ATE101342T1 - Prostaglandinderivate zur behandlung des gruenen stars oder einer okularen hypertension. - Google Patents

Prostaglandinderivate zur behandlung des gruenen stars oder einer okularen hypertension.

Info

Publication number
ATE101342T1
ATE101342T1 AT89850294T AT89850294T ATE101342T1 AT E101342 T1 ATE101342 T1 AT E101342T1 AT 89850294 T AT89850294 T AT 89850294T AT 89850294 T AT89850294 T AT 89850294T AT E101342 T1 ATE101342 T1 AT E101342T1
Authority
AT
Austria
Prior art keywords
treatment
prostagland
individuals
ocular hypertension
green star
Prior art date
Application number
AT89850294T
Other languages
English (en)
Inventor
Johan W Stjernschantz
Bahram Resul
Original Assignee
Kabi Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26660291&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE101342(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from SE8803110A external-priority patent/SE8803110D0/xx
Application filed by Kabi Pharmacia Ab filed Critical Kabi Pharmacia Ab
Application granted granted Critical
Publication of ATE101342T1 publication Critical patent/ATE101342T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5578Eicosanoids, e.g. leukotrienes or prostaglandins having a pentalene ring system, e.g. carbacyclin, iloprost
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT89850294T 1988-09-06 1989-09-06 Prostaglandinderivate zur behandlung des gruenen stars oder einer okularen hypertension. ATE101342T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE8803110A SE8803110D0 (sv) 1988-09-06 1988-09-06 Prostaglandinderivat for behandling av glaukom eller okuler hypertension
SE8803855 1988-10-28
EP89850294A EP0364417B9 (de) 1988-09-06 1989-09-06 Prostaglandinderivate zur Behandlung des grünen Stars oder einer okularen Hypertension

Publications (1)

Publication Number Publication Date
ATE101342T1 true ATE101342T1 (de) 1994-02-15

Family

ID=26660291

Family Applications (3)

Application Number Title Priority Date Filing Date
AT89850294T ATE101342T1 (de) 1988-09-06 1989-09-06 Prostaglandinderivate zur behandlung des gruenen stars oder einer okularen hypertension.
AT93109514T ATE227576T1 (de) 1988-09-06 1989-09-06 Prostaglandinderivate zur behandlung des grünen stars oder einer okularen hypertension
AT02009255T ATE420857T1 (de) 1988-09-06 1989-09-06 Prostaglandin-derivate zur behandlung von glaukom und ocularer hypertension

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT93109514T ATE227576T1 (de) 1988-09-06 1989-09-06 Prostaglandinderivate zur behandlung des grünen stars oder einer okularen hypertension
AT02009255T ATE420857T1 (de) 1988-09-06 1989-09-06 Prostaglandin-derivate zur behandlung von glaukom und ocularer hypertension

Country Status (13)

Country Link
US (6) US5422368A (de)
EP (6) EP1224934A3 (de)
JP (3) JP2721414B2 (de)
AT (3) ATE101342T1 (de)
DE (5) DE1300150T1 (de)
DK (1) DK175842B1 (de)
ES (5) ES2317964T5 (de)
FI (1) FI92690C (de)
HK (2) HK1048106A1 (de)
HU (1) HU211593A9 (de)
LU (1) LU91541I2 (de)
NL (1) NL970039I2 (de)
WO (1) WO1990002553A1 (de)

