DK1438310T3 - Beta-carbolin-derivater som PTP-inhibitorer - Google Patents
Beta-carbolin-derivater som PTP-inhibitorerInfo
- Publication number
- DK1438310T3 DK1438310T3 DK02780494T DK02780494T DK1438310T3 DK 1438310 T3 DK1438310 T3 DK 1438310T3 DK 02780494 T DK02780494 T DK 02780494T DK 02780494 T DK02780494 T DK 02780494T DK 1438310 T3 DK1438310 T3 DK 1438310T3
- Authority
- DK
- Denmark
- Prior art keywords
- diseases
- inhibitors
- beta
- ptpases
- diabetes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Pulmonology (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34617601P | 2001-10-19 | 2001-10-19 | |
US34612501P | 2001-10-19 | 2001-10-19 | |
PCT/US2002/033520 WO2003033496A1 (en) | 2001-10-19 | 2002-10-18 | Beta-carbolin derivatives as ptp-inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1438310T3 true DK1438310T3 (da) | 2007-03-26 |
Family
ID=26994711
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02780494T DK1438310T3 (da) | 2001-10-19 | 2002-10-18 | Beta-carbolin-derivater som PTP-inhibitorer |
Country Status (9)
Country | Link |
---|---|
US (2) | US6933303B2 (da) |
EP (1) | EP1438310B1 (da) |
JP (1) | JP2005508968A (da) |
AT (1) | ATE348828T1 (da) |
DE (1) | DE60216952T2 (da) |
DK (1) | DK1438310T3 (da) |
ES (1) | ES2278064T3 (da) |
HK (1) | HK1067128A1 (da) |
WO (1) | WO2003033496A1 (da) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PA8586801A1 (es) | 2002-10-31 | 2005-02-04 | Pfizer | Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso |
JP2006516606A (ja) | 2003-01-27 | 2006-07-06 | ファイザー インコーポレイテッド | Hivインテグラーゼインヒビター、医薬組成物、およびそれらの使用 |
CN1747936A (zh) * | 2003-02-12 | 2006-03-15 | 特兰斯泰克制药公司 | 作为治疗试剂的取代吡咯衍生物 |
US20040186151A1 (en) * | 2003-02-12 | 2004-09-23 | Mjalli Adnan M.M. | Substituted azole derivatives as therapeutic agents |
US7501538B2 (en) | 2003-08-08 | 2009-03-10 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions and methods of use |
JP2007501844A (ja) | 2003-08-08 | 2007-02-01 | トランス テック ファーマ,インコーポレイテッド | アリール及びヘテロアリール化合物、組成物並びに使用方法 |
US7141596B2 (en) | 2003-10-08 | 2006-11-28 | Incyte Corporation | Inhibitors of proteins that bind phosphorylated molecules |
AU2003300701A1 (en) * | 2003-12-31 | 2005-07-21 | Council Of Scientific And Industrial Research | Beta-carboline derived guanidine alkaloid, tiruchenduramine |
CA2554150A1 (en) | 2004-01-23 | 2005-08-04 | Chiron Corporation | Tetrahydrocarboline compounds as anticancer agents |
JP4898458B2 (ja) * | 2004-02-12 | 2012-03-14 | トランス テック ファーマ,インコーポレイテッド | 置換アゾール誘導体、組成物及び使用方法 |
SG184755A1 (en) * | 2004-03-15 | 2012-10-30 | Ptc Therapeutics Inc | Carboline derivatives useful in the inhibition of angiogenesis |
US7767689B2 (en) | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
US7626025B2 (en) | 2004-03-30 | 2009-12-01 | Council Of Scientific And Industrial Research | Beta-carboline derived guanidine alkaloids, tiruchenduramine |
JP2007534739A (ja) | 2004-04-26 | 2007-11-29 | ファイザー・インク | ピロロピリジン誘導体及びhivインテグラーゼ酵素阻害剤としてのその使用 |
ATE374775T1 (de) | 2004-04-26 | 2007-10-15 | Pfizer | Inhibitoren des hiv-integrase-enzyms |
EP1751156B1 (en) | 2004-05-17 | 2010-09-15 | Tibotec Pharmaceuticals | 6,7,8,9-substituted 1-phenyl-1,5-dihydro-pyrido(3,2-b)indol-2-ones useful as anti-infective pharmaceutical agents |
WO2005121140A1 (en) | 2004-06-09 | 2005-12-22 | Glaxo Group Limited | Pyrrolopyridine derivatives |
AU2007211319B9 (en) | 2006-01-30 | 2012-05-31 | Vtv Therapeutics Llc | Substituted imidazole derivatives and their use as PTPase inhibitors |
JP2010533712A (ja) * | 2007-07-19 | 2010-10-28 | メルク・シャープ・エンド・ドーム・コーポレイション | 抗糖尿病化合物としてのベータカルボリン誘導体 |
US20110015254A1 (en) * | 2008-03-25 | 2011-01-20 | Merck Serono Sa | PTPH1 Inhibitors for the Treatment of Alzheimer's Disease |
KR101732978B1 (ko) | 2009-03-30 | 2017-05-08 | 브이티브이 테라퓨틱스 엘엘씨 | 치환된 아조안트라센 유도체, 약제학적 조성물, 및 그것의 사용방법 |
WO2010138652A1 (en) | 2009-05-27 | 2010-12-02 | Ptc Therapeutics, Inc. | Methods for treating kaposi sarcoma |
MX2020005345A (es) | 2009-05-27 | 2022-07-18 | Ptc Therapeutics Inc | Un método para inhibir o reducir una infección viral por coronavirus. |
EP2435437A4 (en) | 2009-05-27 | 2012-10-31 | Ptc Therapeutics Inc | PROCESSES FOR THE PREPARATION OF SUBSTITUTED TETRAHYDRO BETA-CARBOLINES |
WO2010138685A1 (en) | 2009-05-27 | 2010-12-02 | Ptc Therapeutics, Inc. | Methods for treating prostate conditions |
WO2010147663A1 (en) * | 2009-06-16 | 2010-12-23 | Massechusetts Institute Of Technology | Methods and compositions for inhibiting proliferation of aneuploid cells |
WO2011063223A1 (en) * | 2009-11-20 | 2011-05-26 | Southern Research Institute | TETRAHYDRO-β-CARBOLINE DERIVATIVES, SYNTHESIS AND USE THEREOF |
ES2587856T3 (es) | 2011-03-18 | 2016-10-27 | Ono Pharmaceutical Co., Ltd. | Derivado de tetrahidrocarbolina |
CN102391323B (zh) * | 2011-10-18 | 2013-09-25 | 首都医科大学 | 四氢-β-咔啉衍生物、其制备方法及其用途 |
CN103159758B (zh) * | 2011-12-13 | 2015-08-05 | 首都医科大学 | (1S,3S)-1-对硝基苯基-1,2,3,4-四氢-β-咔啉酰氨基酸、其合成、抗栓活性和作为抗血栓剂的应用 |
WO2013106460A2 (en) * | 2012-01-09 | 2013-07-18 | University Of Washington Through Its Center For Commercialization | Compositions and methods for treating malignant astrocytomas |
CN105153277A (zh) * | 2014-06-11 | 2015-12-16 | 首都医科大学 | KE修饰的β-咔啉,其制备,纳米结构,活性和应用 |
WO2017172957A1 (en) | 2016-04-01 | 2017-10-05 | Kalyra Pharmaceuticals, Inc. | Estrogen receptor modulators |
CN109790136B (zh) | 2016-12-22 | 2024-01-12 | 广州华睿光电材料有限公司 | 含呋喃交联基团的聚合物及其应用 |
WO2018130123A1 (zh) * | 2017-01-11 | 2018-07-19 | 南京圣和药业股份有限公司 | 作为选择性雌激素受体下调剂的五环类化合物及其应用 |
EP3664803A4 (en) | 2017-08-01 | 2021-05-05 | PTC Therapeutics, Inc. | DHODH INHIBITOR FOR USE IN THE TREATMENT OF HEMATOLOGICAL CANCERS |
KR20220044528A (ko) | 2019-08-06 | 2022-04-08 | 리커리엄 아이피 홀딩스, 엘엘씨 | 돌연변이체를 치료하기 위한 에스트로겐 수용체 조절제 |
EP4267578A1 (en) | 2020-12-23 | 2023-11-01 | Recurium IP Holdings, LLC | Estrogen receptor modulators |
WO2024039861A1 (en) * | 2022-08-19 | 2024-02-22 | Olema Pharmaceuticals, Inc. | 2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indole derivatives as estrogen receptor modulators for the treatment of cancer |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5244905A (en) * | 1990-08-31 | 1993-09-14 | Warner-Lambert Company | N-substituted cycloalkyl and polycycloalkyl polyhydro-β-carboline-phenylalanine- and phenethylamine derivatives |
US6388076B1 (en) * | 1995-06-19 | 2002-05-14 | Ontogen Corporation | Protein tyrosine phosphatase-inhibiting compounds |
US5770620A (en) * | 1995-06-19 | 1998-06-23 | Ontogen Corporation | Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors |
JP2000508302A (ja) * | 1996-04-04 | 2000-07-04 | エフ.ホフマン―ラ ロッシュ エイジー | 抗転移剤としてのテトラヒドロ―β―カルボリン誘導体の使用 |
CA2293400A1 (en) | 1997-06-13 | 1998-12-17 | Gerald Mcmahon | Novel heteroaryl compounds for the modulation of protein tyrosine enzyme related cellular signal transduction |
AU2713799A (en) | 1998-03-12 | 1999-09-27 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases (ptpases) |
