DE69121502T2 - Prozess zur darstellung von aspartam aus einem diketopiperazin sowie neue zwischenprodukte und derivate dafür - Google Patents

Prozess zur darstellung von aspartam aus einem diketopiperazin sowie neue zwischenprodukte und derivate dafür

Info

Publication number
DE69121502T2
DE69121502T2 DE69121502T DE69121502T DE69121502T2 DE 69121502 T2 DE69121502 T2 DE 69121502T2 DE 69121502 T DE69121502 T DE 69121502T DE 69121502 T DE69121502 T DE 69121502T DE 69121502 T2 DE69121502 T2 DE 69121502T2
Authority
DE
Germany
Prior art keywords
aspartam
diketopiperazine
presentation
intermediate products
dkp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69121502T
Other languages
English (en)
Other versions
DE69121502D1 (de
Inventor
John Hill
Tse-Lok Ho
Mark Johnson
Russell Klix
Gayle Webber
Robert Erickson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nutrasweet Co
Original Assignee
Nutrasweet Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nutrasweet Co filed Critical Nutrasweet Co
Publication of DE69121502D1 publication Critical patent/DE69121502D1/de
Application granted granted Critical
Publication of DE69121502T2 publication Critical patent/DE69121502T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
DE69121502T 1990-03-15 1991-03-12 Prozess zur darstellung von aspartam aus einem diketopiperazin sowie neue zwischenprodukte und derivate dafür Expired - Fee Related DE69121502T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US49824390A 1990-03-15 1990-03-15
US60665690A 1990-10-31 1990-10-31
US65878491A 1991-02-26 1991-02-26
US66480691A 1991-03-08 1991-03-08
PCT/US1991/001646 WO1991014378A1 (en) 1990-03-15 1991-03-12 Process for manufacturing aspartame from a diketopiperazine and novel intermediates and derivatives therefor

Publications (2)

Publication Number Publication Date
DE69121502D1 DE69121502D1 (de) 1996-09-26
DE69121502T2 true DE69121502T2 (de) 1997-01-16

Family

ID=27504394

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69121502T Expired - Fee Related DE69121502T2 (de) 1990-03-15 1991-03-12 Prozess zur darstellung von aspartam aus einem diketopiperazin sowie neue zwischenprodukte und derivate dafür

Country Status (16)

