EP1356075A4 - Protein scaffolds for antibody mimics and other binding proteins - Google Patents
Protein scaffolds for antibody mimics and other binding proteinsInfo
- Publication number
- EP1356075A4 EP1356075A4 EP01981621A EP01981621A EP1356075A4 EP 1356075 A4 EP1356075 A4 EP 1356075A4 EP 01981621 A EP01981621 A EP 01981621A EP 01981621 A EP01981621 A EP 01981621A EP 1356075 A4 EP1356075 A4 EP 1356075A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- binding proteins
- protein scaffolds
- antibody mimics
- mimics
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09167669A EP2141243A3 (en) | 2000-10-16 | 2001-10-16 | Protein scaffolds for antibody mimics and other binding proteins |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68856600A | 2000-10-16 | 2000-10-16 | |
US688566 | 2000-10-16 | ||
PCT/US2001/032233 WO2002032925A2 (en) | 2000-10-16 | 2001-10-16 | Protein scaffolds for antibody mimics and other binding proteins |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP09167669A Division EP2141243A3 (en) | 2000-10-16 | 2001-10-16 | Protein scaffolds for antibody mimics and other binding proteins |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1356075A2 EP1356075A2 (en) | 2003-10-29 |
EP1356075A4 true EP1356075A4 (en) | 2005-04-13 |
Family
ID=24764915
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP09167669A Ceased EP2141243A3 (en) | 2000-10-16 | 2001-10-16 | Protein scaffolds for antibody mimics and other binding proteins |
EP01981621A Withdrawn EP1356075A4 (en) | 2000-10-16 | 2001-10-16 | Protein scaffolds for antibody mimics and other binding proteins |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP09167669A Ceased EP2141243A3 (en) | 2000-10-16 | 2001-10-16 | Protein scaffolds for antibody mimics and other binding proteins |
Country Status (5)
Country | Link |
---|---|
EP (2) | EP2141243A3 (en) |
JP (4) | JP2004526419A (en) |
AU (2) | AU1325102A (en) |
CA (1) | CA2418835A1 (en) |
WO (1) | WO2002032925A2 (en) |
Families Citing this family (168)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
US6818418B1 (en) * | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
EP2385067A1 (en) | 2000-07-11 | 2011-11-09 | Research Corporation Technologies, Inc. | Artificial antibody polypeptides |
JP2004526419A (en) * | 2000-10-16 | 2004-09-02 | フィロス インク. | Protein scaffolds for antibody mimics and other binding proteins |
DE60305919T2 (en) * | 2002-06-28 | 2007-01-18 | Domantis Limited, Cambridge | DUAL SPECIFIC LIGANDS WITH INCREASED HALF TIME |
US20050074865A1 (en) | 2002-08-27 | 2005-04-07 | Compound Therapeutics, Inc. | Adzymes and uses thereof |
PT2382990E (en) | 2003-04-30 | 2014-12-29 | Univ Zuerich | Methods for treating cancer using an immunotoxin |
KR20060129246A (en) | 2003-12-05 | 2006-12-15 | 컴파운드 쎄라퓨틱스, 인크. | Inhibitors of type 2 vascular endothelial growth factor receptors |
CA2549884A1 (en) * | 2003-12-16 | 2005-06-30 | Commonwealth Scientific And Industrial Research Organisation | Cytokine binding domains |
US7977071B2 (en) * | 2004-06-02 | 2011-07-12 | Adalta Pty Ltd. | Binding moieties based on shark ignar domains |
CA2580796C (en) | 2004-09-24 | 2013-03-26 | Amgen Inc. | Modified fc molecules having peptides inserted in internal loop regions |
DE602006003695D1 (en) * | 2005-01-05 | 2009-01-02 | F Star Biotech Forsch & Entw | Synthetic immunoglobulin domains with modified binding properties in regions of the molecule other than the complementarity determining regions |
US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
WO2007056812A1 (en) * | 2005-11-16 | 2007-05-24 | Apollo Life Sciences Limited | A molecule and chimeric molecules thereof |
