ES2166710B1 - Nuevos compuestos heterociclicos con actividad antiinflamatoria. - Google Patents

Nuevos compuestos heterociclicos con actividad antiinflamatoria.

Info

Publication number
ES2166710B1
ES2166710B1 ES200001138A ES200001138A ES2166710B1 ES 2166710 B1 ES2166710 B1 ES 2166710B1 ES 200001138 A ES200001138 A ES 200001138A ES 200001138 A ES200001138 A ES 200001138A ES 2166710 B1 ES2166710 B1 ES 2166710B1
Authority
ES
Spain
Prior art keywords
inflammatory activity
compounds
new
heterociclic compounds
new heterociclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200001138A
Other languages
English (en)
Other versions
ES2166710A1 (es
Inventor
Carmen Almansa
Concepcion Gonzalez
M. Carmen Torres
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noucor Health SA
Original Assignee
J Uriach y Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J Uriach y Cia SA filed Critical J Uriach y Cia SA
Priority to ES200001138A priority Critical patent/ES2166710B1/es
Priority to ARP010101803A priority patent/AR032451A1/es
Priority to MXPA02010595A priority patent/MXPA02010595A/es
Priority to KR1020027014345A priority patent/KR20020093952A/ko
Priority to AU2001248382A priority patent/AU2001248382A1/en
Priority to JP2001580903A priority patent/JP2003531903A/ja
Priority to US10/258,471 priority patent/US20030114456A1/en
Priority to CA002407418A priority patent/CA2407418A1/en
Priority to EP01921386A priority patent/EP1281709B1/en
Priority to AT01921386T priority patent/ATE289302T1/de
Priority to DE60108953T priority patent/DE60108953D1/de
Priority to BR0110328-8A priority patent/BR0110328A/pt
Priority to PCT/ES2001/000152 priority patent/WO2001083475A1/es
Priority to NO20025101A priority patent/NO20025101L/no
Publication of ES2166710A1 publication Critical patent/ES2166710A1/es
Application granted granted Critical
Publication of ES2166710B1 publication Critical patent/ES2166710B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

Nuevos compuestos heterocíclicos con actividad antiinflamatoria. Nuevos compuestos heterocíclicos de fórmula I y sus sales, solvatos y prodrogas, en donde los significados de los distintos sustituyentes son como se han indicado en la parte descriptiva. Dichos compuestos son útiles como antiinflamatorios.
ES200001138A 2000-04-25 2000-04-25 Nuevos compuestos heterociclicos con actividad antiinflamatoria. Expired - Fee Related ES2166710B1 (es)

Priority Applications (14)

Application Number Priority Date Filing Date Title
ES200001138A ES2166710B1 (es) 2000-04-25 2000-04-25 Nuevos compuestos heterociclicos con actividad antiinflamatoria.
ARP010101803A AR032451A1 (es) 2000-04-25 2001-04-18 Compuesto heterociclico, un procedimiento para preparar dicho compuesto y la composicion farmaceutica que lo comprende
BR0110328-8A BR0110328A (pt) 2000-04-25 2001-04-23 Compostos heterocìclicos com atividade antiinflamatória
AU2001248382A AU2001248382A1 (en) 2000-04-25 2001-04-23 Novel heterocyclic compounds with anti-inflammatory activity
JP2001580903A JP2003531903A (ja) 2000-04-25 2001-04-23 抗炎症作用を有する新規な複素環式化合物
US10/258,471 US20030114456A1 (en) 2000-04-25 2001-04-23 Novel heterocylic compounds with anti-inflamatory activity
CA002407418A CA2407418A1 (en) 2000-04-25 2001-04-23 Novel heterocyclic compounds with anti-inflammatory activity
EP01921386A EP1281709B1 (en) 2000-04-25 2001-04-23 Novel heterocyclic compounds with anti-inflammatory activity
MXPA02010595A MXPA02010595A (es) 2000-04-25 2001-04-23 Nuevos compuestos heterociclicos con actividad antiinflamatoria.
DE60108953T DE60108953D1 (de) 2000-04-25 2001-04-23 Heterozyklische verbindungen mit entzündungshemmender wirkung
KR1020027014345A KR20020093952A (ko) 2000-04-25 2001-04-23 항염증 작용을 갖는 신규한 헤테로시클릭 화합물
PCT/ES2001/000152 WO2001083475A1 (es) 2000-04-25 2001-04-23 Nuevos compuestos heterociclicos con actividad antiinflamatoria
AT01921386T ATE289302T1 (de) 2000-04-25 2001-04-23 Heterozyklische verbindungen mit entzündungshemmender wirkung
NO20025101A NO20025101L (no) 2000-04-25 2002-10-24 Nye, heterosykliske forbindelser med antiinflammatorisk aktivitet

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200001138A ES2166710B1 (es) 2000-04-25 2000-04-25 Nuevos compuestos heterociclicos con actividad antiinflamatoria.