Families Citing this family (253)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5151444B1 (en) * 1987-09-18 1999-07-06 R Tech Ueno Ltd Ocular hypotensive agents
US5236907A (en) * 1988-10-01 1993-08-17 R-Tech Ueno Ltd. Ocular hypotensive agents
US5212200A (en) * 1987-09-18 1993-05-18 R-Tech Ueno, Ltd. Ocular hypotensive agents
US6420422B1 (en) 1987-09-18 2002-07-16 Sucampo Pharmaceuticals, Inc. Ocular hypotensive agents
US5166178B1 (en) * 1987-09-18 1998-07-21 R Tech Ueno Ltd Ocular hypotensive agents
US5565492A (en) * 1988-07-18 1996-10-15 Alcon Laboratories, Inc. Prostaglandin combinations in glaucoma therapy
ATE101342T1 (de) * 1988-09-06 1994-02-15 Kabi Pharmacia Ab Prostaglandinderivate zur behandlung des gruenen stars oder einer okularen hypertension.
US6187813B1 (en) 1990-04-10 2001-02-13 Pharmacia & Upjohn Aktiebolag Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US5321128A (en) * 1988-09-06 1994-06-14 Kabi Pharmacia Ab Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US5296504A (en) * 1988-09-06 1994-03-22 Kabi Pharmacia Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US5194429A (en) * 1988-10-01 1993-03-16 K.K. Ueno Seiyaku Oyo Kenkyujo Ocular hypotensive agents
HU212570B (en) * 1991-06-24 1996-08-29 Chinoin Gyogyszer Es Vegyeszet Process for producing 13,14-dihydro-15(r)-17-phenyl-18,19,20-trinor-pgf2alfa-isopropylester
US5223537A (en) * 1991-07-23 1993-06-29 Kabi Pharmacia Ab Method and composition for treatment of gastric and duodenal disorders
US5352708A (en) * 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5688819A (en) * 1992-09-21 1997-11-18 Allergan Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US6602900B2 (en) 1992-09-21 2003-08-05 Allergan, Inc. Cyclopentane heptan(ENE)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5834498A (en) * 1992-09-21 1998-11-10 Allergan Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5972991A (en) 1992-09-21 1999-10-26 Allergan Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5468778A (en) * 1992-09-24 1995-11-21 Allergan, Inc. Method of lowering intraocular pressure by administering a pharmaceutical composition containing 7-(5-substituted cyclopentyl) and 7-(5-substituted-cyclopentenyl) 5-heptenoic acids and derivatives
ES2105333T3 (es) * 1992-10-13 1997-10-16 Alcon Lab Inc Combinaciones de prostaglandinas y derivados de clonidina para el tratamiento del glaucoma.
US5332730A (en) * 1992-10-16 1994-07-26 Allergan, Inc. Azido derivatives of cyclopentane heptanoic or heptenoic acid
US5385945A (en) * 1992-10-21 1995-01-31 Allergan, Inc. 7-(5-substituted cyclopentyl) and (5-substituted cyclopentenyl) heptyl alcohols, heptylamines and heptanoic acid amides, and method of lowering intraocular pressure in the eye of a mammal by administration of these novel compounds
US5328933A (en) * 1992-10-28 1994-07-12 Allergan, Inc. Cyclopentane heptenylnitro and heptanylnitro-2-aliphatic or aryl aliphatic derivatives and homologues
US5312842A (en) * 1992-10-30 1994-05-17 Allergan, Inc. Cyclopentane heptenylsulfinylalkyl and heptanylsulfinylalkyl-2-aliphatic or aryl aliphatic derivatives
US5510383A (en) * 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US6184250B1 (en) * 1993-08-03 2001-02-06 Alcon Laboratories, Inc. Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension
US5387608A (en) * 1993-08-17 1995-02-07 Allergan, Inc. Cyclopentane(ene) heptanoic or cyclopentane(ene) heptenoic acid, 2-hydrocarbyl sulfonamidomethyl and derivatives thereof as therapeutic agents
US5476872A (en) * 1993-10-18 1995-12-19 Allergan, Inc. 1,11-diesters of prostaglandin-F2α having a polar ester group at C-1
US5486540A (en) * 1993-10-28 1996-01-23 Allergan, Inc. Cyclopentane heptanoic or heptenoic acid, 2-arylalkyl or arylalkenyl and derivatives as therapeutic agents
US5627209A (en) * 1993-12-15 1997-05-06 Alcon Laboratories, Inc. Use of certain 9-haloprostaglandins to treat glaucoma and ocular hypertension
US5721273A (en) 1993-12-15 1998-02-24 Alcon Laboratories, Inc. Use of certain 9-halo-13,14-dihydroprostaglandins to treat glaucoma and ocular hypertension
US5741812A (en) * 1993-12-28 1998-04-21 Allergan Thromboxane ligands without blood clotting side effects
US5416106A (en) * 1993-12-28 1995-05-16 Allergan, Inc. 7-[carboxyalkyl or alkenyl]-6-[alkyl or alkenyl]3-oxo-2,4-dioxobicyclo-[3.2.1] octane and derivatives thereof
US5650431A (en) * 1993-12-28 1997-07-22 Allergan Thromboxane ligands without blood clotting side effects
US5545665A (en) * 1993-12-28 1996-08-13 Allergan Cyclopentane(ene) heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents
US6462077B1 (en) 1993-12-28 2002-10-08 Allergan, Inc. Thromboxane ligands without blood clotting side effects
US5462968A (en) * 1994-01-19 1995-10-31 Allergan, Inc. EP2 -receptor agonists as agents for lowering intraocular pressure
US5516796A (en) * 1994-03-24 1996-05-14 Kabi Pharmacia Ab Thioprostaglandins and -prostaglandin-like compounds and therapeutic uses thereof
SE9401087D0 (sv) * 1994-03-31 1994-03-31 Pharmacia Ab New prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
SE9403158D0 (sv) * 1994-09-21 1994-09-21 Pharmacia Ab New use of prostaglandins
US5807892A (en) * 1994-09-30 1998-09-15 Alcon Laboratories, Inc. Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension
US5698733A (en) * 1994-09-30 1997-12-16 Alcon Laboratories, Inc. Use of 9-deoxy prostaglandin derivatives to treat glaucoma
US6294563B1 (en) 1994-10-27 2001-09-25 Allergan Sales, Inc. Combinations of prostaglandins and brimonidine or derivatives thereof
WO1996036599A1 (en) * 1995-05-18 1996-11-21 Allergan Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents for the treatment of ocular hypertension