CN104844713B (en) | 2005-11-23 | 2021-05-14 | 阿塞勒隆制药公司 | Activin-ActRIIa antagonists and uses thereof for promoting bone growth |
ZA200810836B (en) | 2006-05-26 | 2010-07-28 | Obodies Ltd | OB fold domains |
AT503889B1 (en) * | 2006-07-05 | 2011-12-15 | Star Biotechnologische Forschungs Und Entwicklungsges M B H F | MULTIVALENT IMMUNE LOBULINE |
WO2008031098A1 (en) * | 2006-09-09 | 2008-03-13 | The University Of Chicago | Binary amino acid libraries for fibronectin type iii polypeptide monobodies |
PL2068921T3 (en) | 2006-10-19 | 2014-12-31 | Csl Ltd | High affinity antibody antagonists of interleukin-13 receptor alpha 1 |
CA2670471A1 (en) | 2006-11-22 | 2008-06-05 | Adnexus, A Bristol-Myers Squibb R&D Company (A Delaware Corporation) | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including igf-ir |
ATE542830T1 (en) | 2006-12-04 | 2012-02-15 | Pasteur Institut | OB-FOLD USED AS A SCAFFOLD FOR THE DEVELOPMENT OF NEW SPECIFIC BINDERS |
BRPI0720476B1 (en) | 2006-12-18 | 2022-05-31 | Acceleron Pharma Inc | Use of an actii polypeptide to treat anemia in a human patient |
BRPI0806861A2 (en) | 2007-02-01 | 2014-08-05 | Acceleron Pharma Inc | ATIVIN-ACTRIE ANTAGONISTS AND USES TO TREAT OR PREVENT BREAST CANCER |
US20100144599A1 (en) | 2007-02-02 | 2010-06-10 | Bristol-Myers Squibb Company | Vegf pathway blockade |
TWI525102B (en) | 2007-02-09 | 2016-03-11 | 艾瑟勒朗法瑪公司 | Pharmaceutical composition comprising an actriia-fc fusion protein; use of an actriia-fc fusion protein for treatment or prevention of cancer-related bone loss; use of an actriia-fc fusion protein for the treatment or prevention of multiple myeloma |
CA2683559C (en) | 2007-04-13 | 2019-09-24 | Dana Farber Cancer Institute, Inc. | Methods for treating cancer resistant to erbb therapeutics |
US8492328B2 (en) | 2007-05-17 | 2013-07-23 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to insulin growth factor-1 receptor modulators |
WO2008144610A1 (en) * | 2007-05-18 | 2008-11-27 | Medimmune, Llc | Il-33 in inflammatory disease |
ES2627223T3 (en) | 2007-06-26 | 2017-07-27 | F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H | Presentation of binding agents |
AU2008287426B2 (en) * | 2007-08-10 | 2014-06-26 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
US8680019B2 (en) | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
CN103877564A (en) | 2007-09-18 | 2014-06-25 | 阿塞勒隆制药公司 | Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion |
BRPI0818810A2 (en) | 2007-10-31 | 2014-10-29 | Medimmune Llc | RECOMBINANT AND MULTIMERIC POLYPEPTIDE SKELETONS, ISOLATED N UCLEIC ACID MOLECULE, EXPRESSION VECTOR, HOST STONE POLYPETEID, MUSCLE ESTEXE MUSCLE TELECLE MUSCLE COLLECTION LIBRARY A COMPOUND IN A SAMPLE, TO CAPTURE A COMPOUND IN A SAMPLE, TO PREVENT, TREAT, CONTROL OR IMPROVE A DISEASE, FOR DIAGNOSIS OR IMAGE FORMATION OF A DISEASE TO PURIFY AND PRODUCE A SKELETON, TO TEST OR DELECT A SLAKE TO A TARGET, TO USE SKELETON AND TO PREVENT, TREAT, IMPROVE, OR CONTROL CANCER, STERILE COMPOSITION, PYROGEN FREE, PHARMACEUTICAL COMPOSITION, AND SCALABLE PROCESS. |
NZ583632A (en) | 2007-11-16 | 2012-05-25 | Univ Rockefeller | Antibodies specific for the protofibril form of beta-amyloid protein |
WO2009083804A2 (en) * | 2007-12-27 | 2009-07-09 | Novartis Ag | Improved fibronectin-based binding molecules and their use |
US9493747B2 (en) | 2008-01-03 | 2016-11-15 | The General Hospital Corporation | Engineered transglutaminase barrel proteins |
JP2011517314A (en) | 2008-02-14 | 2011-06-02 | ブリストル−マイヤーズ スクイブ カンパニー | Targeted therapeutics based on engineered proteins that bind to EGFR |
TWI564021B (en) | 2008-04-11 | 2017-01-01 | Chugai Pharmaceutical Co Ltd | Repeated binding of antigen to antigen binding molecules |
EP2439212B1 (en) * | 2008-05-02 | 2016-12-21 | Novartis AG | Improved fibronectin-based binding molecules and uses thereof |
EP2113255A1 (en) | 2008-05-02 | 2009-11-04 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Cytotoxic immunoglobulin |
EP2799448A1 (en) | 2008-05-22 | 2014-11-05 | Bristol-Myers Squibb Company | Multivalent fibronectin based scaffold domain proteins |
DK2318028T3 (en) | 2008-06-26 | 2020-05-04 | Acceleron Pharma Inc | ANTAGONISTS OF SOLVABLE ACTIVIN ACTIVIA AND APPLICATIONS TO INCREASE RED BLOOD CELL LEVELS |
US20100015144A1 (en) | 2008-06-26 | 2010-01-21 | Acceleron Pharma Inc. | Methods for dosing an activin-actriia antagonist and monitoring of treated patients |
AU2009308935B2 (en) * | 2008-10-31 | 2015-02-26 | Janssen Biotech, Inc. | Fibronectin type III domain based scaffold compositions, methods and uses |
US8415291B2 (en) * | 2008-10-31 | 2013-04-09 | Centocor Ortho Biotech Inc. | Anti-TNF alpha fibronectin type III domain based scaffold compositions, methods and uses |
TWI496582B (en) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | Bispecific egfr/igfir binding molecules |
AU2009327189B2 (en) | 2008-12-16 | 2012-09-06 | Novartis Ag | Yeast display systems |
CN102596992B (en) * | 2009-02-12 | 2015-09-09 | 詹森生物科技公司 | Based on the holder combination thing of III type fibronectin domain, method and purposes |
KR101805201B1 (en) | 2009-03-30 | 2017-12-05 | 악셀레론 파마 인코포레이티드 | Bmp-alk3 antagonists and uses for promoting bone growth |
US8067201B2 (en) | 2009-04-17 | 2011-11-29 | Bristol-Myers Squibb Company | Methods for protein refolding |
CA2773494A1 (en) | 2009-09-09 | 2011-03-17 | Acceleron Pharma Inc. | Actriib antagonists and dosing and uses thereof |
EP2494070A2 (en) | 2009-10-30 | 2012-09-05 | Bristol-Myers Squibb Company | Methods for treating cancer in patients having igf-1r inhibitor resistance |
ES2691717T3 (en) | 2009-10-30 | 2018-11-28 | Novartis Ag | Universal libraries of the binding domain of the inferior side of type III fibronectin type III |
AU2011218243A1 (en) * | 2010-02-18 | 2012-10-04 | Bristol-Myers Squibb Company | Fibronectin based scaffold domain proteins that bind IL-23 |
TWI667257B (en) | 2010-03-30 | 2019-08-01 | 中外製藥股份有限公司 | Antibodies with modified affinity to fcrn that promote antigen clearance |
EP2558495B1 (en) | 2010-04-13 | 2019-07-17 | MedImmune, LLC | Trail r2-specific multimeric scaffolds |
KR101863033B1 (en) | 2010-04-30 | 2018-06-01 | 얀센 바이오테크 인코포레이티드 | Stabilized fibronectin domain compositions, methods and uses |
TW201138808A (en) | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
JP6023703B2 (en) | 2010-05-26 | 2016-11-09 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Fibronectin based scaffold proteins with improved stability |
JP6092773B2 (en) * | 2010-07-30 | 2017-03-08 | ノバルティス アーゲー | Fibronectin cradle molecule and its library |
MX355060B (en) | 2010-11-17 | 2018-04-03 | Chugai Pharmaceutical Co Ltd | Multi-specific antigen-binding molecule having alternative function to function of blood coagulation factor viii. |
MX365235B (en) | 2010-11-30 | 2019-05-28 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly. |
EP3539991A1 (en) | 2011-01-07 | 2019-09-18 | Chugai Seiyaku Kabushiki Kaisha | Method for improving physical properties of antibody |
US20140093496A1 (en) | 2011-02-25 | 2014-04-03 | Chugai Seiyaku Kabushiki Kaisha | Fc-gamma-RIIb-SPECIFIC Fc ANTIBODY |
CN107375293A (en) | 2011-03-11 | 2017-11-24 | 细胞基因公司 | Utilize the method for the one for treating cancers of 3 (base of 5 amino, 2 methyl, 4 oxygen 4H quinazolines 3) piperidines 2,6 2 |
RS56770B1 (en) | 2011-03-11 | 2018-04-30 | Celgene Corp | Solid forms of 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses |
EP3825325A3 (en) | 2011-03-30 | 2021-10-13 | Chugai Seiyaku Kabushiki Kaisha | Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity |
EP3415528B1 (en) * | 2011-04-13 | 2021-05-26 | Bristol-Myers Squibb Company | Fc fusion proteins comprising novel linkers or arrangements |
US20140187488A1 (en) | 2011-05-17 | 2014-07-03 | Bristol-Myers Squibb Company | Methods for maintaining pegylation of polypeptides |
ES2848531T3 (en) | 2011-05-17 | 2021-08-10 | Bristol Myers Squibb Co | Improved methods for the selection of binding proteins |
DK2728002T3 (en) | 2011-06-30 | 2022-04-04 | Chugai Pharmaceutical Co Ltd | HETERODIMERIZED POLYPEPTIDE |
IL277891B2 (en) | 2011-09-27 | 2024-01-01 | Janssen Biotech Inc | Fibronectin type iii repeat based protein scaffolds with alternative binding surfaces |
TW201817745A (en) | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | Therapeutic antigen-binding molecule with a FcRn-binding domain that promotes antigen clearance |
WO2013046722A1 (en) | 2011-09-30 | 2013-04-04 | 中外製薬株式会社 | Ion concentration-dependent binding molecule library |
US20150050269A1 (en) | 2011-09-30 | 2015-02-19 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities |
SG11201401101XA (en) | 2011-09-30 | 2014-08-28 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule for promoting loss of antigens |
CA2850322C (en) | 2011-09-30 | 2023-10-10 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule inducing immune response to target antigen |
EP2765192A4 (en) | 2011-10-05 | 2015-04-15 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule for promoting clearance from plasma of antigen comprising saccharide chain receptor-binding domain |
SG10201707813YA (en) | 2011-10-11 | 2017-11-29 | Medimmune Llc | Cd40l-specific tn3-derived scaffolds and methods of use thereof |
WO2013056069A1 (en) | 2011-10-13 | 2013-04-18 | Bristol-Myers Squibb Company | Methods for selecting and treating cancer in patients with igf-1r/ir inhibitors |
CN104053670A (en) | 2011-10-31 | 2014-09-17 | 百时美施贵宝公司 | Fibronectin binding domains with reduced immunogenicity |
US20150056182A1 (en) | 2011-11-30 | 2015-02-26 | Chugai Seiyaku Kabushiki Kaisha | Drug containing carrier into cell for forming immune complex |
SG11201404751UA (en) | 2012-02-09 | 2014-09-26 | Chugai Pharmaceutical Co Ltd | Modified fc region of antibody |
TW202015731A (en) | 2012-02-24 | 2020-05-01 | 日商中外製藥股份有限公司 | Antigen-Binding Molecule for Promoting Disappearance of Antigen via Fc[gamma]RIIB |
DK2857419T3 (en) | 2012-05-30 | 2021-03-29 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule for the elimination of aggregated antigens |
CA2874721A1 (en) | 2012-05-30 | 2013-12-05 | Tomoyuki Igawa | Target tissue-specific antigen-binding molecule |
US11142563B2 (en) | 2012-06-14 | 2021-10-12 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule containing modified Fc region |
RS60416B1 (en) | 2012-08-09 | 2020-07-31 | Celgene Corp | Treatment of immune-related and inflammatory diseases |
SI2882737T1 (en) | 2012-08-09 | 2019-05-31 | Celgene Corporation | A solid form of (s)-3-(4-((4-morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride |
IL288506B2 (en) | 2012-08-09 | 2023-09-01 | Celgene Corp | Methods of treating cancer using 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione |
MX371442B (en) | 2012-08-24 | 2020-01-30 | Chugai Pharmaceutical Co Ltd | Fcyriib-specific fc region variant. |
EP3597747B1 (en) | 2012-08-24 | 2023-03-15 | Chugai Seiyaku Kabushiki Kaisha | Mouse fcgammarii-specific fc antibody |
US9938325B2 (en) | 2012-09-07 | 2018-04-10 | Rutgers, The State University Of New York | HIV-1 antigens with discrete conformational forms in the V1/V2 domain and methods of use thereof |
ES2727453T3 (en) | 2012-09-13 | 2019-10-16 | Bristol Myers Squibb Co | Fibronectin-based framework domain proteins that bind myostatin |
US11078518B2 (en) | 2012-09-28 | 2021-08-03 | Chugai Seiyaku Kabushiki Kaisha | Method for evaluating blood coagulation reaction |
ES2753811T3 (en) | 2012-10-24 | 2020-04-14 | Celgene Corp | Biomarker for use in treating anemia |
EP3964224A1 (en) | 2012-11-02 | 2022-03-09 | Celgene Corporation | Activin-actrii antagonists and uses for use in treating renal disease |
EP2940197B1 (en) | 2012-12-27 | 2019-02-27 | National Institute of Advanced Industrial Science and Technology | Molecule library constructed on the basis of backbone structure of microprotein |
WO2014104165A1 (en) | 2012-12-27 | 2014-07-03 | 中外製薬株式会社 | Heterodimerized polypeptide |
US20150361159A1 (en) | 2013-02-01 | 2015-12-17 | Bristol-Myers Squibb Company | Fibronectin based scaffold proteins |
ES2689372T3 (en) | 2013-02-06 | 2018-11-13 | Bristol-Myers Squibb Company | Fibronectin type III domain proteins with enhanced solubility |
US10065987B2 (en) | 2013-02-12 | 2018-09-04 | Bristol-Myers Squibb Company | High pH protein refolding methods |
EP2968587A2 (en) | 2013-03-13 | 2016-01-20 | Bristol-Myers Squibb Company | Fibronectin based scaffold domains linked to serum albumin or a moiety binding thereto |
EP3783017A1 (en) | 2013-04-02 | 2021-02-24 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
SG11201604495PA (en) | 2013-12-04 | 2016-07-28 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecules, the antigen-binding activity of which varies according to the concentration of compounds, and libraries of said molecules |
JP6591437B2 (en) | 2014-03-20 | 2019-10-16 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Serum albumin binding fibronectin type III domain |
MX371403B (en) * | 2014-03-20 | 2020-01-29 | Bristol Myers Squibb Co | Stabilized fibronectin based scaffold molecules. |
TWI831106B (en) | 2014-06-20 | 2024-02-01 | 日商中外製藥股份有限公司 | Pharmaceutical compositions for the prevention and/or treatment of diseases that develop and/or progress due to reduced or deficient activity of coagulation factor VIII and/or activated coagulation factor VIII |
MA41052A (en) | 2014-10-09 | 2017-08-15 | Celgene Corp | TREATMENT OF CARDIOVASCULAR DISEASE USING ACTRII LIGAND TRAPS |
ES2946160T3 (en) | 2014-12-03 | 2023-07-13 | Celgene Corp | Activin-ActRII Antagonists and Uses to Treat Myelodysplastic Syndrome |
CN111388680B (en) * | 2015-01-28 | 2024-01-05 | 中国科学院天津工业生物技术研究所 | Application of polypeptide complex as polypeptide or protein drug carrier, method and fusion protein complex thereof |
EA201791754A1 (en) | 2015-02-05 | 2019-01-31 | Чугаи Сейяку Кабусики Кайся | ANTIBODIES CONTAINING ANTIGEN-BINDING DOMAIN DEPENDING ON THE CONCENTRATION OF IONS, Fc-AREA OPTIONS, IL-8-CONNECTING ANTIBODIES AND THEIR APPLICATIONS |
AU2016248817A1 (en) | 2015-04-17 | 2017-08-17 | F. Hoffmann-La Roche Ag | Combination therapy with coagulation factors and multispecific antibodies |
KR102625793B1 (en) * | 2015-05-06 | 2024-01-15 | 얀센 바이오테크 인코포레이티드 | Prostate-specific membrane antigen-binding fibronectin type III domain |
EP3291836A4 (en) * | 2015-05-06 | 2018-11-14 | Janssen Biotech, Inc. | Prostate specific membrane antigen (psma) bispecific binding agents and uses thereof |
EP4190805A3 (en) | 2015-05-20 | 2023-08-16 | Celgene Corporation | In vitro cell culture methods for beta-thalassemia using activin type ii receptor ligand traps |
KR102538745B1 (en) | 2015-09-18 | 2023-06-01 | 추가이 세이야쿠 가부시키가이샤 | Il-8-binding antibodies and uses thereof |
US10766946B2 (en) | 2015-09-23 | 2020-09-08 | Bristol-Myers Squibb Company | Fast-off rate serum albumin binding fibronectin type III domains |
JP6951340B2 (en) * | 2015-09-23 | 2021-10-20 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Glypican-3 binding fibronectin-based scaffold molecule |
CA3006758A1 (en) | 2015-12-02 | 2017-06-08 | Celgene Corporation | Cycling therapy using 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione |
LT3402491T (en) | 2016-01-11 | 2022-02-25 | Rubius Therapeutics, Inc. | Compositions and methods related to multimodal therapeutic cell systems for cancer indications |
US11634705B2 (en) | 2016-03-30 | 2023-04-25 | Epsilon Molecular Engineering Inc. | High-speed in vitro screening method |
ES2929650T3 (en) | 2016-03-30 | 2022-11-30 | Epsilon Molecular Eng Inc | Method for high speed in vitro screening |
CN109661241A (en) | 2016-09-06 | 2019-04-19 | 中外制药株式会社 | Use the method for identification plasma thromboplastin component and/or the bispecific antibody of activated clotting factor IX and Stuart factor and/or activated clotting factor X |
KR102221364B1 (en) | 2016-11-21 | 2021-03-04 | 쿠레아브 게엠베하 | Anti-GP73 Antibody and Immunoconjugate |
KR102533814B1 (en) | 2016-11-28 | 2023-05-19 | 추가이 세이야쿠 가부시키가이샤 | Ligand-binding molecules capable of tunable ligand-binding activity |
TWI797097B (en) | 2016-11-28 | 2023-04-01 | 日商中外製藥股份有限公司 | Polypeptides comprising an antigen-binding domain and a transport moiety |
WO2018111976A1 (en) | 2016-12-14 | 2018-06-21 | Janssen Biotech, Inc. | Pd-l1 binding fibronectin type iii domains |
BR112019012154A2 (en) | 2016-12-14 | 2019-11-12 | Janssen Biotech Inc | cd8a-binding fibronectin type iii domains |
US10611823B2 (en) | 2016-12-14 | 2020-04-07 | Hanssen Biotech, Inc | CD137 binding fibronectin type III domains |
US20180258064A1 (en) | 2017-03-07 | 2018-09-13 | Celgene Corporation | Solid forms of 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses |
US20210107994A1 (en) | 2017-03-31 | 2021-04-15 | Public University Corporation Nara Medical University | Medicinal composition usable for preventing and/or treating blood coagulation factor ix abnormality, comprising multispecific antigen binding molecule replacing function of blood coagulation factor viii |
EP3654991A1 (en) | 2017-07-19 | 2020-05-27 | Rubius Therapeutics, Inc. | Compositions and methods related to multimodal therapeutic cell systems for infectious disease |
EP3654992A1 (en) | 2017-07-19 | 2020-05-27 | Rubius Therapeutics, Inc. | Compositions and methods related to multimodal therapeutic cell systems for cardiometabolic disease |
MX2020002710A (en) | 2017-09-29 | 2020-07-20 | Chugai Pharmaceutical Co Ltd | Multispecific antigen-binding molecule having blood coagulation factor viii (fviii) cofactor function-substituting activity, and pharmaceutical formulation containing said molecule as active ingredient. |
BR112020010248A2 (en) | 2017-11-28 | 2020-11-10 | Chugai Seiyaku Kabushiki Kaisha | ligand binding molecule having adjustable ligand binding activity |
AU2018377783A1 (en) | 2017-11-28 | 2020-06-11 | Chugai Seiyaku Kabushiki Kaisha | Polypeptide including antigen-binding domain and carrying section |
AU2019205090A1 (en) | 2018-01-05 | 2020-08-06 | Ac Immune Sa | Misfolded TDP-43 binding molecules |
