DE60326069D1 - 4-(heterocyclyl)-benzenesulfoximin verbindungen zur behandlung entzündlicher erkrankungenen - Google Patents
4-(heterocyclyl)-benzenesulfoximin verbindungen zur behandlung entzündlicher erkrankungenenInfo
- Publication number
- DE60326069D1 DE60326069D1 DE60326069T DE60326069T DE60326069D1 DE 60326069 D1 DE60326069 D1 DE 60326069D1 DE 60326069 T DE60326069 T DE 60326069T DE 60326069 T DE60326069 T DE 60326069T DE 60326069 D1 DE60326069 D1 DE 60326069D1
- Authority
- DE
- Germany
- Prior art keywords
- benzenesulfoximine
- compounds
- treatment
- inflammatory diseases
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/38—One oxygen atom attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN327MU2002 | 2002-04-05 | ||
PCT/IN2003/000133 WO2003087062A2 (en) | 2002-04-05 | 2003-04-01 | 4-(heterocyclyl)-benzenesulfoximine compounds for the treatment of inflammation |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60326069D1 true DE60326069D1 (de) | 2009-03-19 |
Family
ID=29415974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60326069T Expired - Lifetime DE60326069D1 (de) | 2002-04-05 | 2003-04-01 | 4-(heterocyclyl)-benzenesulfoximin verbindungen zur behandlung entzündlicher erkrankungenen |
Country Status (22)
Country | Link |
---|---|
US (1) | US7348342B2 (de) |
EP (1) | EP1492773B1 (de) |
JP (1) | JP4541711B2 (de) |
KR (1) | KR100659283B1 (de) |
CN (1) | CN100351237C (de) |
AT (1) | ATE422201T1 (de) |
AU (1) | AU2003238667B2 (de) |
BR (1) | BR0308957A (de) |
CA (1) | CA2480678C (de) |
CY (1) | CY1108932T1 (de) |
DE (1) | DE60326069D1 (de) |
DK (1) | DK1492773T3 (de) |
EA (1) | EA008303B1 (de) |
ES (1) | ES2321502T3 (de) |
HK (1) | HK1075450A1 (de) |
IL (2) | IL163951A0 (de) |
MX (1) | MXPA04009463A (de) |
NO (1) | NO328028B1 (de) |
PT (1) | PT1492773E (de) |
SI (1) | SI1492773T1 (de) |
WO (1) | WO2003087062A2 (de) |
ZA (1) | ZA200407293B (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE422201T1 (de) | 2002-04-05 | 2009-02-15 | Cadila Healthcare Ltd | 4-(heterocyclyl)-benzenesulfoximin verbindungen zur behandlung entzündlicher erkrankungenen |
MXPA05005742A (es) * | 2002-12-02 | 2005-08-16 | Astellas Pharma Inc | Derivados de pirazol utiles como inhibidores de cox-i. |
ES2214130B1 (es) * | 2003-02-13 | 2005-12-01 | Almirall Prodesfarma, S.A. | 2-3'-bipiridinas. |
ES2213485B1 (es) | 2003-02-13 | 2005-12-16 | Almirall Prodesfarma, S.A. | Derivados de la 2-fenilpiran-4-ona. |
JP2006523719A (ja) | 2003-04-18 | 2006-10-19 | メモリー・ファーマシューティカルズ・コーポレイション | ホスホジエステラーゼ4抑制剤としてのピラゾール誘導体 |
ITMI20040019A1 (it) * | 2004-01-12 | 2004-04-12 | Univ Bari | Derivati isossazolici e loro impiego come inibitori della ciclossigenasi |
WO2006044528A1 (en) | 2004-10-15 | 2006-04-27 | Memory Pharmaceuticals Corporation | Pyrazole derivatives as phosphodiesterase 4 inhibitors |
CA2613522A1 (en) * | 2005-06-27 | 2007-01-04 | Exelixis, Inc. | Imidazole based lxr modulators |
US7989450B2 (en) | 2008-01-11 | 2011-08-02 | Universita' Degli Studi Di Bari | Functionalized diarylisoxazoles inhibitors of ciclooxygenase |
US8815881B2 (en) * | 2010-08-09 | 2014-08-26 | Hoffmann-La Roche Inc. | 1,4,5,6-tetrahydro-pyrimidin-2-ylamine compounds |
CN103204803A (zh) * | 2012-01-13 | 2013-07-17 | 阿尔弗雷德·E·蒂芬巴赫尔有限责任两合公司 | 用于合成依托考昔的方法 |
CN104926797B (zh) * | 2014-06-10 | 2019-04-16 | 北京元博方医药科技有限公司 | 呋喃酮衍生物、制备方法及用途 |
US10023567B2 (en) | 2014-07-18 | 2018-07-17 | Ohio University | Imidazole and thiazole compositions for modifying biological signaling |
CN106278970A (zh) * | 2016-08-09 | 2017-01-04 | 孙冉 | 一种二芳基亚砜胺类化合物的合成方法 |
WO2018029117A1 (en) * | 2016-08-10 | 2018-02-15 | Rheinisch-Westfälische Technische Hochschule Aachen (RWTH) | New atr inhibitors for the use in cancer therapy |
CN107721941B (zh) * | 2017-10-10 | 2020-05-22 | 浦拉司科技(上海)有限责任公司 | 一种3-氨基-5-甲基异噁唑的制备方法 |
WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4036849A (en) * | 1974-05-15 | 1977-07-19 | American Cyanamid Company | 1-(Para-substituted-phenyl)-1H-tetrazoles |