US6169111B1 (en) 1995-06-07 2001-01-02 Alcon Laboratories, Inc. Conformationally rigid aryl prostaglandins for use in glaucoma therapy
US5698598A (en) * 1995-08-04 1997-12-16 Allergan EP2 -receptor agonists as agents for lowering intraocular pressure
AU7680096A (en) * 1995-12-22 1997-07-17 Alcon Laboratories, Inc. Combinations of dp and fp type prostaglandins for lowering iop
US5700835A (en) * 1995-12-22 1997-12-23 Alcon Laboratories, Inc. 3-Oxa-D-prostaglandins for lowering IOP
US5658897A (en) * 1996-04-08 1997-08-19 Allergan Cyclopentane(ene) heptanoic or cyclopentane(ene) heptenoic acid, 2-hydrocarbyl phosphinyloxyalkyl or phosphonamidoalkyl as therapeutic agents
ATE221048T1 (de) * 1996-09-17 2002-08-15 Asahi Glass Co Ltd Fluorierte prostaglandinderivate und medikamente
KR20000053228A (ko) * 1996-11-12 2000-08-25 제임스 에이. 아노 안압강하제로서의 프로스타글란딘의 시스-δ⁴ 유사체
US6353000B1 (en) * 1996-11-12 2002-03-05 Alcon Laboratories, Inc. 11-halo prostaglandins for the treatment of glaucoma or ocular hypertension
AU750039B2 (en) 1997-02-04 2002-07-11 Murray A. Johnstone Method of enhancing hair growth
AU6545498A (en) 1997-03-07 1998-09-22 Alcon Laboratories, Inc. 13-thia prostaglandins for use in glaucoma therapy
US6770675B2 (en) 1997-03-17 2004-08-03 Novartis Ag Compositions and methods for reducing ocular hypertension
CA2293325C (en) * 1997-05-09 2008-09-02 The Mount Sinai School Of Medicine Of The City University Of New York 8-iso-prostaglandins for glaucoma therapy
JP2001515882A (ja) * 1997-09-09 2001-09-25 ザ プロクター アンド ギャンブル カンパニー Fpアゴニストとして有用な、芳香族のあるc16〜c20が置換されたテトラヒドロプロスタグランジン類
HUP0004427A3 (en) * 1997-09-09 2001-09-28 Procter & Gamble Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists
ES2265166T3 (es) * 1997-10-13 2007-02-01 R-Tech Ueno, Ltd. Composicion para tratamiento de hipertension intraocular o glaucoma.
WO1999018970A1 (en) * 1997-10-14 1999-04-22 Senju Pharmaceutical Co., Ltd. Preventives and remedies for ophthalmic circulatory disturbance
US6646001B2 (en) 1997-12-19 2003-11-11 Alcon Manufacturing, Ltd. Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension
US6066671A (en) 1997-12-19 2000-05-23 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides
US6492417B1 (en) 1997-12-22 2002-12-10 Alcon Manufacturing, Ltd. 11-deoxy-16-fluoro-PGF2α analogs as FP receptor antagonists
US6441033B1 (en) 1997-12-22 2002-08-27 Alcon Manufacturing, Ltd. 11β-fluoro 15β-hydroxy PGF2α analogs as FP receptor antagonists
US6410780B1 (en) * 1998-03-31 2002-06-25 The Procter & Gamble Co. C11 oxymyl and hydroxylamino prostaglandins useful as medicaments
US6225348B1 (en) 1998-08-20 2001-05-01 Alfred W. Paulsen Method of treating macular degeneration with a prostaglandin derivative
US6160013A (en) * 1998-12-17 2000-12-12 Alcon Laboratories, Inc. 14-aza prostaglandins for the treatment of glaucoma and ocular hypertension
SE9900672D0 (sv) 1999-02-25 1999-02-25 Synphora Ab Method and composition for prevention of scar formation in glaucoma filtration bleb and drainage fistula
AU766163B2 (en) 1999-03-05 2003-10-09 Duke University C16 unsaturated fp-selective prostaglandins analogs
US6894175B1 (en) 1999-08-04 2005-05-17 The Procter & Gamble Company 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
TWI290470B (en) 1999-12-01 2007-12-01 Sankyo Co The composition for treating glaucoma
US6458836B1 (en) 2000-03-16 2002-10-01 Sucampo, A.G. Treatment of ocular hypertension and glaucoma
WO2001068072A2 (en) * 2000-03-16 2001-09-20 Sucampo Ag Composition for use in treatment of ocular hypertension and glaucoma
US6956036B1 (en) 2000-03-17 2005-10-18 Alcon, Inc. 6-hydroxy-indazole derivatives for treating glaucoma
US20030119846A1 (en) * 2000-03-17 2003-06-26 Collier Jr Robert J. Compounds with 5-ht activity useful for controlling visual field loss
US6927233B1 (en) 2000-03-17 2005-08-09 Alcon, Inc. 5ht2 agonists for controlling IOP and treating glaucoma
US6660870B1 (en) 2000-03-17 2003-12-09 Alcon, Inc. 2-acylaminobenzimidazole derivatives for treating glaucoma
US7012090B1 (en) 2000-03-17 2006-03-14 Alcon, Inc. Pyranoindoles for treating glaucoma
US7005443B1 (en) * 2000-03-17 2006-02-28 Alcon, Inc. 5-Hydroxy indazole derivatives for treating glaucoma
US6806285B1 (en) 2000-03-17 2004-10-19 Alcon, Inc. 5-Hydroxyl indole derivatives for treating glaucoma
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020172693A1 (en) * 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020146439A1 (en) * 2000-03-31 2002-10-10 Delong Mitchell Anthony Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
AU2001261019A1 (en) * 2000-05-15 2001-11-26 Pharmacia And Upjohn Company Process and intermediates to prepare latanoprost
GB0012249D0 (en) * 2000-05-19 2000-07-12 Chirotech Technology Ltd Process for the preparation of 11-oxaprostaglandins
US6726918B1 (en) 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
US20020035148A1 (en) 2000-07-20 2002-03-21 Ryuji Ueno Treatment of ocular hypertension
US6376533B1 (en) * 2000-10-20 2002-04-23 Allergan Sales, Inc. Omega-cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists
US6586462B2 (en) 2000-10-20 2003-07-01 Allergan, Inc. ω-Cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists
WO2004098807A1 (en) * 2000-11-21 2004-11-18 Barsplice Products, Inc. Method of making steel couplers for joining concrete reinforcing bars
JP2004514702A (ja) 2000-11-29 2004-05-20 オキュレックス ファーマシューティカルズ, インコーポレイテッド 眼における移植拒絶を予防するための眼内インプラント
CA2443937A1 (en) * 2001-04-23 2002-10-31 Randall D. Glickman Prostanoids augment ocular drug penetration
KR100437873B1 (ko) 2001-05-08 2004-06-26 연성정밀화학(주) 프로스타글란딘 유도체의 제조방법 및 그의 입체특이적출발물질