Country Link
EP (1) EP0478729B1 (de)
CN (1) CN1057835A (de)
AT (1) ATE141613T1 (de)
AU (1) AU628257B2 (de)
CA (1) CA2060515A1 (de)
CS (1) CS70091A2 (de)
DE (1) DE69121502T2 (de)
DK (1) DK0478729T3 (de)
ES (1) ES2091324T3 (de)
GR (1) GR3020839T3 (de)
HU (1) HUT60712A (de)
IE (1) IE910896A1 (de)
NO (1) NO920193D0 (de)
NZ (1) NZ237469A (de)
PT (1) PT97049B (de)
WO (1) WO1991014378A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04234375A (ja) * 1990-12-27 1992-08-24 Ajinomoto Co Inc 新規２，５−ジオキソピペラジン化合物及びその製造法
JPH04234374A (ja) * 1990-12-27 1992-08-24 Ajinomoto Co Inc ジケトピペラジン誘導体の製造方法
JPH05117246A (ja) * 1991-10-23 1993-05-14 Ajinomoto Co Inc 新規２，５−ジオキソピペラジン化合物とその製造法及びα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル誘導体の製造法
US6465677B1 (en) * 1998-11-19 2002-10-15 The Nutrasweet Company Method for the preparation of N-neohexyl-α-aspartyl-L-phenylalanine methyl ester from imidazolidin-4-one intermediates
DE10019879A1 (de) * 2000-04-20 2001-10-25 Degussa Verfahren zur Herstellung von 2,5-Diketopiperazinen, neue 2,5-Diketopiperazine und deren Verwendung
CN100553636C (zh) 2000-08-04 2009-10-28 Dmi生物科学公司 二酮基哌嗪和包含它们的组合物的使用方法
US6967202B2 (en) 2000-08-04 2005-11-22 Dmi Biosciences, Inc. Method of synthesizing diketopiperazines
CN103142599A (zh) 2003-05-15 2013-06-12 Dmi生物科学公司 T-细胞介导的疾病的治疗
EP2300011A4 (de) 2008-05-27 2012-06-20 Dmi Life Sciences Inc Therapeutische verfahren und verbindungen
WO2012033792A2 (en) 2010-09-07 2012-03-15 Dmi Acquisition Corp. Treatment of diseases
EP2766029B1 (de) 2011-10-10 2020-03-25 Ampio Pharmaceuticals, Inc. Behandlung degenerativer gelenkerkrankungen
US9925300B2 (en) 2011-10-10 2018-03-27 Ampio Pharmaceuticals, Inc. Implantable medical devices with increased immune tolerance, and methods for making and implanting
SG11201400283RA (en) 2011-10-28 2014-03-28 Ampio Pharmaceuticals Inc Treatment of rhinitis
SG10201707619RA (en) 2013-03-15 2017-10-30 Ampio Pharmaceuticals Inc Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
RU2020136589A (ru) 2014-08-18 2020-12-24 Ампио Фармасьютикалз, Инк. Лечение дегенеративных заболеваний суставов
US11389512B2 (en) 2015-06-22 2022-07-19 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
ES2957286T3 (es) * 2016-12-21 2024-01-16 Suntory Holdings Ltd Alimentos y bebidas que contienen ciclo(aspartil-glicina), glucosa y maltosa

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2038106A1 (de) * 1970-07-31 1972-02-10 Henkel & Cie Gmbh Aktivatoren fuer Perverbindungen
JPS58185545A (ja) * 1982-04-22 1983-10-29 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法
IT1197461B (it) * 1983-05-13 1988-11-30 Debi Derivati Biologici Procedimento per la preparazione dell'estere metilico di alfa-l-aspartil-l-fenil-alanina
JPS60174799A (ja) * 1984-02-21 1985-09-09 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法
AU586669B2 (en) * 1985-03-29 1989-07-20 Mitsui Toatsu Chemicals Inc. Preparation process of ```-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof
JPH0647600B2 (ja) * 1985-06-04 1994-06-22 味の素株式会社 β−アスパルチルフエニルアラニン誘導体のα−アスパルチルフエニルアラニン誘導体への変換法
US4677220A (en) * 1985-10-31 1987-06-30 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester
DE3600731A1 (de) * 1986-01-13 1987-07-16 Green Cross Korea Verfahren zur herstellung von (alpha)-l-aspartyl-l-phenylalaninmethylester
US4992552A (en) * 1988-08-31 1991-02-12 Eastman Kodak Company Process for preparation of amino acids

Also Published As

Publication number Publication date
CN1057835A (zh) 1992-01-15
NZ237469A (en) 1993-08-26
EP0478729A4 (en) 1993-06-16
WO1991014378A1 (en) 1991-10-03
PT97049A (pt) 1991-12-31
ATE141613T1 (de) 1996-09-15
IE910896A1 (en) 1991-09-25
DK0478729T3 (da) 1996-09-16
AU7564891A (en) 1991-10-21
NO920193L (no) 1992-01-15
HUT60712A (en) 1992-10-28
EP0478729B1 (de) 1996-08-21
DE69121502D1 (de) 1996-09-26
PT97049B (pt) 1998-07-31
CS70091A2 (en) 1991-10-15
AU628257B2 (en) 1992-09-10
EP0478729A1 (de) 1992-04-08
CA2060515A1 (en) 1991-09-16
GR3020839T3 (en) 1996-11-30
NO920193D0 (no) 1992-01-15
ES2091324T3 (es) 1996-11-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee