MX345300B - Moléculas andamio de fibronectina y bibliotecas de las mismas. - Google Patents

Moléculas andamio de fibronectina y bibliotecas de las mismas.

Info

Publication number
MX345300B
MX345300B MX2013001144A MX2013001144A MX345300B MX 345300 B MX345300 B MX 345300B MX 2013001144 A MX2013001144 A MX 2013001144A MX 2013001144 A MX2013001144 A MX 2013001144A MX 345300 B MX345300 B MX 345300B
Authority
MX
Mexico
Prior art keywords
fibronectin
libraries
fnlll
cradle molecules
library
Prior art date
Application number
MX2013001144A
Other languages
English (en)
Other versions
MX2013001144A (es
Inventor
Loew Andreas
Edward Vash Brian
Koide Shohei
Bernard Wojcik John
Koide Akiko
Nicholas Gilbreth Ryan
Original Assignee
Novartis Ag *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag * filed Critical Novartis Ag *
Publication of MX2013001144A publication Critical patent/MX2013001144A/es
Publication of MX345300B publication Critical patent/MX345300B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La presente invención se refiere a una combinación de una biblioteca de enlazadores de bucle superior y de fondo que usa los bucles CD y FG de un número de dominios FfIII (FfIII) (por ejemplo FnIII7, FnIII10 y FfIII14) junto con los residuos expuestos en la superficie de la hoja o lámina beta. La invención también se refiere a un método para formar una biblioteca de polipéptidos de dominio FnIII útiles en la clasificación para la presencia de uno o más polipéptidos que tienen una actividad de enlace o enzimática seleccionada.
MX2013001144A 2010-07-30 2011-08-01 Moléculas andamio de fibronectina y bibliotecas de las mismas. MX345300B (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US36922210P 2010-07-30 2010-07-30
US36920310P 2010-07-30 2010-07-30
US36916010P 2010-07-30 2010-07-30
US201161474648P 2011-04-12 2011-04-12
US201161474632P 2011-04-12 2011-04-12
PCT/US2011/046160 WO2012016245A2 (en) 2010-07-30 2011-08-01 Fibronectin cradle molecules and libraries thereof

Publications (2)

Publication Number Publication Date
MX2013001144A MX2013001144A (es) 2013-06-05
MX345300B true MX345300B (es) 2017-01-24

Family

ID=44504247

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013001144A MX345300B (es) 2010-07-30 2011-08-01 Moléculas andamio de fibronectina y bibliotecas de las mismas.

Country Status (12)

Country Link
US (1) US9512199B2 (es)
EP (3) EP2598529A2 (es)
JP (2) JP6092773B2 (es)
KR (1) KR20130136443A (es)
CN (2) CN103403027A (es)
AU (1) AU2011283646B2 (es)
CA (1) CA2805862A1 (es)
IL (1) IL224220A (es)
MX (1) MX345300B (es)
RU (1) RU2013108962A (es)
SG (1) SG187225A1 (es)
WO (1) WO2012016245A2 (es)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0417302A (pt) 2003-12-05 2007-03-06 Compound Therapeutics Inc inibidores de receptores de fator de crescimento endotelial vascular do tipo 2
AU2007325838B2 (en) 2006-11-22 2013-09-19 Bristol-Myers Squibb Company Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR
EP2247615B1 (en) 2008-02-14 2014-07-30 Bristol-Myers Squibb Company Targeted therapeutics based on engineered proteins that bind egfr
AU2009242038B2 (en) 2008-05-02 2013-05-30 Novartis Ag Improved fibronectin-based binding molecules and uses thereof
JP2011520961A (ja) 2008-05-22 2011-07-21 ブリストル−マイヤーズ スクイブ カンパニー 多価フィブロネクチンをベースとする足場ドメインタンパク質
KR101781907B1 (ko) 2008-10-31 2017-09-26 얀센 바이오테크 인코포레이티드 파이브로넥틴 타입 ⅲ 도메인 기반 스캐폴드 조성물, 방법 및 용도
TWI496582B (zh) 2008-11-24 2015-08-21 必治妥美雅史谷比公司 雙重專一性之ｅｇｆｒ／ｉｇｆｉｒ結合分子
US9139825B2 (en) 2009-10-30 2015-09-22 Novartis Ag Universal fibronectin type III bottom-side binding domain libraries
PT2571531T (pt) 2010-04-30 2016-08-31 Janssen Biotech Inc Composições do domínio da fibronectina estabilizadas, métodos e utilizações
TW201138808A (en) 2010-05-03 2011-11-16 Bristol Myers Squibb Co Serum albumin binding molecules
WO2011150133A2 (en) 2010-05-26 2011-12-01 Bristol-Myers Squibb Company Fibronectin based scaffold proteins having improved stability
US20140112922A1 (en) 2011-03-28 2014-04-24 Cornell University Targeted protein silencing using chimeras between antibodies and ubiquitination enzymes
PL2697257T3 (pl) 2011-04-13 2017-04-28 Bristol-Myers Squibb Company Białka fuzyjne fc o nowatorskim układzie lub zawierające nowatorskie łączniki
WO2012158678A1 (en) 2011-05-17 2012-11-22 Bristol-Myers Squibb Company Methods for maintaining pegylation of polypeptides
ES2848531T3 (es) 2011-05-17 2021-08-10 Bristol Myers Squibb Co Métodos mejorados para la selección de proteínas de unión
WO2013049275A1 (en) 2011-09-27 2013-04-04 Janssen Biotech, Inc. Fibronectin type iii repeat based protein scaffolds with alternative binding surfaces
EP2773659A2 (en) 2011-10-31 2014-09-10 Bristol-Myers Squibb Company Fibronectin binding domains with reduced immunogenicity
LT3835310T (lt) 2012-09-13 2024-04-25 Bristol-Myers Squibb Company Fibronektino pagrindo karkaso domeno baltymai, kurie rišasi prie miostatino
EP2951206A2 (en) 2013-02-01 2015-12-09 Bristol-Myers Squibb Company Fibronectin based scaffold proteins
EP3406629B1 (en) 2013-02-06 2020-06-24 Bristol-Myers Squibb Company Fibronectin type iii domain proteins with enhanced solubility
US10183967B2 (en) 2013-02-12 2019-01-22 Bristol-Myers Squibb Company Tangential flow filtration based protein refolding methods
EP3299378B1 (en) 2013-02-12 2019-07-31 Bristol-Myers Squibb Company High ph protein refolding methods
US20160152686A1 (en) 2013-03-13 2016-06-02 Bristol-Myers Squibb Company Fibronectin based scaffold domains linked to serum albumin or moiety binding thereto
ES2750563T3 (es) 2014-03-20 2020-03-26 Bristol Myers Squibb Co Moléculas con una estructura basada en fibronectina estabilizada
CN113150117A (zh) * 2014-03-20 2021-07-23 百时美施贵宝公司 新的结合血清白蛋白的纤连蛋白iii型结构域
CN107001474B (zh) 2014-11-21 2021-10-01 百时美施贵宝公司 抗cd73抗体及其用途
WO2016086036A2 (en) 2014-11-25 2016-06-02 Bristol-Myers Squibb Company Methods and compositions for 18f-radiolabeling of biologics
ES2809125T3 (es) * 2015-09-23 2021-03-03 Bristol Myers Squibb Co Moléculas de armazón a base de fibronectina de unión a glipicano-3
ES2781207T3 (es) 2015-09-23 2020-08-31 Bristol Myers Squibb Co Dominios de fibronectina de tipo iii de unión a seroalbúmina con velocidad de disociación rápida
RU2605326C1 (ru) * 2015-12-07 2016-12-20 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт биохимии" (НИИ биохимии) РЕКОМБИНАНТНЫЙ ХИМЕРНЫЙ БЕЛОК SUMO3-apoA-I ДЛЯ ПОЛУЧЕНИЯ ЗРЕЛОГО АПОЛИПОПРОТЕИНА A-I ЧЕЛОВЕКА, ШТАММ ДРОЖЖЕЙ Pichia pastoris - ПРОДУЦЕНТ РЕКОМБИНАНТНОГО ХИМЕРНОГО БЕЛКА SUMO3-apoA-I И СПОСОБ ПОЛУЧЕНИЯ ЗРЕЛОГО АПОЛИПОПРОТЕИНА A-I ЧЕЛОВЕКА
US10994033B2 (en) 2016-06-01 2021-05-04 Bristol-Myers Squibb Company Imaging methods using 18F-radiolabeled biologics
US10597438B2 (en) 2016-12-14 2020-03-24 Janssen Biotech, Inc. PD-L1 binding fibronectin type III domains
CA3046963A1 (en) 2016-12-14 2018-06-21 Janssen Biotech, Inc. Cd8a-binding fibronectin type iii domains
US10611823B2 (en) 2016-12-14 2020-04-07 Hanssen Biotech, Inc CD137 binding fibronectin type III domains
IL272305B1 (en) * 2017-07-31 2024-07-01 Univ Tokyo A versatile method for displaying a cyclic peptide on a protein structure
US11680091B2 (en) 2018-02-23 2023-06-20 The University Of Chicago Methods and composition involving thermophilic fibronectin type III (FN3) monobodies
WO2019178604A1 (en) * 2018-03-16 2019-09-19 Cornell University Broad-spectrum proteome editing with an engineered bacterial ubiquitin ligase mimic
US11781138B2 (en) 2019-10-14 2023-10-10 Aro Biotherapeutics Company FN3 domain-siRNA conjugates and uses thereof
CN114786682B (zh) 2019-10-14 2024-07-16 Aro生物疗法公司 结合cd71的纤维粘连蛋白iii型结构域
CN111217903B (zh) * 2020-02-25 2022-11-15 芜湖天明生物技术有限公司 一种重组人纤连蛋白ⅲ1-c及其制备方法和应用
WO2021174045A1 (en) 2020-02-28 2021-09-02 Bristol-Myers Squibb Company Radiolabeled fibronectin based scaffolds and antibodies and theranostic uses thereof
US12049483B2 (en) * 2020-12-05 2024-07-30 New York University Selective and noncovalent inhibitors of oncogenic RAS mutants
AU2022258566A1 (en) 2021-04-14 2023-10-12 Aro Biotherapeutics Company Cd71 binding fibronectin type iii domains
CN113527526B (zh) * 2021-09-14 2021-12-17 美慕(北京)科技有限公司 一种重组蛋白及其构建方法、用途
CN113527525B (zh) * 2021-09-14 2021-12-17 美慕(北京)科技有限公司 重组蛋白及其构建方法、用途
TW202340235A (zh) * 2021-12-17 2023-10-16 美商戴納立製藥公司 多肽工程、文庫及工程ｃｄ９８重鏈以及轉鐵蛋白受體結合多肽
WO2023145861A1 (ja) * 2022-01-27 2023-08-03 公益財団法人東京都医学総合研究所 ユビキチンに対する人工抗体
CN115976031B (zh) * 2022-07-18 2023-06-23 烟台市华昕生物医药科技有限公司 一种重组纤连蛋白及其应用

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
DE3329892A1 (de) 1983-08-18 1985-03-07 Köster, Hubert, Prof. Dr., 2000 Hamburg Verfahren zur herstellung von oligonucleotiden
US4888286A (en) 1984-02-06 1989-12-19 Creative Biomolecules, Inc. Production of gene and protein analogs through synthetic gene design using double stranded synthetic oligonucleotides
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
ATE126535T1 (de) 1990-04-05 1995-09-15 Roberto Crea ''walk-through''-mutagenese.
US7063943B1 (en) 1990-07-10 2006-06-20 Cambridge Antibody Technology Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5843701A (en) 1990-08-02 1998-12-01 Nexstar Pharmaceticals, Inc. Systematic polypeptide evolution by reverse translation
JP4124480B2 (ja) 1991-06-14 2008-07-23 ジェネンテック・インコーポレーテッド 免疫グロブリン変異体
US5492817A (en) 1993-11-09 1996-02-20 Promega Corporation Coupled transcription and translation in eukaryotic cell-free extract
US5665563A (en) 1991-10-11 1997-09-09 Promega Corporation Coupled transcription and translation in eukaryotic cell-free extract
ATE147104T1 (de) 1991-10-11 1997-01-15 Promega Corp Gekoppelte transkription und translation in zellfreien eukaryoten-extrakten
US20030036092A1 (en) 1991-11-15 2003-02-20 Board Of Regents, The University Of Texas System Directed evolution of enzymes and antibodies
US5866344A (en) 1991-11-15 1999-02-02 Board Of Regents, The University Of Texas System Antibody selection methods using cell surface expressed libraries
US5922545A (en) 1993-10-29 1999-07-13 Affymax Technologies N.V. In vitro peptide and antibody display libraries
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6300065B1 (en) 1996-05-31 2001-10-09 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
US6699658B1 (en) 1996-05-31 2004-03-02 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
EP0971946B1 (en) 1997-01-21 2006-07-05 The General Hospital Corporation Selection of proteins using rna-protein fusions
US6261804B1 (en) 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
CA2289691C (en) 1997-04-23 2008-01-15 Andreas Pluckthun Methods for identifying nucleic acid molecules encoding (poly)peptides that interact with target molecules
DK0985039T3 (da) 1997-06-12 2008-06-09 Novartis Int Pharm Ltd Kunstige antistof-polypeptider
DK1137812T3 (da) 1998-12-02 2007-05-21 Adnexus Therapeutics Inc DNA-proteinfusioner og anvendelser deraf
AU781783B2 (en) 1999-07-27 2005-06-16 Bristol-Myers Squibb Company Peptide acceptor ligation methods
US7022479B2 (en) 2000-01-24 2006-04-04 Compound Therapeutics, Inc. Sensitive, multiplexed diagnostic assays for protein analysis
AU2001277867B2 (en) * 2000-07-11 2006-12-07 Research Corporation Technologies, Inc. Artificial antibody polypeptides
EP1356075A4 (en) 2000-10-16 2005-04-13 Compound Therapeutics Inc PROTEIN EQUIPMENT FOR ANTIBODY MIMETICS AND OTHER TIE PROTEINS
US7094571B2 (en) 2000-10-27 2006-08-22 The Board Of Regents Of The University Of Texas System Combinatorial protein library screening by periplasmic expression
US7598352B2 (en) 2000-11-17 2009-10-06 University Of Rochester Method of identifying polypeptide monobodies which bind to target proteins and use thereof
US20030157561A1 (en) 2001-11-19 2003-08-21 Kolkman Joost A. Combinatorial libraries of monomer domains
AU2002310502A1 (en) 2001-06-21 2003-01-08 Phylos, Inc. In vitro protein interaction detection systems
WO2003104418A2 (en) * 2002-06-06 2003-12-18 Research Corporation Technologies, Inc. Reconstituted polypeptides
EP2284192A3 (en) 2002-11-08 2011-07-20 Ablynx N.V. Camelidae antibodies for sublingual administration
WO2005003345A2 (en) 2003-06-27 2005-01-13 R. Crea & Co. Look-through mutagenesis
MX2007000105A (es) 2004-07-06 2007-07-18 Bioren Inc Mutagenesis look-through para crear polipeptidos alterados con propiedades mejoradas.
AR056857A1 (es) 2005-12-30 2007-10-24 U3 Pharma Ag Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
CA2655205A1 (en) 2006-06-12 2007-12-21 Receptor Biologix Inc. Pan-cell surface receptor- specific therapeutics
CN201113075Y (zh) 2007-07-10 2008-09-10 富士康(昆山)电脑接插件有限公司 电源连接器
JP5781762B2 (ja) 2007-08-10 2015-09-24 プロテリックス、インク ユニバーサルｉｉｉ型フィブロネクチン結合ドメインのライブラリ
WO2009023266A1 (en) 2007-08-14 2009-02-19 Ludwig Institute For Cancer Research Generation of antibodies to cell-surface receptors and cancer-associated proteins including egfr family members
RU2010119556A (ru) 2007-10-16 2011-11-27 Симфоген А/С (Dk) Композиции, содержащие оптимизированные мультимеры her1 и her3, и способы их применения
AU2009242038B2 (en) * 2008-05-02 2013-05-30 Novartis Ag Improved fibronectin-based binding molecules and uses thereof
TWI496582B (zh) * 2008-11-24 2015-08-21 必治妥美雅史谷比公司 雙重專一性之ｅｇｆｒ／ｉｇｆｉｒ結合分子
US9139825B2 (en) * 2009-10-30 2015-09-22 Novartis Ag Universal fibronectin type III bottom-side binding domain libraries
MX357972B (es) 2009-11-13 2018-08-01 Amgen Inc Materiales y metodos para el tratamiento o prevencion de enfermedades asociadas al her-3.

Also Published As

Publication number Publication date
EP2598529A2 (en) 2013-06-05
CA2805862A1 (en) 2012-02-02
MX2013001144A (es) 2013-06-05
JP2016192973A (ja) 2016-11-17
EP3222631A2 (en) 2017-09-27
WO2012016245A3 (en) 2012-08-09
KR20130136443A (ko) 2013-12-12
RU2013108962A (ru) 2014-09-10
SG187225A1 (en) 2013-02-28
EP3222631A3 (en) 2017-11-22
JP6092773B2 (ja) 2017-03-08
US20140057807A1 (en) 2014-02-27
WO2012016245A2 (en) 2012-02-02
US9512199B2 (en) 2016-12-06
JP2013539362A (ja) 2013-10-24
EP3248987A1 (en) 2017-11-29
CN103403027A (zh) 2013-11-20
AU2011283646B2 (en) 2015-07-09
IL224220A (en) 2017-07-31
AU2011283646A1 (en) 2013-03-07
CN107903321A (zh) 2018-04-13

Similar Documents

Publication Publication Date Title
MX345300B (es) Moléculas andamio de fibronectina y bibliotecas de las mismas.
PH12018501850A1 (en) Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
EA200970909A1 (ru) Новый антиген, ассоциированный с новообразованными сосудами опухолевых метастазов
MX2010007767A (es) Anticuerpos manipulados con cisteina para conjugacion especifica de sitio.
MX2010004726A (es) Antigeno asociado con artritis reumatoide.
MX2012006983A (es) Absorbente especifico para unir proteinas y peptidos, y metodo de separacion que utiliza el mismo.
WO2010138814A3 (en) Disrupting fcrn-albumin interactions
MY159553A (en) Detection and treatment of pancreatic, ovarian and other cancers
ATE513833T1 (de) Thienopyridinverbindungen und verfahren zu ihrer verwendung
ATE555128T1 (de) Verbesserte immunglobulin-bibliotheken
EA201000979A1 (ru) Улучшенные связывающие молекулы на основе фибронектина и их применение
WO2012099973A3 (en) Compositions and methods for treating cancer
EP2464663A4 (en) RECOMBINANT PROTEINS COMPRISING MUTANT DOMAINS OF FIBRONECTIN
MY177062A (en) Cd37-binding molecules and immunoconjugates thereof
MX337586B (es) Anticuerpos anti-interleucina-1beta para usarse en el tratamiento de condiciones relacionadas con interleucina-1beta.
NZ592830A (en) Process for the modulation of the antagonistic activity of a monoclonal antibody
GEP20166504B (en) Anti-gcc antibody molecules and related compositions and methods
WO2006133107A3 (en) Specific binding sites in collagen for integrins and use thereof
WO2009013619A3 (en) The ed-a antigen of fibrinogen is associated with the neovas culature of tumor metastases
MX2009004167A (es) Anticuerpos que enlazan epitopos cxcr7.
IN2014DN08158A (es)
DE602006006691D1 (de) Umlenken von ausgestrahlten signalen für aufzeichnung von programmmaterial
IN2015MN00027A (es)
WO2009097014A3 (en) Therapeutic kinase modulators
MX2020011199A (es) Instrumentacion automatizada para la produccion de bibliotecas de peptidos de receptores de celulas t.

Legal Events

Date Code Title Description
FG Grant or registration