US20030212107A1 (en) * 2001-05-10 2003-11-13 Kapin Michael A. R-reliprodil for treating glaucoma
GB0112699D0 (en) * 2001-05-24 2001-07-18 Resolution Chemicals Ltd Process for the preparation of prostglandins and analogues thereof
TWI298257B (en) 2001-05-31 2008-07-01 Allergan Inc Hypotensive lipid and timolol compositions and methods of using same
JP2004532887A (ja) * 2001-06-01 2004-10-28 アルコン,インコーポレイテッド 新規な融合インダゾールおよびインドールおよび緑内障治療へのこれらの使用
WO2002098400A1 (en) * 2001-06-01 2002-12-12 Alcon, Inc. Novel arylaminopropane analogues and their use for the treatment of glaucoma
MXPA03010807A (es) * 2001-06-01 2004-11-22 Alcon Inc Piranoidazoles y su uso para el tratamiento del glaucoma.
US7872045B2 (en) * 2001-06-14 2011-01-18 Allergan, Inc. Combination therapy for glaucoma treatment
US20050222094A1 (en) * 2001-06-14 2005-10-06 Burk Robert M Treatment of inflammatory bowel disease
US20030027853A1 (en) * 2001-06-14 2003-02-06 Allergan Sales, Inc. 3, 7or3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure
US6713268B2 (en) * 2001-06-26 2004-03-30 Allergan, Inc. Methods of identifying ocular hypotensive compounds having reduced hyperpigmentation
US20030187071A1 (en) * 2001-07-17 2003-10-02 Henegar Kevin E. Process and intermediates to prepare latanoprost
KR100581647B1 (ko) 2001-07-17 2006-05-22 파마시아 앤드 업존 캄파니 엘엘씨 라타노프로스트 제조를 위한 방법 및 중간체
MXPA04001604A (es) * 2001-08-23 2004-07-08 Sucampo Ag Metodo y composicion para tratamiento de hipertension ocular y glaucoma.
US6884816B2 (en) 2001-08-31 2005-04-26 Alcon, Inc. Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma
US20040254230A1 (en) * 2001-12-03 2004-12-16 Ogidigben Miller J. Method for treating ocular hypertension
TW200305424A (en) 2002-01-29 2003-11-01 Santen Pharmaceutical Co Ltd Glaucoma-treating agent comprising bunazosin and prostaglandin
US9216183B2 (en) 2002-02-04 2015-12-22 Allergan, Inc. Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists
US8758733B2 (en) 2002-02-04 2014-06-24 Allergan, Inc. Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists
US7351404B2 (en) 2002-02-04 2008-04-01 Allergan, Inc. Method of enhancing hair growth
US20040110776A1 (en) * 2002-02-22 2004-06-10 Iok-Hou Pang Use of propentofylline to control intraocular pressure
WO2003103664A1 (en) * 2002-06-06 2003-12-18 Merck Frosst Canada & Co. 1,5-disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases
ATE487514T1 (de) 2002-06-06 2010-11-15 Merck Frosst Canada Ltd 1,5-disubstituierte pyrrolid-2-on-derivate zur verwendung als ep4 rezeptor agonisten zur behandlung von augenkrankheiten wie z.b. glaukom
US6864282B2 (en) 2002-08-05 2005-03-08 Allergan, Inc. 9,11-cycloendoperoxide pro-drugs of prostaglandin analogues for treatment of ocular hypertension and glaucoma
US20040076678A1 (en) * 2002-08-21 2004-04-22 Sucampo Ag Opthalmic solution
US8580851B2 (en) 2002-08-21 2013-11-12 Sucampo Ag Ophthalmic solution
WO2004019938A1 (en) * 2002-08-28 2004-03-11 Merck Frosst Canada & Co. Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma
EP1541151B1 (de) * 2002-08-29 2012-02-22 Santen Pharmaceutical Co., Ltd. MITTEL ZUR BEHANDLUNG VON GLAUKOM MIT EINEM Rho-KINASE-HEMMER UND PROSTAGLANDINEN
CN1678302A (zh) * 2002-08-30 2005-10-05 爱尔康公司 取代的5-苯并二氢吡喃-5-基-乙胺化合物及其在治疗青光眼中的用途
CA2707067C (en) 2002-09-09 2013-07-16 Santen Pharmaceutical Co., Ltd. Clear ophthalmic solution comprising latanoprost as active ingredient
US7074827B2 (en) * 2002-10-24 2006-07-11 Sucampo Ag (Usa) Inc. Method for treating ocular hypertension and glaucoma
WO2004037786A2 (en) * 2002-10-25 2004-05-06 Merck Frosst Canada & Co. 2-pyrrolidones as ep4 receptor agonists
AU2003287481B2 (en) * 2002-11-08 2009-04-23 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
US7196082B2 (en) 2002-11-08 2007-03-27 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
CA2504226A1 (en) * 2002-11-12 2004-05-27 Alcon, Inc. Histone deacetylase inhibitors for treating degenerative diseases of the eye
US20080004311A1 (en) * 2002-11-12 2008-01-03 Alcon, Inc. Histone deacetylase inhibitors for treating degenerative diseases of the eye
KR101223886B1 (ko) 2002-11-18 2013-01-17 산텐 세이야꾸 가부시키가이샤 Rho 키나아제 억제제와 β 차단약으로 이루어진 녹내장 치료제
US7053085B2 (en) 2003-03-26 2006-05-30 Merck & Co. Inc. EP4 receptor agonist, compositions and methods thereof
WO2004054572A2 (en) * 2002-12-13 2004-07-01 Alcon, Inc. Novel benzopyran analogs and their use for the treatment of glaucoma
US20050048099A1 (en) 2003-01-09 2005-03-03 Allergan, Inc. Ocular implant made by a double extrusion process
US20040225014A1 (en) * 2003-02-14 2004-11-11 Sucampo Ag Method for treating ocular hypertension and glaucoma
AU2004253543B2 (en) * 2003-07-01 2009-02-19 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
US20050119262A1 (en) * 2003-08-21 2005-06-02 Pharmacia Corporation Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent
KR101118935B1 (ko) * 2003-08-21 2012-03-13 가부시키가이샤 아루떼꾸 우에노 안과용 조성물
CN1845914A (zh) * 2003-09-02 2006-10-11 默克公司 用于治疗眼压过高的眼用组合物
JP2007504236A (ja) * 2003-09-04 2007-03-01 メルク エンド カムパニー インコーポレーテッド 高眼圧症を治療するための眼用組成物
NZ545401A (en) * 2003-09-04 2008-10-31 Merck & Co Inc Ophthalmic compositions for treating ocular hypertension
US20050058730A1 (en) * 2003-09-15 2005-03-17 Xushan Wan Compositions and methods for preventing or treating eyestrain
EP1675588A4 (de) * 2003-10-22 2010-04-21 Univ Rochester Verwendung von peroxisom-proliferator-aktiviertem rezeptor-gamm (ppar gamma) und/oder retinsäure-rezeptor (rxr)-agonisten zur hemmung der thrombozytenfunktionen
CN100484528C (zh) 2003-11-07 2009-05-06 千寿制药株式会社 含有前列腺素的药物组合物
US20090148527A1 (en) * 2007-12-07 2009-06-11 Robinson Michael R Intraocular formulation
