ATE520981T1 - Diagnose und überwachung von krankheiten - Google Patents
Diagnose und überwachung von krankheitenInfo
- Publication number
- ATE520981T1 ATE520981T1 AT03773099T AT03773099T ATE520981T1 AT E520981 T1 ATE520981 T1 AT E520981T1 AT 03773099 T AT03773099 T AT 03773099T AT 03773099 T AT03773099 T AT 03773099T AT E520981 T1 ATE520981 T1 AT E520981T1
- Authority
- AT
- Austria
- Prior art keywords
- monitoring
- diseases
- diagnosis
- disease
- amino acids
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/285—Demyelinating diseases; Multipel sclerosis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41590802P | 2002-10-02 | 2002-10-02 | |
US48903903P | 2003-07-21 | 2003-07-21 | |
US50318503P | 2003-09-15 | 2003-09-15 | |
PCT/US2003/031226 WO2004030522A2 (en) | 2002-10-02 | 2003-10-02 | Diagnosis and monitoring of diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE520981T1 true ATE520981T1 (de) | 2011-09-15 |
Family
ID=32074376
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03773099T ATE520981T1 (de) | 2002-10-02 | 2003-10-02 | Diagnose und überwachung von krankheiten |
Country Status (9)
Country | Link |
---|---|
US (2) | US7575929B2 (de) |
EP (1) | EP1571970B1 (de) |
JP (1) | JP4674317B2 (de) |
AT (1) | ATE520981T1 (de) |
AU (1) | AU2003279761B2 (de) |
CA (1) | CA2500652A1 (de) |
DK (1) | DK1571970T3 (de) |
NZ (1) | NZ539735A (de) |
WO (1) | WO2004030522A2 (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7070937B1 (en) | 1998-10-02 | 2006-07-04 | Ischemia Technologies, Inc. | Marker useful for detection and measurement of free radical damage and method |
US6475743B1 (en) * | 1998-10-02 | 2002-11-05 | Ischemia Technologies, Inc. | Marker useful for detection and measurement of free radical damage and method |
US20050142613A1 (en) * | 1998-10-02 | 2005-06-30 | David Bar-Or | Test for the rapid evaluation of ischemic states and kits |
US7449338B2 (en) * | 1998-10-02 | 2008-11-11 | Ischemia Technologies, Inc. | Tests for the rapid evaluation of ischemic states and kits |
US7282369B2 (en) * | 1998-10-02 | 2007-10-16 | Ischemia Technologies, Inc. | Tests for the rapid evaluation of ischemic states and kits |
US6555543B2 (en) * | 2000-08-04 | 2003-04-29 | Dmi Biosciences, Inc. | Method of using diketopiperazines and composition containing them |
KR20150080004A (ko) | 2003-05-15 | 2015-07-08 | 앰피오 파마슈티컬스 인코퍼레이티드 | T-세포 매개성 질환의 치료 방법 |
GB0421639D0 (en) * | 2004-09-29 | 2004-10-27 | Proteome Sciences Plc | Methods and compositions relating to alzheimer's disease |
US8206986B2 (en) | 2005-03-14 | 2012-06-26 | Bg Medicine, Inc. | Methods for detecting Alzheimer's disease |
WO2006110621A2 (en) * | 2005-04-11 | 2006-10-19 | Cornell Research Foundation, Inc. | Multiplexed biomarkers for monitoring the alzheimer's disease state of a subject |
US7561975B2 (en) * | 2006-03-21 | 2009-07-14 | Metabolon, Inc. | System, method, and computer program product for analyzing spectrometry data to identify and quantify individual components in a sample |
US9000134B2 (en) * | 2007-05-11 | 2015-04-07 | Wallace B. Haigh | Reagent and kit for early diagnosis of kidney disease |
US7829709B1 (en) | 2007-08-10 | 2010-11-09 | Marquette University | Cysteine prodrugs to treat schizophrenia and drug addiction |
BR122018069446B8 (pt) | 2008-01-18 | 2021-07-27 | Harvard College | método in vitro para detectar a presença de um célula de câncer em um indivíduo |
EP2252596B1 (de) * | 2008-02-07 | 2016-12-28 | Marquette University | Cystein- und cystinprodrugs zur behandlung von schizophrenie und zur verminderung von drogensucht |
JP5856843B2 (ja) * | 2008-05-27 | 2016-02-10 | アンピオ ファーマシューティカルズ,インコーポレイテッド | ジケトピペラジンを用いた医薬組成物 |
MX2012001339A (es) * | 2009-07-30 | 2012-03-07 | Salvat Lab Sa | Compuestos inhibidores de apaf-1. |
AU2011280997A1 (en) | 2010-07-23 | 2013-02-28 | President And Fellows Of Harvard College | Methods of detecting autoimmune or immune-related diseases or conditions |
KR20130041961A (ko) | 2010-07-23 | 2013-04-25 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 체액에서 질환 또는 상태의 특징을 검출하는 방법 |
WO2012012717A1 (en) | 2010-07-23 | 2012-01-26 | President And Fellows Of Harvard College | Methods of detecting prenatal or pregnancy-related diseases or conditions |
EP2596117B1 (de) | 2010-07-23 | 2017-12-27 | President and Fellows of Harvard College | Verfahren zur erkennung von niergenbezogenen erkrankungen oder leiden |
KR20130041962A (ko) | 2010-07-23 | 2013-04-25 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 식작용 세포를 사용하여 질환 또는 상태를 검출하는 방법 |
CA2810844C (en) | 2010-09-07 | 2017-03-21 | Dmi Acquisition Corp. | Diketopiperazine compositions for the treatment of metabolic syndrome and related conditions |
EP2617432B1 (de) * | 2010-09-16 | 2015-09-02 | Calpis Co., Ltd. | Zusammensetzung zur verstärkung der gehirnfunktion und verfahren zur verstärkung der gehirnfunktion |
JP6371219B2 (ja) | 2011-09-19 | 2018-08-08 | シー2エヌ ダイアグノスティクス | 神経性および神経変性の疾患、障害、および関連過程の診断および治療のための方法 |
MY172699A (en) | 2011-10-10 | 2019-12-10 | Ampio Pharmaceuticals Inc | Implantable medical devices with increased immune tolerance, and methods for making and implanting |
WO2013055734A1 (en) | 2011-10-10 | 2013-04-18 | Ampio Pharmaceuticals, Inc. | Treatment of degenerative joint disease |
MX355446B (es) | 2011-10-28 | 2018-04-18 | Ampio Pharmaceuticals Inc | Tratamiento de rinitis. |
EP4202441A3 (de) | 2013-03-09 | 2023-07-26 | Immunis.AI, Inc. | Genexpressionsprofil in makrophagen zur diagnose von krebs |
EP2965086A4 (de) | 2013-03-09 | 2017-02-08 | Harry Stylli | Verfahren zum nachweis von prostatakrebs |
EP2968315B1 (de) | 2013-03-15 | 2020-06-03 | Ampio Pharmaceuticals, Inc. | Zusammensetzungen für mobilisierung, homing, expansion und differenzierung von stammzellen und verfahren zur verwendung davon |
CN103604931B (zh) * | 2013-11-15 | 2016-01-06 | 陆上苏 | 一种人s100蛋白检测试剂及制备方法 |
WO2016028790A1 (en) | 2014-08-18 | 2016-02-25 | Ampio Pharmaceuticals, Inc. | Treatment of joint conditions |
WO2016040843A1 (en) | 2014-09-11 | 2016-03-17 | Harry Stylli | Methods of detecting prostate cancer |
US11389512B2 (en) | 2015-06-22 | 2022-07-19 | Ampio Pharmaceuticals, Inc. | Use of low molecular weight fractions of human serum albumin in treating diseases |
Family Cites Families (93)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3928330A (en) * | 1973-12-19 | 1975-12-23 | Ciba Geigy Corp | Substituted piperazinedione carboxylic acids and metal salts thereof |
GB1459488A (en) * | 1974-03-19 | 1976-12-22 | Wyeth John & Brother Ltd | Piperazinedione derivatives |
US4205057A (en) * | 1978-01-17 | 1980-05-27 | Government Of The United States | Cerebrospinal fluid protein fragments |
DE2940654A1 (de) * | 1979-10-06 | 1981-04-16 | Bayer Ag, 5090 Leverkusen | Dimeres keten der 1,2,,-triazol-3-carbonsaeure |
US4289759A (en) * | 1980-06-23 | 1981-09-15 | Ortho Pharmaceutical Corporation | Immunoregulatory diketopiperazine compounds |
US4331595A (en) * | 1980-06-23 | 1982-05-25 | Ortho Pharmaceutical Corporation | Immunoregulatory diketopiperazine compounds |
JPS5973574A (ja) | 1982-10-21 | 1984-04-25 | Grelan Pharmaceut Co Ltd | 環状ジペプチド類 |
US4694061A (en) * | 1983-10-12 | 1987-09-15 | Ciba-Geigy Corporation | Radiation-sensitive polycondensates, processes for their preparation coated material and its use |
US4806538A (en) * | 1984-11-02 | 1989-02-21 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine compound as PAF-antagonist |
CS254868B1 (cs) | 1985-06-11 | 1988-02-15 | Jiri Vanzura | Způsob výroby cyklických dipeptidů |
US4661500A (en) | 1985-08-29 | 1987-04-28 | Roman Rozencwaig | Method of medical treatment with serotonin antagonists |
US4771056A (en) * | 1985-08-29 | 1988-09-13 | Roman Rozencwaig | Method of medical treatment with serotonin antagonists |
US5047401A (en) * | 1985-09-09 | 1991-09-10 | Board Of Regents, The University Of Texas System | Use of dipeptide alkyl esters to treat GVHD |
US4694081A (en) | 1985-09-23 | 1987-09-15 | Monsanto Company | Process to prepare 2,5-diketopiperazines |
US5512544A (en) * | 1987-09-13 | 1996-04-30 | Yeda Research And Development Co. Ltd. | Pharmaceutical compositions comprising an anticytokine |
US4992552A (en) * | 1988-08-31 | 1991-02-12 | Eastman Kodak Company | Process for preparation of amino acids |
DE3906952A1 (de) * | 1989-03-04 | 1990-09-06 | Boehringer Mannheim Gmbh | (3-(c(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)6(pfeil abwaerts)-c(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)8(pfeil abwaerts))alkansulfinyl- und sulfonyl-2-methoxymethyl-propyl)-(2-trimethylammonio-ethyl) phosphate, verfahren zu deren herstellung diese verbindungen enthaltende arzneimittel |
EP0422282B1 (de) | 1989-10-13 | 1995-04-05 | Phobos N.V. | Verfahren zur kontinuierlichen Herstellung von hochmolekularen Polyester-Harzen |
US6180616B1 (en) * | 1990-05-10 | 2001-01-30 | Atsuo F. Fukunaga | Use of purine receptor agonists to alleviate or normalize physiopathologically excited sensory nerve function |
US5578323A (en) * | 1992-06-15 | 1996-11-26 | Emisphere Technologies, Inc. | Proteinoid carriers and methods for preparation and use thereof |
US6331318B1 (en) * | 1994-09-30 | 2001-12-18 | Emisphere Technologies Inc. | Carbon-substituted diketopiperazine delivery systems |
US5693338A (en) * | 1994-09-29 | 1997-12-02 | Emisphere Technologies, Inc. | Diketopiperazine-based delivery systems |
US6099856A (en) * | 1992-06-15 | 2000-08-08 | Emisphere Technologies, Inc. | Active agent transport systems |
GB9022543D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Antibody production |
EP0557388A4 (en) * | 1990-11-14 | 1994-07-06 | Univ Company Pty Ltd | Diagnosis and treatment of multiple sclerosis |
US5776892A (en) * | 1990-12-21 | 1998-07-07 | Curative Health Services, Inc. | Anti-inflammatory peptides |
JPH04234374A (ja) | 1990-12-27 | 1992-08-24 | Ajinomoto Co Inc | ジケトピペラジン誘導体の製造方法 |
US5543503A (en) * | 1991-03-29 | 1996-08-06 | Genentech Inc. | Antibodies to human IL-8 type A receptor |
US5538993A (en) * | 1991-09-12 | 1996-07-23 | Yissum Research Development Company | Certain tetrahydrocannabinol-7-oic acid derivatives |
JPH05244982A (ja) * | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化b−b10 |
GB9200210D0 (en) | 1992-01-07 | 1992-02-26 | British Bio Technology | Compounds |
US5418218A (en) * | 1992-07-10 | 1995-05-23 | The University Of Maryland At Baltimore | Histidyl-proline diketopiperazine (cyclo his-pro) a cns-active pharmacologic agent |
US5358938A (en) * | 1992-07-13 | 1994-10-25 | Cytomed, Inc. | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase |
US5434151A (en) * | 1992-08-24 | 1995-07-18 | Cytomed, Inc. | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase |
US5648486A (en) * | 1992-07-13 | 1997-07-15 | Cytomed, Inc. | Compounds and methods for the treatment of inflammatory and immune disorders |
US5463083A (en) * | 1992-07-13 | 1995-10-31 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
GB9217331D0 (en) * | 1992-08-14 | 1992-09-30 | Xenova Ltd | Pharmaceutical compounds |
US5728553A (en) * | 1992-09-23 | 1998-03-17 | Delta Biotechnology Limited | High purity albumin and method of producing |
AU689091B2 (en) * | 1992-12-18 | 1998-03-26 | Cell Med, Inc. | Assay and treatment for demyelinating diseases such as multiple sclerosis |
ES2068742B1 (es) | 1993-02-11 | 1995-11-16 | Uriach & Cia Sa J | Nuevos derivados de piridinio. |
US6107050A (en) * | 1993-05-03 | 2000-08-22 | The United States Of America As Represented By The Department Of Health And Human Services | Diagnostic test for alzheimers disease |
FR2717484A1 (fr) | 1994-03-16 | 1995-09-22 | Pf Medicament | Nouveaux composés pseudo-bis-peptidiques analogues de la CCK, leur procédé de préparation, leur utilisation à titre de médicament et les compositions pharmaceutiques les comprenant . |
GB9410387D0 (en) * | 1994-05-24 | 1994-07-13 | Xenova Ltd | Pharmaceutical compounds |
US5550132A (en) * | 1994-06-22 | 1996-08-27 | University Of North Carolina | Hydroxyalkylammonium-pyrimidines or purines and nucleoside derivatives, useful as inhibitors of inflammatory cytokines |
US5990112A (en) * | 1996-06-18 | 1999-11-23 | Affymax Technologies N.V. | Inhibitors of metalloproteases pharmaceutical compositions comprising same and methods of their use |
US5817751A (en) * | 1994-06-23 | 1998-10-06 | Affymax Technologies N.V. | Method for synthesis of diketopiperazine and diketomorpholine derivatives |
US5703093A (en) * | 1995-05-31 | 1997-12-30 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
US5792776A (en) * | 1994-06-27 | 1998-08-11 | Cytomed, Inc., | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
US5750565A (en) * | 1995-05-25 | 1998-05-12 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
EP0801065A4 (de) * | 1994-07-29 | 1998-02-25 | Nikken Chemicals Co Ltd | 1,4-dihydropyridinverbindungen und sie enthaltende medizinische zusammensetzungen |
DK0784476T3 (da) | 1994-10-05 | 2003-03-17 | Cari Loder | Behandling af multipel sklerose (MS) og andre demyelinisationstilstande under anvendelse af lofepramin i kombination med L-phenylalanin, tyrosin eller tryptophan og eventuelt en vitamin B12-forbindelse |
AU691361B2 (en) * | 1994-12-01 | 1998-05-14 | Toyama Chemical Co. Ltd. | Novel 2,3-diketopiperazine derivative or salt thereof |
AU6311996A (en) * | 1995-07-06 | 1997-02-05 | Zeneca Limited | Peptide inhibitors of fibronectine |
US6060452A (en) * | 1996-03-13 | 2000-05-09 | Cytran, Inc. | Analogs of L-Glu-L-Trp having pharmacological activity |
US6541224B2 (en) * | 1996-03-14 | 2003-04-01 | Human Genome Sciences, Inc. | Tumor necrosis factor delta polypeptides |
US5919785A (en) * | 1996-04-03 | 1999-07-06 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
GB2328155B (en) * | 1996-04-12 | 2000-08-02 | Peptide Technology Pty Limited | Methods of treating immunopathologies using polyunsaturated fattyacids |
DE19619478A1 (de) * | 1996-05-14 | 1997-11-20 | Sick Ag | Optische Anordnung mit diffraktivem optischem Element |
US5932579A (en) * | 1996-06-18 | 1999-08-03 | Affymax Technologies N.V. | Collagenase-1 and stromelysin-1 inhibitors, pharmaceutical compositions comprising same and methods of their use |
US5985581A (en) * | 1996-07-25 | 1999-11-16 | The Mclean Hospital Corporation | Use of presenilin-1 for diagnosis of alzheimers disease |
EP0835660A1 (de) | 1996-10-14 | 1998-04-15 | Gaston Edmond Filomena Merckx | Zusammensetzungen enthaltend Methylcobalamin für die Behandlung von Muliple Sklerosis oder andere demyleinisierende Krankheiten |
US6441172B1 (en) * | 1996-11-07 | 2002-08-27 | Torrey Pines Institute For Molecular Studies | Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof |
US6265535B1 (en) * | 1997-05-30 | 2001-07-24 | The Trustees Of The University Of Pennsylvania | Peptides and peptide analogues designed from binding sites of tumor necrosis factor receptor superfamily and their uses |
US6222029B1 (en) * | 1997-08-01 | 2001-04-24 | Genset | 5′ ESTs for secreted proteins expressed in brain |
US5834032A (en) * | 1997-08-11 | 1998-11-10 | Song; Moon K. | Compositions and methods for treating diabetes |
EP0939124A3 (de) | 1998-02-24 | 2001-03-21 | Smithkline Beecham Plc | MBGP1-Sequenzen |
US6461875B1 (en) * | 1998-10-02 | 2002-10-08 | Ischemia Technologies, Inc. | Test for rapid evaluation of ischemic states and kit |
US6492179B1 (en) * | 1998-10-02 | 2002-12-10 | Ischemia Techologies, Inc. | Test for rapid evaluation of ischemic states and kit |
US6475743B1 (en) * | 1998-10-02 | 2002-11-05 | Ischemia Technologies, Inc. | Marker useful for detection and measurement of free radical damage and method |
CA2344762C (en) * | 1998-10-02 | 2008-12-23 | Ischemia Technologies, Inc. | Tests for the rapid evaluation of ischemic states and kits |
DE69939121D1 (de) * | 1998-10-02 | 2008-08-28 | Ischemia Tech Inc | Verfahren und materialien zum nachweis und zur messung von durch freie radikale verursachten schäden |
DE19847690A1 (de) * | 1998-10-15 | 2000-04-20 | Brahms Diagnostica Gmbh | Verfahren und Substanzen für die Diagnose und Therapie von Sepsis und sepsisähnlichen systemischen Infektionen |
US6358957B1 (en) * | 1998-11-12 | 2002-03-19 | Nereus Pharmaceuticals, Inc. | Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds |
US7026322B2 (en) * | 1998-11-12 | 2006-04-11 | Nereus Pharmaceuticals, Inc. | Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds |
US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
EP1166117A2 (de) * | 1999-03-19 | 2002-01-02 | Vanderbilt University | Diagnose und behandlung multipler sklerose |
US6090780A (en) * | 1999-04-07 | 2000-07-18 | Chandon Prasad | Histidyl-proline diketopiperazine and method of use |
US6689765B2 (en) * | 1999-05-04 | 2004-02-10 | Schering Corporation | Piperazine derivatives useful as CCR5 antagonists |
DE19937721A1 (de) | 1999-08-10 | 2001-02-15 | Max Planck Gesellschaft | Neue Diketopiperazine |
AU1624801A (en) * | 1999-11-19 | 2001-05-30 | Corvas International, Inc. | Plasminogen activator inhibitor antagonists related applications |
US20050096323A1 (en) * | 1999-11-30 | 2005-05-05 | Novoscience Pharma Inc. | Diketopiperazine derivatives to inhibit thrombin |
US7288545B2 (en) * | 2000-05-09 | 2007-10-30 | Angiorx Corporation | Piperazinedione compounds |
ATE417614T1 (de) * | 2000-05-09 | 2009-01-15 | Angiorx Corp | Piperazindion-verbindungen |
US20030153575A1 (en) * | 2000-06-08 | 2003-08-14 | Orme Mark W. | Tetracyclic diketopiperazine compounds as pdev inhibitors |
CZ20002681A3 (cs) | 2000-07-21 | 2002-03-13 | Ev®En Ing. Csc. Kasafírek | Cyklické tyrosinové dipeptidy |
CZ20002680A3 (cs) | 2000-07-21 | 2002-03-13 | Ev®En Ing. Csc. Kasafírek | Cyklické alkylthiopeptidy |
GB2382346B (en) * | 2000-08-04 | 2004-08-11 | Dmi Biosciences Inc | Method of synthesizing diketopiperazines |
US6555543B2 (en) * | 2000-08-04 | 2003-04-29 | Dmi Biosciences, Inc. | Method of using diketopiperazines and composition containing them |
WO2002062797A2 (en) * | 2000-12-29 | 2002-08-15 | Celltech R & D, Inc. | Pharmaceutical uses and synthesis of diketopiperazines |
US20040038865A1 (en) * | 2002-08-01 | 2004-02-26 | Mannkind Corporation | Cell transport compositions and uses thereof |
DE10238144A1 (de) * | 2002-08-15 | 2004-02-26 | Basf Ag | Verwendung von Diketopiperazin-Derivaten als photostabile UV-Filter in kosmetischen und pharmazeutischen Zubereitungen |
JP4641796B2 (ja) * | 2002-09-03 | 2011-03-02 | ジョージタウン ユニヴァーシティ | Akt阻害剤、医薬組成物、及びその用途 |
KR20150080004A (ko) * | 2003-05-15 | 2015-07-08 | 앰피오 파마슈티컬스 인코퍼레이티드 | T-세포 매개성 질환의 치료 방법 |
-
2003
- 2003-10-02 JP JP2005500360A patent/JP4674317B2/ja not_active Expired - Fee Related
- 2003-10-02 AT AT03773099T patent/ATE520981T1/de not_active IP Right Cessation
- 2003-10-02 DK DK03773099.1T patent/DK1571970T3/da active
- 2003-10-02 WO PCT/US2003/031226 patent/WO2004030522A2/en active Search and Examination
- 2003-10-02 EP EP03773099A patent/EP1571970B1/de not_active Expired - Lifetime
- 2003-10-02 NZ NZ539735A patent/NZ539735A/en not_active IP Right Cessation
- 2003-10-02 CA CA002500652A patent/CA2500652A1/en not_active Abandoned
- 2003-10-02 AU AU2003279761A patent/AU2003279761B2/en not_active Ceased
- 2003-10-02 US US10/679,699 patent/US7575929B2/en not_active Expired - Fee Related
-
2009
- 2009-07-07 US US12/499,063 patent/US20100120056A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2003279761A1 (en) | 2004-04-23 |
DK1571970T3 (da) | 2011-11-28 |
WO2004030522A2 (en) | 2004-04-15 |
NZ539735A (en) | 2009-07-31 |
US20040209379A1 (en) | 2004-10-21 |
JP4674317B2 (ja) | 2011-04-20 |
EP1571970A2 (de) | 2005-09-14 |
EP1571970A4 (de) | 2008-06-04 |
US7575929B2 (en) | 2009-08-18 |
AU2003279761B2 (en) | 2009-11-12 |
EP1571970B1 (de) | 2011-08-17 |
WO2004030522A3 (en) | 2005-08-11 |
US20100120056A1 (en) | 2010-05-13 |
JP2006502418A (ja) | 2006-01-19 |
CA2500652A1 (en) | 2004-04-15 |
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