GB1285372A - Improvements in or relating to prostaglandins and the preparation thereof - Google Patents
Improvements in or relating to prostaglandins and the preparation thereofInfo
- Publication number
- GB1285372A GB1285372A GB8645/72A GB864572A GB1285372A GB 1285372 A GB1285372 A GB 1285372A GB 8645/72 A GB8645/72 A GB 8645/72A GB 864572 A GB864572 A GB 864572A GB 1285372 A GB1285372 A GB 1285372A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- cis
- trans
- prostaglandins
- formulμ
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940094443 oxytocics prostaglandins Drugs 0.000 title abstract 3
- 150000003180 prostaglandins Chemical class 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000007943 implant Substances 0.000 abstract 1
- 238000007918 intramuscular administration Methods 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000007920 subcutaneous administration Methods 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
1285372 Prostaglandins UPJOHN CO 8 Aug 1969 [29 Aug 1968 12 Nov 1968] 8645/72 Divided out of 1285371 Heading C2C Novel prostaglandins of the formulµ wherein R 1 is H, C 1-8 alkyl, or a pharmacologically acceptable cation, R 2 and R 3 are H or C 1-8 alkanoy], provided that when R 3 is alkanoyl, R 2 is also alkanoyl, m is 0 or 2 and X, Y and Z are -CH 2 CH 2 -, or X is trans -CH = CH-, Y is cis -CH = CH- and Z is -CH 2 CH 2 - or cis -CH = CH- are prepared by reducing the carbonyl group in compounds of the formulµ wherein R 4 is H or C 1-8 alkyl, or compounds of the above Formula I wherein X, Y and Z are -CH 2 -CH 2 - by reducing the corresponding compounds in which X is trans CH = CH and Y and Z are -CH 2 CH 2 - or X is trans CH = CH, Y is cis-CH=CH- and Z is -CH 2 -H 2 - or cis -CH=CH-. Compounds thus obtained of the above Formulae I and II in which R 1 , R 2 and R 3 are H may, if desired, be esterified, basified or acylated by usual methods. Pharmaceutical compositions suitable for topical or sytemic, e.g. intravenous, subcutaneous, intramuscular, oral, rectal, vaginal, buccal, sublingual and as sterile implants, contain the above novel compounds or salts thereof in admixture with pharmaceutically acceptable carriers. The compounds have similar pharmacological properties to natural PGF compounds.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75629468A | 1968-08-29 | 1968-08-29 | |
| US77511068A | 1968-11-12 | 1968-11-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1285372A true GB1285372A (en) | 1972-08-16 |
Family
ID=27116201
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8645/72A Expired GB1285372A (en) | 1968-08-29 | 1969-08-08 | Improvements in or relating to prostaglandins and the preparation thereof |
| GB39883/69A Expired GB1285371A (en) | 1968-08-29 | 1969-08-08 | Improvements in or relating to therapeutic methods using prostaglandins |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB39883/69A Expired GB1285371A (en) | 1968-08-29 | 1969-08-08 | Improvements in or relating to therapeutic methods using prostaglandins |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS541697B1 (en) |
| BE (1) | BE738173A (en) |
| CH (2) | CH517684A (en) |
| DE (1) | DE1943440A1 (en) |
| DK (1) | DK129389B (en) |
| ES (1) | ES370889A1 (en) |
| FR (1) | FR2016593B1 (en) |
| GB (2) | GB1285372A (en) |
| IL (1) | IL32897A0 (en) |
| NL (1) | NL6912922A (en) |
| PH (1) | PH9347A (en) |
| SE (1) | SE383877B (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6894175B1 (en) | 1999-08-04 | 2005-05-17 | The Procter & Gamble Company | 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use |
| USRE43372E1 (en) | 1999-03-05 | 2012-05-08 | Duke University | C16 unsaturated FP-selective prostaglandins analogs |
| US8541466B2 (en) | 2000-03-31 | 2013-09-24 | Duke University | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US8618086B2 (en) | 2000-03-31 | 2013-12-31 | Duke University | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
| US8623918B2 (en) | 2008-10-29 | 2014-01-07 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| US8722739B2 (en) | 2008-10-29 | 2014-05-13 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| US9346837B2 (en) | 2000-03-31 | 2016-05-24 | Duke University | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2317019A1 (en) * | 1972-04-27 | 1973-11-08 | Upjohn Co | NEW 4,5 DIDEHYDRO PROSTAGLANDIN |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3505386A (en) * | 1965-12-29 | 1970-04-07 | Upjohn Co | Compounds related to prostaglandins |
| GB1198071A (en) * | 1966-08-09 | 1970-07-08 | George Erich Just | Improvements in or relating to Prostaglandin Analogues and the Manufacture thereof |
-
1969
- 1969-08-08 GB GB8645/72A patent/GB1285372A/en not_active Expired
- 1969-08-08 GB GB39883/69A patent/GB1285371A/en not_active Expired
- 1969-08-12 PH PH10629*UA patent/PH9347A/en unknown
- 1969-08-22 CH CH1279069A patent/CH517684A/en not_active IP Right Cessation
- 1969-08-22 JP JP6607769A patent/JPS541697B1/ja active Pending
- 1969-08-22 CH CH1764871A patent/CH518251A/en not_active IP Right Cessation
- 1969-08-25 NL NL6912922A patent/NL6912922A/xx unknown
- 1969-08-26 ES ES370889A patent/ES370889A1/en not_active Expired
- 1969-08-27 IL IL32897A patent/IL32897A0/en unknown
- 1969-08-27 SE SE6911876A patent/SE383877B/en unknown
- 1969-08-27 DE DE19691943440 patent/DE1943440A1/en active Pending
- 1969-08-28 FR FR696929487A patent/FR2016593B1/fr not_active Expired
- 1969-08-28 DK DK462369AA patent/DK129389B/en unknown
- 1969-08-29 BE BE738173D patent/BE738173A/xx not_active IP Right Cessation
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE43372E1 (en) | 1999-03-05 | 2012-05-08 | Duke University | C16 unsaturated FP-selective prostaglandins analogs |
| US6894175B1 (en) | 1999-08-04 | 2005-05-17 | The Procter & Gamble Company | 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use |
| US7074942B2 (en) | 1999-08-04 | 2006-07-11 | The Procter & Gamble Company | 2-decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use |
| US7115659B2 (en) | 1999-08-04 | 2006-10-03 | The Procter & Gamble Company | Method of treating a condition by administering a prostaglandin derivative |
| US8541466B2 (en) | 2000-03-31 | 2013-09-24 | Duke University | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US8618086B2 (en) | 2000-03-31 | 2013-12-31 | Duke University | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
| US8906962B2 (en) | 2000-03-31 | 2014-12-09 | Duke University | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US9346837B2 (en) | 2000-03-31 | 2016-05-24 | Duke University | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
| US9579270B2 (en) | 2000-03-31 | 2017-02-28 | Duke University | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US9675539B2 (en) | 2000-03-31 | 2017-06-13 | Duke University | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
| US8623918B2 (en) | 2008-10-29 | 2014-01-07 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| US8722739B2 (en) | 2008-10-29 | 2014-05-13 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
Also Published As
| Publication number | Publication date |
|---|---|
| CH518251A (en) | 1972-01-31 |
| PH9347A (en) | 1975-10-06 |
| FR2016593A1 (en) | 1970-05-08 |
| DK129389C (en) | 1975-02-24 |
| BE738173A (en) | 1970-03-02 |
| FR2016593B1 (en) | 1973-01-12 |
| NL6912922A (en) | 1970-03-03 |
| DK129389B (en) | 1974-10-07 |
| ES370889A1 (en) | 1972-03-16 |
| JPS541697B1 (en) | 1979-01-27 |
| GB1285371A (en) | 1972-08-16 |
| CH517684A (en) | 1972-01-15 |
| SE383877B (en) | 1976-04-05 |
| DE1943440A1 (en) | 1970-03-05 |
| IL32897A0 (en) | 1969-11-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1405886A (en) | Synergistic compositions comprising penicillin and cephalosporin antibiotics | |
| GB1213162A (en) | Serum lipid lowering pyridine derivatives and their preparation | |
| GB1285372A (en) | Improvements in or relating to prostaglandins and the preparation thereof | |
| GB1355147A (en) | Oxoprostanoic acid derivatives | |
| ES451979A1 (en) | Phenylethanolamine derivatives | |
| GB1506822A (en) | Prostaglandins | |
| GB1497218A (en) | Thiaprostaglandins | |
| GB1506817A (en) | Prostaglandins | |
| GB1496491A (en) | Dihydroergopeptine derivatives | |
| GB1424415A (en) | Prostaglandin intermediates and their preparation | |
| GB1432503A (en) | Cycloalkylalkylesters and process for their preparation | |
| GB1251750A (en) | ||
| GB1495778A (en) | Hexahydroazepines | |
| GB1314952A (en) | 3,4,5-trialkoxy-benzoic acid derivatives and their uses | |
| GB1508168A (en) | 11-deoxy-15-substituted-16,17,18,19,20-pentanorprostaglandins | |
| GB1347598A (en) | Lincomycin derivatives and the manufacture thereof | |
| GB1438260A (en) | Sulphoxides and sulphones processes for their preparation and compositions containing them | |
| GB1112909A (en) | Ergoline derivatives | |
| GB1202010A (en) | Prostaglandins and the manufacture thereof | |
| GB1351526A (en) | Tropan-3-ol derivatives and processes for their preparation | |
| ES427614A1 (en) | 9-Hydroxy prosta-5-cis, 11,13-trans-trienoic acids and derivatives thereof | |
| GB1504683A (en) | Pharmaceutical compositions containing substituted pyrimido-quinoline derivatives | |
| GB1490023A (en) | Prostaglandin analogues | |
| GB1244881A (en) | New piperidine derivatives, process for their production and preparations containing same | |
| ES364980A1 (en) | A method for preparing new adamantan derivatives. (Machine-translation by Google Translate, not legally binding) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |