SG10201911917WA - Macromolecule analysis employing nucleic acid encoding - Google Patents

Macromolecule analysis employing nucleic acid encoding

Info

Publication number
SG10201911917WA
SG10201911917WA SG10201911917WA SG10201911917WA SG10201911917WA SG 10201911917W A SG10201911917W A SG 10201911917WA SG 10201911917W A SG10201911917W A SG 10201911917WA SG 10201911917W A SG10201911917W A SG 10201911917WA SG 10201911917W A SG10201911917W A SG 10201911917WA
Authority
SG
Singapore
Prior art keywords
nucleic acid
acid encoding
analysis employing
employing nucleic
macromolecule analysis
Prior art date
Application number
SG10201911917WA
Inventor
Mark Chee
Kevin Gunderson
Michael Phillip Weiner
Original Assignee
Encodia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Encodia Inc filed Critical Encodia Inc
Publication of SG10201911917WA publication Critical patent/SG10201911917WA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818—Sequencing of polypeptides
    • G01N33/6824—Sequencing of polypeptides involving N-terminal degradation, e.g. Edman degradation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/6416—Metalloendopeptidases (3.4.24)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/619—Detection means characterised by use of a special device being a video camera
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
SG10201911917WA 2016-05-02 2017-05-02 Macromolecule analysis employing nucleic acid encoding SG10201911917WA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662330841P 2016-05-02 2016-05-02
US201662339071P 2016-05-19 2016-05-19
US201662376886P 2016-08-18 2016-08-18

Publications (1)

Publication Number Publication Date
SG10201911917WA true SG10201911917WA (en) 2020-01-30

Family

ID=60203299

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201911917WA SG10201911917WA (en) 2016-05-02 2017-05-02 Macromolecule analysis employing nucleic acid encoding
SG11201809649WA SG11201809649WA (en) 2016-05-02 2017-05-02 Macromolecule analysis employing nucleic acid encoding

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201809649WA SG11201809649WA (en) 2016-05-02 2017-05-02 Macromolecule analysis employing nucleic acid encoding

Country Status (12)

