HUP9700886A2 - Új tienil-etilamino-halogénfenil-acetonitril intermedierek és eljárás előállításukra - Google Patents

Új tienil-etilamino-halogénfenil-acetonitril intermedierek és eljárás előállításukra

Info

Publication number
HUP9700886A2
HUP9700886A2 HU9700886A HUP9700886A HUP9700886A2 HU P9700886 A2 HUP9700886 A2 HU P9700886A2 HU 9700886 A HU9700886 A HU 9700886A HU P9700886 A HUP9700886 A HU P9700886A HU P9700886 A2 HUP9700886 A2 HU P9700886A2
Authority
HU
Hungary
Prior art keywords
halogenphenyl
ethylamino
thienil
novel
producing
Prior art date
Application number
HU9700886A
Other languages
English (en)
Inventor
Mária Bakonyi
Alain Heymes
Bertrand Castro
Nagy Marianna Csatáriné
Leventéné Molnár
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Priority to HU9700886A priority Critical patent/HU225504B1/hu
Publication of HU9700886D0 publication Critical patent/HU9700886D0/hu
Priority to BRPI9809113-1A priority patent/BR9809113B1/pt
Priority to ES98921668T priority patent/ES2213900T3/es
Priority to AT98921668T priority patent/ATE258551T1/de
Priority to AU74446/98A priority patent/AU7444698A/en
Priority to DE69821347T priority patent/DE69821347T2/de
Priority to US09/423,548 priority patent/US6215005B1/en
Priority to EP98921668A priority patent/EP0981525B1/en
Priority to JP54895498A priority patent/JP4279903B2/ja
Priority to DK98921668T priority patent/DK0981525T3/da
Priority to PT98921668T priority patent/PT981525E/pt
Priority to CA002288637A priority patent/CA2288637C/en
Priority to PCT/HU1998/000046 priority patent/WO1998051682A1/en
Publication of HUP9700886A2 publication Critical patent/HUP9700886A2/hu
Priority to NO19995531A priority patent/NO325305B1/no
Publication of HUP9700886A3 publication Critical patent/HUP9700886A3/hu
Publication of HU225504B1 publication Critical patent/HU225504B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A találmány tárgya az (I) általánős képletű[2-(2-tienil)-etilaminő]-(2-halőgénfenil)-acetőnitrilek és eljárás előállításűkra 2-(2-tienil)-etil-aminból alkáli-cianidból és ő-halőgén-benzaldehidből. Az (I)általánős képletű vegyületek antitrőmbőlitikűs hatású vegyületekintermedierei. ŕ
HU9700886A 1997-05-13 1997-05-13 Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them HU225504B1 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
HU9700886A HU225504B1 (en) 1997-05-13 1997-05-13 Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them
PCT/HU1998/000046 WO1998051682A1 (en) 1997-05-13 1998-05-11 New intermediates and process for the preparation thereof
US09/423,548 US6215005B1 (en) 1997-05-13 1998-05-11 Intermediates and process for the preparation thereof
JP54895498A JP4279903B2 (ja) 1997-05-13 1998-05-11 新規中間体及びこれらの調製方法
AT98921668T ATE258551T1 (de) 1997-05-13 1998-05-11 (2-(2-thienyl)-ethylamino)-(2-halophenyl)- acetonitrile als zwischenprodukte und verfahren zu ihrer herstellung
AU74446/98A AU7444698A (en) 1997-05-13 1998-05-11 New intermediates and process for the preparation thereof
DE69821347T DE69821347T2 (de) 1997-05-13 1998-05-11 (2-(2-thienyl)-ethylamino)-(2-halophenyl)-acetonitrile als zwischenprodukte und verfahren zu ihrer herstellung
BRPI9809113-1A BR9809113B1 (pt) 1997-05-13 1998-05-11 [2-(2-tienil) -etilamino] -(2-halogeno-fenil) -acetonitilas como intermediários e processo para sua preparação.
EP98921668A EP0981525B1 (en) 1997-05-13 1998-05-11 (2-(2-thienyl)-ethylamino)-(2-halophenyl)-acetonitriles as intermediates and process for the preparation thereof
ES98921668T ES2213900T3 (es) 1997-05-13 1998-05-11 (2-(2-tienil)-etilamino)-(2-halofenil)-acetonitrilos como intermediarios y procedimiento para su preparacion.
DK98921668T DK0981525T3 (da) 1997-05-13 1998-05-11 (2-(2-Thienyl)-ethylamino)-(2-halophenyl)-acetonitriler som mellemprodukter og fremgangsmåde til deres fremstilling
PT98921668T PT981525E (pt) 1997-05-13 1998-05-11 Novos intermediarios e processo para a sua preparacao
CA002288637A CA2288637C (en) 1997-05-13 1998-05-11 Process for the preparation of 2-[(2-thienyl)-ethylamino-(2-halogenophe nyl)-acetonitriles
NO19995531A NO325305B1 (no) 1997-05-13 1999-11-12 Nye mellomprodukter, isomerer derav og fremgangsmate for fremstilling av disse

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9700886A HU225504B1 (en) 1997-05-13 1997-05-13 Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them

Publications (4)