WO2019158645A1 (en) | 2018-02-14 | 2019-08-22 | Abba Therapeutics Ag | Anti-human pd-l2 antibodies |
US20210261669A1 (en) | 2018-06-20 | 2021-08-26 | Chugai Seiyaku Kabushiki Kaisha | Method for activating immune response of target cell and composition therefor |
SG11202003531WA (en) | 2018-08-10 | 2020-05-28 | Chugai Pharmaceutical Co Ltd | Anti-cd137 antigen-binding molecule and utilization thereof |
US20220153875A1 (en) | 2019-03-19 | 2022-05-19 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule containing antigen-binding domain of which binding activity to antigen is changed depending on mta, and library for obtaining said antigen-binding domain |
MX2021011903A (en) | 2019-04-02 | 2021-10-26 | Chugai Pharmaceutical Co Ltd | Method of introducing target-specific foreign gene. |
CA3133909A1 (en) | 2019-04-18 | 2020-10-22 | Elpida TSIKA | Novel molecules for therapy and diagnosis |
WO2020234473A1 (en) | 2019-05-23 | 2020-11-26 | Ac Immune Sa | Anti-tdp-43 binding molecules and uses thereof |
EP4023230A4 (en) | 2019-06-05 | 2023-11-15 | Chugai Seiyaku Kabushiki Kaisha | Antibody cleavage site-binding molecule |
CN114127277A (en) | 2019-06-05 | 2022-03-01 | 中外制药株式会社 | Protease substrates and polypeptides comprising protease cleavage sequences |
EP3982369A4 (en) | 2019-06-07 | 2023-06-14 | Chugai Seiyaku Kabushiki Kaisha | Information processing system, information processing method, program, and method for producing antigen-binding molecule or protein |
CN113993548A (en) | 2019-06-18 | 2022-01-28 | 马克思—普朗克科学促进协会公司 | Site-specific kinetic inert conjugation of tags and/or vectors to target molecules, e.g., His-tagged proteins, via metal complex reagents |
WO2021076574A2 (en) | 2019-10-14 | 2021-04-22 | Aro Biotherapeutics Company | Fn3 domain-sirna conjugates and uses thereof |
EP4045061A4 (en) | 2019-10-14 | 2024-04-17 | ARO Biotherapeutics Company | Cd71 binding fibronectin type iii domains |
AU2020385631A1 (en) | 2019-11-20 | 2022-06-02 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Archaeal peptide recombinase – a novel peptide ligating enzyme |
AU2020387034A1 (en) | 2019-11-20 | 2022-06-02 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing preparation |
US20230000918A1 (en) | 2019-11-29 | 2023-01-05 | Suzhou Nova Therapeutics Co. Ltd | Chimeric antigen receptors, compositions and applications thereof |
EP3845553A1 (en) | 2019-12-30 | 2021-07-07 | Johann Wolfgang Goethe-Universität | Carrier matrix comprising dodecin protein |
TW202144395A (en) | 2020-02-12 | 2021-12-01 | 日商中外製藥股份有限公司 | Anti-CD137 antigen-binding molecule for use in cancer treatment |
KR20230048059A (en) | 2020-07-31 | 2023-04-10 | 추가이 세이야쿠 가부시키가이샤 | Pharmaceutical composition comprising cells expressing chimeric receptors |
TW202221008A (en) | 2020-08-07 | 2022-06-01 | 瑞士商赫孚孟拉羅股份公司 | Method for producing protein compositions |
US20230322908A1 (en) | 2020-08-14 | 2023-10-12 | Ac Immune Sa | Humanized Anti-TDP-43 Binding Molecules and Uses Thereof |
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EP4229082A1 (en) | 2020-10-16 | 2023-08-23 | AC Immune SA | Antibodies binding to alpha-synuclein for therapy and diagnosis |
JPWO2022244838A1 (en) | 2021-05-19 | 2022-11-24 | ||
WO2023088959A1 (en) | 2021-11-16 | 2023-05-25 | Ac Immune Sa | Novel molecules for therapy and diagnosis |
WO2023156549A1 (en) | 2022-02-16 | 2023-08-24 | Ac Immune Sa | Humanized anti-tdp-43 binding molecules and uses thereof |
WO2023194565A1 (en) | 2022-04-08 | 2023-10-12 | Ac Immune Sa | Anti-tdp-43 binding molecules |
