 (tr)
HU (1) HUP0300318A3 (tr)
IL (1) IL145764A0 (tr)
JO (1) JO2248B1 (tr)
MA (1) MA26782A1 (tr)
NO (1) NO20015065D0 (tr)
NZ (1) NZ514523A (tr)
PE (1) PE20010054A1 (tr)
PL (1) PL200933B1 (tr)
PT (1) PT1185529E (tr)
RU (1) RU2249593C2 (tr)
SI (1) SI1185529T1 (tr)
TR (1) TR200103016T2 (tr)
TW (1) TW585866B (tr)
WO (1) WO2000064900A1 (tr)
YU (1) YU73101A (tr)
ZA (1) ZA200108016B (tr)

Families Citing this family (34)

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PT1443937E (pt) * 2001-11-13 2008-09-23 Ortho Mcneil Janssen Pharm 1,4-benzodiazepinas substituídas e as suas utilizações para o tratamento de cancro
FR2847253B1 (fr) * 2002-11-19 2007-05-18 Aventis Pharma Sa Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant
MXPA05009151A (es) * 2003-02-27 2005-10-20 Abbott Lab Inhibidores de cinasa heterociclica.
ES2308551T3 (es) * 2004-10-13 2008-12-01 F. Hoffmann-La Roche Ag Pirazolobenzodiazepinas disustituidas utiles como inhibidores para cdk2 y angiogenesis, y para el tratamiento de cancer de mama, colon, pulmon y prostata.
CA2624025A1 (en) * 2005-10-14 2007-04-19 F. Hoffmann-La Roche Ag Regimen of administration for 5-(2-chlorophenyl)-1 ,2-dihydro-7-fluoro-8-methoxy-3-methyl-pyrazolo [3, 4.-b] [1, 4] benzodiazepine
KR20170091770A (ko) 2006-07-10 2017-08-09 파이온 유케이 리미티드 속효형 벤조디아제핀 염 및 이의 중합체 형태
KR20100073454A (ko) * 2008-12-23 2010-07-01 국립암센터 트란스글루타미나제 억제제로 사용되는 신규한 피라졸로디아제핀계 화합물, 이의 제조방법 및 이를 포함하는 조성물
EP2305647A1 (en) 2009-09-18 2011-04-06 PAION UK Limited Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
EA028595B1 (ru) * 2012-02-02 2017-12-29 Сенекс Биотекнолоджи Инк. Селективные ингибиторы cdk8/cdk19 и их применение в качестве противометастатических и химиопрофилактических агентов для лечения рака
CN102603743B (zh) * 2012-02-24 2014-05-28 南京天易生物科技有限公司 抗肿瘤的氮杂苯并[f]薁衍生物其制备方法及其用途
CN103288830A (zh) * 2012-02-24 2013-09-11 中国科学院大连化学物理研究所 一种合成手性二氢-5H-吡咯并[2,1-c][1,4]-苯并二氮杂卓的方法
CN103288828A (zh) * 2012-02-24 2013-09-11 中国科学院大连化学物理研究所 一种合成手性二氢-6H-吲哚并[2,1-c][1,4]-苯并二氮杂卓的方法
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
CN106608877B (zh) * 2015-10-21 2018-11-13 新发药业有限公司 一种依鲁替尼中间体4-氨基-3-（4-苯氧基）苯基-1H-吡唑并[3,4-d]嘧啶的制备方法
EP3535253A1 (en) * 2016-11-01 2019-09-11 H. Hoffnabb-La Roche Ag 1,3-dihydro-1,4-benzodiazepine-2-thiones for the treatment of cns related diseases
JP6594571B2 (ja) * 2016-12-13 2019-10-23 南京薬捷安康生物科技有限公司 マルチキナーゼ阻害剤化合物、並びにその結晶形及びその使用
CN109020980B (zh) * 2017-06-09 2020-11-20 华东师范大学 一类抗肿瘤作用的吡唑并嘧啶二氮*衍生物
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
WO2020168197A1 (en) 2019-02-15 2020-08-20 Incyte Corporation Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
US11472791B2 (en) 2019-03-05 2022-10-18 Incyte Corporation Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors
WO2020205560A1 (en) 2019-03-29 2020-10-08 Incyte Corporation Sulfonylamide compounds as cdk2 inhibitors
WO2020223469A1 (en) 2019-05-01 2020-11-05 Incyte Corporation N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer
US11447494B2 (en) 2019-05-01 2022-09-20 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
WO2021030537A1 (en) 2019-08-14 2021-02-18 Incyte Corporation Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors
PE20221905A1 (es) 2019-10-11 2022-12-23 Incyte Corp Aminas biciclicas como inhibidoras de la cdk2
WO2021223751A1 (zh) * 2020-05-08 2021-11-11 南京药捷安康生物科技有限公司 抗肿瘤化合物的合成方法及其中间体
WO2022113003A1 (en) 2020-11-27 2022-06-02 Rhizen Pharmaceuticals Ag Cdk inhibitors
WO2022149057A1 (en) 2021-01-05 2022-07-14 Rhizen Pharmaceuticals Ag Cdk inhibitors
TW202309030A (zh) 2021-05-07 2023-03-01 美商凱麥拉醫療公司 Cdk2降解劑及其用途
WO2022237765A1 (zh) * 2021-05-10 2022-11-17 药捷安康(南京)科技股份有限公司 多激酶抑制剂的药物组合物及其用途
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors
WO2024030399A2 (en) * 2022-08-02 2024-02-08 Lab1636, Llc Use of a gaba-a pam for reduction of tactile hypersensitivity

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WO1998014450A1 (en) 1996-10-02 1998-04-09 Novartis Ag Pyrimidine derivatives and processes for the preparation thereof
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers

Also Published As

Publication number Publication date
HK1046278A1 (en) 2003-01-03
CN1603314A (zh) 2005-04-06
US20040198976A1 (en) 2004-10-07
PL200933B1 (pl) 2009-02-27
KR100481757B1 (ko) 2005-04-11
CN1196703C (zh) 2005-04-13
RU2249593C2 (ru) 2005-04-10
CN1279029C (zh) 2006-10-11
EP1185529B1 (en) 2004-10-13
ZA200108016B (en) 2003-03-26
CN1348455A (zh) 2002-05-08
TW585866B (en) 2004-05-01
NZ514523A (en) 2003-11-28
EP1185529A1 (en) 2002-03-13
CA2367704C (en) 2008-06-17
YU73101A (sh) 2004-05-12
ATE279413T1 (de) 2004-10-15
DE60014893D1 (de) 2004-11-18
AU768667B2 (en) 2003-12-18
HK1046278B (zh) 2005-08-12
CZ20013738A3 (cs) 2002-08-14
KR20010112435A (ko) 2001-12-20
JP2002543081A (ja) 2002-12-17
NO20015065L (no) 2001-10-18
DE60014893T2 (de) 2005-10-13
SI1185529T1 (en) 2005-02-28
HUP0300318A3 (en) 2004-11-29
PE20010054A1 (es) 2001-02-07
US20020183514A1 (en) 2002-12-05
PT1185529E (pt) 2005-02-28
AR023542A1 (es) 2002-09-04
US6440959B1 (en) 2002-08-27
WO2000064900A1 (en) 2000-11-02
PL354405A1 (en) 2004-01-12
US6838558B2 (en) 2005-01-04
NO20015065D0 (no) 2001-10-18
US6916923B2 (en) 2005-07-12
JP3746680B2 (ja) 2006-02-15
AU4748000A (en) 2000-11-10
BR0009887A (pt) 2002-01-22
CA2367704A1 (en) 2000-11-02
HUP0300318A2 (hu) 2003-06-28
DK1185529T3 (da) 2005-02-07
IL145764A0 (en) 2002-07-25
CO5170444A1 (es) 2002-06-27
ES2228522T3 (es) 2005-04-16
JO2248B1 (en) 2004-10-07
MA26782A1 (fr) 2004-12-20
HRP20010742A2 (en) 2002-12-31

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