Country Link
US (4) US20190145982A1 (en)
EP (2) EP3452591B1 (en)
JP (5) JP7120630B2 (en)
KR (3) KR102379048B1 (en)
CN (1) CN110199019A (en)
AU (1) AU2017259794B2 (en)
CA (1) CA3022863A1 (en)
DK (1) DK3452591T3 (en)
MX (1) MX2018013341A (en)
NZ (1) NZ747941A (en)
SG (2) SG10201911917WA (en)
WO (1) WO2017192633A1 (en)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
WO2016069124A1 (en) 2014-09-15 2016-05-06 Board Of Regents, The University Of Texas System Improved single molecule peptide sequencing
US11435358B2 (en) 2011-06-23 2022-09-06 Board Of Regents, The University Of Texas System Single molecule peptide sequencing
US9625469B2 (en) 2011-06-23 2017-04-18 Board Of Regents, The University Of Texas System Identifying peptides at the single molecule level
EP3244992B1 (en) 2015-01-12 2023-03-08 10X Genomics, Inc. Processes for barcoding nucleic acids
DK3901281T3 (en) 2015-04-10 2023-01-23 Spatial Transcriptomics Ab SPATIALLY SEPARATE, MULTIPLEX NUCLEIC ACID ANALYSIS OF BIOLOGICAL SAMPLES
WO2016210348A2 (en) 2015-06-26 2016-12-29 Ancera, Inc. Background defocusing and clearing in ferrofluid-based capture assays
MX2018013341A (en) 2016-05-02 2019-09-18 Encodia Inc Macromolecule analysis employing nucleic acid encoding.
EP3488018A4 (en) * 2016-07-22 2020-02-12 President and Fellows of Harvard College Methods and compositions for protein identification
KR102363716B1 (en) * 2016-09-26 2022-02-18 셀룰러 리서치, 인크. Determination of protein expression using reagents having barcoded oligonucleotide sequences
US10650312B2 (en) 2016-11-16 2020-05-12 Catalog Technologies, Inc. Nucleic acid-based data storage
WO2018094115A1 (en) 2016-11-16 2018-05-24 Catalog Technologies, Inc. Systems for nucleic acid-based data storage
EP3548652B1 (en) 2016-12-01 2024-04-03 Nautilus Subsidiary, Inc. Methods of assaying proteins
FI3929304T3 (en) * 2016-12-16 2024-03-27 Aratome Llc Molecular detection using ligation amplification
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) * 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
WO2018140966A1 (en) 2017-01-30 2018-08-02 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
GB201707140D0 (en) * 2017-05-04 2017-06-21 Oxford Nanopore Tech Ltd Method
GB201715684D0 (en) * 2017-09-28 2017-11-15 Univ Gent Means and methods for single molecule peptide sequencing
US20200256862A1 (en) * 2017-10-23 2020-08-13 Massachusetts Institute Of Technology Functionalized solid support
WO2019089836A1 (en) * 2017-10-31 2019-05-09 Encodia, Inc. Kits for analysis using nucleic acid encoding and/or label
US20210355483A1 (en) * 2017-10-31 2021-11-18 Encodia, Inc. Methods and kits using nucleic acid encoding and/or label
US20200355673A1 (en) * 2017-11-22 2020-11-12 The University Of Chicago Chemical probe-dependent evaluation of protein activity and uses thereof
WO2019157529A1 (en) 2018-02-12 2019-08-15 10X Genomics, Inc. Methods characterizing multiple analytes from individual cells or cell populations
WO2019178551A1 (en) 2018-03-16 2019-09-19 Catalog Technologies, Inc. Chemical methods for nucleic acid-based data storage
JP7326778B2 (en) 2018-03-19 2023-08-16 株式会社リコー Nucleic Acid Sample Containing Container, Nucleic Acid Sample Containing Container Manufacturing Method, Nucleic Acid Sample Containing Container Manufacturing Device, Nucleic Acid Sample Containing Container Manufacturing Program, and Nucleic Acid Sample
WO2020014586A1 (en) * 2018-07-12 2020-01-16 Board Of Regents, The University Of Texas System Molecular neighborhood detection by oligonucleotides
CN108866046A (en) * 2018-07-25 2018-11-23 辽宁润基生物科技有限公司 A method of excretion body and/or free nucleic acid in separation, purification of samples
US20200032335A1 (en) 2018-07-27 2020-01-30 10X Genomics, Inc. Systems and methods for metabolome analysis
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
CN114127281A (en) * 2018-09-04 2022-03-01 Encodia 公司 Proximity interaction analysis
WO2020061036A1 (en) * 2018-09-17 2020-03-26 California Institute Of Technology Detection of molecular associations
US11078480B2 (en) * 2018-09-19 2021-08-03 California Institute Of Technology High-throughput identification of intermolecular interactions
