PT97049A - Processo para a preparacao de ester de 1-metilo de n-l alfa-aspartil-fenilalanina (aspartame) e de produtos intermediarios e de derivados - Google Patents

Processo para a preparacao de ester de 1-metilo de n-l alfa-aspartil-fenilalanina (aspartame) e de produtos intermediarios e de derivados

Info

Publication number
PT97049A
PT97049A PT97049A PT9704991A PT97049A PT 97049 A PT97049 A PT 97049A PT 97049 A PT97049 A PT 97049A PT 9704991 A PT9704991 A PT 9704991A PT 97049 A PT97049 A PT 97049A
Authority
PT
Portugal
Prior art keywords
alpha
methyl ester
derivatives
phenylenanin
aspartil
Prior art date
Application number
PT97049A
Other languages
English (en)
Other versions
PT97049B (pt
Inventor
John B Hill
Mark R Johnson
Tse-Lok Ho
Russell Klix
Gayle Webber
Robert A Erickson
Original Assignee
Nutrasweet Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nutrasweet Co filed Critical Nutrasweet Co
Publication of PT97049A publication Critical patent/PT97049A/pt
Publication of PT97049B publication Critical patent/PT97049B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
PT97049A 1990-03-15 1991-03-15 Processo para a preparacao de ester de 1-metilo de n-l alfa-aspartil-fenilalanina (aspartame) e de produtos intermediarios e de derivados PT97049B (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US49824390A 1990-03-15 1990-03-15
US60665690A 1990-10-31 1990-10-31
US65878491A 1991-02-26 1991-02-26
US66480691A 1991-03-08 1991-03-08

Publications (2)

Publication Number Publication Date
PT97049A true PT97049A (pt) 1991-12-31
PT97049B PT97049B (pt) 1998-07-31

Family

ID=27504394

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97049A PT97049B (pt) 1990-03-15 1991-03-15 Processo para a preparacao de ester de 1-metilo de n-l alfa-aspartil-fenilalanina (aspartame) e de produtos intermediarios e de derivados

Country Status (16)

Country Link
EP (1) EP0478729B1 (pt)
CN (1) CN1057835A (pt)
AT (1) ATE141613T1 (pt)
AU (1) AU628257B2 (pt)
CA (1) CA2060515A1 (pt)
CS (1) CS70091A2 (pt)
DE (1) DE69121502T2 (pt)
DK (1) DK0478729T3 (pt)
ES (1) ES2091324T3 (pt)
GR (1) GR3020839T3 (pt)
HU (1) HUT60712A (pt)
IE (1) IE910896A1 (pt)
NO (1) NO920193L (pt)
NZ (1) NZ237469A (pt)
PT (1) PT97049B (pt)
WO (1) WO1991014378A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04234375A (ja) * 1990-12-27 1992-08-24 Ajinomoto Co Inc 新規２，５−ジオキソピペラジン化合物及びその製造法
JPH04234374A (ja) * 1990-12-27 1992-08-24 Ajinomoto Co Inc ジケトピペラジン誘導体の製造方法
JPH05117246A (ja) * 1991-10-23 1993-05-14 Ajinomoto Co Inc 新規２，５−ジオキソピペラジン化合物とその製造法及びα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル誘導体の製造法
US6465677B1 (en) * 1998-11-19 2002-10-15 The Nutrasweet Company Method for the preparation of N-neohexyl-α-aspartyl-L-phenylalanine methyl ester from imidazolidin-4-one intermediates
DE10019879A1 (de) * 2000-04-20 2001-10-25 Degussa Verfahren zur Herstellung von 2,5-Diketopiperazinen, neue 2,5-Diketopiperazine und deren Verwendung
WO2002011676A2 (en) 2000-08-04 2002-02-14 Dmi Biosciences, Inc. Method of using diketopiperazines and composition containing them
AU2001284697A1 (en) * 2000-08-04 2002-02-18 Dmi Biosciences, Inc. Method of synthesizing diketopiperazines
WO2004103304A2 (en) 2003-05-15 2004-12-02 Dmi Biosciences, Inc. Treatment of t-cell mediated diseases
EP2300011A4 (en) 2008-05-27 2012-06-20 Dmi Life Sciences Inc METHODS AND THERAPEUTIC COMPOUNDS
JP2013537195A (ja) 2010-09-07 2013-09-30 ディエムアイ アクイジション コーポレイション 疾患の治療
CN103841934A (zh) 2011-10-10 2014-06-04 安皮奥制药股份有限公司 增强免疫耐受的可植入的医疗装置及其制造与植入方法
KR102032400B1 (ko) 2011-10-10 2019-10-15 앰피오 파마슈티컬스 인코퍼레이티드 퇴행성 관절 질환의 치료
EP2771007B1 (en) 2011-10-28 2018-04-04 Ampio Pharmaceuticals, Inc. Treatment of rhinitis
WO2014145729A2 (en) 2013-03-15 2014-09-18 Ampio Pharmaceuticals, Inc. Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
EP4066836A1 (en) 2014-08-18 2022-10-05 Ampio Pharmaceuticals, Inc. Treatment of joint conditions
WO2016209969A1 (en) 2015-06-22 2016-12-29 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
CN110099574B (zh) * 2016-12-21 2023-02-28 三得利控股株式会社 含有环天冬氨酰甘氨酸、葡萄糖及麦芽糖的饮食品

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2038106A1 (de) * 1970-07-31 1972-02-10 Henkel & Cie Gmbh Aktivatoren fuer Perverbindungen
JPS58185545A (ja) * 1982-04-22 1983-10-29 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法
IT1197461B (it) * 1983-05-13 1988-11-30 Debi Derivati Biologici Procedimento per la preparazione dell'estere metilico di alfa-l-aspartil-l-fenil-alanina
JPS60174799A (ja) * 1984-02-21 1985-09-09 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法
AU586669B2 (en) * 1985-03-29 1989-07-20 Mitsui Toatsu Chemicals Inc. Preparation process of ```-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof
JPH0647600B2 (ja) * 1985-06-04 1994-06-22 味の素株式会社 β−アスパルチルフエニルアラニン誘導体のα−アスパルチルフエニルアラニン誘導体への変換法
US4677220A (en) * 1985-10-31 1987-06-30 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester
DE3600731A1 (de) * 1986-01-13 1987-07-16 Green Cross Korea Verfahren zur herstellung von (alpha)-l-aspartyl-l-phenylalaninmethylester
US4992552A (en) * 1988-08-31 1991-02-12 Eastman Kodak Company Process for preparation of amino acids

Also Published As

Publication number Publication date
WO1991014378A1 (en) 1991-10-03
AU7564891A (en) 1991-10-21
AU628257B2 (en) 1992-09-10
IE910896A1 (en) 1991-09-25
NO920193D0 (no) 1992-01-15
DK0478729T3 (da) 1996-09-16
HUT60712A (en) 1992-10-28
PT97049B (pt) 1998-07-31
NO920193L (no) 1992-01-15
DE69121502D1 (de) 1996-09-26
EP0478729A4 (en) 1993-06-16
GR3020839T3 (en) 1996-11-30
DE69121502T2 (de) 1997-01-16
NZ237469A (en) 1993-08-26
EP0478729A1 (en) 1992-04-08
ATE141613T1 (de) 1996-09-15
CA2060515A1 (en) 1991-09-16
ES2091324T3 (es) 1996-11-01
EP0478729B1 (en) 1996-08-21
CN1057835A (zh) 1992-01-15
CS70091A2 (en) 1991-10-15

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Legal Events

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BB1A Laying open of patent application

Effective date: 19910909

FG3A Patent granted, date of granting

Effective date: 19980414

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19991031