US20050101582A1 (en) 2003-11-12 2005-05-12 Allergan, Inc. Compositions and methods for treating a posterior segment of an eye
US20070224278A1 (en) 2003-11-12 2007-09-27 Lyons Robert T Low immunogenicity corticosteroid compositions
WO2005053688A1 (en) * 2003-11-26 2005-06-16 Alcon, Inc. Substituted furo[2,3-g] indazoles for the treatment of glaucoma
US7129257B1 (en) * 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
AR046890A1 (es) * 2003-12-15 2005-12-28 Alcon Inc [1,4] oxazino [2,3-g] indazoles sustituidos para el tratamiento del glaucoma.
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
EP3643702A1 (de) 2004-01-05 2020-04-29 Nicox S.A. Prostaglandinderivate
WO2005072701A1 (en) 2004-01-20 2005-08-11 Allergan, Inc. Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
BRPI0510245A (pt) * 2004-04-26 2007-10-23 Alcon Inc estatinas para o tratamento de hipertensão ocular e glaucoma
WO2005107708A1 (en) 2004-04-30 2005-11-17 Allergan, Inc. Biodegradable intravitreal tyrosine kinase inhibitors implants
US9498457B2 (en) 2004-04-30 2016-11-22 Allergan, Inc. Hypotensive prostamide-containing biodegradable intraocular implants and related implants
US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
US8425929B2 (en) 2004-04-30 2013-04-23 Allergan, Inc. Sustained release intraocular implants and methods for preventing retinal dysfunction
US8147865B2 (en) 2004-04-30 2012-04-03 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US7771742B2 (en) 2004-04-30 2010-08-10 Allergan, Inc. Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
US8673341B2 (en) 2004-04-30 2014-03-18 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
US8455656B2 (en) 2004-04-30 2013-06-04 Allergan, Inc. Kinase inhibitors
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
US8119154B2 (en) 2004-04-30 2012-02-21 Allergan, Inc. Sustained release intraocular implants and related methods
US20050244458A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular neuropathies
US20050244463A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular vasculopathies
US7993634B2 (en) 2004-04-30 2011-08-09 Allergan, Inc. Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods
US8591885B2 (en) 2004-04-30 2013-11-26 Allergan, Inc. Carbonic anhydrase inhibitor sustained release intraocular drug delivery systems
US7563816B2 (en) 2004-07-20 2009-07-21 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
US7183310B2 (en) 2004-08-10 2007-02-27 Allergan, Inc. Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
SE0402029D0 (sv) * 2004-08-17 2004-08-17 Synphora Ab Prostaglandin a derivatieves for the treatment of psoriasis
US9993558B2 (en) 2004-10-01 2018-06-12 Ramscor, Inc. Sustained release eye drop formulations
US8541413B2 (en) * 2004-10-01 2013-09-24 Ramscor, Inc. Sustained release eye drop formulations
JP2008515973A (ja) * 2004-10-13 2008-05-15 メルク エンド カムパニー インコーポレーテッド 高眼圧症を治療するための眼科組成物
JP2008515982A (ja) * 2004-10-13 2008-05-15 メルク エンド カムパニー インコーポレーテッド 高眼圧症を治療するための眼科組成物
US7425572B2 (en) * 2004-12-08 2008-09-16 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
US7851504B2 (en) 2005-03-16 2010-12-14 Allergan, Inc. Enhanced bimatoprost ophthalmic solution
WO2010102078A1 (en) 2009-03-04 2010-09-10 Allergan, Inc. Enhanced bimatoprost ophthalmic solution
CN101151034B (zh) 2005-03-31 2012-06-06 旭硝子株式会社 含有前列腺素F2α衍生物作为有效成分的视网膜神经细胞保护剂
CA2604956A1 (en) 2005-04-13 2006-10-26 Ube Industries, Ltd. Protective agent for retinal neuronal cell comprising indazole derivative as active ingredient
WO2007002670A2 (en) * 2005-06-28 2007-01-04 Bausch & Lomb Incorporated Method of lowering intraocular pressure
CA2613748A1 (en) 2005-06-29 2007-01-04 Pfizer Inc. Prostaglandin derivatives
JP2009502982A (ja) * 2005-08-03 2009-01-29 メルク フロスト カナダ リミテツド Ep4受容体アゴニスト、この組成物および方法
TW200744567A (en) * 2005-09-23 2007-12-16 Alcon Inc Phenylethylamine analogs and their use for treating glaucoma
EP1960353B1 (de) 2005-11-03 2014-03-12 Allergan, Inc. Prostaglandine und analoga als mittel zur absenkung des augeninnendrucks
EP2004193A2 (de) * 2006-03-13 2008-12-24 Merck & Co., Inc. Ophthalmische zusammensetzungen zur behandlung von augenhochdruck
CA2681668C (en) 2006-03-23 2014-04-01 Michael S. Singer Compositions comprising prostaglandin f2-alpha analogs and methods for reducing body fat
JP2009541219A (ja) * 2006-06-12 2009-11-26 メルク エンド カムパニー インコーポレーテッド 高眼圧治療のための眼科組成物
US8802128B2 (en) 2006-06-23 2014-08-12 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US7642370B2 (en) 2006-08-07 2010-01-05 Daiichi Fine Chemical Co., Ltd. Method for preparing prostaglandin derivative
JP5378219B2 (ja) 2006-10-02 2013-12-25 テックフィールズ バイオケム カンパニー リミテッド 非常に高い皮膚浸透率を有するプロスタグランジン及び関連化合物の正荷電水溶性プロドラッグ
EP2792670A1 (de) 2006-10-03 2014-10-22 Techfields Biochem Co. Ltd Positiv geladene, wasserlösliche Prodrugs von Senfen und verwandte Verbindungen mit sehr hohen Hautpenetrierungswerten
US8969415B2 (en) 2006-12-01 2015-03-03 Allergan, Inc. Intraocular drug delivery systems
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
UY30883A1 (es) 2007-01-31 2008-05-31 Alcon Res Tapones punctales y metodos de liberacion de agentes terapeuticos
JPWO2008096804A1 (ja) 2007-02-07 2010-05-27 テイカ製薬株式会社 ラタノプロスト含有点眼剤
US20090018204A1 (en) * 2007-07-13 2009-01-15 Brinkenhoff Michael C Composition and method for enhancing hair growth
US20090169629A1 (en) * 2008-01-02 2009-07-02 Novagali Pharma Sa Micellar compositions with ophthalmic applications
US20090170944A1 (en) * 2008-01-02 2009-07-02 Novagali Pharma Sa Ophthalmic micellar compositions with enhanced stability
EP2077105A1 (de) 2008-01-02 2009-07-08 Novagali Pharma SA Ophthalmische mizellare Zusammensetzung mit erhöhter Stabilität
