HK1067128A1 - Beta-carbolin derivatives as ptp-inhibitors - Google Patents
Beta-carbolin derivatives as ptp-inhibitorsInfo
- Publication number
- HK1067128A1 HK1067128A1 HK05100283A HK05100283A HK1067128A1 HK 1067128 A1 HK1067128 A1 HK 1067128A1 HK 05100283 A HK05100283 A HK 05100283A HK 05100283 A HK05100283 A HK 05100283A HK 1067128 A1 HK1067128 A1 HK 1067128A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- diseases
- inhibitors
- ptpases
- diabetes
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34617601P | 2001-10-19 | 2001-10-19 | |
US34612501P | 2001-10-19 | 2001-10-19 | |
PCT/US2002/033520 WO2003033496A1 (en) | 2001-10-19 | 2002-10-18 | Beta-carbolin derivatives as ptp-inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1067128A1 true HK1067128A1 (en) | 2005-04-01 |
Family
ID=26994711
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK05100283A HK1067128A1 (en) | 2001-10-19 | 2005-01-13 | Beta-carbolin derivatives as ptp-inhibitors |
Country Status (9)
Country | Link |
---|---|
US (2) | US6933303B2 (de) |
EP (1) | EP1438310B1 (de) |
JP (1) | JP2005508968A (de) |
AT (1) | ATE348828T1 (de) |
DE (1) | DE60216952T2 (de) |
DK (1) | DK1438310T3 (de) |
ES (1) | ES2278064T3 (de) |
HK (1) | HK1067128A1 (de) |
WO (1) | WO2003033496A1 (de) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PA8586801A1 (es) | 2002-10-31 | 2005-02-04 | Pfizer | Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso |
BRPI0407052A (pt) * | 2003-01-27 | 2006-01-17 | Pfizer | Inibidores da hiv-integrase, composições farmacêuticas, e métodos para sua utilização |
WO2004071448A2 (en) * | 2003-02-12 | 2004-08-26 | Transtech Pharma Inc. | Substituted azole derivatives as inhibitors of protein tyrosine phosphatases |
JP2006518738A (ja) * | 2003-02-12 | 2006-08-17 | トランス テック ファーマ,インコーポレイテッド | 治療薬としての置換アゾール誘導体 |
WO2005014533A2 (en) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
WO2005014534A1 (en) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
US7141596B2 (en) | 2003-10-08 | 2006-11-28 | Incyte Corporation | Inhibitors of proteins that bind phosphorylated molecules |
AU2003300701A1 (en) * | 2003-12-31 | 2005-07-21 | Council Of Scientific And Industrial Research | Beta-carboline derived guanidine alkaloid, tiruchenduramine |
US7855295B2 (en) | 2004-01-23 | 2010-12-21 | Novartis Vaccines And Diagnostics, Inc. | Tetrahydrocarboline compounds as anticancer agents |
CN1922151A (zh) * | 2004-02-12 | 2007-02-28 | 特兰斯泰克制药公司 | 取代的吡咯衍生物、组合物和使用方法 |
US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
CN1980672B (zh) * | 2004-03-15 | 2011-05-04 | Ptc医疗公司 | 用于抑制血管生成的咔啉衍生物 |
US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
US7767689B2 (en) | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
US7626025B2 (en) | 2004-03-30 | 2009-12-01 | Council Of Scientific And Industrial Research | Beta-carboline derived guanidine alkaloids, tiruchenduramine |
MXPA06012342A (es) | 2004-04-26 | 2007-01-17 | Pfizer | Inhibidores de la enzima integrasa del virus de la inmunodeficiencia humana. |
WO2005103003A2 (en) | 2004-04-26 | 2005-11-03 | Pfizer Inc. | Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors |
ES2351702T3 (es) * | 2004-05-17 | 2011-02-09 | Tibotec Pharmaceuticals | 1-fenil-1,5-dihidro-pirido[3,2-b]indol-2-onas 6,7,8,9-sustituidas útiles como agentes farmacéuticos antiinfecciosos. |
UY28945A1 (es) | 2004-06-09 | 2006-01-31 | Glaxo Group Ltd | Derivados de pirrolopiridina |
AU2007211319B9 (en) | 2006-01-30 | 2012-05-31 | Vtv Therapeutics Llc | Substituted imidazole derivatives and their use as PTPase inhibitors |
EP2178537A4 (de) * | 2007-07-19 | 2011-08-17 | Merck Sharp & Dohme | Beta-carbolin-derivate als antidiabetische verbindungen |
WO2009118259A1 (en) * | 2008-03-25 | 2009-10-01 | Merck Serono S.A. | Ptph1 inhibitors for the treatment of alzheimer's disease |
AU2010232750B2 (en) * | 2009-03-30 | 2015-10-29 | Vtv Therapeutics Llc | Substituted azoanthracene derivatives, pharmaceutical compositions, and methods of use thereof |
CN102459263A (zh) | 2009-05-27 | 2012-05-16 | Ptc医疗公司 | 取代的四氢β-咔啉的制备工艺 |
US8703726B2 (en) | 2009-05-27 | 2014-04-22 | Ptc Therapeutics, Inc. | Methods for treating prostate conditions |
WO2010138652A1 (en) | 2009-05-27 | 2010-12-02 | Ptc Therapeutics, Inc. | Methods for treating kaposi sarcoma |
ES2826950T3 (es) | 2009-05-27 | 2021-05-19 | Ptc Therapeutics Inc | Métodos para tratar cáncer y afecciones no neoplásicas |
WO2010147663A1 (en) * | 2009-06-16 | 2010-12-23 | Massechusetts Institute Of Technology | Methods and compositions for inhibiting proliferation of aneuploid cells |
WO2011063223A1 (en) * | 2009-11-20 | 2011-05-26 | Southern Research Institute | TETRAHYDRO-β-CARBOLINE DERIVATIVES, SYNTHESIS AND USE THEREOF |
TW201309698A (zh) | 2011-03-18 | 2013-03-01 | Ono Pharmaceutical Co | 四氫咔啉衍生物 |
CN102391323B (zh) * | 2011-10-18 | 2013-09-25 | 首都医科大学 | 四氢-β-咔啉衍生物、其制备方法及其用途 |
CN103159758B (zh) * | 2011-12-13 | 2015-08-05 | 首都医科大学 | (1S,3S)-1-对硝基苯基-1,2,3,4-四氢-β-咔啉酰氨基酸、其合成、抗栓活性和作为抗血栓剂的应用 |
US20150018369A1 (en) * | 2012-01-09 | 2015-01-15 | University Of Washington Through Its Center For Commercialization | Compositions and Methods for Treating Malignant Astrocytomas |
CN105153277A (zh) * | 2014-06-11 | 2015-12-16 | 首都医科大学 | KE修饰的β-咔啉,其制备,纳米结构,活性和应用 |
RU2738646C2 (ru) | 2016-04-01 | 2020-12-15 | РЕКЬЮРИУМ АйПи ХОЛДИНГС, ЛЛС | Модуляторы эстрогеновых рецепторов |
CN109790136B (zh) | 2016-12-22 | 2024-01-12 | 广州华睿光电材料有限公司 | 含呋喃交联基团的聚合物及其应用 |
WO2018130123A1 (zh) * | 2017-01-11 | 2018-07-19 | 南京圣和药业股份有限公司 | 作为选择性雌激素受体下调剂的五环类化合物及其应用 |
WO2019028171A1 (en) | 2017-08-01 | 2019-02-07 | Ptc Therapeutics, Inc. | DHODH INHIBITOR FOR USE IN THE TREATMENT OF HEMATOLOGICAL CANCERS |
JP2022543832A (ja) | 2019-08-06 | 2022-10-14 | リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー | 変異体を治療するためのエストロゲン受容体調節剤 |
JP2024502270A (ja) | 2020-12-23 | 2024-01-18 | リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー | エストロゲン受容体調節薬 |
WO2024039861A1 (en) * | 2022-08-19 | 2024-02-22 | Olema Pharmaceuticals, Inc. | 2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indole derivatives as estrogen receptor modulators for the treatment of cancer |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5244905A (en) * | 1990-08-31 | 1993-09-14 | Warner-Lambert Company | N-substituted cycloalkyl and polycycloalkyl polyhydro-β-carboline-phenylalanine- and phenethylamine derivatives |
US5770620A (en) * | 1995-06-19 | 1998-06-23 | Ontogen Corporation | Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors |
US6388076B1 (en) * | 1995-06-19 | 2002-05-14 | Ontogen Corporation | Protein tyrosine phosphatase-inhibiting compounds |
DE69710182T2 (de) * | 1996-04-04 | 2002-08-29 | Hoffmann La Roche | Verwendung von tetrahydrobetacarbolin-derivaten zur vorbeugung der metastasenbildung |
CA2293400A1 (en) * | 1997-06-13 | 1998-12-17 | Gerald Mcmahon | Novel heteroaryl compounds for the modulation of protein tyrosine enzyme related cellular signal transduction |
AU2713799A (en) * | 1998-03-12 | 1999-09-27 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases (ptpases) |
-
2002
- 2002-10-18 DE DE60216952T patent/DE60216952T2/de not_active Expired - Fee Related
- 2002-10-18 WO PCT/US2002/033520 patent/WO2003033496A1/en active IP Right Grant
- 2002-10-18 JP JP2003536235A patent/JP2005508968A/ja active Pending
- 2002-10-18 DK DK02780494T patent/DK1438310T3/da active
- 2002-10-18 ES ES02780494T patent/ES2278064T3/es not_active Expired - Lifetime
- 2002-10-18 US US10/274,546 patent/US6933303B2/en not_active Expired - Fee Related
- 2002-10-18 AT AT02780494T patent/ATE348828T1/de not_active IP Right Cessation
- 2002-10-18 EP EP02780494A patent/EP1438310B1/de not_active Expired - Lifetime
-
2004
- 2004-12-15 US US11/012,636 patent/US20050096335A1/en not_active Abandoned
-
2005
- 2005-01-13 HK HK05100283A patent/HK1067128A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2003033496A1 (en) | 2003-04-24 |
DK1438310T3 (da) | 2007-03-26 |
EP1438310A1 (de) | 2004-07-21 |
US20040014778A1 (en) | 2004-01-22 |
US20050096335A1 (en) | 2005-05-05 |
EP1438310B1 (de) | 2006-12-20 |
DE60216952T2 (de) | 2007-07-05 |
DE60216952D1 (de) | 2007-02-01 |
US6933303B2 (en) | 2005-08-23 |
ES2278064T3 (es) | 2007-08-01 |
JP2005508968A (ja) | 2005-04-07 |
ATE348828T1 (de) | 2007-01-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20101018 |