ES2091324T3 - Proceso para la preparacion de aspartama a partir de una dicetopiperazina y nuevos compuestos intermedios y derivados para dicho proceso. - Google Patents

Proceso para la preparacion de aspartama a partir de una dicetopiperazina y nuevos compuestos intermedios y derivados para dicho proceso.

Info

Publication number
ES2091324T3
ES2091324T3 ES91906948T ES91906948T ES2091324T3 ES 2091324 T3 ES2091324 T3 ES 2091324T3 ES 91906948 T ES91906948 T ES 91906948T ES 91906948 T ES91906948 T ES 91906948T ES 2091324 T3 ES2091324 T3 ES 2091324T3
Authority
ES
Spain
Prior art keywords
derivatives
aspartama
dicetopiperazine
dkp
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91906948T
Other languages
English (en)
Inventor
John B Hill
Tse-Lok Ho
Mark R Johnson
Russell Klix
Gayle Webber
Robert A Erickson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nutrasweet Co
Original Assignee
Nutrasweet Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nutrasweet Co filed Critical Nutrasweet Co
Application granted granted Critical
Publication of ES2091324T3 publication Critical patent/ES2091324T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

ESTA INVENCION SE REFIERE A UN PROCESO PARA LA FABRICACION DE (ALFA)-L-ASPARTIL-L-FENILALANINA METIL ESTER ("(ALFA)-APM") PARA SU UTILIZACION EN 5(S)-BENZIL-3,6,-DIOXOPIPERIRAZINE-2(S)-ACIDO ACETICO ("AP-DKP") O METIL 5(S)-BENZIL-3,6-DIOXOPIPERIRAZINE-2(S)-ACETATO ("MAP-DKP") O RESPECTIVO 1-ACIL DERIVADOS DE LO ANTERIOR ("1-ACIL AP-DKP" Y "1-ACIL MAP-DKP") E INTERMEDIARIOS NOVELES PRODUCIDOS POR ELLOS.
ES91906948T 1990-03-15 1991-03-12 Proceso para la preparacion de aspartama a partir de una dicetopiperazina y nuevos compuestos intermedios y derivados para dicho proceso. Expired - Lifetime ES2091324T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US49824390A 1990-03-15 1990-03-15
US60665690A 1990-10-31 1990-10-31
US65878491A 1991-02-26 1991-02-26
US66480691A 1991-03-08 1991-03-08

Publications (1)

Publication Number Publication Date
ES2091324T3 true ES2091324T3 (es) 1996-11-01

Family

ID=27504394

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91906948T Expired - Lifetime ES2091324T3 (es) 1990-03-15 1991-03-12 Proceso para la preparacion de aspartama a partir de una dicetopiperazina y nuevos compuestos intermedios y derivados para dicho proceso.

Country Status (16)

