ATE348828T1 - Beta-carbolin-derivate als ptp-inhibitoren - Google Patents

Beta-carbolin-derivate als ptp-inhibitoren

Info

Publication number
ATE348828T1
ATE348828T1 AT02780494T AT02780494T ATE348828T1 AT E348828 T1 ATE348828 T1 AT E348828T1 AT 02780494 T AT02780494 T AT 02780494T AT 02780494 T AT02780494 T AT 02780494T AT E348828 T1 ATE348828 T1 AT E348828T1
Authority
AT
Austria
Prior art keywords
diseases
inhibitors
beta
ptpases
diabetes
Prior art date
Application number
AT02780494T
Other languages
English (en)
Inventor
Adnan M M Mjalli
Robert C Andrews
Rongyuan Xie
Tan Yarragunta Ravindra R Ren
Original Assignee
Transtech Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transtech Pharma Inc filed Critical Transtech Pharma Inc
Application granted granted Critical
Publication of ATE348828T1 publication Critical patent/ATE348828T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT02780494T 2001-10-19 2002-10-18 Beta-carbolin-derivate als ptp-inhibitoren ATE348828T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34617601P 2001-10-19 2001-10-19
US34612501P 2001-10-19 2001-10-19

Publications (1)

Publication Number Publication Date
ATE348828T1 true ATE348828T1 (de) 2007-01-15

Family

ID=26994711

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02780494T ATE348828T1 (de) 2001-10-19 2002-10-18 Beta-carbolin-derivate als ptp-inhibitoren

Country Status (9)

Country Link
US (2) US6933303B2 (de)
EP (1) EP1438310B1 (de)
JP (1) JP2005508968A (de)
AT (1) ATE348828T1 (de)
DE (1) DE60216952T2 (de)
DK (1) DK1438310T3 (de)
ES (1) ES2278064T3 (de)
HK (1) HK1067128A1 (de)
WO (1) WO2003033496A1 (de)

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PA8586801A1 (es) 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
BRPI0407052A (pt) * 2003-01-27 2006-01-17 Pfizer Inibidores da hiv-integrase, composições farmacêuticas, e métodos para sua utilização
WO2004071448A2 (en) * 2003-02-12 2004-08-26 Transtech Pharma Inc. Substituted azole derivatives as inhibitors of protein tyrosine phosphatases
JP2006518738A (ja) * 2003-02-12 2006-08-17 トランス　テック　ファーマ，インコーポレイテッド 治療薬としての置換アゾール誘導体
JP2007501844A (ja) 2003-08-08 2007-02-01 トランス　テック　ファーマ，インコーポレイテッド アリール及びヘテロアリール化合物、組成物並びに使用方法
US7459472B2 (en) * 2003-08-08 2008-12-02 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
US7141596B2 (en) 2003-10-08 2006-11-28 Incyte Corporation Inhibitors of proteins that bind phosphorylated molecules
AU2003300701A1 (en) * 2003-12-31 2005-07-21 Council Of Scientific And Industrial Research Beta-carboline derived guanidine alkaloid, tiruchenduramine
CA2554150A1 (en) 2004-01-23 2005-08-04 Chiron Corporation Tetrahydrocarboline compounds as anticancer agents
JP4898458B2 (ja) * 2004-02-12 2012-03-14 トランス テック ファーマ，インコーポレイテッド 置換アゾール誘導体、組成物及び使用方法
PL1737461T3 (pl) 2004-03-15 2013-05-31 Ptc Therapeutics Inc Pochodne karbolinowe użyteczne w hamowaniu angiogenezy
US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US7626025B2 (en) 2004-03-30 2009-12-01 Council Of Scientific And Industrial Research Beta-carboline derived guanidine alkaloids, tiruchenduramine
EP1756103A2 (de) 2004-04-26 2007-02-28 Pfizer, Inc. Pyrrolopyridinderivate und deren verwendung als inhibitoren der hiv-integrase
CA2563761C (en) 2004-04-26 2009-12-29 Pfizer Inc. Inhibitors of the hiv integrase enzyme
CN1976930B (zh) 2004-05-17 2011-01-19 泰博特克药品有限公司 用作抗感染药物的6,7,8,9-取代的1-苯基-1,5-二氢吡啶并(3,2-b)吲哚-2-酮
PT1753764E (pt) 2004-06-09 2009-01-28 Glaxo Group Ltd Derivados de pirrolopiridina
EP1991544B1 (de) 2006-01-30 2018-08-15 vTv Therapeutics LLC Substituierte imidazol- derivate und ihre verwendung als ptpase inhibitoren
JP2010533712A (ja) * 2007-07-19 2010-10-28 メルク・シャープ・エンド・ドーム・コーポレイション 抗糖尿病化合物としてのベータカルボリン誘導体
CA2718093A1 (en) * 2008-03-25 2009-10-01 Merck Serono S.A. Ptph1 inhibitors for the treatment of alzheimer's disease
BRPI1013579A2 (pt) * 2009-03-30 2020-11-03 Transtech Pharma, Inc. derivados de azoantraceno substituídos, composições farmacêuticas e métodos de uso dos mesmos
JP2012528181A (ja) 2009-05-27 2012-11-12 ピーティーシー セラピューティクス，インコーポレーテッド 置換テトラヒドロβ−カルボリンの製造方法
MX348817B (es) 2009-05-27 2017-06-30 Ptc Therapeutics Inc Metodos para tratar cancer y estados no neoplasicos.
WO2010138652A1 (en) 2009-05-27 2010-12-02 Ptc Therapeutics, Inc. Methods for treating kaposi sarcoma
US8703726B2 (en) 2009-05-27 2014-04-22 Ptc Therapeutics, Inc. Methods for treating prostate conditions
WO2010147663A1 (en) * 2009-06-16 2010-12-23 Massechusetts Institute Of Technology Methods and compositions for inhibiting proliferation of aneuploid cells
US9169247B2 (en) 2009-11-20 2015-10-27 Southern Research Institute Tetrahydro-beta-carboline derivatives, synthesis and use thereof
ES2587856T3 (es) 2011-03-18 2016-10-27 Ono Pharmaceutical Co., Ltd. Derivado de tetrahidrocarbolina
CN102391323B (zh) * 2011-10-18 2013-09-25 首都医科大学 四氢-β-咔啉衍生物、其制备方法及其用途
CN103159758B (zh) * 2011-12-13 2015-08-05 首都医科大学 (1S,3S)-1-对硝基苯基-1,2,3,4-四氢-β-咔啉酰氨基酸、其合成、抗栓活性和作为抗血栓剂的应用
WO2013106460A2 (en) * 2012-01-09 2013-07-18 University Of Washington Through Its Center For Commercialization Compositions and methods for treating malignant astrocytomas
CN105153277A (zh) * 2014-06-11 2015-12-16 首都医科大学 KE修饰的β-咔啉,其制备,纳米结构,活性和应用
MX2018011419A (es) 2016-04-01 2019-06-06 Zeno Royalties & Milestones Llc Moduladores de receptores estrogénicos.
US11289654B2 (en) 2016-12-22 2022-03-29 Guangzhou Chinaray Optoelectronic Materials Ltd. Polymers containing furanyl crosslinkable groups and uses thereof
WO2018130123A1 (zh) * 2017-01-11 2018-07-19 南京圣和药业股份有限公司 作为选择性雌激素受体下调剂的五环类化合物及其应用
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Also Published As

Publication number Publication date
DE60216952D1 (de) 2007-02-01
EP1438310B1 (de) 2006-12-20
JP2005508968A (ja) 2005-04-07
US6933303B2 (en) 2005-08-23
US20050096335A1 (en) 2005-05-05
WO2003033496A1 (en) 2003-04-24
DK1438310T3 (da) 2007-03-26
HK1067128A1 (en) 2005-04-01
ES2278064T3 (es) 2007-08-01
US20040014778A1 (en) 2004-01-22
DE60216952T2 (de) 2007-07-05
EP1438310A1 (de) 2004-07-21

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