Publications (2)

Publication Number Publication Date
ES2166710A1 ES2166710A1 (es) 2003-12-01
ES2166710B1 true ES2166710B1 (es) 2004-10-16

Family

ID=8493411

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200001138A Expired - Fee Related ES2166710B1 (es) 2000-04-25 2000-04-25 Nuevos compuestos heterociclicos con actividad antiinflamatoria.

Country Status (14)

Country Link
US (1) US20030114456A1 (es)
EP (1) EP1281709B1 (es)
JP (1) JP2003531903A (es)
KR (1) KR20020093952A (es)
AR (1) AR032451A1 (es)
AT (1) ATE289302T1 (es)
AU (1) AU2001248382A1 (es)
BR (1) BR0110328A (es)
CA (1) CA2407418A1 (es)
DE (1) DE60108953D1 (es)
ES (1) ES2166710B1 (es)
MX (1) MXPA02010595A (es)
NO (1) NO20025101L (es)
WO (1) WO2001083475A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL163951A0 (en) * 2002-04-05 2005-12-18 Cadila Healthcare Ltd New heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in medicine
ES2215474B1 (es) 2002-12-24 2005-12-16 J. URIACH & CIA S.A. Nuevos derivados de fosforamida.
CN101088242B (zh) * 2004-12-23 2012-07-11 Nxp股份有限公司 低复杂度的盲传输格式检测

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026731A1 (en) * 1993-05-13 1994-11-24 Merck Frosst Canada Inc. 2-substituted-3,4-diarylthiophene derivatives as inhibitors of cyclooxygenase
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
ATE236130T1 (de) * 1996-01-26 2003-04-15 Searle & Co Heterocyclisch substituierte imidazole zur behandlung von entzündungen
ATE408607T1 (de) * 1996-04-12 2008-10-15 Searle Llc Substituierte benzensulfonamid-derivate als wirkstoff-vorläufer von cox-2 inhibitoren
ES2131015B1 (es) * 1997-09-12 2000-03-01 Almirall Prodesfarma Sa Nuevos derivados de 2-(3h)-oxazolona, procedimientos para su preparacion y su empleo en composiciones farmaceuticas.
US6133292A (en) * 1997-10-30 2000-10-17 Merck Frosst Canada & Co. Diaryl-5-alkyl-5-methyl-2-(5H)-furanones as selective cyclooxygenase-2-inhibitors
TNSN99111A1 (fr) * 1998-06-11 2005-11-10 Pfizer Derives de sulfonylbenzene nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant.
AR024222A1 (es) * 1998-10-16 2002-09-25 Palau Pharma Sa Imidazoles con actividad antiinflamatoria un procedimiento para su preparacion y composiciones farmaceuticas que lo contienen
AU4308300A (en) * 1999-05-03 2000-11-17 Dr. Reddy's Research Foundation Pyrazoles having antiinflammatory activity
JP2003508401A (ja) * 1999-08-27 2003-03-04 アボット・ラボラトリーズ Ｃｏｘ−２阻害薬として有用なスルホニルフェニルピラゾール化合物
WO2001017996A1 (en) * 1999-09-08 2001-03-15 Merck Frosst Canada & Co. 1,2,3-thiadiazoles and their use as cox-2 inhibitors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Actualités de Chimie Thérapeutique, 1999, Vol. 25, páginas 123-134. J. TALLEY et al. "Discovery of Selective COX-2 inhibitors". Páginas 127,128,130,133. *
Annual Reports in Medicinal Chemistry, 1997, Vol. 32, capítulo 21, páginas 211-220. P. PRASIT et al. "Selective Cyclooxygenase-2 inhibitors". Páginas 213 (final)-215. *
Journal Medicinal Chemistry, 1997, Vol. 40, páginas 1634-1647. I. KHANNA et al. "1,2-Diarylimidazoles as potent, Cyclooxygenase-2 selective and orally active antiinflammatory agents". Todo el documento. *

Also Published As

Publication number Publication date
DE60108953D1 (de) 2005-03-24
CA2407418A1 (en) 2001-11-08
US20030114456A1 (en) 2003-06-19
AU2001248382A1 (en) 2001-11-12
AR032451A1 (es) 2003-11-12
ATE289302T1 (de) 2005-03-15
EP1281709A1 (en) 2003-02-05
BR0110328A (pt) 2003-01-07
NO20025101L (no) 2002-12-20
JP2003531903A (ja) 2003-10-28
NO20025101D0 (no) 2002-10-24
EP1281709B1 (en) 2005-02-16
KR20020093952A (ko) 2002-12-16
MXPA02010595A (es) 2003-03-10
WO2001083475A1 (es) 2001-11-08
ES2166710A1 (es) 2003-12-01

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