Publication Number Publication Date
HU9700886D0 HU9700886D0 (en) 1997-07-28
HUP9700886A2 true HUP9700886A2 (hu) 1999-09-28
HUP9700886A3 HUP9700886A3 (en) 2000-06-28
HU225504B1 HU225504B1 (en) 2007-01-29

Family

ID=89995121

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9700886A HU225504B1 (en) 1997-05-13 1997-05-13 Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them

Country Status (14)

Country Link
US (1) US6215005B1 (hu)
EP (1) EP0981525B1 (hu)
JP (1) JP4279903B2 (hu)
AT (1) ATE258551T1 (hu)
AU (1) AU7444698A (hu)
BR (1) BR9809113B1 (hu)
CA (1) CA2288637C (hu)
DE (1) DE69821347T2 (hu)
DK (1) DK0981525T3 (hu)
ES (1) ES2213900T3 (hu)
HU (1) HU225504B1 (hu)
NO (1) NO325305B1 (hu)
PT (1) PT981525E (hu)
WO (1) WO1998051682A1 (hu)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU226421B1 (en) 1998-11-09 2008-12-29 Sanofi Aventis Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides
US6495691B1 (en) 2001-07-06 2002-12-17 Brantford Chemicals Inc. Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
US6767913B2 (en) 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en) 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
HUP0200438A3 (en) * 2002-02-06 2003-10-28 Egis Gyogyszergyar Nyilvanosan Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
US6800759B2 (en) * 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
IL166593A0 (en) 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
US7872019B2 (en) 2003-03-12 2011-01-18 Cadila Healthcare Limited Polymorphs and amorphous form of (S)-(+)-clopidogrel bisulfate
US20040250673A1 (en) * 2003-06-10 2004-12-16 Salerno Paul Michael Ergonomic pedal board
GB0321256D0 (en) 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
KR101110738B1 (ko) 2003-11-03 2012-02-17 카딜라 핼쓰캐어 리미티드 (ｓ)-(+)-클로피도그렐 비설페이트의 상이한 형태의 제조 방법
US20060154957A1 (en) * 2004-09-21 2006-07-13 Nina Finkelstein Crystalline clopidogrel hydrobromide and processes for preparation thereof
EP1851231A2 (en) * 2005-02-24 2007-11-07 Teva Pharmaceutical Industries Ltd Clopidogrel base suitable for pharmaceutical formulation and preparation thereof
WO2007032023A2 (en) 2005-07-12 2007-03-22 Rpg Life Sciences Limited A process for preparation of methyl-(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4h)-acetic acid methyl ester or salts thereof having higher chiral purity and products thereof
RU2008146758A (ru) * 2006-04-27 2010-06-10 Инд-Свифт Лэборетриз Лимитед (In) Способ получения полиморфных форм клопидогрела гидросульфата
US20090247569A1 (en) * 2006-08-03 2009-10-01 Claude Singer Process for Preparing Clopidogrel Bisulphate
EP1980563A1 (en) 2007-04-09 2008-10-15 BATTULA, Srinivasa Reddy Procedure for the preparation of methyl (+)-(S)-Alpha-(O-chlorophenyl)-6,7-dihydrothieno-[3,2-C]pyridine-5(4H) acetate
WO2010046476A1 (en) * 2008-10-24 2010-04-29 Sandoz Ag A process for the preparation of s-clopidogrel

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2508455A1 (fr) * 1981-06-30 1982-12-31 Sanofi Sa Procede de preparation de derives des (thienyl-2)- et (thienyl-3)-2 ethylamines
FR2530247B1 (fr) 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2608607B1 (fr) 1986-12-23 1989-04-28 Sanofi Sa Procede de preparation de thienylethylamines et dithienylethylamines ainsi obtenues
FR2623810B2 (fr) 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2614619B1 (fr) * 1987-04-29 1989-09-15 Sanofi Sa Procede de preparation de n-((chloro-2)-benzyl) (thienyl-2)-2 ethylamine
FR2652575B1 (fr) * 1989-09-29 1992-01-24 Sanofi Sa Procede de preparation d'acides alpha-bromo phenylacetiques.
FR2664596B1 (fr) * 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
CN1112354C (zh) * 1996-09-12 2003-06-25 阿温蒂斯药物公司 手性1－芳基－和1－杂芳基－2－取代的乙基－2－胺的立体选择性制备

Also Published As

Publication number Publication date
NO995531D0 (no) 1999-11-12
CA2288637C (en) 2005-11-15
ES2213900T3 (es) 2004-09-01
WO1998051682A1 (en) 1998-11-19
BR9809113B1 (pt) 2010-03-09
CA2288637A1 (en) 1998-11-19
EP0981525A1 (en) 2000-03-01
DE69821347T2 (de) 2004-12-02
PT981525E (pt) 2004-05-31
HUP9700886A3 (en) 2000-06-28
HU9700886D0 (en) 1997-07-28
BR9809113A (pt) 2000-08-01
ATE258551T1 (de) 2004-02-15
DK0981525T3 (da) 2004-05-10
JP4279903B2 (ja) 2009-06-17
NO995531L (no) 1999-12-13
DE69821347D1 (de) 2004-03-04
US6215005B1 (en) 2001-04-10
JP2001525817A (ja) 2001-12-11
NO325305B1 (no) 2008-03-25
EP0981525B1 (en) 2004-01-28
AU7444698A (en) 1998-12-08
HU225504B1 (en) 2007-01-29

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