PT97049A - Processo para a preparacao de ester de 1-metilo de n-l alfa-aspartil-fenilalanina (aspartame) e de produtos intermediarios e de derivados - Google Patents
Processo para a preparacao de ester de 1-metilo de n-l alfa-aspartil-fenilalanina (aspartame) e de produtos intermediarios e de derivadosInfo
- Publication number
- PT97049A PT97049A PT97049A PT9704991A PT97049A PT 97049 A PT97049 A PT 97049A PT 97049 A PT97049 A PT 97049A PT 9704991 A PT9704991 A PT 9704991A PT 97049 A PT97049 A PT 97049A
- Authority
- PT
- Portugal
- Prior art keywords
- alpha
- methyl ester
- derivatives
- phenylenanin
- aspartil
- Prior art date
Links
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 235000010357 aspartame Nutrition 0.000 title 2
- FGOJCPKOOGIRPA-UHFFFAOYSA-N 1-o-tert-butyl 4-o-ethyl 5-oxoazepane-1,4-dicarboxylate Chemical compound CCOC(=O)C1CCN(C(=O)OC(C)(C)C)CCC1=O FGOJCPKOOGIRPA-UHFFFAOYSA-N 0.000 title 1
- 108010011485 Aspartame Proteins 0.000 title 1
- 229960003438 aspartame Drugs 0.000 title 1
- 239000000605 aspartame Substances 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49824390A | 1990-03-15 | 1990-03-15 | |
| US60665690A | 1990-10-31 | 1990-10-31 | |
| US65878491A | 1991-02-26 | 1991-02-26 | |
| US66480691A | 1991-03-08 | 1991-03-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT97049A true PT97049A (pt) | 1991-12-31 |
| PT97049B PT97049B (pt) | 1998-07-31 |
Family
ID=27504394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97049A PT97049B (pt) | 1990-03-15 | 1991-03-15 | Processo para a preparacao de ester de 1-metilo de n-l alfa-aspartil-fenilalanina (aspartame) e de produtos intermediarios e de derivados |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0478729B1 (pt) |
| CN (1) | CN1057835A (pt) |
| AT (1) | ATE141613T1 (pt) |
| AU (1) | AU628257B2 (pt) |
| CA (1) | CA2060515A1 (pt) |
| CS (1) | CS70091A2 (pt) |
| DE (1) | DE69121502T2 (pt) |
| DK (1) | DK0478729T3 (pt) |
| ES (1) | ES2091324T3 (pt) |
| GR (1) | GR3020839T3 (pt) |
| HU (1) | HUT60712A (pt) |
| IE (1) | IE910896A1 (pt) |
| NO (1) | NO920193D0 (pt) |
| NZ (1) | NZ237469A (pt) |
| PT (1) | PT97049B (pt) |
| WO (1) | WO1991014378A1 (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04234375A (ja) * | 1990-12-27 | 1992-08-24 | Ajinomoto Co Inc | 新規２，５−ジオキソピペラジン化合物及びその製造法 |
| JPH04234374A (ja) * | 1990-12-27 | 1992-08-24 | Ajinomoto Co Inc | ジケトピペラジン誘導体の製造方法 |
| JPH05117246A (ja) * | 1991-10-23 | 1993-05-14 | Ajinomoto Co Inc | 新規２，５−ジオキソピペラジン化合物とその製造法及びα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル誘導体の製造法 |
| US6465677B1 (en) * | 1998-11-19 | 2002-10-15 | The Nutrasweet Company | Method for the preparation of N-neohexyl-α-aspartyl-L-phenylalanine methyl ester from imidazolidin-4-one intermediates |
| DE10019879A1 (de) * | 2000-04-20 | 2001-10-25 | Degussa | Verfahren zur Herstellung von 2,5-Diketopiperazinen, neue 2,5-Diketopiperazine und deren Verwendung |
| AU2001284697A1 (en) | 2000-08-04 | 2002-02-18 | Dmi Biosciences, Inc. | Method of synthesizing diketopiperazines |
| AU2001279313B2 (en) | 2000-08-04 | 2007-03-01 | Ampio Pharmaceuticals, Inc. | Method of using diketopiperazines and composition containing them |
| ATE520981T1 (de) | 2002-10-02 | 2011-09-15 | Dmi Biosciences Inc | Diagnose und überwachung von krankheiten |
| CA3050734A1 (en) | 2003-05-15 | 2004-12-02 | Ampio Pharmaceuticals, Inc. | Treatment of t-cell mediated diseases |
| WO2009146320A1 (en) | 2008-05-27 | 2009-12-03 | Dmi Life Sciences, Inc. | Therapeutic methods and compounds |
| US8507496B2 (en) | 2010-09-07 | 2013-08-13 | Dmi Acquisition Corp. | Treatment of diseases |
| EA027343B1 (ru) | 2011-10-10 | 2017-07-31 | Ампио Фармасьютикалз, Инк. | Имплантируемые устройства медицинского назначения с повышенной иммунной толерантностью и способы изготовления и имплантирования |
| EP2766029B1 (en) | 2011-10-10 | 2020-03-25 | Ampio Pharmaceuticals, Inc. | Treatment of degenerative joint disease |
| CA2846394A1 (en) | 2011-10-28 | 2013-05-02 | Ampio Pharmaceuticals, Inc. | Treatment of rhinitis |
| BR112015020469A2 (pt) | 2013-03-15 | 2020-01-28 | Ampio Pharmaceuticals Inc | Usos de da-dkp, composição e método para fornecimento de células-tronco a umindivíduo |
| AU2015305611B2 (en) | 2014-08-18 | 2020-04-23 | Ampio Pharmaceuticals, Inc. | Treatment of joint conditions |
| US11389512B2 (en) | 2015-06-22 | 2022-07-19 | Ampio Pharmaceuticals, Inc. | Use of low molecular weight fractions of human serum albumin in treating diseases |
| ES2957286T3 (es) * | 2016-12-21 | 2024-01-16 | Suntory Holdings Ltd | Alimentos y bebidas que contienen ciclo(aspartil-glicina), glucosa y maltosa |
| WO2024075813A1 (ja) * | 2022-10-07 | 2024-04-11 | 学校法人中部大学 | ジケトピペラジン化合物を用いるポリペプチド合成 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2038106A1 (de) * | 1970-07-31 | 1972-02-10 | Henkel & Cie Gmbh | Aktivatoren fuer Perverbindungen |
| JPS58185545A (ja) * | 1982-04-22 | 1983-10-29 | Ajinomoto Co Inc | α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法 |
| IT1197461B (it) * | 1983-05-13 | 1988-11-30 | Debi Derivati Biologici | Procedimento per la preparazione dell'estere metilico di alfa-l-aspartil-l-fenil-alanina |
| JPS60174799A (ja) * | 1984-02-21 | 1985-09-09 | Ajinomoto Co Inc | α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法 |
| AU586669B2 (en) * | 1985-03-29 | 1989-07-20 | Mitsui Toatsu Chemicals Inc. | Preparation process of ```-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof |
| JPH0647600B2 (ja) * | 1985-06-04 | 1994-06-22 | 味の素株式会社 | β−アスパルチルフエニルアラニン誘導体のα−アスパルチルフエニルアラニン誘導体への変換法 |
| US4677220A (en) * | 1985-10-31 | 1987-06-30 | Monsanto Company | Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester |
| DE3600731A1 (de) * | 1986-01-13 | 1987-07-16 | Green Cross Korea | Verfahren zur herstellung von (alpha)-l-aspartyl-l-phenylalaninmethylester |
| US4992552A (en) * | 1988-08-31 | 1991-02-12 | Eastman Kodak Company | Process for preparation of amino acids |
-
1991
- 1991-03-12 WO PCT/US1991/001646 patent/WO1991014378A1/en not_active Ceased
- 1991-03-12 CA CA002060515A patent/CA2060515A1/en not_active Abandoned
- 1991-03-12 AT AT91906948T patent/ATE141613T1/de not_active IP Right Cessation
- 1991-03-12 EP EP91906948A patent/EP0478729B1/en not_active Expired - Lifetime
- 1991-03-12 DE DE69121502T patent/DE69121502T2/de not_active Expired - Fee Related
- 1991-03-12 AU AU75648/91A patent/AU628257B2/en not_active Ceased
- 1991-03-12 ES ES91906948T patent/ES2091324T3/es not_active Expired - Lifetime
- 1991-03-12 HU HU913921A patent/HUT60712A/hu unknown
- 1991-03-12 DK DK91906948.4T patent/DK0478729T3/da active
- 1991-03-15 PT PT97049A patent/PT97049B/pt not_active IP Right Cessation
- 1991-03-15 CN CN91102471.9A patent/CN1057835A/zh active Pending
- 1991-03-15 CS CS91700A patent/CS70091A2/cs unknown
- 1991-03-15 IE IE089691A patent/IE910896A1/en unknown
- 1991-03-18 NZ NZ237469A patent/NZ237469A/en unknown
-
1992
- 1992-01-15 NO NO920193A patent/NO920193D0/no unknown
-
1996
- 1996-08-22 GR GR960402052T patent/GR3020839T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CS70091A2 (en) | 1991-10-15 |
| CN1057835A (zh) | 1992-01-15 |
| DK0478729T3 (da) | 1996-09-16 |
| EP0478729B1 (en) | 1996-08-21 |
| PT97049B (pt) | 1998-07-31 |
| AU7564891A (en) | 1991-10-21 |
| ATE141613T1 (de) | 1996-09-15 |
| DE69121502D1 (de) | 1996-09-26 |
| EP0478729A4 (en) | 1993-06-16 |
| ES2091324T3 (es) | 1996-11-01 |
| NZ237469A (en) | 1993-08-26 |
| WO1991014378A1 (en) | 1991-10-03 |
| CA2060515A1 (en) | 1991-09-16 |
| AU628257B2 (en) | 1992-09-10 |
| HUT60712A (en) | 1992-10-28 |
| NO920193L (no) | 1992-01-15 |
| IE910896A1 (en) | 1991-09-25 |
| GR3020839T3 (en) | 1996-11-30 |
| NO920193D0 (no) | 1992-01-15 |
| EP0478729A1 (en) | 1992-04-08 |
| DE69121502T2 (de) | 1997-01-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT641343E (pt) | Derivados de 4-mercaptoacetilamino-¬2|benzazapinona (3) e a sua utilizacao como inibidores de encefalinase | |
| ES2091324T3 (es) | Proceso para la preparacion de aspartama a partir de una dicetopiperazina y nuevos compuestos intermedios y derivados para dicho proceso. | |
| FI945776L (fi) | Yhden astian menetelmä 3-kinolonikarboksyylihaapojohdannaisten valmistamiseksi | |
| IT1217658B (it) | Processo perfezionato per la produzione di perfluoropolieteri costituiti sostanzialmente da unita' perfludossietilenche e perfluoroossipropileniche | |
| FI902435A7 (fi) | Menetelmä 2-asyylialkonoinihappojen valmistamiseksi | |
| ITMI940726A0 (it) | Procedimento per la produzione di d-alfa-amminoacidi | |
| FI942581A0 (fi) | Menetelmä 5-bromi-6-metoksi-1-naftoehappometyyliesterin valmistamiseksi | |
| BR9303969A (pt) | Processo para produção de ácidos 2-arilbenzimidazol-5-sulfônicos | |
| BR8804931A (pt) | Processo para a producao de uma tetra-hidro-1,3,5-tiadiazin-4-ona,e,composicao inseticida | |
| MX9300026A (es) | Procedimiento para la preparacion de benzoesteres y benzoacidos. | |
| FI93216C (fi) | Analogiamenetelmä terapeuttisesti käyttökelpoisten 1,3-dioksaanialkeenihappojohdannaisten valmistamiseksi | |
| ITPD910141A1 (it) | Procedimento perfezionato per la realizzazione di calzature | |
| FI905930A7 (fi) | Menetelmä uusien, farmakologisesti käyttökelpoisten bispilokarpiinihapon esterijohdannaisten valmistamiseksi | |
| FI910662A7 (fi) | Menetelmä 7-amino-3-metoksimetyyli-kef-3-emi-4-karboksyylihapon valmistamiseksi | |
| FI922268L (fi) | Menetelmä uusien terapeuttisesti käyttökelpoisten N-difenyylialkyylialkoksisubstituoitujen 3-piperidiinikarboksyylihappojohdannaisten valmistamiseksi | |
| IT1137381B (it) | Processo per la preparazione di derivati esterei di acidi ciclopropancarbossilici | |
| FI953617A7 (fi) | Menetelmä substituoitujen 4-hydroksikumariinien valmistamiseksi | |
| IT1172237B (it) | Derivati di amminoacidi particolarmente utili come medicammenti e procedimento per la loro preparazione | |
| ITRM930260A0 (it) | Procedimento per la produzione di acidi perfluoroetercarbossilici. | |
| IT1226387B (it) | Processo per la preparazione di acidi 1,4-diaril-3-pirazol-acetici | |
| IT9019111A0 (it) | Procedimento perfezionato per la produzione di vanadio areni | |
| FI902157A7 (fi) | Menetelmä 1,6-hekseenidiohappojen valmistamiseksi | |
| FI930383A7 (fi) | Menetelmä ja välituote 2-hydroksi-3-sulfido-3-fenyylipropaanihappojen valmistamiseksi | |
| FI945119A7 (fi) | Menetelmä 3(S)-metyyliheptaanihapon valmistamiseksi ja välituotteet | |
| PT88578A (pt) | Process for the manufacture of 2,6-methanopyrrolo-3-benzazocines of intermediates useful for their manufacture and of pharmaceutical compositions containing them |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19910909 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19980414 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19991031 |