GB1285371A - Improvements in or relating to therapeutic methods using prostaglandins - Google Patents
Improvements in or relating to therapeutic methods using prostaglandinsInfo
- Publication number
- GB1285371A GB1285371A GB39883/69A GB3988369A GB1285371A GB 1285371 A GB1285371 A GB 1285371A GB 39883/69 A GB39883/69 A GB 39883/69A GB 3988369 A GB3988369 A GB 3988369A GB 1285371 A GB1285371 A GB 1285371A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compositions
- estradiol
- cis
- trans
- aug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940094443 oxytocics prostaglandins Drugs 0.000 title 1
- 150000003180 prostaglandins Chemical class 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 abstract 2
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229960002568 ethinylestradiol Drugs 0.000 abstract 2
- -1 hydrocarbon carboxylic acid Chemical class 0.000 abstract 2
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 abstract 1
- PROQIPRRNZUXQM-UHFFFAOYSA-N (16alpha,17betaOH)-Estra-1,3,5(10)-triene-3,16,17-triol Natural products OC1=CC=C2C3CCC(C)(C(C(O)C4)O)C4C3CCC2=C1 PROQIPRRNZUXQM-UHFFFAOYSA-N 0.000 abstract 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 abstract 1
- PBBGSZCBWVPOOL-HDICACEKSA-N 4-[(1r,2s)-1-ethyl-2-(4-hydroxyphenyl)butyl]phenol Chemical compound C1([C@H](CC)[C@H](CC)C=2C=CC(O)=CC=2)=CC=C(O)C=C1 PBBGSZCBWVPOOL-HDICACEKSA-N 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- UOACKFBJUYNSLK-XRKIENNPSA-N Estradiol Cypionate Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H](C4=CC=C(O)C=C4CC3)CC[C@@]21C)C(=O)CCC1CCCC1 UOACKFBJUYNSLK-XRKIENNPSA-N 0.000 abstract 1
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 abstract 1
- XAZOGOMZALBXHE-LBSXMSKVSA-N S(=O)(=O)(O)O.[C@@H]12CCC[C@@]1(C)CC[C@@H]1[C@H]3CCCCC3CC[C@@H]21 Chemical compound S(=O)(=O)(O)O.[C@@H]12CCC[C@@]1(C)CC[C@@H]1[C@H]3CCCCC3CC[C@@H]21 XAZOGOMZALBXHE-LBSXMSKVSA-N 0.000 abstract 1
- VZMLEMYJUIIHNF-DQRAZIAOSA-N [4-[(z)-4-(4-propanoyloxyphenyl)hex-3-en-3-yl]phenyl] propanoate Chemical compound C1=CC(OC(=O)CC)=CC=C1C(\CC)=C(\CC)C1=CC=C(OC(=O)CC)C=C1 VZMLEMYJUIIHNF-DQRAZIAOSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- DUTFBSAKKUNBAL-UHFFFAOYSA-N benzestrol Chemical compound C=1C=C(O)C=CC=1C(CC)C(CC)C(C)C1=CC=C(O)C=C1 DUTFBSAKKUNBAL-UHFFFAOYSA-N 0.000 abstract 1
- 229950000135 benzestrol Drugs 0.000 abstract 1
- 230000037396 body weight Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003433 contraceptive agent Substances 0.000 abstract 1
- 230000002254 contraceptive effect Effects 0.000 abstract 1
- 229960003839 dienestrol Drugs 0.000 abstract 1
- NFDFQCUYFHCNBW-SCGPFSFSSA-N dienestrol Chemical compound C=1C=C(O)C=CC=1\C(=C/C)\C(=C\C)\C1=CC=C(O)C=C1 NFDFQCUYFHCNBW-SCGPFSFSSA-N 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229960005309 estradiol Drugs 0.000 abstract 1
- 229930182833 estradiol Natural products 0.000 abstract 1
- 229960005416 estradiol cypionate Drugs 0.000 abstract 1
- PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 abstract 1
- 229960001348 estriol Drugs 0.000 abstract 1
- 229940106582 estrogenic substances Drugs 0.000 abstract 1
- 229960003399 estrone Drugs 0.000 abstract 1
- JKKFKPJIXZFSSB-CBZIJGRNSA-N estrone 3-sulfate Chemical compound OS(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 JKKFKPJIXZFSSB-CBZIJGRNSA-N 0.000 abstract 1
- 229950001996 hexestrol Drugs 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002440 hydroxy compounds Chemical class 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000001850 reproductive effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000007910 systemic administration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1285371 Contraceptive &c compositions UPJOHN CO 8 Aug 1969 [29 Aug 1968 12 Nov 1968] 39883/69 Heading A5B A pharmaceutical preparation for controlling the reproductive cycle in an ovulating female mammal consist of a member selected from the free acids, pharmaceutically acceptable salts, acylates wherein the acyl radical radical is that of a hydrocarbon carboxylic acid having 1 to 8 carbon atoms inclusive and carboxylate esters derived from a hydroxy compound having 