MX345300B - Moléculas andamio de fibronectina y bibliotecas de las mismas. - Google Patents
Moléculas andamio de fibronectina y bibliotecas de las mismas.Info
- Publication number
- MX345300B MX345300B MX2013001144A MX2013001144A MX345300B MX 345300 B MX345300 B MX 345300B MX 2013001144 A MX2013001144 A MX 2013001144A MX 2013001144 A MX2013001144 A MX 2013001144A MX 345300 B MX345300 B MX 345300B
- Authority
- MX
- Mexico
- Prior art keywords
- fibronectin
- libraries
- fnlll
- cradle molecules
- library
- Prior art date
Links
- 102000016359 Fibronectins Human genes 0.000 title 1
- 108010067306 Fibronectins Proteins 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 230000027455 binding Effects 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
La presente invención se refiere a una combinación de una biblioteca de enlazadores de bucle superior y de fondo que usa los bucles CD y FG de un número de dominios FfIII (FfIII) (por ejemplo FnIII7, FnIII10 y FfIII14) junto con los residuos expuestos en la superficie de la hoja o lámina beta. La invención también se refiere a un método para formar una biblioteca de polipéptidos de dominio FnIII útiles en la clasificación para la presencia de uno o más polipéptidos que tienen una actividad de enlace o enzimática seleccionada.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36922210P | 2010-07-30 | 2010-07-30 | |
US36920310P | 2010-07-30 | 2010-07-30 | |
US36916010P | 2010-07-30 | 2010-07-30 | |
US201161474648P | 2011-04-12 | 2011-04-12 | |
US201161474632P | 2011-04-12 | 2011-04-12 | |
PCT/US2011/046160 WO2012016245A2 (en) | 2010-07-30 | 2011-08-01 | Fibronectin cradle molecules and libraries thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013001144A MX2013001144A (es) | 2013-06-05 |
MX345300B true MX345300B (es) | 2017-01-24 |
Family
ID=44504247
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013001144A MX345300B (es) | 2010-07-30 | 2011-08-01 | Moléculas andamio de fibronectina y bibliotecas de las mismas. |
Country Status (12)
Country | Link |
---|---|
US (1) | US9512199B2 (es) |
EP (3) | EP2598529A2 (es) |
JP (2) | JP6092773B2 (es) |
KR (1) | KR20130136443A (es) |
CN (2) | CN103403027A (es) |
AU (1) | AU2011283646B2 (es) |
CA (1) | CA2805862A1 (es) |
IL (1) | IL224220A (es) |
MX (1) | MX345300B (es) |
RU (1) | RU2013108962A (es) |
SG (1) | SG187225A1 (es) |
WO (1) | WO2012016245A2 (es) |
Families Citing this family (48)
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BRPI0417302A (pt) | 2003-12-05 | 2007-03-06 | Compound Therapeutics Inc | inibidores de receptores de fator de crescimento endotelial vascular do tipo 2 |
AU2007325838B2 (en) | 2006-11-22 | 2013-09-19 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR |
EP2247615B1 (en) | 2008-02-14 | 2014-07-30 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins that bind egfr |
AU2009242038B2 (en) | 2008-05-02 | 2013-05-30 | Novartis Ag | Improved fibronectin-based binding molecules and uses thereof |
JP2011520961A (ja) | 2008-05-22 | 2011-07-21 | ブリストル−マイヤーズ スクイブ カンパニー | 多価フィブロネクチンをベースとする足場ドメインタンパク質 |
KR101781907B1 (ko) | 2008-10-31 | 2017-09-26 | 얀센 바이오테크 인코포레이티드 | 파이브로넥틴 타입 ⅲ 도메인 기반 스캐폴드 조성물, 방법 및 용도 |
TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之egfr/igfir結合分子 |
US9139825B2 (en) | 2009-10-30 | 2015-09-22 | Novartis Ag | Universal fibronectin type III bottom-side binding domain libraries |
PT2571531T (pt) | 2010-04-30 | 2016-08-31 | Janssen Biotech Inc | Composições do domínio da fibronectina estabilizadas, métodos e utilizações |
