ATE141613T1 - Prozess zur darstellung von aspartam aus einem diketopiperazin sowie neue zwischenprodukte und derivate dafür - Google Patents
Prozess zur darstellung von aspartam aus einem diketopiperazin sowie neue zwischenprodukte und derivate dafürInfo
- Publication number
- ATE141613T1 ATE141613T1 AT91906948T AT91906948T ATE141613T1 AT E141613 T1 ATE141613 T1 AT E141613T1 AT 91906948 T AT91906948 T AT 91906948T AT 91906948 T AT91906948 T AT 91906948T AT E141613 T1 ATE141613 T1 AT E141613T1
- Authority
- AT
- Austria
- Prior art keywords
- diketopiperazine
- intermediate products
- dkp
- new intermediate
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49824390A | 1990-03-15 | 1990-03-15 | |
| US60665690A | 1990-10-31 | 1990-10-31 | |
| US65878491A | 1991-02-26 | 1991-02-26 | |
| US66480691A | 1991-03-08 | 1991-03-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE141613T1 true ATE141613T1 (de) | 1996-09-15 |
Family
ID=27504394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91906948T ATE141613T1 (de) | 1990-03-15 | 1991-03-12 | Prozess zur darstellung von aspartam aus einem diketopiperazin sowie neue zwischenprodukte und derivate dafür |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0478729B1 (de) |
| CN (1) | CN1057835A (de) |
| AT (1) | ATE141613T1 (de) |
| AU (1) | AU628257B2 (de) |
| CA (1) | CA2060515A1 (de) |
| CS (1) | CS70091A2 (de) |
| DE (1) | DE69121502T2 (de) |
| DK (1) | DK0478729T3 (de) |
| ES (1) | ES2091324T3 (de) |
| GR (1) | GR3020839T3 (de) |
| HU (1) | HUT60712A (de) |
| IE (1) | IE910896A1 (de) |
| NO (1) | NO920193L (de) |
| NZ (1) | NZ237469A (de) |
| PT (1) | PT97049B (de) |
| WO (1) | WO1991014378A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04234375A (ja) * | 1990-12-27 | 1992-08-24 | Ajinomoto Co Inc | 新規２，５−ジオキソピペラジン化合物及びその製造法 |
| JPH04234374A (ja) * | 1990-12-27 | 1992-08-24 | Ajinomoto Co Inc | ジケトピペラジン誘導体の製造方法 |
| JPH05117246A (ja) * | 1991-10-23 | 1993-05-14 | Ajinomoto Co Inc | 新規２，５−ジオキソピペラジン化合物とその製造法及びα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル誘導体の製造法 |
| US6465677B1 (en) * | 1998-11-19 | 2002-10-15 | The Nutrasweet Company | Method for the preparation of N-neohexyl-α-aspartyl-L-phenylalanine methyl ester from imidazolidin-4-one intermediates |
| DE10019879A1 (de) * | 2000-04-20 | 2001-10-25 | Degussa | Verfahren zur Herstellung von 2,5-Diketopiperazinen, neue 2,5-Diketopiperazine und deren Verwendung |
| JP5048201B2 (ja) | 2000-08-04 | 2012-10-17 | ディーエムアイ バイオサイエンシズ インコーポレイテッド | ジケトピペラジン類の使用方法とジケトピペラジン類を含む組成物 |
| US6967202B2 (en) | 2000-08-04 | 2005-11-22 | Dmi Biosciences, Inc. | Method of synthesizing diketopiperazines |
| ES2572975T3 (es) | 2003-05-15 | 2016-06-03 | Ampio Pharmaceuticals, Inc. | Tratamiento de enfermedades mediadas por los linfocitos T |
| JP5856843B2 (ja) | 2008-05-27 | 2016-02-10 | アンピオ ファーマシューティカルズ，インコーポレイテッド | ジケトピペラジンを用いた医薬組成物 |
| EP2613786A4 (de) | 2010-09-07 | 2013-10-23 | Dmi Acquisition Corp | Behandlung von erkrankungen |
| KR102032400B1 (ko) | 2011-10-10 | 2019-10-15 | 앰피오 파마슈티컬스 인코퍼레이티드 | 퇴행성 관절 질환의 치료 |
| WO2013055749A1 (en) | 2011-10-10 | 2013-04-18 | Ampio Pharmaceuticals, Inc. | Implantable medical devices with increased immune tolerance, and methods for making and implanting |
| SG10201605205VA (en) | 2011-10-28 | 2016-08-30 | Ampio Pharmaceuticals Inc | Treatment of rhinitis |
| WO2014145729A2 (en) | 2013-03-15 | 2014-09-18 | Ampio Pharmaceuticals, Inc. | Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same |