WO2020073008A1 (en) * 2018-10-05 2020-04-09 University Of Washington Reporter constructs for nanopore-based detection of biological activity
AU2019380606A1 (en) 2018-11-15 2021-05-27 Quantum-Si Incorporated Methods and compositions for protein sequencing
WO2020123320A2 (en) 2018-12-10 2020-06-18 10X Genomics, Inc. Imaging system hardware
US11459607B1 (en) 2018-12-10 2022-10-04 10X Genomics, Inc. Systems and methods for processing-nucleic acid molecules from a single cell using sequential co-partitioning and composite barcodes
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11499979B2 (en) * 2019-01-08 2022-11-15 Massachusetts Institute Of Technology Single-molecule protein and peptide sequencing
WO2020154208A1 (en) * 2019-01-21 2020-07-30 Encodia, Inc. Methods and compositions of accelerating reactions for polypeptide analysis and related uses
CA3134776A1 (en) * 2019-03-26 2020-10-01 Encodia, Inc. Modified cleavases, uses thereof and related kits
US11427814B2 (en) 2019-03-26 2022-08-30 Encodia, Inc. Modified cleavases, uses thereof and related kits
WO2021194908A1 (en) * 2020-03-24 2021-09-30 Encodia, Inc. Modified dipeptide cleavases, uses thereof and related kits
AU2020261334A1 (en) * 2019-04-23 2021-11-18 Encodia, Inc. Methods for spatial analysis of proteins and related kits
CA3138367A1 (en) 2019-04-30 2020-11-05 Encodia, Inc. Methods for preparing analytes and related kits
EP3962930A4 (en) * 2019-04-30 2024-03-27 Encodia Inc Methods and reagents for cleavage of the n-terminal amino acid from a polypeptide
KR20220017409A (en) 2019-05-09 2022-02-11 카탈로그 테크놀로지스, 인크. Data structures and behaviors for searching, computing, and indexing in DNA-based data stores.
US20220235405A1 (en) * 2019-05-20 2022-07-28 Encodia, Inc. Methods and related kits for spatial analysis
WO2020243579A1 (en) 2019-05-30 2020-12-03 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
WO2020254672A1 (en) * 2019-06-19 2020-12-24 Therycell Gmbh Spatial characterisation of target structures in a sample
US11346842B2 (en) 2019-06-20 2022-05-31 Massachusetts Institute Of Technology Single molecule peptide sequencing methods
CN110689929B (en) * 2019-08-29 2021-12-17 浙江工业大学 Protein ATP docking method based on contact probability assistance
AU2020364250A1 (en) 2019-10-11 2022-04-28 Catalog Technologies, Inc. Nucleic acid security and authentication
WO2021086913A1 (en) * 2019-10-28 2021-05-06 Quantum-Si Incorporated Methods of single-cell protein and nucleic acid sequencing
CA3159402A1 (en) * 2019-10-28 2021-05-06 Quantum-Si Incorporated Methods, kits and devices of preparing samples for multiplex polypeptide sequencing
EP4025711A2 (en) 2019-11-08 2022-07-13 10X Genomics, Inc. Enhancing specificity of analyte binding
ES2946357T3 (en) 2019-12-23 2023-07-17 10X Genomics Inc Methods for spatial analysis using RNA template ligation
EP4073263A4 (en) 2020-01-07 2023-11-08 Encodia, Inc. Methods for stable complex formation and related kits
WO2021141924A1 (en) * 2020-01-07 2021-07-15 Encodia, Inc. Methods for stable complex formation and related kits
US20230056532A1 (en) * 2020-01-07 2023-02-23 Encodia, Inc. Methods for information transfer and related kits
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
AU2021224760A1 (en) * 2020-02-21 2022-09-15 10X Genomics, Inc. Capturing genetic targets using a hybridization approach
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
KR102376443B1 (en) 2020-02-26 2022-03-17 포항공과대학교 산학협력단 A nanostructure, a biosensor including the nanostructure, and a screening method
KR102482668B1 (en) * 2020-03-10 2022-12-29 사회복지법인 삼성생명공익재단 A method for improving the labeling accuracy of Unique Molecular Identifiers
CN112280829B (en) * 2020-04-07 2023-12-26 南方科技大学 Kit, sample marking method and single-cell sequencing method
CN115956115A (en) * 2020-04-16 2023-04-11 新格元(南京)生物科技有限公司 Methods and compositions for single cell high throughput target sequencing
EP4242325A3 (en) 2020-04-22 2023-10-04 10X Genomics, Inc. Methods for spatial analysis using targeted rna depletion
AU2021271639A1 (en) 2020-05-11 2022-12-08 Catalog Technologies, Inc. Programs and functions in DNA-based data storage
