DE60015508T2 - C-16 ungesätigte fp-selektive prostaglandin analoge - Google Patents

C-16 ungesätigte fp-selektive prostaglandin analoge Download PDF

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Publication number
DE60015508T2
DE60015508T2 DE60015508T DE60015508T DE60015508T2 DE 60015508 T2 DE60015508 T2 DE 60015508T2 DE 60015508 T DE60015508 T DE 60015508T DE 60015508 T DE60015508 T DE 60015508T DE 60015508 T2 DE60015508 T2 DE 60015508T2
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DE
Germany
Prior art keywords
unaudited
prostaglandin analogue
selective prostaglandin
selective
analogue
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Expired - Lifetime
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DE60015508T
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English (en)
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DE60015508D1 (de
Inventor
Anthony Delong
Lindsey Soper
August Wos
Biswanath De
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University of Durham
Duke University
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University of Durham
Duke University
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Publication of DE60015508D1 publication Critical patent/DE60015508D1/de
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Publication of DE60015508T2 publication Critical patent/DE60015508T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Furan Compounds (AREA)
DE60015508T 1999-03-05 2000-02-29 C-16 ungesätigte fp-selektive prostaglandin analoge Expired - Lifetime DE60015508T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12292499P 1999-03-05 1999-03-05
PCT/US2000/005301 WO2000051980A1 (en) 1999-03-05 2000-02-29 C16 unsaturated fp-selective prostaglandins analogs

Publications (2)

Publication Number Publication Date
DE60015508D1 DE60015508D1 (de) 2004-12-09
DE60015508T2 true DE60015508T2 (de) 2005-04-21

Family

ID=22405663

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60015508T Expired - Lifetime DE60015508T2 (de) 1999-03-05 2000-02-29 C-16 ungesätigte fp-selektive prostaglandin analoge

Country Status (20)

Country Link
US (2) US6586463B2 (de)
EP (1) EP1159266B1 (de)
JP (2) JP4834224B2 (de)
KR (1) KR20010108316A (de)
CN (1) CN1350521A (de)
AT (1) ATE281432T1 (de)
AU (1) AU766163B2 (de)
BR (1) BR0008776A (de)
CA (1) CA2364948C (de)
CO (1) CO5160251A1 (de)
CZ (1) CZ20013174A3 (de)
DE (1) DE60015508T2 (de)
ES (1) ES2232434T3 (de)
HU (1) HUP0200258A2 (de)
IL (1) IL145122A0 (de)
MX (1) MXPA01008955A (de)
NO (1) NO20014241L (de)
NZ (1) NZ513825A (de)
PL (1) PL350917A1 (de)
WO (1) WO2000051980A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ513825A (en) * 1999-03-05 2001-09-28 Procter & Gamble C 16 unsaturated FP-selective prostaglandins analogs
US20020037914A1 (en) * 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US6531504B2 (en) * 2001-05-17 2003-03-11 Allergan, Inc. Prostanoic acid derivatives as agents for lowering intraocular pressure
CA2450466C (en) * 2001-06-14 2011-07-05 Allergan, Inc. 3, 7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure
US7169807B2 (en) * 2004-04-09 2007-01-30 Allergan, Inc. 10-Hydroxy-11-dihydroprostaglandin analogs as selective EP4 agonists
JP2008517941A (ja) * 2004-10-21 2008-05-29 デューク・ユニバーシティー 眼科用薬剤
US20070254920A1 (en) * 2006-04-26 2007-11-01 Aerie Pharmaceuticals, Inc. Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use
ES2358558T3 (es) * 2007-02-01 2011-05-11 Allergan, Inc. Derivados de tiofeno como medicamentos para el tratamiento de la hipertensión ocular.
US7964595B2 (en) * 2008-01-18 2011-06-21 Allergan, Inc. Thiophenyl prostaglandin derivatives for treating glaucoma and ocular hypertension
US8623918B2 (en) * 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
CN108084074B (zh) * 2017-12-25 2018-11-20 厦门欧瑞捷生物科技有限公司 一种简便高效合成地诺前列素的方法

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ATE281432T1 (de) 2004-11-15
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CN1350521A (zh) 2002-05-22
HUP0200258A2 (hu) 2002-05-29
CA2364948C (en) 2011-04-26
US6586463B2 (en) 2003-07-01
JP2011037861A (ja) 2011-02-24
CA2364948A1 (en) 2000-09-08
PL350917A1 (en) 2003-02-10
BR0008776A (pt) 2001-12-18

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