1 to 8 carbon atoms of a compound represented by the formula: wherein X is -CH 2 CH 2 - or trans -CH=CH-, and both Y and Z are -CH 2 CH 2 -; X is trans -CH=CH-, Y is cis -CH=CH- and Z is -CH 2 CH 2 - or cis -CH=CH- m is 0, 1 or 2 and n is 2, 3, 4 or 5 and a pharmaceutical carrier. The compositions are suitable for systemic administration and designed to provide to said female from 0.01 mg to 20 mg/kilo of body weight of said female mammal. The compositions may also contain estrogenic substances such as estriol, estrone, estradiol, estradiol cyclopentylpropionate, ethinyl estradiol, ethinyl estradiol 3-methyl ester, piperazine estrane sulphate, benzestrol, dienestrol, diethylstilbestrol dipropionate, hexestrol and methalenstril.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75629468A | 1968-08-29 | 1968-08-29 | |
| US77511068A | 1968-11-12 | 1968-11-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1285371A true GB1285371A (en) | 1972-08-16 |
Family
ID=27116201
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB39883/69A Expired GB1285371A (en) | 1968-08-29 | 1969-08-08 | Improvements in or relating to therapeutic methods using prostaglandins |
| GB8645/72A Expired GB1285372A (en) | 1968-08-29 | 1969-08-08 | Improvements in or relating to prostaglandins and the preparation thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8645/72A Expired GB1285372A (en) | 1968-08-29 | 1969-08-08 | Improvements in or relating to prostaglandins and the preparation thereof |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS541697B1 (en) |
| BE (1) | BE738173A (en) |
| CH (2) | CH518251A (en) |
| DE (1) | DE1943440A1 (en) |
| DK (1) | DK129389B (en) |
| ES (1) | ES370889A1 (en) |
| FR (1) | FR2016593B1 (en) |
| GB (2) | GB1285371A (en) |
| IL (1) | IL32897A0 (en) |
| NL (1) | NL6912922A (en) |
| PH (1) | PH9347A (en) |
| SE (1) | SE383877B (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6894175B1 (en) | 1999-08-04 | 2005-05-17 | The Procter & Gamble Company | 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use |
| USRE43372E1 (en) | 1999-03-05 | 2012-05-08 | Duke University | C16 unsaturated FP-selective prostaglandins analogs |
| US8541466B2 (en) | 2000-03-31 | 2013-09-24 | Duke University | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US8618086B2 (en) | 2000-03-31 | 2013-12-31 | Duke University | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
| US8623918B2 (en) | 2008-10-29 | 2014-01-07 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| US8722739B2 (en) | 2008-10-29 | 2014-05-13 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| US9346837B2 (en) | 2000-03-31 | 2016-05-24 | Duke University | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2317019A1 (en) * | 1972-04-27 | 1973-11-08 | Upjohn Co | NEW 4,5 DIDEHYDRO PROSTAGLANDIN |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3505386A (en) * | 1965-12-29 | 1970-04-07 | Upjohn Co | Compounds related to prostaglandins |
| GB1198071A (en) * | 1966-08-09 | 1970-07-08 | George Erich Just | Improvements in or relating to Prostaglandin Analogues and the Manufacture thereof |
-
1969
- 1969-08-08 GB GB39883/69A patent/GB1285371A/en not_active Expired
- 1969-08-08 GB GB8645/72A patent/GB1285372A/en not_active Expired
- 1969-08-12 PH PH10629*UA patent/PH9347A/en unknown
- 1969-08-22 JP JP6607769A patent/JPS541697B1/ja active Pending
- 1969-08-22 CH CH1764871A patent/CH518251A/en not_active IP Right Cessation
- 1969-08-22 CH CH1279069A patent/CH517684A/en not_active IP Right Cessation
- 1969-08-25 NL NL6912922A patent/NL6912922A/xx unknown
- 1969-08-26 ES ES370889A patent/ES370889A1/en not_active Expired
- 1969-08-27 SE SE6911876A patent/SE383877B/en unknown
- 1969-08-27 IL IL32897A patent/IL32897A0/en unknown
- 1969-08-27 DE DE19691943440 patent/DE1943440A1/en active Pending
- 1969-08-28 DK DK462369AA patent/DK129389B/en unknown
- 1969-08-28 FR FR696929487A patent/FR2016593B1/fr not_active Expired
- 1969-08-29 BE BE738173D patent/BE738173A/xx not_active IP Right Cessation
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE43372E1 (en) | 1999-03-05 | 2012-05-08 | Duke University | C16 unsaturated FP-selective prostaglandins analogs |