EP2077104A1 (de) 2008-01-02 2009-07-08 Novagali Pharma SA Mizellare Zusammensetzungen mit ophtalmischen Anwendungen
EP2135860A1 (de) 2008-06-20 2009-12-23 Sandoz AG Verbesserter Herstellungsverfahren für Bimatoprost
EP2143712A1 (de) * 2008-07-10 2010-01-13 Sandoz AG Verbessertes Verfahren zur Herstellung von Prostaglandinen und Prostaglandin-Analogen
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
US8623918B2 (en) * 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
WO2010096123A2 (en) 2008-10-29 2010-08-26 Aerie Pharmaceuticals, Inc. Amino acid salts of prostaglandins
US20100204335A1 (en) * 2008-12-01 2010-08-12 Allergan, Inc. Kit and composition for eyelash growth
IT1392492B1 (it) 2008-12-24 2012-03-09 Ind Chimica Srl Processo per la purificazione del latanoprost, analogo sintetico della prostaglandina pgf2alfa.
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
WO2010112615A1 (en) 2009-04-03 2010-10-07 Dsm Ip Assets B.V. Lysine derivatives functionalised with lipids
ES2834451T3 (es) 2009-05-01 2021-06-17 Aerie Pharmaceuticals Inc Inhibidores de mecanismo doble para el tratamiento de enfermedades
WO2011034192A1 (ja) 2009-09-17 2011-03-24 千寿製薬株式会社 ラタノプロストを含有する水性点眼剤、並びにラタノプロストの樹脂への吸着の抑制方法
US20120322882A1 (en) 2009-11-09 2012-12-20 Allergan, Inc. Compositions And Methods For Stimulating Hair Growth
US9149484B2 (en) 2009-11-09 2015-10-06 Allergan, Inc. Compositions and methods for stimulating hair growth
US9522153B2 (en) 2009-12-22 2016-12-20 Allergan, Inc. Compositions and methods for lowering intraocular pressure
PH12012501320A1 (en) * 2010-01-11 2013-01-21 Inotek Pharmaceuticals Corp Combination, kit and method of reducing intraocular pressure
WO2011095990A2 (en) 2010-02-03 2011-08-11 Fdc Limited Process for the purification of prostaglandins and analogues thereof
SG184221A1 (en) 2010-03-26 2012-10-30 Inotek Pharmaceuticals Corp Method of reducing intraocular pressure in humans using n6 -cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof
WO2012012282A1 (en) * 2010-07-19 2012-01-26 Inspire Pharmaceuticals, Inc. Bifunctional rho kinase inhibitor compounds, composition and use
EP2598118B1 (de) 2010-07-29 2018-09-05 Allergan, Inc. Bimatoprost- und timolollösungen ohne konservierungsstoffe
US9061034B2 (en) 2010-07-29 2015-06-23 Allergan, Inc. Preservative free bimatoprost and timolol solutions
AU2010358560B2 (en) 2010-08-02 2015-02-12 Ac Patent Holding Inc. Composition, method and kit for enhancing hair
EP2648676A4 (de) 2010-12-06 2016-05-04 Follica Inc Verfahren zur behandlung von kahlköpfigkeit und zur förderung des haarwuchses
CA2866067C (en) 2011-01-19 2015-04-21 Topokine Therapeutics, Inc. Uses of certain f-series prostaglandin analogs for treating diabetes and dyslipidemia
US8859616B2 (en) 2011-01-21 2014-10-14 Allergan, Inc. Compounds and methods for enhancing hair growth
EP2671586B1 (de) 2011-02-04 2018-05-30 Kowa Co., Ltd. Medikamentöse therapie zur prävention oder behandlung von glaukomen
EP2495235B1 (de) 2011-03-04 2015-08-05 Newchem S.p.A. Herstellungsverfahren zur Synthese von Prostaglandinen und Zwischenprodukte davon
CN102690219A (zh) * 2011-03-24 2012-09-26 天津信汇制药股份有限公司 纯化贝美前列素的方法
US8715713B2 (en) 2011-04-29 2014-05-06 Allergan, Inc. Solvent cast film sustained release latanoprost implant
BR122021008918B1 (pt) * 2011-06-02 2021-08-10 Chinoin Zrt Forma cristalina ii de bimatoproposta e processo para a preparação da mesma
US8426471B1 (en) 2011-12-19 2013-04-23 Topokine Therapeutics, Inc. Methods and compositions for reducing body fat and adipocytes
RS56150B1 (sr) 2012-01-26 2017-11-30 Inotek Pharmaceuticals Corp Anhidrovani polimorfi (2r,3s,4r,5r)-5-(6-(ciklopentilamino)-9h-purin-9-yl)-3,4-dihidroksitetrahidrofuran-2-yl)} metil-nitrata i postupak njegove pripreme
WO2013133730A1 (en) * 2012-03-09 2013-09-12 Instytut Farmaceutyczny PROCESS FOR PREPARATION OF PROSTAGLANDIN F2α ANALOGUES
AU2013347949A1 (en) 2012-11-21 2015-06-11 Velakine Therapeutics, Inc. Methods and compositions for locally increasing body fat
US9120738B2 (en) * 2012-12-28 2015-09-01 Allergan, Inc. Crystalline forms of bimatoprost acid, methods for preparation, and methods for use thereof
AU2014216112B2 (en) 2013-02-15 2019-02-21 Allergan, Inc. Sustained drug delivery implant
CN110396085B (zh) 2013-03-15 2024-11-15 爱尔康公司 联合治疗
WO2014152723A1 (en) 2013-03-15 2014-09-25 Inotek Pharmaceuticals Corporation Ophthalmic formulations
NO2753788T3 (de) 2013-05-10 2018-06-16
US9820993B2 (en) 2013-05-15 2017-11-21 Topokine Therapeutics, Inc. Methods and compositions for topical delivery of prostaglandins to subcutaneous fat
ITMI20132193A1 (it) * 2013-12-23 2015-06-24 Ind Chimica Srl Processo microbiologico per la preparazione di intermedi utili nella sintesi di prostaglandine
HU231214B1 (hu) * 2014-03-13 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás nagytisztaságú prosztaglandinok előállítására
US10188661B2 (en) 2014-06-27 2019-01-29 Topokine Therapeutics, Inc. Topical dosage regimen
US11285163B2 (en) 2014-10-20 2022-03-29 Sentiss Pharma Private Limited Ophthalmic solution
KR102511830B1 (ko) 2014-11-25 2023-03-17 엑시모어 엘티디. 단일 및 다수 생체활성제를 전달하기 위한 조성물 및 방법
EP3355799B1 (de) 2015-09-27 2021-09-01 Follica, Inc. Nadelungsvorrichtung und arzneimittelapplikator
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
CN109640966A (zh) 2016-08-31 2019-04-16 爱瑞制药公司 眼用组合物
KR20190135027A (ko) 2017-03-31 2019-12-05 에어리 파마슈티컬즈, 인코포레이티드 아릴 시클로프로필-아미노-이소퀴놀리닐 아미드 화합물
CA3112391A1 (en) 2018-09-14 2020-03-19 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
CN112142703A (zh) * 2020-09-30 2020-12-29 东北制药集团股份有限公司 一种卡前列素氨丁三醇相关杂质左旋丁基15-酮及其制备方法

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1324737A (en) * 1970-11-02 1973-07-25 Upjohn Co Prostaglandins and the preparation thereof
JPS4920766B1 (de) 1970-11-10 1974-05-27
JPS4924911B1 (de) 1970-12-07 1974-06-26
BE786251A (fr) * 1971-07-14 1973-01-15 Ici Ltd Nouveaux derives du cyclopentane
US3987087A (en) * 1971-07-29 1976-10-19 The Upjohn Company Phenyl-substituted prostaglandin-f type analogs
US4304907A (en) * 1972-05-10 1981-12-08 The Upjohn Company Bicyclo lactone intermediates for prostaglandin analogs
US4011262A (en) * 1972-07-13 1977-03-08 Pfizer Inc. 13,14-Dihydro-15-substituted-ω-pentanorprostaglandins of the two series
US3956284A (en) * 1972-07-13 1976-05-11 Pfizer Inc. Heterocyclic 15-substituted-ω-pentanorprostoglandins
US3962312A (en) * 1972-09-21 1976-06-08 Ono Pharmaceutical Company 9,11,15-Trihydroxy prost-5-enoic acid analogues
JPS5720305B2 (de) * 1973-02-28 1982-04-27
IT1053781B (it) * 1974-09-25 1981-10-10 Erba C S P A Ora Farmitalia Omega nor cicloalcil 13.14 deidro prostaglandine
US4001300A (en) * 1975-02-24 1977-01-04 The Upjohn Company 2,2-Difluoro-16-phenoxy-PGF2 analogs
US4117119A (en) * 1975-03-11 1978-09-26 Ono Pharmaceutical Company 15-cyclobutyl-prostaglandins
US4097489A (en) 1977-06-17 1978-06-27 The Upjohn Company 9-Deoxy-9α,6-nitrilo or 6,9α-imino-PGF compounds
US4131738A (en) 1977-07-05 1978-12-26 The Upjohn Company 6-Hydroxy-PGE1 compounds
US4115586A (en) * 1977-07-18 1978-09-19 The Upjohn Company Antihyperthermic use for prostaglandins
US4128713A (en) * 1977-12-15 1978-12-05 The Upjohn Company 6,7-Didehydro-PGI1 compounds
US4599353A (en) 1982-05-03 1986-07-08 The Trustees Of Columbia University In The City Of New York Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma
ATE48991T1 (de) * 1984-07-31 1990-01-15 Syntex Inc 11-substituierte-16-phenoxy und 16phenoxysubstituierte prostatriensaeurederivate.
US5057621A (en) * 1984-07-31 1991-10-15 Syntex (U.S.A.) Inc. 11-substituted-16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives
DE3510978A1 (de) * 1985-03-22 1986-09-25 Schering AG, Berlin und Bergkamen, 1000 Berlin Neue 9-halogenprostaglandine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4820728A (en) * 1985-11-25 1989-04-11 G. D. Searle & Co. Tetraenyl prostaglandins
US4883819A (en) * 1986-07-31 1989-11-28 The Trustees Of Columbia University In The City Of New York Use of A, B and C prostaglandins and derivatives thereof to treat ocular hypertension and glaucoma
DE3785602T2 (de) * 1986-03-13 1993-09-02 Univ Columbia Verwendung von a-, b- und c-prostaglandinen und deren derivaten zur behandlung von augen-hypertension und glaukom.
EP0238135B1 (de) * 1986-03-21 1992-12-02 Shell Internationale Researchmaatschappij B.V. Schmelzdichtungsmasse
US4824857A (en) * 1986-05-16 1989-04-25 Yasumasa Goh Use of prostaglandin D2 -active substances
CA1322749C (en) * 1987-01-28 1993-10-05 Ryuzo Ueno Prostaglandins of the d series, and tranquilizers and soporifics containing the same
CA1324129C (en) * 1987-04-30 1993-11-09 Ryuzo Ueno Prostaglandins of the f series
JPH0739344B2 (ja) * 1988-10-01 1995-05-01 株式会社アールテック・ウエノ 眼圧降下剤
EP0455264B1 (de) * 1987-09-18 1994-07-13 R-Tech Ueno Ltd. Hypotensive okulare Mittel
JPH0739343B2 (ja) * 1988-10-01 1995-05-01 株式会社アールテック・ウエノ 眼圧降下剤
US5166178B1 (en) * 1987-09-18 1998-07-21 R Tech Ueno Ltd Ocular hypotensive agents
US5151444B1 (en) * 1987-09-18 1999-07-06 R Tech Ueno Ltd Ocular hypotensive agents
JP2597629B2 (ja) * 1988-02-26 1997-04-09 株式会社 上野製薬応用研究所 13,14−ジヒドロ−15−ケトプロスタグランジン類の安定化
ATE101342T1 (de) * 1988-09-06 1994-02-15 Kabi Pharmacia Ab Prostaglandinderivate zur behandlung des gruenen stars oder einer okularen hypertension.
US5194429A (en) * 1988-10-01 1993-03-16 K.K. Ueno Seiyaku Oyo Kenkyujo Ocular hypotensive agents
DE68928551T2 (de) * 1988-10-01 1998-04-23 Ueno Seiyaku Oyo Kenkyujo Kk Oculare hypotensive Mittel

Also Published As

Publication number Publication date
ES2062102T3 (es) 1994-12-16
DK175842B1 (da) 2005-03-29
AU4189889A (en) 1990-04-02
DE68929435D1 (de) 2002-12-19
WO1990002553A1 (en) 1990-03-22
DE68913000T2 (de) 1994-06-16
JP2721414B2 (ja) 1998-03-04
DE68929435T2 (de) 2003-07-17
US5578618A (en) 1996-11-26
ES2186670T3 (es) 2003-05-16
EP1225168B8 (de) 2015-03-18
NL970039I2 (nl) 1998-04-01
US5627208A (en) 1997-05-06
HU211593A9 (en) 1995-12-28
JP2955213B2 (ja) 1999-10-04
LU91541I2 (fr) 2009-05-11
DK112190A (da) 1990-05-04
DE68913000D1 (de) 1994-03-24
ES2193901T1 (es) 2003-11-16
HK1048106A1 (en) 2003-03-21
ES2062102T5 (es) 2004-12-01
NL970039I1 (nl) 1998-02-02
EP0364417B2 (de) 2004-04-14
FI92690C (fi) 1994-12-27
FI92690B (fi) 1994-09-15
US6030999A (en) 2000-02-29
ES2317964T3 (es) 2009-05-01
DK112190D0 (da) 1990-05-04
DE03014533T1 (de) 2004-07-15
ATE420857T1 (de) 2009-01-15
EP1225168B2 (de) 2015-01-21
JP3612178B2 (ja) 2005-01-19
EP0569046A1 (de) 1993-11-10
US5849791A (en) 1998-12-15
AU625096B2 (en) 1992-07-02
DE1300150T1 (de) 2003-09-18
EP0364417A1 (de) 1990-04-18
ES2213504T1 (es) 2004-09-01
US6429226B1 (en) 2002-08-06
JPH1081624A (ja) 1998-03-31
DE68929563D1 (de) 2009-03-05
EP1224934A2 (de) 2002-07-24
ATE227576T1 (de) 2002-11-15
EP1348437A3 (de) 2003-11-19
EP1224935A3 (de) 2003-03-26
US5422368A (en) 1995-06-06
EP0364417B9 (de) 2004-10-06
JPH08109132A (ja) 1996-04-30
HK1048251A1 (en) 2003-03-28
EP1224934A3 (de) 2003-03-26
EP1225168A3 (de) 2003-03-26
ES2317964T5 (es) 2015-02-20
EP0364417B1 (de) 1994-02-09
JPH03501025A (ja) 1991-03-07
EP1225168A2 (de) 2002-07-24
DE68913000T3 (de) 2004-10-21
EP1225168B1 (de) 2009-01-14
EP1224935A2 (de) 2002-07-24
EP0569046B1 (de) 2002-11-13
EP1348437A2 (de) 2003-10-01
FI902258A0 (fi) 1990-05-04

Similar Documents

Publication Publication Date Title
ATE101342T1 (de) Prostaglandinderivate zur behandlung des gruenen stars oder einer okularen hypertension.
DE69019774D1 (de) Isochinolin-Derivate zur Behandlung des Glaukoms oder der okulären Hypertonie.
DE69634414D1 (de) Verwendung von substituierten isochinolinsulfonyl-verbindungen zur herstellung eines medikaments für die behandlung von glaukom und okularer ischämie
DE69521620D1 (de) Verwendung von 9-deoxyprostaglandinderivaten zur behandlung von glaukom
DE3684190D1 (de) Verwendung von tetrahydrobiopterinen zur herstellung eines medikaments zur behandlung von kinderautismus.
DE69930252D1 (de) Verwendung von tetracyclinen zur behandlung von störungen der meibomschen drüsen
DE3788984D1 (de) Verwendung von Prostaglandin-D2-aktiven-Substanzen zur Behandlung von Augen-Hypertension und von Glaukom.
ATE78031T1 (de) Prostaglandin-derivate zur behandlung von glaucoma oder augenueberdruck.
ATE161725T1 (de) Verwendung von phosphatdiestern zur behandlung von erkrankungen der retina
ATE216889T1 (de) Anwendung von prostagrandin-analogen für die behandlung von glaukome und okuläre hypertension
CA2237194A1 (en) Furan- and thiophenecarbothioamide derivatives, their preparation and their use as inhibitors of the replication of hiv-1 and hiv-1 mutants
NO890801D0 (no) Fremgangsmaate for fremstilling av lysyloxydaseinhibitorer.
SE9401087D0 (sv) New prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
ATE213634T1 (de) Verwendung von prostaglandinen zur herstellung eines arzneimittels zur prävention und behandlung des sekundären katarakts
ATE108335T1 (de) Kit oder zusammensetzung zur vorbeugung oder behandlung von hiv-1 infektionen.
HUP9802314A2 (hu) Zeaxantin tiszta 3R-3'R sztereoizomerje makuláris degeneráció emberben való kezelésére
SU648187A1 (ru) Состав дл консервировани роговиц человека
DE69424415D1 (de) Verwendung von efaroxan und dessen derivaten zur herstellung eines arzneimittels zur behandlung parkinsonscher krankheit
DE69109293D1 (de) Verwendung von 20(r)-22-oxa-vitamin d analoge zur herstellung eines medikaments für die behandlung des altershaut.
RU93047354A (ru) Способ лечения сенильной макулярной дегенерации сетчатки
DE68906028D1 (de) Verwendung von acetyl-d-carnitin zur therapeutischen behandlung von glaukom.