TW201138808A (en) | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
WO2011150133A2 (en) | 2010-05-26 | 2011-12-01 | Bristol-Myers Squibb Company | Fibronectin based scaffold proteins having improved stability |
US20140112922A1 (en) | 2011-03-28 | 2014-04-24 | Cornell University | Targeted protein silencing using chimeras between antibodies and ubiquitination enzymes |
PL2697257T3 (pl) | 2011-04-13 | 2017-04-28 | Bristol-Myers Squibb Company | Białka fuzyjne fc o nowatorskim układzie lub zawierające nowatorskie łączniki |
WO2012158678A1 (en) | 2011-05-17 | 2012-11-22 | Bristol-Myers Squibb Company | Methods for maintaining pegylation of polypeptides |
ES2848531T3 (es) | 2011-05-17 | 2021-08-10 | Bristol Myers Squibb Co | Métodos mejorados para la selección de proteínas de unión |
WO2013049275A1 (en) | 2011-09-27 | 2013-04-04 | Janssen Biotech, Inc. | Fibronectin type iii repeat based protein scaffolds with alternative binding surfaces |
EP2773659A2 (en) | 2011-10-31 | 2014-09-10 | Bristol-Myers Squibb Company | Fibronectin binding domains with reduced immunogenicity |
LT3835310T (lt) | 2012-09-13 | 2024-04-25 | Bristol-Myers Squibb Company | Fibronektino pagrindo karkaso domeno baltymai, kurie rišasi prie miostatino |
EP2951206A2 (en) | 2013-02-01 | 2015-12-09 | Bristol-Myers Squibb Company | Fibronectin based scaffold proteins |
EP3406629B1 (en) | 2013-02-06 | 2020-06-24 | Bristol-Myers Squibb Company | Fibronectin type iii domain proteins with enhanced solubility |
US10183967B2 (en) | 2013-02-12 | 2019-01-22 | Bristol-Myers Squibb Company | Tangential flow filtration based protein refolding methods |
EP3299378B1 (en) | 2013-02-12 | 2019-07-31 | Bristol-Myers Squibb Company | High ph protein refolding methods |
US20160152686A1 (en) | 2013-03-13 | 2016-06-02 | Bristol-Myers Squibb Company | Fibronectin based scaffold domains linked to serum albumin or moiety binding thereto |
ES2750563T3 (es) | 2014-03-20 | 2020-03-26 | Bristol Myers Squibb Co | Moléculas con una estructura basada en fibronectina estabilizada |
CN113150117A (zh) * | 2014-03-20 | 2021-07-23 | 百时美施贵宝公司 | 新的结合血清白蛋白的纤连蛋白iii型结构域 |
CN107001474B (zh) | 2014-11-21 | 2021-10-01 | 百时美施贵宝公司 | 抗cd73抗体及其用途 |
WO2016086036A2 (en) | 2014-11-25 | 2016-06-02 | Bristol-Myers Squibb Company | Methods and compositions for 18f-radiolabeling of biologics |
ES2809125T3 (es) * | 2015-09-23 | 2021-03-03 | Bristol Myers Squibb Co | Moléculas de armazón a base de fibronectina de unión a glipicano-3 |
ES2781207T3 (es) | 2015-09-23 | 2020-08-31 | Bristol Myers Squibb Co | Dominios de fibronectina de tipo iii de unión a seroalbúmina con velocidad de disociación rápida |
RU2605326C1 (ru) * | 2015-12-07 | 2016-12-20 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт биохимии" (НИИ биохимии) | РЕКОМБИНАНТНЫЙ ХИМЕРНЫЙ БЕЛОК SUMO3-apoA-I ДЛЯ ПОЛУЧЕНИЯ ЗРЕЛОГО АПОЛИПОПРОТЕИНА A-I ЧЕЛОВЕКА, ШТАММ ДРОЖЖЕЙ Pichia pastoris - ПРОДУЦЕНТ РЕКОМБИНАНТНОГО ХИМЕРНОГО БЕЛКА SUMO3-apoA-I И СПОСОБ ПОЛУЧЕНИЯ ЗРЕЛОГО АПОЛИПОПРОТЕИНА A-I ЧЕЛОВЕКА |
US10994033B2 (en) | 2016-06-01 | 2021-05-04 | Bristol-Myers Squibb Company | Imaging methods using 18F-radiolabeled biologics |
US10597438B2 (en) | 2016-12-14 | 2020-03-24 | Janssen Biotech, Inc. | PD-L1 binding fibronectin type III domains |
CA3046963A1 (en) | 2016-12-14 | 2018-06-21 | Janssen Biotech, Inc. | Cd8a-binding fibronectin type iii domains |
US10611823B2 (en) | 2016-12-14 | 2020-04-07 | Hanssen Biotech, Inc | CD137 binding fibronectin type III domains |
IL272305B1 (en) * | 2017-07-31 | 2024-07-01 | Univ Tokyo | A versatile method for displaying a cyclic peptide on a protein structure |
US11680091B2 (en) | 2018-02-23 | 2023-06-20 | The University Of Chicago | Methods and composition involving thermophilic fibronectin type III (FN3) monobodies |
WO2019178604A1 (en) * | 2018-03-16 | 2019-09-19 | Cornell University | Broad-spectrum proteome editing with an engineered bacterial ubiquitin ligase mimic |
US11781138B2 (en) | 2019-10-14 | 2023-10-10 | Aro Biotherapeutics Company | FN3 domain-siRNA conjugates and uses thereof |
CN114786682B (zh) | 2019-10-14 | 2024-07-16 | Aro生物疗法公司 | 结合cd71的纤维粘连蛋白iii型结构域 |
CN111217903B (zh) * | 2020-02-25 | 2022-11-15 | 芜湖天明生物技术有限公司 | 一种重组人纤连蛋白ⅲ1-c及其制备方法和应用 |
WO2021174045A1 (en) | 2020-02-28 | 2021-09-02 | Bristol-Myers Squibb Company | Radiolabeled fibronectin based scaffolds and antibodies and theranostic uses thereof |
US12049483B2 (en) * | 2020-12-05 | 2024-07-30 | New York University | Selective and noncovalent inhibitors of oncogenic RAS mutants |
AU2022258566A1 (en) | 2021-04-14 | 2023-10-12 | Aro Biotherapeutics Company | Cd71 binding fibronectin type iii domains |
CN113527526B (zh) * | 2021-09-14 | 2021-12-17 | 美慕(北京)科技有限公司 | 一种重组蛋白及其构建方法、用途 |
CN113527525B (zh) * | 2021-09-14 | 2021-12-17 | 美慕(北京)科技有限公司 | 重组蛋白及其构建方法、用途 |
TW202340235A (zh) * | 2021-12-17 | 2023-10-16 | 美商戴納立製藥公司 | 多肽工程、文庫及工程cd98重鏈以及轉鐵蛋白受體結合多肽 |
WO2023145861A1 (ja) * | 2022-01-27 | 2023-08-03 | 公益財団法人東京都医学総合研究所 | ユビキチンに対する人工抗体 |
CN115976031B (zh) * | 2022-07-18 | 2023-06-23 | 烟台市华昕生物医药科技有限公司 | 一种重组纤连蛋白及其应用 |
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-
2011
- 2011-08-01 CN CN2011800474318A patent/CN103403027A/zh active Pending
- 2011-08-01 SG SG2013006580A patent/SG187225A1/en unknown
- 2011-08-01 EP EP11746713.4A patent/EP2598529A2/en not_active Withdrawn
- 2011-08-01 US US13/813,409 patent/US9512199B2/en active Active
- 2011-08-01 CN CN201710585677.XA patent/CN107903321A/zh active Pending
- 2011-08-01 KR KR1020137005001A patent/KR20130136443A/ko not_active Application Discontinuation
- 2011-08-01 AU AU2011283646A patent/AU2011283646B2/en not_active Ceased
- 2011-08-01 MX MX2013001144A patent/MX345300B/es active IP Right Grant
- 2011-08-01 EP EP17167946.7A patent/EP3248987A1/en not_active Withdrawn
- 2011-08-01 JP JP2013523251A patent/JP6092773B2/ja not_active Expired - Fee Related
- 2011-08-01 RU RU2013108962/10A patent/RU2013108962A/ru not_active Application Discontinuation
- 2011-08-01 EP EP16187306.2A patent/EP3222631A3/en not_active Withdrawn
- 2011-08-01 WO PCT/US2011/046160 patent/WO2012016245A2/en active Application Filing
- 2011-08-01 CA CA2805862A patent/CA2805862A1/en not_active Abandoned
-
2013
- 2013-01-14 IL IL224220A patent/IL224220A/en active IP Right Grant
-
2016
- 2016-06-23 JP JP2016124152A patent/JP2016192973A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP2598529A2 (en) | 2013-06-05 |
CA2805862A1 (en) | 2012-02-02 |
MX2013001144A (es) | 2013-06-05 |
JP2016192973A (ja) | 2016-11-17 |
EP3222631A2 (en) | 2017-09-27 |
WO2012016245A3 (en) | 2012-08-09 |
KR20130136443A (ko) | 2013-12-12 |
RU2013108962A (ru) | 2014-09-10 |
SG187225A1 (en) | 2013-02-28 |
EP3222631A3 (en) | 2017-11-22 |
JP6092773B2 (ja) | 2017-03-08 |
US20140057807A1 (en) | 2014-02-27 |
WO2012016245A2 (en) | 2012-02-02 |
US9512199B2 (en) | 2016-12-06 |
JP2013539362A (ja) | 2013-10-24 |
EP3248987A1 (en) | 2017-11-29 |
CN103403027A (zh) | 2013-11-20 |
AU2011283646B2 (en) | 2015-07-09 |
IL224220A (en) | 2017-07-31 |
AU2011283646A1 (en) | 2013-03-07 |
CN107903321A (zh) | 2018-04-13 |
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