Country Link
EP (1) EP0478729B1 (es)
CN (1) CN1057835A (es)
AT (1) ATE141613T1 (es)
AU (1) AU628257B2 (es)
CA (1) CA2060515A1 (es)
CS (1) CS70091A2 (es)
DE (1) DE69121502T2 (es)
DK (1) DK0478729T3 (es)
ES (1) ES2091324T3 (es)
GR (1) GR3020839T3 (es)
HU (1) HUT60712A (es)
IE (1) IE910896A1 (es)
NO (1) NO920193L (es)
NZ (1) NZ237469A (es)
PT (1) PT97049B (es)
WO (1) WO1991014378A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04234374A (ja) * 1990-12-27 1992-08-24 Ajinomoto Co Inc ジケトピペラジン誘導体の製造方法
JPH04234375A (ja) * 1990-12-27 1992-08-24 Ajinomoto Co Inc 新規２，５−ジオキソピペラジン化合物及びその製造法
JPH05117246A (ja) * 1991-10-23 1993-05-14 Ajinomoto Co Inc 新規２，５−ジオキソピペラジン化合物とその製造法及びα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル誘導体の製造法
US6465677B1 (en) 1998-11-19 2002-10-15 The Nutrasweet Company Method for the preparation of N-neohexyl-α-aspartyl-L-phenylalanine methyl ester from imidazolidin-4-one intermediates
DE10019879A1 (de) * 2000-04-20 2001-10-25 Degussa Verfahren zur Herstellung von 2,5-Diketopiperazinen, neue 2,5-Diketopiperazine und deren Verwendung
GB2382346B (en) * 2000-08-04 2004-08-11 Dmi Biosciences Inc Method of synthesizing diketopiperazines
ES2381775T3 (es) 2000-08-04 2012-05-31 Dmi Biosciences, Inc. Procedimiento del uso de dicetopiperazinas y composición que las contiene
EP2799114A3 (en) 2003-05-15 2015-02-18 Ampio Pharmaceuticals, Inc. Treatment of T-cell mediated diseases
JP5856843B2 (ja) 2008-05-27 2016-02-10 アンピオ ファーマシューティカルズ，インコーポレイテッド ジケトピペラジンを用いた医薬組成物
WO2012033792A2 (en) 2010-09-07 2012-03-15 Dmi Acquisition Corp. Treatment of diseases
MX2014003856A (es) 2011-10-10 2015-01-16 Ampio Pharmaceuticals Inc Dispositivos medicos implantables con tolerancia inmune incrementada y metodos para hacerlos e implantarlos.
MY167804A (en) 2011-10-10 2018-09-26 Ampio Pharmaceuticals Inc Treatment of degenerative joint disease
EP2771007B1 (en) 2011-10-28 2018-04-04 Ampio Pharmaceuticals, Inc. Treatment of rhinitis
JP6588005B2 (ja) 2013-03-15 2019-10-09 アンピオ ファーマシューティカルズ，インコーポレイテッド 軟骨形成を刺激するために使用される医薬組成物
RU2736513C2 (ru) 2014-08-18 2020-11-17 Ампио Фармасьютикалз, Инк. Лечение патологических состояний суставов
US11389512B2 (en) 2015-06-22 2022-07-19 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
EP3560345B1 (en) * 2016-12-21 2023-08-09 Suntory Holdings Limited Food and beverages containing cyclo(aspartyl-glycine), glucose, and maltose

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2038106A1 (de) * 1970-07-31 1972-02-10 Henkel & Cie Gmbh Aktivatoren fuer Perverbindungen
JPS58185545A (ja) * 1982-04-22 1983-10-29 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法
IT1197461B (it) * 1983-05-13 1988-11-30 Debi Derivati Biologici Procedimento per la preparazione dell'estere metilico di alfa-l-aspartil-l-fenil-alanina
JPS60174799A (ja) * 1984-02-21 1985-09-09 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法
AU586669B2 (en) * 1985-03-29 1989-07-20 Mitsui Toatsu Chemicals Inc. Preparation process of ```-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof
JPH0647600B2 (ja) * 1985-06-04 1994-06-22 味の素株式会社 β−アスパルチルフエニルアラニン誘導体のα−アスパルチルフエニルアラニン誘導体への変換法
US4677220A (en) * 1985-10-31 1987-06-30 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester
DE3600731A1 (de) * 1986-01-13 1987-07-16 Green Cross Korea Verfahren zur herstellung von (alpha)-l-aspartyl-l-phenylalaninmethylester
US4992552A (en) * 1988-08-31 1991-02-12 Eastman Kodak Company Process for preparation of amino acids

Also Published As

Publication number Publication date
EP0478729A4 (en) 1993-06-16
HUT60712A (en) 1992-10-28
AU7564891A (en) 1991-10-21
GR3020839T3 (en) 1996-11-30
EP0478729A1 (en) 1992-04-08
PT97049A (pt) 1991-12-31
DK0478729T3 (da) 1996-09-16
CA2060515A1 (en) 1991-09-16
ATE141613T1 (de) 1996-09-15
NO920193D0 (no) 1992-01-15
DE69121502D1 (de) 1996-09-26
EP0478729B1 (en) 1996-08-21
CS70091A2 (en) 1991-10-15
NO920193L (no) 1992-01-15
CN1057835A (zh) 1992-01-15
NZ237469A (en) 1993-08-26
IE910896A1 (en) 1991-09-25
WO1991014378A1 (en) 1991-10-03
DE69121502T2 (de) 1997-01-16
PT97049B (pt) 1998-07-31
AU628257B2 (en) 1992-09-10

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