JPS59165090A (ja) * | 1983-03-07 | 1984-09-18 | インタ−ナショナル ビジネス マシ−ンズ コ−ポレ−ション | 文字発生器 |
DE3522230A1 (de) * | 1985-06-21 | 1987-01-02 | Thomae Gmbh Dr K | Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
DE3621112A1 (de) * | 1986-06-24 | 1988-01-07 | Merck Patent Gmbh | Nichtracemische sulfoxide |
US5633272A (en) | 1995-02-13 | 1997-05-27 | Talley; John J. | Substituted isoxazoles for the treatment of inflammation |
JP3267300B2 (ja) | 1995-02-13 | 2002-03-18 | ジー.ディー.サール アンド カンパニー | 炎症の治療のための置換イソオキサゾール |
US6020343A (en) | 1995-10-13 | 2000-02-01 | Merck Frosst Canada, Inc. | (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors |
US5981576A (en) | 1995-10-13 | 1999-11-09 | Merck Frosst Canada, Inc. | (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors |
ES2166710B1 (es) | 2000-04-25 | 2004-10-16 | J. URIACH & CIA, S.A. | Nuevos compuestos heterociclicos con actividad antiinflamatoria. |
US6673818B2 (en) | 2001-04-20 | 2004-01-06 | Pharmacia Corporation | Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation |
ATE422201T1 (de) | 2002-04-05 | 2009-02-15 | Cadila Healthcare Ltd | 4-(heterocyclyl)-benzenesulfoximin verbindungen zur behandlung entzündlicher erkrankungenen |
-
2003
- 2003-04-01 AT AT03733003T patent/ATE422201T1/de active
- 2003-04-01 KR KR1020047015837A patent/KR100659283B1/ko not_active IP Right Cessation
- 2003-04-01 SI SI200331561T patent/SI1492773T1/sl unknown
- 2003-04-01 EA EA200401319A patent/EA008303B1/ru not_active IP Right Cessation
- 2003-04-01 MX MXPA04009463A patent/MXPA04009463A/es active IP Right Grant
- 2003-04-01 BR BR0308957-6A patent/BR0308957A/pt not_active IP Right Cessation
- 2003-04-01 CN CNB038073528A patent/CN100351237C/zh not_active Expired - Fee Related
- 2003-04-01 US US10/509,894 patent/US7348342B2/en not_active Expired - Fee Related
- 2003-04-01 IL IL16395103A patent/IL163951A0/xx unknown
- 2003-04-01 DK DK03733003T patent/DK1492773T3/da active
- 2003-04-01 DE DE60326069T patent/DE60326069D1/de not_active Expired - Lifetime
- 2003-04-01 JP JP2003584018A patent/JP4541711B2/ja not_active Expired - Fee Related
- 2003-04-01 EP EP03733003A patent/EP1492773B1/de not_active Expired - Lifetime
- 2003-04-01 WO PCT/IN2003/000133 patent/WO2003087062A2/en active Application Filing
- 2003-04-01 PT PT03733003T patent/PT1492773E/pt unknown
- 2003-04-01 CA CA2480678A patent/CA2480678C/en not_active Expired - Fee Related
- 2003-04-01 ES ES03733003T patent/ES2321502T3/es not_active Expired - Lifetime
- 2003-04-01 AU AU2003238667A patent/AU2003238667B2/en not_active Ceased
-
2004
- 2004-04-19 ZA ZA200407293A patent/ZA200407293B/en unknown
- 2004-09-07 IL IL163951A patent/IL163951A/en not_active IP Right Cessation
- 2004-09-10 NO NO20043792A patent/NO328028B1/no not_active IP Right Cessation
-
2005
- 2005-10-27 HK HK05109544A patent/HK1075450A1/xx not_active IP Right Cessation
-
2009
- 2009-03-30 CY CY20091100370T patent/CY1108932T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE422201T1 (de) | 2009-02-15 |
NO328028B1 (no) | 2009-11-16 |
AU2003238667A1 (en) | 2003-10-27 |
CN100351237C (zh) | 2007-11-28 |
PT1492773E (pt) | 2009-05-07 |
MXPA04009463A (es) | 2005-01-25 |
EA200401319A1 (ru) | 2005-04-28 |
EP1492773B1 (de) | 2009-02-04 |
US20050277678A1 (en) | 2005-12-15 |
CY1108932T1 (el) | 2014-07-02 |
WO2003087062A3 (en) | 2003-11-20 |
NO20043792L (no) | 2005-01-04 |
US7348342B2 (en) | 2008-03-25 |
DK1492773T3 (da) | 2009-04-14 |
KR20040099400A (ko) | 2004-11-26 |
ES2321502T3 (es) | 2009-06-08 |
EP1492773A2 (de) | 2005-01-05 |
IL163951A (en) | 2010-11-30 |
CA2480678A1 (en) | 2003-10-23 |
ZA200407293B (en) | 2006-07-26 |
AU2003238667B2 (en) | 2006-07-20 |
KR100659283B1 (ko) | 2006-12-19 |
IL163951A0 (en) | 2005-12-18 |
CN1642918A (zh) | 2005-07-20 |
WO2003087062A2 (en) | 2003-10-23 |
JP4541711B2 (ja) | 2010-09-08 |
SI1492773T1 (sl) | 2009-06-30 |
BR0308957A (pt) | 2005-02-01 |
CA2480678C (en) | 2011-06-14 |
EA008303B1 (ru) | 2007-04-27 |
JP2005530728A (ja) | 2005-10-13 |
HK1075450A1 (en) | 2005-12-16 |
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