| RU2020136589A (ru) | 2014-08-18 | 2020-12-24 | Ампио Фармасьютикалз, Инк. | Лечение дегенеративных заболеваний суставов |
| US11389512B2 (en) | 2015-06-22 | 2022-07-19 | Ampio Pharmaceuticals, Inc. | Use of low molecular weight fractions of human serum albumin in treating diseases |
| ES2957286T3 (es) * | 2016-12-21 | 2024-01-16 | Suntory Holdings Ltd | Alimentos y bebidas que contienen ciclo(aspartil-glicina), glucosa y maltosa |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2038106A1 (de) * | 1970-07-31 | 1972-02-10 | Henkel & Cie Gmbh | Aktivatoren fuer Perverbindungen |
| JPS58185545A (ja) * | 1982-04-22 | 1983-10-29 | Ajinomoto Co Inc | α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法 |
| IT1197461B (it) * | 1983-05-13 | 1988-11-30 | Debi Derivati Biologici | Procedimento per la preparazione dell'estere metilico di alfa-l-aspartil-l-fenil-alanina |
| JPS60174799A (ja) * | 1984-02-21 | 1985-09-09 | Ajinomoto Co Inc | α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法 |
| AU586669B2 (en) * | 1985-03-29 | 1989-07-20 | Mitsui Toatsu Chemicals Inc. | Preparation process of ```-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof |
| JPH0647600B2 (ja) * | 1985-06-04 | 1994-06-22 | 味の素株式会社 | β−アスパルチルフエニルアラニン誘導体のα−アスパルチルフエニルアラニン誘導体への変換法 |
| US4677220A (en) * | 1985-10-31 | 1987-06-30 | Monsanto Company | Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester |
| DE3600731A1 (de) * | 1986-01-13 | 1987-07-16 | Green Cross Korea | Verfahren zur herstellung von (alpha)-l-aspartyl-l-phenylalaninmethylester |
| US4992552A (en) * | 1988-08-31 | 1991-02-12 | Eastman Kodak Company | Process for preparation of amino acids |
-
1991
- 1991-03-12 DK DK91906948.4T patent/DK0478729T3/da active
- 1991-03-12 AU AU75648/91A patent/AU628257B2/en not_active Ceased
- 1991-03-12 WO PCT/US1991/001646 patent/WO1991014378A1/en active IP Right Grant
- 1991-03-12 AT AT91906948T patent/ATE141613T1/de not_active IP Right Cessation
- 1991-03-12 CA CA002060515A patent/CA2060515A1/en not_active Abandoned
- 1991-03-12 EP EP91906948A patent/EP0478729B1/de not_active Expired - Lifetime
- 1991-03-12 DE DE69121502T patent/DE69121502T2/de not_active Expired - Fee Related
- 1991-03-12 ES ES91906948T patent/ES2091324T3/es not_active Expired - Lifetime
- 1991-03-12 HU HU913921A patent/HUT60712A/hu unknown
- 1991-03-15 IE IE089691A patent/IE910896A1/en unknown
- 1991-03-15 CS CS91700A patent/CS70091A2/cs unknown
- 1991-03-15 CN CN91102471.9A patent/CN1057835A/zh active Pending
- 1991-03-15 PT PT97049A patent/PT97049B/pt not_active IP Right Cessation
- 1991-03-18 NZ NZ237469A patent/NZ237469A/en unknown
-
1992
- 1992-01-15 NO NO92920193A patent/NO920193L/no unknown
-
1996
- 1996-08-22 GR GR960402052T patent/GR3020839T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU7564891A (en) | 1991-10-21 |
| ES2091324T3 (es) | 1996-11-01 |
| AU628257B2 (en) | 1992-09-10 |
| DK0478729T3 (da) | 1996-09-16 |
| GR3020839T3 (en) | 1996-11-30 |
| PT97049A (pt) | 1991-12-31 |
| EP0478729A1 (de) | 1992-04-08 |
| WO1991014378A1 (en) | 1991-10-03 |
| DE69121502T2 (de) | 1997-01-16 |
| NO920193D0 (no) | 1992-01-15 |
| CA2060515A1 (en) | 1991-09-16 |
| PT97049B (pt) | 1998-07-31 |
| CS70091A2 (en) | 1991-10-15 |
| HUT60712A (en) | 1992-10-28 |
| NZ237469A (en) | 1993-08-26 |
| EP0478729A4 (en) | 1993-06-16 |
| IE910896A1 (en) | 1991-09-25 |
| EP0478729B1 (de) | 1996-08-21 |
| DE69121502D1 (de) | 1996-09-26 |
| CN1057835A (zh) | 1992-01-15 |
| NO920193L (no) | 1992-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |