MX2018013341A - Analisis de macromoleculas que emplea la codificacion de acido nucleico. - Google Patents

Analisis de macromoleculas que emplea la codificacion de acido nucleico.

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Publication number
MX2018013341A
MX2018013341A MX2018013341A MX2018013341A MX2018013341A MX 2018013341 A MX2018013341 A MX 2018013341A MX 2018013341 A MX2018013341 A MX 2018013341A MX 2018013341 A MX2018013341 A MX 2018013341A MX 2018013341 A MX2018013341 A MX 2018013341A
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MX
Mexico
Prior art keywords
nucleic acid
acid encoding
analysis employing
employing nucleic
macromolecule analysis
Prior art date
Application number
MX2018013341A
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English (en)
Inventor
Gunderson Kevin
Phillip Weiner Michael
Original Assignee
Encodia Inc
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Publication date
Application filed by Encodia Inc filed Critical Encodia Inc
Publication of MX2018013341A publication Critical patent/MX2018013341A/es

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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818—Sequencing of polypeptides
    • G01N33/6824—Sequencing of polypeptides involving N-terminal degradation, e.g. Edman degradation
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/6416—Metalloendopeptidases (3.4.24)
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • C—CHEMISTRY; METALLURGY
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
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    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/619—Detection means characterised by use of a special device being a video camera
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
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    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes

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  • Life Sciences & Earth Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Immunology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
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  • General Physics & Mathematics (AREA)
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  • Investigating Or Analysing Biological Materials (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se describe un método para analizar macromoléculas, incluyendo péptidos, polipéptidos y proteínas, que emplea la codificación de ácido nucleico.
MX2018013341A 2016-05-02 2017-05-02 Analisis de macromoleculas que emplea la codificacion de acido nucleico. MX2018013341A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662330841P 2016-05-02 2016-05-02
US201662339071P 2016-05-19 2016-05-19
US201662376886P 2016-08-18 2016-08-18
PCT/US2017/030702 WO2017192633A1 (en) 2016-05-02 2017-05-02 Macromolecule analysis employing nucleic acid encoding

Publications (1)

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MX2018013341A true MX2018013341A (es) 2019-09-18

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MX2018013341A MX2018013341A (es) 2016-05-02 2017-05-02 Analisis de macromoleculas que emplea la codificacion de acido nucleico.

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US (5) US20190145982A1 (es)
EP (2) EP4299803A3 (es)
JP (5) JP7120630B2 (es)
KR (3) KR102379048B1 (es)
CN (1) CN110199019A (es)
AU (1) AU2017259794B2 (es)
CA (1) CA3022863A1 (es)
DK (1) DK3452591T3 (es)
MX (1) MX2018013341A (es)
NZ (1) NZ747941A (es)
SG (2) SG10201911917WA (es)
WO (1) WO2017192633A1 (es)

Families Citing this family (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
GB2577626B (en) 2011-06-23 2020-09-23 Univ Texas Identifying peptides at the single molecule level
US11435358B2 (en) 2011-06-23 2022-09-06 Board Of Regents, The University Of Texas System Single molecule peptide sequencing
CA2961493C (en) 2014-09-15 2023-10-03 Board Of Regents, The University Of Texas System Improved single molecule peptide sequencing
CN107427808B (zh) 2015-01-12 2020-10-23 10X基因组学有限公司 用于制备核酸测序文库的方法和系统以及用其制备的文库
EP4119677B1 (en) 2015-04-10 2023-06-28 Spatial Transcriptomics AB Spatially distinguished, multiplex nucleic acid analysis of biological specimens
US11285490B2 (en) 2015-06-26 2022-03-29 Ancera, Llc Background defocusing and clearing in ferrofluid-based capture assays
KR102379048B1 (ko) * 2016-05-02 2022-03-28 엔코디아, 인코포레이티드 암호화 핵산을 사용한 거대분자 분석
EP3488018A4 (en) * 2016-07-22 2020-02-12 President and Fellows of Harvard College METHODS AND COMPOSITIONS FOR THE IDENTIFICATION OF PROTEINS
KR102522023B1 (ko) * 2016-09-26 2023-04-17 셀룰러 리서치, 인크. 바코딩된 올리고뉴클레오티드 서열을 갖는 시약을 이용한 단백질 발현의 측정
EP3542295A4 (en) 2016-11-16 2020-10-21 Catalog Technologies, Inc. SYSTEMS FOR NUCLEIC ACID-BASED DATA STORAGE
US10650312B2 (en) 2016-11-16 2020-05-12 Catalog Technologies, Inc. Nucleic acid-based data storage
CN110249082B (zh) 2016-12-01 2023-07-07 诺迪勒思附属公司 测定蛋白质的方法
JP7093355B2 (ja) * 2016-12-16 2022-06-29 アラトム， エルエルシー ライゲーション増幅を使用する分子検出
US10815525B2 (en) * 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
CN117512066A (zh) 2017-01-30 2024-02-06 10X基因组学有限公司 用于基于微滴的单细胞条形编码的方法和系统
GB201707140D0 (en) * 2017-05-04 2017-06-21 Oxford Nanopore Tech Ltd Method
GB201715684D0 (en) * 2017-09-28 2017-11-15 Univ Gent Means and methods for single molecule peptide sequencing
WO2019084058A2 (en) * 2017-10-23 2019-05-02 Massachusetts Institute Of Technology FUNCTIONALIZED SOLID SUPPORT
MX2020004559A (es) * 2017-10-31 2020-10-05 Encodia Inc Kits para análisis utilizando codificación y/o etiqueta de ácido nucleico.
WO2019089851A1 (en) * 2017-10-31 2019-05-09 Encodia, Inc. Methods and kits using nucleic acid encoding and/or label
EP3714053A4 (en) * 2017-11-22 2021-11-24 The University of Chicago CHEMICAL-DEPENDENT PROBE EVALUATION OF PROTEIN ACTIVITY AND ITS USES
EP3752832A1 (en) 2018-02-12 2020-12-23 10X Genomics, Inc. Methods characterizing multiple analytes from individual cells or cell populations
WO2019178551A1 (en) 2018-03-16 2019-09-19 Catalog Technologies, Inc. Chemical methods for nucleic acid-based data storage
JP7326778B2 (ja) * 2018-03-19 2023-08-16 株式会社リコー 核酸試料含有容器、核酸試料含有容器の製造方法、核酸試料含有容器の製造装置及び核酸試料含有容器の製造プログラム、並びに、核酸試料
JP2021531750A (ja) * 2018-07-12 2021-11-25 ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System オリゴヌクレオチドによる分子近傍検出
CN108866046A (zh) * 2018-07-25 2018-11-23 辽宁润基生物科技有限公司 一种分离、纯化样品中外泌体和/或游离核酸的方法
US20200032335A1 (en) 2018-07-27 2020-01-30 10X Genomics, Inc. Systems and methods for metabolome analysis
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
CN114127281A (zh) * 2018-09-04 2022-03-01 Encodia 公司 邻近相互作用分析
WO2020061036A1 (en) * 2018-09-17 2020-03-26 California Institute Of Technology Detection of molecular associations
US11078480B2 (en) * 2018-09-19 2021-08-03 California Institute Of Technology High-throughput identification of intermolecular interactions
US20210340192A1 (en) * 2018-10-05 2021-11-04 University Of Washington Reporter constructs for nanopore-based detection of biological activity
KR20210091243A (ko) 2018-11-15 2021-07-21 퀀텀-에스아이 인코포레이티드 단백질 시퀀싱을 위한 방법 및 조성물
US11459607B1 (en) 2018-12-10 2022-10-04 10X Genomics, Inc. Systems and methods for processing-nucleic acid molecules from a single cell using sequential co-partitioning and composite barcodes
US20220064630A1 (en) 2018-12-10 2022-03-03 10X Genomics, Inc. Resolving spatial arrays using deconvolution
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
SG11202106771QA (en) * 2019-01-08 2021-07-29 Massachusetts Inst Technology Single-molecule protein and peptide sequencing
EP3914706A4 (en) * 2019-01-21 2022-12-28 Encodia, Inc. METHODS AND COMPOSITIONS OF ACCELERATION REACTIONS FOR POLYPEPTIDE ANALYSIS AND RELATED USES
US11427814B2 (en) 2019-03-26 2022-08-30 Encodia, Inc. Modified cleavases, uses thereof and related kits
AU2020247918B2 (en) * 2019-03-26 2022-06-30 Encodia, Inc. Modified cleavases, uses thereof and related kits
WO2020219365A1 (en) * 2019-04-23 2020-10-29 Encodia, Inc. Methods for spatial analysis of proteins and related kits
US20220227889A1 (en) * 2019-04-30 2022-07-21 Encodia, Inc. Methods and reagents for cleavage of the n-terminal amino acid from a polypeptide
CA3138367A1 (en) * 2019-04-30 2020-11-05 Encodia, Inc. Methods for preparing analytes and related kits
CA3139819A1 (en) 2019-05-09 2020-11-12 Catalog Technologies, Inc. Data structures and operations for searching, computing, and indexing in dna-based data storage
CA3141321A1 (en) * 2019-05-20 2020-11-26 Encodia, Inc. Methods and related kits for spatial analysis
EP3976820A1 (en) 2019-05-30 2022-04-06 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
WO2020254672A1 (en) * 2019-06-19 2020-12-24 Therycell Gmbh Spatial characterisation of target structures in a sample
US11346842B2 (en) 2019-06-20 2022-05-31 Massachusetts Institute Of Technology Single molecule peptide sequencing methods
CN110689929B (zh) * 2019-08-29 2021-12-17 浙江工业大学 一种基于接触概率辅助的蛋白质atp对接方法
US11535842B2 (en) 2019-10-11 2022-12-27 Catalog Technologies, Inc. Nucleic acid security and authentication
US20210139973A1 (en) * 2019-10-28 2021-05-13 Quantum-Si Incorporated Methods of single-cell polypeptide sequencing
JP2023500486A (ja) * 2019-10-28 2023-01-06 クアンタム－エスアイ インコーポレイテッド 多重化ポリペプチド配列決定用のサンプルを調製する方法、キット、及びデバイス
EP4025711A2 (en) 2019-11-08 2022-07-13 10X Genomics, Inc. Enhancing specificity of analyte binding
ES2946357T3 (es) 2019-12-23 2023-07-17 10X Genomics Inc Métodos para el análisis espacial usando ligación con molde de ARN
WO2021141924A1 (en) * 2020-01-07 2021-07-15 Encodia, Inc. Methods for stable complex formation and related kits
EP4073263A4 (en) * 2020-01-07 2023-11-08 Encodia, Inc. METHODS FOR FORMING A STABLE COMPLEX AND ASSOCIATED KITS
US20230056532A1 (en) * 2020-01-07 2023-02-23 Encodia, Inc. Methods for information transfer and related kits
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
EP4107282A1 (en) * 2020-02-21 2022-12-28 10X Genomics, Inc. Capturing genetic targets using a hybridization approach
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
KR102376443B1 (ko) 2020-02-26 2022-03-17 포항공과대학교 산학협력단 나노구조체, 나노구조체를 포함하는 바이오센서, 및 스크리닝 방법
KR102482668B1 (ko) * 2020-03-10 2022-12-29 사회복지법인 삼성생명공익재단 고유 분자 식별자의 표지 정확도를 증진하는 방법
US20240011009A1 (en) * 2020-03-24 2024-01-11 Encodia, Inc. Modified dipeptide cleavases, uses thereof and related kits
CN112280829B (zh) * 2020-04-07 2023-12-26 南方科技大学 一种试剂盒、样本标记方法、单细胞测序方法
CN115956115A (zh) * 2020-04-16 2023-04-11 新格元(南京)生物科技有限公司 用于单细胞高通量靶标测序的方法和组合物
ES2965354T3 (es) 2020-04-22 2024-04-12 10X Genomics Inc Métodos para análisis espacial que usan eliminación de ARN elegido como diana
AU2021271639A1 (en) 2020-05-11 2022-12-08 Catalog Technologies, Inc. Programs and functions in DNA-based data storage
WO2021237087A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Spatial analysis to detect sequence variants
EP4153775A1 (en) 2020-05-22 2023-03-29 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
WO2021247543A2 (en) 2020-06-02 2021-12-09 10X Genomics, Inc. Nucleic acid library methods
WO2021252499A1 (en) 2020-06-08 2021-12-16 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
WO2021252591A1 (en) 2020-06-10 2021-12-16 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
US11935311B2 (en) 2020-06-11 2024-03-19 Nautilus Subsidiary, Inc. Methods and systems for computational decoding of biological, chemical, and physical entities
WO2021263111A1 (en) 2020-06-25 2021-12-30 10X Genomics, Inc. Spatial analysis of dna methylation
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
WO2022015845A2 (en) * 2020-07-14 2022-01-20 Ancera Llc Systems, devices and methods for analysis
EP4121561A4 (en) 2020-08-06 2024-04-17 Singular Genomics Systems, Inc. METHODS FOR IN SITU TRANSCRIPTOMICS AND PROTEOMICS
US20230136966A1 (en) * 2020-08-19 2023-05-04 Encodia, Inc. Sequential encoding methods and related kits
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
EP4200436A1 (en) * 2020-08-21 2023-06-28 Ancera, Inc. Systems, devices and methods for determining most probable number in biological sample analysis
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
WO2022094148A1 (en) * 2020-10-30 2022-05-05 Encodia, Inc. Conjugation reagents and methods using 1,2-cyclohexanediones
EP4244382A1 (en) 2020-11-11 2023-09-20 Nautilus Subsidiary, Inc. Affinity reagents having enhanced binding and detection characteristics
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
WO2022140028A1 (en) 2020-12-21 2022-06-30 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
US20240067956A1 (en) * 2021-01-13 2024-02-29 The Regents Of The University Of Colorado, A Body Corporate Methods and compositions for molecular tracking in individual cells in vivo
WO2022159520A2 (en) 2021-01-20 2022-07-28 Nautilus Biotechnology, Inc. Systems and methods for biomolecule quantitation
EP4281775A1 (en) 2021-01-21 2023-11-29 Nautilus Subsidiary, Inc. Systems and methods for biomolecule preparation
US11505796B2 (en) 2021-03-11 2022-11-22 Nautilus Biotechnology, Inc. Systems and methods for biomolecule retention
CA3222270A1 (en) 2021-06-24 2022-12-29 Vadim Lobanov Methods and systems for assay refinement
US11521947B1 (en) * 2021-07-14 2022-12-06 Nxp Usa, Inc. Space efficient flip chip joint design
EP4196605A1 (en) 2021-09-01 2023-06-21 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array
US20230070896A1 (en) 2021-09-09 2023-03-09 Nautilus Biotechnology, Inc. Characterization and localization of protein modifications
US20230090454A1 (en) 2021-09-22 2023-03-23 Nautilus Biotechnology, Inc. Methods and systems for determining polypeptide interactions
WO2023081728A1 (en) 2021-11-03 2023-05-11 Nautilus Biotechnology, Inc. Systems and methods for surface structuring
US11753677B2 (en) * 2021-11-10 2023-09-12 Encodia, Inc. Methods for barcoding macromolecules in individual cells
AU2022416435A1 (en) * 2021-12-14 2024-07-04 Glyphic Biotechnologies, Inc. Single-molecule peptide sequencing through molecular barcoding and ex-situ analysis
EP4206674A1 (en) 2021-12-28 2023-07-05 Encodia, Inc. High-throughput serotyping and antibody profiling assays
WO2023192917A1 (en) 2022-03-29 2023-10-05 Nautilus Subsidiary, Inc. Integrated arrays for single-analyte processes
US20230360732A1 (en) 2022-04-25 2023-11-09 Nautilus Subsidiary, Inc. Systems and methods for assessing and improving the quality of multiplex molecular assays
WO2023250364A1 (en) 2022-06-21 2023-12-28 Nautilus Subsidiary, Inc. Method for detecting analytes at sites of optically non-resolvable distances
US20240087679A1 (en) 2022-09-13 2024-03-14 Nautilus Subsidiary, Inc. Systems and methods of validating new affinity reagents
WO2024059655A1 (en) 2022-09-15 2024-03-21 Nautilus Subsidiary, Inc. Characterizing accessibility of macromolecule structures
WO2024073599A1 (en) 2022-09-29 2024-04-04 Nautilus Subsidiary, Inc. Preparation of array surfaces for single-analyte processes
CN115951051B (zh) * 2022-10-18 2024-01-12 北京卓诚惠生生物科技股份有限公司 一种高灵敏度新型冠状病毒抗原胶体金检测试剂盒及其制备方法
WO2024124073A1 (en) 2022-12-09 2024-06-13 Nautilus Subsidiary, Inc. A method comprising performing on a single-analyte array at least 50 cycles of a process
US20240201182A1 (en) 2022-12-15 2024-06-20 Nautilus Subsidiary, Inc. Inhibition of photon phenomena on single molecule arrays

Family Cites Families (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863870A (en) 1988-03-10 1989-09-05 Bio-Affinity Systems, Inc. Method of thioacylation peptide sequencing with alcoholysis of thiazolinones
US5484735A (en) 1989-08-23 1996-01-16 Northwestern University Immunoassay of glycosylated proteins employing antibody directed to reductively glycosylated N-terminal amino acids
US5049507A (en) 1989-12-21 1991-09-17 Applied Biosystems, Inc. Method of C-terminal peptide sequencing
AU669489B2 (en) 1991-09-18 1996-06-13 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
SE9400088D0 (sv) 1994-01-14 1994-01-14 Kabi Pharmacia Ab Bacterial receptor structures
US5834252A (en) 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
CA2176414A1 (en) 1995-05-18 1996-11-19 S. David Kimball Acyl guanidine and amidine prodrugs
ATE319477T1 (de) 1995-08-03 2006-03-15 Univ Leiden Antigen presentierende bläschen, die von zellen ableiten
JP3124507B2 (ja) 1996-05-24 2001-01-15 セイコーインスツルメンツ株式会社 タンパク質あるいはペプチドのカルボキシ末端からのアミノ酸配列を決定する方法
US5900481A (en) 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
RU2233878C2 (ru) 1997-01-21 2004-08-10 Дзе Дженерал Хоспитал Корпорейшн Способ отбора желательного белка и нуклеиновой кислоты, средства для его осуществления
US6306588B1 (en) 1997-02-07 2001-10-23 Invitrogen Corporation Polymerases for analyzing or typing polymorphic nucleic acid fragments and uses thereof
US6465193B2 (en) 1998-12-11 2002-10-15 The Regents Of The University Of California Targeted molecular bar codes and methods for using the same
US6875851B1 (en) 1999-03-05 2005-04-05 University Of Georgia Research Foundation, Inc. Prolyl tripeptidyl peptidases nucleic acid of Porphyromonas gingivalis
KR20020021779A (ko) * 1999-03-23 2002-03-22 바이오베이션 리미티드 단백질 단리 및 분석
WO2000071755A2 (en) 1999-05-25 2000-11-30 Praelux Incorporated Method for sequency and characterizing polymeric biomolecules using aptamers and a method for producing aptamers
ES2383332T3 (es) 1999-07-27 2012-06-20 Bristol-Myers Squibb Company Procedimiento de ligación de aceptores de péptidos
GB9927320D0 (en) 1999-11-18 2000-01-12 Chiron Spa Exosome separation
US7306904B2 (en) 2000-02-18 2007-12-11 Olink Ab Methods and kits for proximity probing
US6511809B2 (en) 2000-06-13 2003-01-28 E. I. Du Pont De Nemours And Company Method for the detection of an analyte by means of a nucleic acid reporter
CA2314398A1 (en) 2000-08-10 2002-02-10 Edward Shipwash Microarrays and microsystems for amino acid analysis and protein sequencing
WO2002059601A1 (en) 2001-01-23 2002-08-01 President And Fellows Of Harvard College Nucleic-acid programmable protein arrays
US20030087232A1 (en) 2001-01-25 2003-05-08 Fred Christians Methods for screening polypeptides
EP1401850A1 (en) 2001-06-20 2004-03-31 Nuevolution A/S Nucleoside derivatives for library preparation
AU2002330671B2 (en) 2001-07-06 2008-04-03 Centre National De La Recherche Scientifique (Cnrs) Method for obtaining cells with new properties
US7169894B2 (en) 2001-11-14 2007-01-30 Mirari Biosciences, Inc. Methods and compositions for reverse translation
CA2462819A1 (en) 2001-11-23 2003-05-30 Simon Fredriksson Method and kit for proximity probing with multivalent proximity probes
EP1578935A2 (en) 2002-10-10 2005-09-28 Diversa Corporation Proteases, nucleic acids encoding them and methods for making and using them
US20090246879A1 (en) * 2002-12-20 2009-10-01 Callida Genomics Materials and Methods Relating to Nano-Tags and Nano-Brands
WO2005015239A2 (en) 2003-08-07 2005-02-17 Cornell Research Foundation, Inc. Method for n-terminal labeling of proteins
US7198900B2 (en) 2003-08-29 2007-04-03 Applera Corporation Multiplex detection compositions, methods, and kits
DE602004023960D1 (de) * 2003-09-18 2009-12-17 Nuevolution As Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
US7579165B2 (en) 2003-10-16 2009-08-25 Shimadzu Corporation Methods for derivatizing protein or peptide with sulfonic acid groups
MXPA06006863A (es) 2003-12-17 2006-09-04 Praecis Pharm Inc Metodo para la sintesis de bibliotecas codificadas.
GB0404187D0 (en) 2004-02-25 2004-03-31 Biotransformations Ltd Binding agents
DK1730277T3 (da) 2004-03-22 2010-03-01 Nuevolution As Kodning ved ligering under anvendelse af byggebloksoligonukleotider
EP1737982A4 (en) 2004-04-14 2009-09-23 Harvard College NUCLEIC ACID PROGRAMMABLE PROTEIN ARRANGEMENTS
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
US20060199279A1 (en) 2005-03-07 2006-09-07 Viorica Lopez-Avila Methods for identifying post-translationally modified polypeptides
US7229769B2 (en) 2005-03-25 2007-06-12 Illumina, Inc. Compositions and methods for detecting protease activity
US7883848B2 (en) 2005-07-08 2011-02-08 Olink Ab Regulation analysis by cis reactivity, RACR
US20070020640A1 (en) 2005-07-21 2007-01-25 Mccloskey Megan L Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
US7611834B2 (en) 2005-09-30 2009-11-03 Sandia Corporation Methods and devices for protein assays
SI2341140T1 (sl) * 2005-12-01 2017-12-29 Nuevolution A/S Postopki encimskega kodiranja za učinkovito sintezo velikih knjižnic
US20070218503A1 (en) 2006-02-13 2007-09-20 Mitra Robi D Methods of polypeptide identification, and compositions therefor
DE102006015001A1 (de) 2006-03-31 2007-10-11 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Verfahren zum Nachweis und/oder zur Anreicherung von Analytproteinen und/oder Analytpeptiden aus einer komplexen Proteinmischung
WO2007127848A1 (en) 2006-04-26 2007-11-08 University Of Louisville Research Foundation, Inc Isolation of membrane vesicles from biological fluids and methods of using same
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
US8568994B2 (en) 2007-08-03 2013-10-29 Dkfz Deutsches Krebsforschungszentrum, Stiftung Des Offentlichen Rechts Method for prenatal diagnosis
WO2009050261A1 (en) * 2007-10-19 2009-04-23 Pronota N.V. Preparation of samples for proteome analysis
CA2745197A1 (en) 2008-12-01 2010-06-10 Research Triangle Institute Concurrent identification of multitudes of polypeptides
WO2010065531A1 (en) 2008-12-01 2010-06-10 Robi David Mitra Single molecule protein screening
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
US9566335B1 (en) 2009-09-25 2017-02-14 The Governing Council Of The University Of Toronto Protein sequencing method and reagents
WO2011056185A2 (en) 2009-11-04 2011-05-12 President And Fellows Of Harvard College Reactivity-dependent and interaction-dependent pcr
WO2011127006A1 (en) 2010-04-05 2011-10-13 Prognosys Biosciences, Inc. Co-localization affinity assays
PL2556171T3 (pl) * 2010-04-05 2016-04-29 Prognosys Biosciences Inc Oznaczenia biologiczne kodowane przestrzennie
CA2795776A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers for disease
WO2011143583A1 (en) * 2010-05-13 2011-11-17 Illumina, Inc. Binding assays for markers
DK2622073T5 (en) 2010-09-27 2019-02-25 Vipergen Method of Preparing an Enriched Library
WO2012064993A1 (en) 2010-11-10 2012-05-18 Exosome Diagnosties, Inc. Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
US9150852B2 (en) * 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
US20120258871A1 (en) 2011-04-08 2012-10-11 Prognosys Biosciences, Inc. Peptide constructs and assay systems
US9476095B2 (en) 2011-04-15 2016-10-25 The Johns Hopkins University Safe sequencing system
ES2744589T3 (es) 2011-05-11 2020-02-25 Exosome Diagnostics Inc Extracción de ácido nucleico de materiales biológicos heterogéneos
GB2577626B (en) 2011-06-23 2020-09-23 Univ Texas Identifying peptides at the single molecule level
EP2748335B1 (en) 2011-08-22 2018-10-03 Exosome Diagnostics, Inc. Urine biomarkers
US20130052665A1 (en) 2011-08-25 2013-02-28 Bruce Xuefeng Ling Methods for diagnosis of systemic juvenile idiopathic arthritis
US9335292B2 (en) 2011-10-13 2016-05-10 Auburn University Electrochemical proximity assay
US10174361B2 (en) 2011-11-10 2019-01-08 Exosome Diagnostics, Inc. Cerebrospinal fluid assay
US20150087526A1 (en) 2012-01-24 2015-03-26 The Regents Of The University Of Colorado, A Body Corporate Peptide identification and sequencing by single-molecule detection of peptides undergoing degradation
LT3363901T (lt) 2012-02-17 2021-04-12 Fred Hutchinson Cancer Research Center Kompozicijos ir būdai, skirti tiksliam mutacijų nustatymui
EP2825675B1 (en) 2012-03-13 2017-12-27 Patel, Abhijit Ajit Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing
ES2828661T3 (es) 2012-03-20 2021-05-27 Univ Washington Through Its Center For Commercialization Métodos para reducir la tasa de error de la secuenciación de ADN masiva en paralelo mediante el uso de la secuenciación de secuencia consenso bicatenaria
US9005888B2 (en) 2012-06-14 2015-04-14 System Biosciences, Llc Methods for microvesicle isolation and selective removal
NL2009191C2 (en) 2012-07-16 2014-01-20 Univ Delft Tech Single molecule protein sequencing.
US20140155295A1 (en) 2012-08-14 2014-06-05 10X Technologies, Inc. Capsule array devices and methods of use
US20140378322A1 (en) * 2012-08-14 2014-12-25 10X Technologies, Inc. Compositions and methods for sample processing
US9557336B2 (en) * 2012-09-07 2017-01-31 University Of Rochester Methods and compositions for site-specific labeling of peptides and proteins
EP2903597B1 (en) 2012-10-03 2019-12-18 Exosome Diagnostics Inc. Use of microvesicles in diagnosis, prognosis, and treatment of medical diseases and conditions
BR112015009138A2 (pt) 2012-10-23 2020-10-20 Caris Life Sciences Switzerland Holdings, S.A.R.L. métodos para caracterizar um câncer
WO2014144822A2 (en) 2013-03-15 2014-09-18 Immumetrix, Inc. Methods and compositions for tagging and analyzing samples
US9435810B2 (en) 2013-03-15 2016-09-06 Washington University Molecules and methods for iterative polypeptide analysis and processing
WO2014142981A1 (en) * 2013-03-15 2014-09-18 Illumina, Inc. Enzyme-linked nucleotides
US10006919B2 (en) * 2013-03-15 2018-06-26 Arizona Board Of Regents On Behalf Of Arizona State University Peptide array quality control
US10053725B2 (en) 2013-04-23 2018-08-21 President And Fellows Of Harvard College In situ interaction determination
US10011830B2 (en) * 2013-05-19 2018-07-03 The Board of Trustee of theLeland Stanford junior University Devices and methods for display of encoded peptides, polypeptides, and proteins on DNA
CN118240918A (zh) 2013-06-25 2024-06-25 普罗格诺西斯生物科学公司 采用微流控装置的空间编码生物分析
US10876177B2 (en) * 2013-07-10 2020-12-29 President And Fellows Of Harvard College Compositions and methods relating to nucleic acid-protein complexes
CN105980615A (zh) 2013-08-28 2016-09-28 卡里斯生命科学瑞士控股有限公司 寡核苷酸探针及其用途
WO2015042506A1 (en) 2013-09-23 2015-03-26 The Trustees Of Columbia University In The City Of New York High-throughput single molecule protein identification
WO2015070037A2 (en) 2013-11-08 2015-05-14 Prognosys Biosciences, Inc. Polynucleotide conjugates and methods for analyte detection
US9834814B2 (en) * 2013-11-22 2017-12-05 Agilent Technologies, Inc. Spatial molecular barcoding of in situ nucleic acids
CN106030304B (zh) 2014-02-27 2018-02-06 得克萨斯大学体系董事会 用于分离外来体的方法和组合物
US10858698B2 (en) 2014-03-25 2020-12-08 President And Fellows Of Harvard College Barcoded protein array for multiplex single-molecule interaction profiling
LT3456846T (lt) * 2014-04-21 2022-09-12 President And Fellows Of Harvard College Nukleorūgšties unikalios sekos įvedimo sistemos ir būdai
US10590407B2 (en) * 2014-04-24 2020-03-17 Nanyang Technological University Asx-specific protein ligase
US10738352B2 (en) 2014-05-02 2020-08-11 Idac Theranostics, Inc. Method for analyzing nucleic acid derived from single cell
US20170074855A1 (en) 2014-05-15 2017-03-16 Two Pore Guys, Inc. Scaffold Data Storage and Target Detection in a Sample Using a Nanopore
MX2016016902A (es) 2014-06-26 2017-03-27 10X Genomics Inc Metodos para analizar acidos nucleicos de celulas individuales o poblaciones de celulas.
MX2016016904A (es) 2014-06-26 2017-03-27 10X Genomics Inc Analisis de secuencias de acidos nucleicos.
US11229607B2 (en) * 2014-06-30 2022-01-25 President And Fellows Of Harvard College Hydrogel compositions comprising encapsulated cells and methods of use thereof
CN107002075B (zh) 2014-07-09 2021-07-30 外来体诊断公司 从生物样品中分离微泡和提取核酸的方法
US20170212101A1 (en) 2014-07-18 2017-07-27 Cdi Laboratories, Inc. Methods and compositions to identify, quantify, and characterize target analytes and binding moieties
EP3174980A4 (en) * 2014-08-01 2018-01-17 Dovetail Genomics, LLC Tagging nucleic acids for sequence assembly
CA2961493C (en) 2014-09-15 2023-10-03 Board Of Regents, The University Of Texas System Improved single molecule peptide sequencing
JP6808617B2 (ja) 2014-10-17 2021-01-06 イルミナ ケンブリッジ リミテッド 連続性を維持した転位
US9771412B2 (en) * 2014-10-31 2017-09-26 Wisconsin Alumni Research Foundation Engineered intein for improved production of protein-intein fusions
EP3725893A1 (en) 2015-02-10 2020-10-21 Illumina, Inc. Compositions for analyzing cellular components
EP3262192B1 (en) 2015-02-27 2020-09-16 Becton, Dickinson and Company Spatially addressable molecular barcoding
US20180284125A1 (en) 2015-03-11 2018-10-04 The Broad Institute, Inc. Proteomic analysis with nucleic acid identifiers
WO2016164530A1 (en) 2015-04-07 2016-10-13 University Of Maryland, College Park Compositions and methods for high throughput protein sequencing
EP3307243A4 (en) 2015-06-09 2019-01-02 The Board of Regents of The University of Texas System Diagnostic test for early stage cancer
US11965891B2 (en) 2015-12-30 2024-04-23 Bio-Rad Laboratories, Inc. Digital protein quantification
EP4239079A3 (en) 2016-02-17 2023-10-04 President And Fellows Of Harvard College Molecular programming tools
KR102379048B1 (ko) 2016-05-02 2022-03-28 엔코디아, 인코포레이티드 암호화 핵산을 사용한 거대분자 분석
US11208676B2 (en) 2016-05-27 2021-12-28 President And Fellows Of Harvard College Conditional primer extension for single-molecule detection
WO2018005720A1 (en) 2016-06-30 2018-01-04 President And Fellows Of Harvard College Method of determining the molecular binding between libraries of molecules
EP3488018A4 (en) 2016-07-22 2020-02-12 President and Fellows of Harvard College METHODS AND COMPOSITIONS FOR THE IDENTIFICATION OF PROTEINS
CN117512066A (zh) 2017-01-30 2024-02-06 10X基因组学有限公司 用于基于微滴的单细胞条形编码的方法和系统
DK3583214T3 (da) 2017-02-02 2023-12-18 New York Genome Center Inc Fremgangsmåder og sammensætninger til identificering eller kvantificering af mål i en biologisk prøve
MX2020004559A (es) 2017-10-31 2020-10-05 Encodia Inc Kits para análisis utilizando codificación y/o etiqueta de ácido nucleico.
WO2019089851A1 (en) 2017-10-31 2019-05-09 Encodia, Inc. Methods and kits using nucleic acid encoding and/or label
WO2019089846A1 (en) 2017-10-31 2019-05-09 Encodia, Inc. Methods and compositions for polypeptide analysis
KR20200105497A (ko) 2017-12-29 2020-09-07 노틸러스 바이오테크놀로지, 인크. 단백질 식별을 위한 디코딩 접근법
EP3740567A4 (en) 2018-01-18 2022-03-09 Nanosomix Inc. DETECTION OF EXOSOMES AND EXOSOMAL BIOMARKERS FOR DIAGNOSIS AND PROGNOSIS OF DISEASES AND DISORDERS
US20190301985A1 (en) 2018-04-03 2019-10-03 Tymora Analytical Operations, Inc. Methods for affinity-based non-antibody capture and purification of extracellular vesicles

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