AU2001284697A1 - Method of synthesizing diketopiperazines - Google Patents

Method of synthesizing diketopiperazines

Info

Publication number
AU2001284697A1
AU2001284697A1 AU2001284697A AU8469701A AU2001284697A1 AU 2001284697 A1 AU2001284697 A1 AU 2001284697A1 AU 2001284697 A AU2001284697 A AU 2001284697A AU 8469701 A AU8469701 A AU 8469701A AU 2001284697 A1 AU2001284697 A1 AU 2001284697A1
Authority
AU
Australia
Prior art keywords
synthesizing diketopiperazines
diketopiperazines
synthesizing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001284697A
Inventor
Nagaraja K. R. Rao
Stephen Turner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DMI Biosciences Inc
Original Assignee
DMI Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DMI Biosciences Inc filed Critical DMI Biosciences Inc
Publication of AU2001284697A1 publication Critical patent/AU2001284697A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2001284697A 2000-08-04 2001-08-02 Method of synthesizing diketopiperazines Abandoned AU2001284697A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22307500P 2000-08-04 2000-08-04
US60223075 2000-08-04
PCT/US2001/024281 WO2002012201A1 (en) 2000-08-04 2001-08-02 Method of synthesizing diketopiperazines

Publications (1)

Publication Number Publication Date
AU2001284697A1 true AU2001284697A1 (en) 2002-02-18

Family

ID=22834911

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001284697A Abandoned AU2001284697A1 (en) 2000-08-04 2001-08-02 Method of synthesizing diketopiperazines

Country Status (4)

Country Link
US (1) US6967202B2 (en)
AU (1) AU2001284697A1 (en)
GB (1) GB2382346B (en)
WO (1) WO2002012201A1 (en)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US6555543B2 (en) * 2000-08-04 2003-04-29 Dmi Biosciences, Inc. Method of using diketopiperazines and composition containing them
CA2475529A1 (en) * 2002-03-19 2003-10-02 Abgenix, Inc. Methods for treating chronic obstructive pulmonary disease (copd)
ATE385193T1 (en) 2002-03-20 2008-02-15 Mannkind Corp INHALATION DEVICE
JP4674317B2 (en) * 2002-10-02 2011-04-20 ディエムアイ アクイジション コーポレイション Disease determination and monitoring
KR20150080004A (en) 2003-05-15 2015-07-08 앰피오 파마슈티컬스 인코퍼레이티드 Treatment of t-cell mediated diseases
CA2575692C (en) 2004-08-20 2014-10-14 Mannkind Corporation Catalysis of diketopiperazine synthesis
BR122019022692B1 (en) 2004-08-23 2023-01-10 Mannkind Corporation THERAPEUTIC DRY POWDER COMPOSITION CONTAINING DICETOPIPERAZINE, AT LEAST ONE TYPE OF CATION AND ONE BIOLOGICALLY ACTIVE AGENT
DK1937219T3 (en) 2005-09-14 2016-02-15 Mannkind Corp A method for drug formulation based on increasing the affinity of the crystalline surfaces of the microparticle of active principles
IN2015DN00888A (en) 2006-02-22 2015-07-10 Mannkind Corp
WO2009099763A1 (en) 2008-01-30 2009-08-13 Indiana University Research And Technology Corporation Ester-based peptide prodrugs
JP5856843B2 (en) 2008-05-27 2016-02-10 アンピオ ファーマシューティカルズ，インコーポレイテッド Pharmaceutical composition using diketopiperazine
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
KR101933816B1 (en) 2008-06-13 2019-03-29 맨카인드 코포레이션 A dry powder inhaler and system for drug delivery
EP2609954B1 (en) 2008-06-20 2021-12-29 MannKind Corporation An interactive apparatus for real-time profiling of inhalation efforts
TWI532497B (en) 2008-08-11 2016-05-11 曼凱公司 Use of ultrarapid acting insulin
US8697632B2 (en) 2008-12-19 2014-04-15 Indiana University Research And Technology Corporation Amide based insulin prodrugs
CA2747195A1 (en) * 2008-12-19 2010-07-15 Indiana University Research And Technology Corporation Dipeptide linked medicinal agents
WO2010071807A1 (en) 2008-12-19 2010-06-24 Indiana University Research And Technology Corporation Amide based glucagon superfamily peptide prodrugs
JP5789515B2 (en) 2008-12-19 2015-10-07 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ Insulin analogue
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2379511B1 (en) * 2008-12-29 2014-12-17 MannKind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US8538707B2 (en) 2009-03-11 2013-09-17 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
MY157166A (en) 2009-06-12 2016-05-13 Mankind Corp Diketopiperazine microparticles with defined specific surface areas
JP5784622B2 (en) 2009-11-03 2015-09-24 マンカインド コーポレ−ション Apparatus and method for simulating inhalation activity
CA2802485C (en) 2010-06-16 2019-09-17 Indiana University Research And Technology Corporation Single chain insulin agonists exhibiting high activity at the insulin receptor
RU2531455C2 (en) 2010-06-21 2014-10-20 Маннкайнд Корпорейшн Systems and methods for dry powder drugs delivery
US8946147B2 (en) 2010-06-24 2015-02-03 Indiana University Research And Technology Corporation Amide-based insulin prodrugs
KR20130102470A (en) 2010-06-24 2013-09-17 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 Amide based glucagon superfamily peptide prodrugs
CA2810844C (en) 2010-09-07 2017-03-21 Dmi Acquisition Corp. Diketopiperazine compositions for the treatment of metabolic syndrome and related conditions
JP6133270B2 (en) 2011-04-01 2017-05-24 マンカインド コーポレイション Blister packaging for drug cartridge
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
MY172699A (en) 2011-10-10 2019-12-10 Ampio Pharmaceuticals Inc Implantable medical devices with increased immune tolerance, and methods for making and implanting
WO2013055734A1 (en) 2011-10-10 2013-04-18 Ampio Pharmaceuticals, Inc. Treatment of degenerative joint disease
CA2852536A1 (en) 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
MX355446B (en) 2011-10-28 2018-04-18 Ampio Pharmaceuticals Inc Treatment of rhinitis.
BR112014015156A2 (en) 2011-12-20 2020-10-27 Indiana University Research And Technology Corporation ctp-based insulin analogues, their methods of production and use in the treatment of hyperglycemia, as well as nucleic acid and host cell sequences
ES2624294T3 (en) 2012-07-12 2017-07-13 Mannkind Corporation Dry powder drug delivery systems
WO2014052451A2 (en) 2012-09-26 2014-04-03 Indiana University Research And Technology Corporation Insulin analog dimers
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
KR20150131213A (en) 2013-03-14 2015-11-24 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 Insulin-incretin conjugates
EP2970149B1 (en) 2013-03-15 2019-08-21 MannKind Corporation Microcrystalline diketopiperazine compositions and methods
EP2968315B1 (en) 2013-03-15 2020-06-03 Ampio Pharmaceuticals, Inc. Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
BR112016000937A8 (en) 2013-07-18 2021-06-22 Mannkind Corp dry powder pharmaceutical formulations, method for making a dry powder formulation and use of a dry powder pharmaceutical formulation
CA2920488C (en) 2013-08-05 2022-04-26 Mannkind Corporation Insufflation apparatus and methods
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
WO2016028790A1 (en) 2014-08-18 2016-02-25 Ampio Pharmaceuticals, Inc. Treatment of joint conditions
JP6701208B2 (en) 2014-09-24 2020-05-27 インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション Lipidated amide insulin prodrug
EP3206710B1 (en) 2014-09-24 2020-05-06 Indiana University Research & Technology Corporation Incretin-insulin conjugates
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US11389512B2 (en) 2015-06-22 2022-07-19 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
CN111875668B (en) * 2020-07-29 2022-05-27 陕西慧康生物科技有限责任公司 Synthetic method of cyclic dipeptide containing glutamine or asparagine
CN112321515A (en) * 2020-10-21 2021-02-05 上海馨远医药科技有限公司 Preparation method of chiral 1-tert-butyl-3-methyl-6-methylpiperazine-1, 3-diformate
CN116043230A (en) * 2023-02-08 2023-05-02 福建工程学院 Aqueous phase modification method of amino acid corrosion inhibitor
CN116375654A (en) * 2023-03-22 2023-07-04 湖北三峡实验室 Method for preparing 2, 5-diketopiperazine from diglycolamine

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3928330A (en) 1973-12-19 1975-12-23 Ciba Geigy Corp Substituted piperazinedione carboxylic acids and metal salts thereof
DE2940654A1 (en) 1979-10-06 1981-04-16 Bayer Ag, 5090 Leverkusen DIMERES KETEN OF 1,2 ,, - TRIAZOL-3-CARBONIC ACID
US4331595A (en) 1980-06-23 1982-05-25 Ortho Pharmaceutical Corporation Immunoregulatory diketopiperazine compounds
US4289759A (en) 1980-06-23 1981-09-15 Ortho Pharmaceutical Corporation Immunoregulatory diketopiperazine compounds
US4694061A (en) 1983-10-12 1987-09-15 Ciba-Geigy Corporation Radiation-sensitive polycondensates, processes for their preparation coated material and its use
US4806538A (en) 1984-11-02 1989-02-21 Fujisawa Pharmaceutical Co., Ltd. Piperazine compound as PAF-antagonist
US5047401A (en) 1985-09-09 1991-09-10 Board Of Regents, The University Of Texas System Use of dipeptide alkyl esters to treat GVHD
US4694081A (en) 1985-09-23 1987-09-15 Monsanto Company Process to prepare 2,5-diketopiperazines
US4992552A (en) 1988-08-31 1991-02-12 Eastman Kodak Company Process for preparation of amino acids
DE69121502T2 (en) 1990-03-15 1997-01-16 Nutrasweet Co PROCESS FOR THE PRESENTATION OF ASPARTAM FROM A DIKETOPIPERAZINE AND NEW INTERMEDIATE PRODUCTS AND DERIVATIVES THEREFOR
JPH04234374A (en) * 1990-12-27 1992-08-24 Ajinomoto Co Inc Production of diketopiperazine derivative
WO1996000391A1 (en) 1994-06-23 1996-01-04 Affymax Technologies N.V. Methods for the synthesis of diketopiperazines
US5990112A (en) 1996-06-18 1999-11-23 Affymax Technologies N.V. Inhibitors of metalloproteases pharmaceutical compositions comprising same and methods of their use
US5817751A (en) 1994-06-23 1998-10-06 Affymax Technologies N.V. Method for synthesis of diketopiperazine and diketomorpholine derivatives
AU715667B2 (en) 1996-04-03 2000-02-10 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5932579A (en) * 1996-06-18 1999-08-03 Affymax Technologies N.V. Collagenase-1 and stromelysin-1 inhibitors, pharmaceutical compositions comprising same and methods of their use
US7202279B1 (en) 1998-02-11 2007-04-10 Georgetown University Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders
US6555543B2 (en) * 2000-08-04 2003-04-29 Dmi Biosciences, Inc. Method of using diketopiperazines and composition containing them

Also Published As

Publication number Publication date
GB2382346A (en) 2003-05-28
US6967202B2 (en) 2005-11-22
GB0301542D0 (en) 2003-02-26
GB2382346B (en) 2004-08-11
WO2002012201A1 (en) 2002-02-14
US20020038026A1 (en) 2002-03-28

Similar Documents

Publication Publication Date Title
AU2001284697A1 (en) Method of synthesizing diketopiperazines
AU2002237527A1 (en) Method of synthesizing camptothecin-relating compounds
AU2001280201A1 (en) Methods of synthesizing cell-free protein
AU2557500A (en) Methods of making compounds
HUP0302755A3 (en) Method of synthesizing camptothecin-relating compounds
AU2001286983A1 (en) Method of treatment
AU2000265991A1 (en) Novel method of preparing p-phenylenediamine
AU2002219900A1 (en) Minimal identification of features
AU2964500A (en) Method of micro-fabrication
AU2001288092A1 (en) Method of crystallization
AU2002227035A1 (en) Methods of stabilizing fruit-concentrate powders
AU2001294258A1 (en) Method of purifying plavastatin
AU2002231683A1 (en) Method of producing alk-3-ene-1-ols
AU2001265935A1 (en) Production of biohydrolysates
AU2002214976A1 (en) Process for the preparation of benzotriazoles
AUPQ904100A0 (en) Method of encryption
AU2728901A (en) Method of making hydrofluorocarbons
AU4124101A (en) Method of making silver-contained candle
AU2002210816A1 (en) Process for preparation of beta-phenethylamine derivative
AU2001262177A1 (en) Method of treatment
AU6352301A (en) Method of synthesizing glyceryl mono-esters
AU2002222687A1 (en) Process for preparation of polyhydric alcohols
AU2002213477A1 (en) Process for preparation of n-substituted 2-sulfanylimidazoles
AU2003235231A1 (en) Method of synthesizing cf3-chf-cf2-nr2
AU2000258438A1 (en) An improved process for the preparation of acylferrocenes