| US6894175B1 (en) | 1999-08-04 | 2005-05-17 | The Procter & Gamble Company | 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use |
| US7074942B2 (en) | 1999-08-04 | 2006-07-11 | The Procter & Gamble Company | 2-decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use |
| US7115659B2 (en) | 1999-08-04 | 2006-10-03 | The Procter & Gamble Company | Method of treating a condition by administering a prostaglandin derivative |
| US8541466B2 (en) | 2000-03-31 | 2013-09-24 | Duke University | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US8618086B2 (en) | 2000-03-31 | 2013-12-31 | Duke University | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
| US8906962B2 (en) | 2000-03-31 | 2014-12-09 | Duke University | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US9346837B2 (en) | 2000-03-31 | 2016-05-24 | Duke University | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
| US9579270B2 (en) | 2000-03-31 | 2017-02-28 | Duke University | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US9675539B2 (en) | 2000-03-31 | 2017-06-13 | Duke University | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
| US8623918B2 (en) | 2008-10-29 | 2014-01-07 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| US8722739B2 (en) | 2008-10-29 | 2014-05-13 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
Also Published As
| Publication number | Publication date |
|---|---|
| IL32897A0 (en) | 1969-11-12 |
| NL6912922A (en) | 1970-03-03 |
| BE738173A (en) | 1970-03-02 |
| FR2016593B1 (en) | 1973-01-12 |
| DE1943440A1 (en) | 1970-03-05 |
| JPS541697B1 (en) | 1979-01-27 |
| GB1285372A (en) | 1972-08-16 |
| PH9347A (en) | 1975-10-06 |
| CH517684A (en) | 1972-01-15 |
| SE383877B (en) | 1976-04-05 |
| FR2016593A1 (en) | 1970-05-08 |
| ES370889A1 (en) | 1972-03-16 |
| DK129389C (en) | 1975-02-24 |
| CH518251A (en) | 1972-01-31 |
| DK129389B (en) | 1974-10-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4212864A (en) | Branched chain and cycloaliphatic esters of the androstane and oestrane series and pharmaceutical compositions containing same | |
| AU640396B2 (en) | 7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha-reductase | |
| GB1285371A (en) | Improvements in or relating to therapeutic methods using prostaglandins | |
| US3639599A (en) | Uterotropic composition | |
| GB1497985A (en) | Oxazolo-pyridines their preparation and use and compositions containing them | |
| GB1506823A (en) | Prostaglandins | |
| GB1015787A (en) | Tris-(p-methoxyphenyl)ethylene derivatives | |
| US3833725A (en) | Dialkylated glycol compositions and medicament preparations containing same | |
| GB1031905A (en) | Novel steroid compounds, their preparation and pharmaceutical compositions containing them | |
| GB1326528A (en) | Method of contraception and compositions used therein | |
| GB1473574A (en) | Sitosterol esters | |
| GB1175820A (en) | Amino-Adamantane Derivatives | |
| IL59479A (en) | 7-alkylated steroid derivatives,process for preparing them,their use as a medicament and the pharmaceutical compositions containing them | |
| GB1496851A (en) | Prostynoic acid derivatives | |
| GB1474749A (en) | Pharmaceutical preparations based on cyproterone | |
| GB1487544A (en) | Dermatological composition | |
| PT64966B (en) | Process for the preparation of d-homosteroids | |
| HUT34995A (en) | Process for producing 7-alpha-substituted-3-oxo-17-alpha-pregn-4-ene-21,17-carbolactone derivatives and pharmaceutical compositions containing them as active agents | |
| GB1202010A (en) | Prostaglandins and the manufacture thereof | |
| IE780386L (en) | 17-alkynyl steroids | |
| ES395599A1 (en) | Orally administered contrast agents for cholecystography | |
| GB1185381A (en) | 05,16beta-Methylene Steroids of the 19-Nor-Androstane Series and Process for their Manufacture | |
| GB1310731A (en) | Azamorphinan compounds | |
| GB1023719A (en) | Substituted 19-norandrosta-5(10),9(11)-dienes and method of preparing same | |
| GB1185114A (en) | 3-Amino-2,4,6-Ttriiodobenzoic Acid Derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PE20 | Patent expired after termination of 20 years |