WO2021237087A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Spatial analysis to detect sequence variants
WO2021236929A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
EP4025692A2 (en) 2020-06-02 2022-07-13 10X Genomics, Inc. Nucleic acid library methods
WO2021252499A1 (en) 2020-06-08 2021-12-16 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
EP4165207A1 (en) 2020-06-10 2023-04-19 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
US11935311B2 (en) 2020-06-11 2024-03-19 Nautilus Subsidiary, Inc. Methods and systems for computational decoding of biological, chemical, and physical entities
WO2021263111A1 (en) 2020-06-25 2021-12-30 10X Genomics, Inc. Spatial analysis of dna methylation
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
WO2022015845A2 (en) * 2020-07-14 2022-01-20 Ancera Llc Systems, devices and methods for analysis
EP4121561A4 (en) 2020-08-06 2024-04-17 Singular Genomics Systems Inc Methods for in situ transcriptomics and proteomics
EP4196581A1 (en) * 2020-08-19 2023-06-21 Encodia, Inc. Sequential encoding methods and related kits
US20230332202A1 (en) * 2020-08-21 2023-10-19 Ancera, Inc. Systems, devices and methods for determing most probable number in biological sample analysis
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
WO2022094148A1 (en) * 2020-10-30 2022-05-05 Encodia, Inc. Conjugation reagents and methods using 1,2-cyclohexanediones
EP4244382A1 (en) 2020-11-11 2023-09-20 Nautilus Subsidiary, Inc. Affinity reagents having enhanced binding and detection characteristics
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
EP4121555A1 (en) 2020-12-21 2023-01-25 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
US20240067956A1 (en) * 2021-01-13 2024-02-29 The Regents Of The University Of Colorado, A Body Corporate Methods and compositions for molecular tracking in individual cells in vivo
US20220236282A1 (en) 2021-01-20 2022-07-28 Nautilus Biotechnology, Inc. Systems and methods for biomolecule quantitation
AU2022209365A1 (en) 2021-01-21 2023-07-20 Nautilus Subsidiary, Inc. Systems and methods for biomolecule preparation
AU2022232933A1 (en) 2021-03-11 2023-09-07 Nautilus Subsidiary, Inc. Systems and methods for biomolecule retention
WO2022271983A1 (en) 2021-06-24 2022-12-29 Nautilus Biotechnology, Inc. Methods and systems for assay refinement
US11521947B1 (en) * 2021-07-14 2022-12-06 Nxp Usa, Inc. Space efficient flip chip joint design
WO2023034489A1 (en) 2021-09-01 2023-03-09 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array
CA3227872A1 (en) 2021-09-09 2023-03-16 James Henry JOLY Characterization and localization of protein modifications
US20230090454A1 (en) 2021-09-22 2023-03-23 Nautilus Biotechnology, Inc. Methods and systems for determining polypeptide interactions
US20230149883A1 (en) 2021-11-03 2023-05-18 Nautilus Biotechnology, Inc. Systems and methods for surface structuring
WO2023086847A1 (en) 2021-11-10 2023-05-19 Encodia, Inc. Methods for barcoding macromolecules in individual cells
WO2023114732A2 (en) * 2021-12-14 2023-06-22 Glyphic Biotechnologies, Inc. Single-molecule peptide sequencing through molecular barcoding and ex-situ analysis
US20230203562A1 (en) 2021-12-28 2023-06-29 Encodia, Inc. High-throughput serotyping and antibody profiling assays
WO2023192917A1 (en) 2022-03-29 2023-10-05 Nautilus Subsidiary, Inc. Integrated arrays for single-analyte processes
WO2023212490A1 (en) 2022-04-25 2023-11-02 Nautilus Subsidiary, Inc. Systems and methods for assessing and improving the quality of multiplex molecular assays
WO2023250364A1 (en) 2022-06-21 2023-12-28 Nautilus Subsidiary, Inc. Method for detecting analytes at sites of optically non-resolvable distances
US20240087679A1 (en) 2022-09-13 2024-03-14 Nautilus Subsidiary, Inc. Systems and methods of validating new affinity reagents
US20240094215A1 (en) 2022-09-15 2024-03-21 Nautilus Subsidiary, Inc. Characterizing accessibility of macromolecule structures
WO2024073599A1 (en) 2022-09-29 2024-04-04 Nautilus Subsidiary, Inc. Preparation of array surfaces for single-analyte processes
CN115951051B (en) * 2022-10-18 2024-01-12 北京卓诚惠生生物科技股份有限公司 Novel high-sensitivity coronavirus antigen colloidal gold detection kit and preparation method thereof

Family Cites Families (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863870A (en) 1988-03-10 1989-09-05 Bio-Affinity Systems, Inc. Method of thioacylation peptide sequencing with alcoholysis of thiazolinones
US5484735A (en) * 1989-08-23 1996-01-16 Northwestern University Immunoassay of glycosylated proteins employing antibody directed to reductively glycosylated N-terminal amino acids
US5049507A (en) 1989-12-21 1991-09-17 Applied Biosystems, Inc. Method of C-terminal peptide sequencing
AU669489B2 (en) * 1991-09-18 1996-06-13 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
SE9400088D0 (en) 1994-01-14 1994-01-14 Kabi Pharmacia Ab Bacterial receptor structures
US5834252A (en) 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
CA2176414A1 (en) 1995-05-18 1996-11-19 S. David Kimball Acyl guanidine and amidine prodrugs
CA2225553A1 (en) 1995-08-03 1997-02-20 Rijksuniversiteit Te Leiden Cell derived antigen presenting vesicles
JP3124507B2 (en) 1996-05-24 2001-01-15 セイコーインスツルメンツ株式会社 Method for determining amino acid sequence from carboxy terminus of protein or peptide
US5900481A (en) 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
WO1998031700A1 (en) * 1997-01-21 1998-07-23 The General Hospital Corporation Selection of proteins using rna-protein fusions
US6306588B1 (en) 1997-02-07 2001-10-23 Invitrogen Corporation Polymerases for analyzing or typing polymorphic nucleic acid fragments and uses thereof
US6465193B2 (en) 1998-12-11 2002-10-15 The Regents Of The University Of California Targeted molecular bar codes and methods for using the same
US6875851B1 (en) 1999-03-05 2005-04-05 University Of Georgia Research Foundation, Inc. Prolyl tripeptidyl peptidases nucleic acid of Porphyromonas gingivalis
HUP0200400A3 (en) * 1999-03-23 2006-06-28 Biovation Ltd Aberdeen Protein isolation and analysis
US6515120B1 (en) 1999-05-25 2003-02-04 Praelux Incorporated Method for sequencing and characterizing polymeric biomolecules using aptamers and a method for producing aptamers
ES2383332T3 (en) 1999-07-27 2012-06-20 Bristol-Myers Squibb Company Peptide Acceptor Ligation Procedure
GB9927320D0 (en) 1999-11-18 2000-01-12 Chiron Spa Exosome separation
US7306904B2 (en) 2000-02-18 2007-12-11 Olink Ab Methods and kits for proximity probing
US6511809B2 (en) 2000-06-13 2003-01-28 E. I. Du Pont De Nemours And Company Method for the detection of an analyte by means of a nucleic acid reporter
CA2314398A1 (en) 2000-08-10 2002-02-10 Edward Shipwash Microarrays and microsystems for amino acid analysis and protein sequencing
WO2002059601A1 (en) 2001-01-23 2002-08-01 President And Fellows Of Harvard College Nucleic-acid programmable protein arrays
US20030087232A1 (en) 2001-01-25 2003-05-08 Fred Christians Methods for screening polypeptides
WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
EP1404846B1 (en) 2001-07-06 2013-09-11 Institut Pasteur Method for obtaining cells with new properties
US7169894B2 (en) 2001-11-14 2007-01-30 Mirari Biosciences, Inc. Methods and compositions for reverse translation
JP2005509444A (en) 2001-11-23 2005-04-14 シモン・フレデリックソン Methods and kits for proximity probing with multivalent proximity probes
EP1578935A2 (en) 2002-10-10 2005-09-28 Diversa Corporation Proteases, nucleic acids encoding them and methods for making and using them
US20090246879A1 (en) * 2002-12-20 2009-10-01 Callida Genomics Materials and Methods Relating to Nano-Tags and Nano-Brands
WO2005015239A2 (en) 2003-08-07 2005-02-17 Cornell Research Foundation, Inc. Method for n-terminal labeling of proteins
US7198900B2 (en) 2003-08-29 2007-04-03 Applera Corporation Multiplex detection compositions, methods, and kits
WO2005026387A1 (en) * 2003-09-18 2005-03-24 Nuevolution A/S A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
US7579165B2 (en) 2003-10-16 2009-08-25 Shimadzu Corporation Methods for derivatizing protein or peptide with sulfonic acid groups
NZ547723A (en) 2003-12-17 2009-09-25 Praecis Pharm Inc Methods for synthesis of encoded libraries
GB0404187D0 (en) * 2004-02-25 2004-03-31 Biotransformations Ltd Binding agents
EP1730277B1 (en) 2004-03-22 2009-10-28 Nuevolution A/S Ligational encoding using building block oligonucleotides
WO2005108615A2 (en) 2004-04-14 2005-11-17 President And Fellows Of Harvard College Nucleic-acid programmable protein arrays
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
US20060199279A1 (en) 2005-03-07 2006-09-07 Viorica Lopez-Avila Methods for identifying post-translationally modified polypeptides
US7229769B2 (en) 2005-03-25 2007-06-12 Illumina, Inc. Compositions and methods for detecting protease activity
US7883848B2 (en) 2005-07-08 2011-02-08 Olink Ab Regulation analysis by cis reactivity, RACR
US20070020640A1 (en) 2005-07-21 2007-01-25 Mccloskey Megan L Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
US7611834B2 (en) 2005-09-30 2009-11-03 Sandia Corporation Methods and devices for protein assays
LT3305900T (en) 2005-12-01 2021-11-10 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries
US20070218503A1 (en) 2006-02-13 2007-09-20 Mitra Robi D Methods of polypeptide identification, and compositions therefor
DE102006015001A1 (en) 2006-03-31 2007-10-11 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Method for detecting and / or enriching analyte proteins and / or analyte peptides from a complex protein mixture
WO2007127848A1 (en) 2006-04-26 2007-11-08 University Of Louisville Research Foundation, Inc Isolation of membrane vesicles from biological fluids and methods of using same
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
WO2009019215A1 (en) 2007-08-03 2009-02-12 Dkfz Deutsches Krebsforschungszentrum Method for prenatal diagnosis using exosomes and cd24 as a marker
US20100311114A1 (en) 2007-10-19 2010-12-09 Pronota N.V. Preparation of samples for proteome analysis
WO2010065531A1 (en) 2008-12-01 2010-06-10 Robi David Mitra Single molecule protein screening
CA2745197A1 (en) 2008-12-01 2010-06-10 Research Triangle Institute Concurrent identification of multitudes of polypeptides
WO2010127186A1 (en) 2009-04-30 2010-11-04 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
US9566335B1 (en) 2009-09-25 2017-02-14 The Governing Council Of The University Of Toronto Protein sequencing method and reagents
WO2011056185A2 (en) 2009-11-04 2011-05-12 President And Fellows Of Harvard College Reactivity-dependent and interaction-dependent pcr
DK2556171T3 (en) * 2010-04-05 2015-12-14 Prognosys Biosciences Inc Spatially CODED BIOLOGICAL ASSAYS
WO2011127006A1 (en) 2010-04-05 2011-10-13 Prognosys Biosciences, Inc. Co-localization affinity assays
BR112012025593A2 (en) 2010-04-06 2019-06-25 Caris Life Sciences Luxembourg Holdings circulating biomarkers for disease
WO2011143583A1 (en) 2010-05-13 2011-11-17 Illumina, Inc. Binding assays for markers
CA2808656C (en) 2010-09-27 2019-12-03 Vipergen A method for making an enriched library
US20130295574A1 (en) 2010-11-10 2013-11-07 Exosome Diagnostics, Inc. Method for Isolation of Nucleic Acid Containing Particles and Extraction of Nucleic Acids Therefrom
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
EP3150750B1 (en) 2011-04-08 2018-12-26 Prognosys Biosciences, Inc. Peptide constructs and assay systems
EP3246416A1 (en) 2011-04-15 2017-11-22 The Johns Hopkins University Safe sequencing system
ES2744589T3 (en) 2011-05-11 2020-02-25 Exosome Diagnostics Inc Nucleic acid extraction from heterogeneous biological materials
US9625469B2 (en) 2011-06-23 2017-04-18 Board Of Regents, The University Of Texas System Identifying peptides at the single molecule level
WO2016069124A1 (en) 2014-09-15 2016-05-06 Board Of Regents, The University Of Texas System Improved single molecule peptide sequencing
WO2013028788A1 (en) 2011-08-22 2013-02-28 Exosome Diagnostics, Inc. Urine biomarkers
US20130052665A1 (en) * 2011-08-25 2013-02-28 Bruce Xuefeng Ling Methods for diagnosis of systemic juvenile idiopathic arthritis
US9335292B2 (en) 2011-10-13 2016-05-10 Auburn University Electrochemical proximity assay
EP2776587A4 (en) 2011-11-10 2015-07-15 Exosome Diagnostics Inc Cerebrospinal fluid assay
US20150087526A1 (en) 2012-01-24 2015-03-26 The Regents Of The University Of Colorado, A Body Corporate Peptide identification and sequencing by single-molecule detection of peptides undergoing degradation
DK3363901T3 (en) 2012-02-17 2021-02-22 Hutchinson Fred Cancer Res Compositions and methods for accurately identifying mutations
EP2825675B1 (en) 2012-03-13 2017-12-27 Patel, Abhijit Ajit Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing
ES2828661T3 (en) 2012-03-20 2021-05-27 Univ Washington Through Its Center For Commercialization Methods to Reduce the Error Rate of Parallel Massive DNA Sequencing Using Double-stranded Consensus Sequence Sequencing
US9005888B2 (en) 2012-06-14 2015-04-14 System Biosciences, Llc Methods for microvesicle isolation and selective removal
NL2009191C2 (en) 2012-07-16 2014-01-20 Univ Delft Tech Single molecule protein sequencing.
US20140378322A1 (en) 2012-08-14 2014-12-25 10X Technologies, Inc. Compositions and methods for sample processing
WO2014028537A1 (en) 2012-08-14 2014-02-20 10X Technologies, Inc. Microcapsule compositions and methods
WO2014039715A1 (en) * 2012-09-07 2014-03-13 University Of Rochester Methods and compositions for site-specific labeling of peptides and proteins
CA2887058C (en) 2012-10-03 2022-02-22 Exosome Diagnostics, Inc. Use of microvesicles in diagnosis, prognosis, and treatment of medical diseases and conditions
ES2912033T3 (en) 2012-10-23 2022-05-24 Caris Science Inc Aptamers and uses thereof
CN105189748B (en) * 2013-03-15 2021-06-08 血统生物科学公司 Method for sequencing an immune repertoire
US9435810B2 (en) 2013-03-15 2016-09-06 Washington University Molecules and methods for iterative polypeptide analysis and processing
WO2014142981A1 (en) 2013-03-15 2014-09-18 Illumina, Inc. Enzyme-linked nucleotides
WO2014145123A2 (en) * 2013-03-15 2014-09-18 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State Unversity Peptide array quality control
WO2014176355A1 (en) 2013-04-23 2014-10-30 President And Fellows Of Harvard College In situ interaction determination
WO2014189768A1 (en) * 2013-05-19 2014-11-27 The Board Of Trustees Of The Leland Devices and methods for display of encoded peptides, polypeptides, and proteins on dna
CN111662960B (en) 2013-06-25 2024-04-12 普罗格诺西斯生物科学公司 Spatially encoded bioanalytical analysis using microfluidic devices
CN105555794A (en) * 2013-07-10 2016-05-04 哈佛学院院长及董事 Compositions and methods relating to nucleic acid-protein complexes
KR20160080815A (en) 2013-08-28 2016-07-08 카리스 라이프 사이언스 스위스 홀딩스 게엠베하 Oligonucleotide probes and uses thereof
US10466248B2 (en) 2013-09-23 2019-11-05 The Trustees Of Columbia University In The City Of New York High-throughput single molecule protein identification
WO2015070037A2 (en) 2013-11-08 2015-05-14 Prognosys Biosciences, Inc. Polynucleotide conjugates and methods for analyte detection
US9834814B2 (en) * 2013-11-22 2017-12-05 Agilent Technologies, Inc. Spatial molecular barcoding of in situ nucleic acids
AU2015222755B2 (en) 2014-02-27 2016-12-15 Board Of Regents, The University Of Texas System Methods and compositions for isolating exosomes
US10858698B2 (en) * 2014-03-25 2020-12-08 President And Fellows Of Harvard College Barcoded protein array for multiplex single-molecule interaction profiling
EP3134536B1 (en) * 2014-04-21 2019-12-18 President and Fellows of Harvard College Systems and methods for barcoding nucleic acids
US10590407B2 (en) 2014-04-24 2020-03-17 Nanyang Technological University Asx-specific protein ligase
US10738352B2 (en) 2014-05-02 2020-08-11 Idac Theranostics, Inc. Method for analyzing nucleic acid derived from single cell
US20170074855A1 (en) 2014-05-15 2017-03-16 Two Pore Guys, Inc. Scaffold Data Storage and Target Detection in a Sample Using a Nanopore
CN106795553B (en) 2014-06-26 2021-06-04 10X基因组学有限公司 Methods of analyzing nucleic acids from individual cells or cell populations
KR20170026383A (en) 2014-06-26 2017-03-08 10엑스 제노믹스, 인크. Analysis of nucleic acid sequences
WO2016004068A1 (en) 2014-06-30 2016-01-07 Jae-Won Shin Hydrogel compositions comprising encapsulated cells and methods of use thereof
EP3623792B1 (en) 2014-07-09 2021-09-01 Exosome Diagnostics, Inc. Methods for isolating microvesicles and extracting nucleic acids from biological samples
US20170212101A1 (en) 2014-07-18 2017-07-27 Cdi Laboratories, Inc. Methods and compositions to identify, quantify, and characterize target analytes and binding moieties
US10526641B2 (en) * 2014-08-01 2020-01-07 Dovetail Genomics, Llc Tagging nucleic acids for sequence assembly
US11873480B2 (en) 2014-10-17 2024-01-16 Illumina Cambridge Limited Contiguity preserving transposition
US9771412B2 (en) 2014-10-31 2017-09-26 Wisconsin Alumni Research Foundation Engineered intein for improved production of protein-intein fusions
RU2761432C2 (en) 2015-02-10 2021-12-08 Иллюмина, Инк. Method and composition for analysis of cellular components
WO2016138496A1 (en) * 2015-02-27 2016-09-01 Cellular Research, Inc. Spatially addressable molecular barcoding
US20180284125A1 (en) 2015-03-11 2018-10-04 The Broad Institute, Inc. Proteomic analysis with nucleic acid identifiers
WO2016164530A1 (en) 2015-04-07 2016-10-13 University Of Maryland, College Park Compositions and methods for high throughput protein sequencing
CA2988771A1 (en) 2015-06-09 2016-12-15 The Board Of Regents Of The University Of Texas System Diagnostic test for early stage cancer
US11965891B2 (en) 2015-12-30 2024-04-23 Bio-Rad Laboratories, Inc. Digital protein quantification
CN116949140A (en) 2016-02-17 2023-10-27 哈佛学院院长及董事 Molecular programming tool
MX2018013341A (en) 2016-05-02 2019-09-18 Encodia Inc Macromolecule analysis employing nucleic acid encoding.
CN109312337B (en) 2016-05-27 2022-10-04 哈佛学院院长及董事 Conditional primer extension for single molecule detection
WO2018005720A1 (en) 2016-06-30 2018-01-04 President And Fellows Of Harvard College Method of determining the molecular binding between libraries of molecules
EP3488018A4 (en) 2016-07-22 2020-02-12 President and Fellows of Harvard College Methods and compositions for protein identification
WO2018140966A1 (en) 2017-01-30 2018-08-02 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
FI3583214T3 (en) 2017-02-02 2023-12-19 New York Genome Center Inc Methods and compositions for identifying or quantifying targets in a biological sample
WO2019133892A1 (en) 2017-12-29 2019-07-04 Ignite Biosciences, Inc. Decoding approaches for protein identification
US20210355483A1 (en) 2017-10-31 2021-11-18 Encodia, Inc. Methods and kits using nucleic acid encoding and/or label
WO2019089836A1 (en) 2017-10-31 2019-05-09 Encodia, Inc. Kits for analysis using nucleic acid encoding and/or label
WO2019089846A1 (en) 2017-10-31 2019-05-09 Encodia, Inc. Methods and compositions for polypeptide analysis
EP3740567A4 (en) 2018-01-18 2022-03-09 Nanosomix Inc. Detection of exosomes and exosomal biomarkers for the diagnosis and prognosis of diseases and disorders
US20190301985A1 (en) 2018-04-03 2019-10-03 Tymora Analytical Operations, Inc. Methods for affinity-based non-antibody capture and purification of extracellular vesicles

Also Published As

Publication number Publication date
DK3452591T3 (en) 2023-09-18
MX2018013341A (en) 2019-09-18
KR20220038549A (en) 2022-03-28
US20210302431A1 (en) 2021-09-30
US11959922B2 (en) 2024-04-16
JP2024041969A (en) 2024-03-27
JP7333975B2 (en) 2023-08-28
KR20190035613A (en) 2019-04-03
EP4299803A2 (en) 2024-01-03
US20230054691A1 (en) 2023-02-23
AU2017259794B2 (en) 2023-04-13
JP2019523635A (en) 2019-08-29
EP4299803A3 (en) 2024-03-27
CN110199019A (en) 2019-09-03
CA3022863A1 (en) 2017-11-09
WO2017192633A1 (en) 2017-11-09
WO2017192633A9 (en) 2017-12-14
US20190145982A1 (en) 2019-05-16
EP3452591A4 (en) 2019-12-04
EP3452591A1 (en) 2019-03-13
JP2022065157A (en) 2022-04-26
EP3452591B1 (en) 2023-08-16
JP2022126865A (en) 2022-08-30
NZ747941A (en) 2023-04-28
JP7120630B2 (en) 2022-08-17
KR20230047506A (en) 2023-04-07
KR102516168B1 (en) 2023-03-30
SG11201809649WA (en) 2018-11-29
AU2017259794A1 (en) 2018-11-22
JP7097627B2 (en) 2022-07-08
US20210405058A1 (en) 2021-12-30
KR102379048B1 (en) 2022-03-28
JP2020120682A (en) 2020-08-13

Similar Documents

Publication Publication Date Title
SG10201911917WA (en) Macromolecule analysis employing nucleic acid encoding
IL278000B (en) Synthetic nucleic acid spike-ins
SG11201911430PA (en) Novel nucleic acid molecules
HK1250757A1 (en) Nucleic acid sequence analysis from single cells
IL254000B (en) Nucleic acid sequence assembly
HK1243958A1 (en) Nucleic acid construct
GB201507119D0 (en) Nucleic Acid Construct
SG10201913820TA (en) Nucleic Acid Analysis Apparatus
HK1244021A1 (en) Nucleic acid construct
GB201507115D0 (en) Nucleic Acid Construct
SG10202007321RA (en) Sample preparation for nucleic acid amplification
GB201507111D0 (en) Nucleic acid construct
EP3134550A4 (en) High-throughput structure determination using nucleic acid calipers
SI3094731T1 (en) Saccharide-modified nucleic acid molecules
GB201403216D0 (en) Nucleic acid sample preparation
GB201413318D0 (en) Nucleic acid sample preparation
GB2548733B (en) Nucleic acid analysis device
GB201418621D0 (en) Improved nucleic acid sample preparation using concatenation
EP3158088A4 (en) Nucleic acid sample preparation
GB201506669D0 (en) Nucleic acid sample enrichment
GB201415674D0 (en) Nucleic acid analysis
GB2553907B (en) Nucleic acid analyzer
IL271510A (en) Nucleic acid ratio determination
GB201519323D0 (en) Nucleic acid analysis
EP3559263A4 (en) Nucleic acid based coding process