-
2002
- 2002-10-18 EP EP02780494A patent/EP1438310B1/en not_active Expired - Lifetime
- 2002-10-18 AT AT02780494T patent/ATE348828T1/de not_active IP Right Cessation
- 2002-10-18 ES ES02780494T patent/ES2278064T3/es not_active Expired - Lifetime
- 2002-10-18 DE DE60216952T patent/DE60216952T2/de not_active Expired - Fee Related
- 2002-10-18 JP JP2003536235A patent/JP2005508968A/ja active Pending
- 2002-10-18 US US10/274,546 patent/US6933303B2/en not_active Expired - Fee Related
- 2002-10-18 WO PCT/US2002/033520 patent/WO2003033496A1/en active IP Right Grant
- 2002-10-18 DK DK02780494T patent/DK1438310T3/da active
-
2004
- 2004-12-15 US US11/012,636 patent/US20050096335A1/en not_active Abandoned
-
2005
- 2005-01-13 HK HK05100283A patent/HK1067128A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US20040014778A1 (en) | 2004-01-22 |
ATE348828T1 (de) | 2007-01-15 |
HK1067128A1 (en) | 2005-04-01 |
EP1438310A1 (en) | 2004-07-21 |
US20050096335A1 (en) | 2005-05-05 |
DE60216952T2 (de) | 2007-07-05 |
JP2005508968A (ja) | 2005-04-07 |
EP1438310B1 (en) | 2006-12-20 |
WO2003033496A1 (en) | 2003-04-24 |
US6933303B2 (en) | 2005-08-23 |
ES2278064T3 (es) | 2007-08-01 |
DE60216952D1 (de) | 2007-02-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1438310T3 (da) | Beta-carbolin-derivater som PTP-inhibitorer | |
AU2003282234A1 (en) | Benzofuran derivates, process for their preparation and intermediates thereof | |
EA200801372A1 (ru) | Способы получения замещенных пиримидинов | |
TW200700068A (en) | Phthalazine, aza-and diaza-phthalazine compounds and methods of use | |
MXPA06012613A (es) | Derivados heterociclicos nitrogenados como moduladores de proteina cinasa y uso para el tratamiento de angiogenesis y cancer. | |
RS20050363A (en) | Chk-,pdk-and akt-inhibitory pyrimidines,their production an use as pharmaceutical agents | |
WO2005046603A3 (en) | Pyridine compounds | |
DE60219793D1 (de) | Methode zur behandlung von zytokinvermittelten erkrankungen | |
RS20050104A (en) | Indole or benzimidazole derivatives for modulating ikb kinase | |
MXPA04004301A (es) | Bencimidazoles sustituidos utiles como inhibidores de la proteina cinasa. | |
TN2009000128A1 (en) | Dihydropyridine derivatives useful as protein kinase inhibitors | |
YU84603A (sh) | Novi inhibitori tirozin kinaze | |
UA83194C2 (ru) | Производные пиримидина и их применение как модуляторов св2 | |
ATE301654T1 (de) | Naphthyridinderivate | |
NO20043016L (no) | 6-aminomorfinan-derivater, fremgangsmate for fremstilling og anvendelse derav | |
ATE367380T1 (de) | Zur behandlung von zns-erkrankungen geeignete piperazinylchinolinderivate | |
DE60015508T2 (de) | C-16 ungesätigte fp-selektive prostaglandin analoge | |
AU2003260436A1 (en) | Pyrimidine compounds | |
DE60326069D1 (de) | 4-(heterocyclyl)-benzenesulfoximin verbindungen zur behandlung entzündlicher erkrankungenen | |
EP1441724B8 (en) | Methods of increasing endogenous testosterone levels | |
ATE290857T1 (de) | Bretyliumhaltige zusammensetzungen und kits und deren verwendung zur vorbeugung und behandlung cardiovaskulärer erkrankungen | |
MXPA04005809A (es) | Inhibidores de proteinas quinasas. | |
ATE320255T1 (de) | Tie2 rezeptor-kinase-inhibitoren zur behandlung von angiogenen erkrankungen | |
ATE267194T1 (de) | Medikamente geeignet zur behandlung von proliferativen erkrankungen | |
ATE373658T1 (de) | Pyrazoloisoquinolinenderivaten zur inhibierung von nfkappab-induzierende kinase |