WO2024064646A1 (en) | 2022-09-20 | 2024-03-28 | Celgene Corporation | Salts and solid forms of (s)- or racemic 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and methods of using the same |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000034784A1 (en) * | 1998-12-10 | 2000-06-15 | Phylos, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
WO2001064942A1 (en) * | 2000-02-29 | 2001-09-07 | Phylos, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US700598A (en) | 1901-03-21 | 1902-05-20 | Le Carbone Sa | Primary battery. |
US5773574A (en) * | 1990-12-03 | 1998-06-30 | The Scripps Research Institute | Polypeptides for promoting cell attachment |
RU2233878C2 (en) | 1997-01-21 | 2004-08-10 | Дзе Дженерал Хоспитал Корпорейшн | Method for selection of desirable protein and nucleic acid, agents for its realization |
US6673901B2 (en) * | 1997-06-12 | 2004-01-06 | Research Corporation Technologies, Inc. | Artificial antibody polypeptides |
WO1999051773A1 (en) | 1998-04-03 | 1999-10-14 | Phylos, Inc. | Addressable protein arrays |
US6416950B1 (en) | 1998-12-02 | 2002-07-09 | Phylos, Inc. | DNA-protein fusions and uses thereof |
JP2004526419A (en) * | 2000-10-16 | 2004-09-02 | フィロス インク. | Protein scaffolds for antibody mimics and other binding proteins |
US8068698B2 (en) | 2007-05-29 | 2011-11-29 | Research In Motion Limited | System and method for resizing images prior to upload |
US11054998B1 (en) | 2019-12-12 | 2021-07-06 | Facebook, Inc. | High bandwidth memory system with distributed request broadcasting masters |
-
2001
- 2001-10-16 JP JP2002536306A patent/JP2004526419A/en not_active Withdrawn
- 2001-10-16 EP EP09167669A patent/EP2141243A3/en not_active Ceased
- 2001-10-16 WO PCT/US2001/032233 patent/WO2002032925A2/en active Search and Examination
- 2001-10-16 AU AU1325102A patent/AU1325102A/en active Pending
- 2001-10-16 EP EP01981621A patent/EP1356075A4/en not_active Withdrawn
- 2001-10-16 AU AU2002213251A patent/AU2002213251B2/en not_active Ceased
- 2001-10-16 CA CA002418835A patent/CA2418835A1/en not_active Abandoned
-
2009
- 2009-03-27 JP JP2009078046A patent/JP5460097B2/en not_active Expired - Fee Related
-
2013
- 2013-04-15 JP JP2013084490A patent/JP5868346B2/en not_active Expired - Fee Related
-
2014
- 2014-12-15 JP JP2014252609A patent/JP2015051023A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000034784A1 (en) * | 1998-12-10 | 2000-06-15 | Phylos, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
WO2001064942A1 (en) * | 2000-02-29 | 2001-09-07 | Phylos, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
Non-Patent Citations (2)
Title |
---|
KOIDE A ET AL: "THE FIBRONECTIN TYPE III DOMAIN AS A SCAFFOLD FOR NOVEL BINDING PROTEINS", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 284, 1998, pages 1141 - 1151, XP002944100, ISSN: 0022-2836 * |
NYGREN PER-AKE ET AL: "Scaffolds for engineering novel binding sites in proteins", CURRENT OPINION IN STRUCTURAL BIOLOGY, CURRENT BIOLOGY LTD., LONDON, GB, vol. 7, no. 4, 1997, pages 463 - 469, XP002196760, ISSN: 0959-440X * |
Also Published As
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JP2013162789A (en) | 2013-08-22 |
JP2009183292A (en) | 2009-08-20 |
JP2004526419A (en) | 2004-09-02 |
CA2418835A1 (en) | 2002-04-25 |
JP5868346B2 (en) | 2016-02-24 |
WO2002032925A2 (en) | 2002-04-25 |
AU1325102A (en) | 2002-04-29 |
JP5460097B2 (en) | 2014-04-02 |
EP2141243A3 (en) | 2010-01-27 |
WO2002032925A3 (en) | 2003-08-21 |
EP2141243A2 (en) | 2010-01-06 |
AU2002213251B2 (en) | 2007-06-14 |
JP2015051023A (en) | 2015-03-19 |
EP1356075A2 (en) | 2003-10-29 |
WO2002032925A9 (en) | 2003-02-06 |
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