ATE236130T1 - Heterocyclisch substituierte imidazole zur behandlung von entzündungen - Google Patents
Heterocyclisch substituierte imidazole zur behandlung von entzündungenInfo
- Publication number
- ATE236130T1 ATE236130T1 AT97901952T AT97901952T ATE236130T1 AT E236130 T1 ATE236130 T1 AT E236130T1 AT 97901952 T AT97901952 T AT 97901952T AT 97901952 T AT97901952 T AT 97901952T AT E236130 T1 ATE236130 T1 AT E236130T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- protected
- halo
- forming
- hydroxyimidazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59216796A | 1996-01-26 | 1996-01-26 | |
| PCT/US1997/000300 WO1997027181A1 (en) | 1996-01-26 | 1997-01-24 | Heterocyclo-substituted imidazoles for the treatment of inflammation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE236130T1 true ATE236130T1 (de) | 2003-04-15 |
Family
ID=24369588
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97901952T ATE236130T1 (de) | 1996-01-26 | 1997-01-24 | Heterocyclisch substituierte imidazole zur behandlung von entzündungen |
| AT01123289T ATE346849T1 (de) | 1996-01-26 | 1997-01-24 | Ein verfahren zur herstellung von 4- 2-(aryl oder heterocyclo)-1h-imidazol-1-ylöbenzolsulfonamide |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01123289T ATE346849T1 (de) | 1996-01-26 | 1997-01-24 | Ein verfahren zur herstellung von 4- 2-(aryl oder heterocyclo)-1h-imidazol-1-ylöbenzolsulfonamide |
Country Status (12)
| Country | Link |
|---|---|
| EP (2) | EP1193265B1 (de) |
| JP (1) | JP2000503987A (de) |
| AT (2) | ATE236130T1 (de) |
| AU (1) | AU730642B2 (de) |
| DE (3) | DE69737042T8 (de) |
| DK (2) | DK0880504T3 (de) |
| ES (2) | ES2197983T3 (de) |
| HK (1) | HK1045843B (de) |
| NZ (1) | NZ327022A (de) |
| PT (2) | PT1193265E (de) |
| WO (1) | WO1997027181A1 (de) |
| ZA (1) | ZA97670B (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6512121B2 (en) | 1998-09-14 | 2003-01-28 | G.D. Searle & Co. | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
| NZ333399A (en) | 1997-12-24 | 2000-05-26 | Sankyo Co | Cyclooxygenase-2 inhibitors (COX-2) for the prevention and treatment of tumors, cachexia and tumor-metastasis |
| WO1999038829A1 (fr) | 1998-01-28 | 1999-08-05 | Shionogi & Co., Ltd. | Nouveau compose tricyclique |
| US6294558B1 (en) | 1999-05-31 | 2001-09-25 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
| US6727238B2 (en) | 1998-06-11 | 2004-04-27 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
| US6410562B1 (en) | 1998-12-18 | 2002-06-25 | Eli Lilly And Company | Hypoglycemic imidazoline compounds |
| ES2166710B1 (es) * | 2000-04-25 | 2004-10-16 | J. URIACH & CIA, S.A. | Nuevos compuestos heterociclicos con actividad antiinflamatoria. |
| JP4759207B2 (ja) * | 2000-05-15 | 2011-08-31 | あすか製薬株式会社 | １−（ベンゾチアゾール−２−イル）ピラゾール誘導体およびそれを含有するｃｏｘ−２阻害剤 |
| US6555563B1 (en) * | 2001-11-16 | 2003-04-29 | Medinox, Inc. | Heteroaryl substituted amidinyl and imidazolyl compounds and methods employing same for the treatment of inflammation |
| AU2003216591A1 (en) * | 2002-04-10 | 2003-10-20 | Orichid Chemicals And Pharmaceuticals Limited | Amino substituted pyrimidinone derivatives useful in the treatment of inflammation and immunological |
| US6878735B2 (en) * | 2002-05-31 | 2005-04-12 | Board Of Trustees Of Michigan State University | Multi-substituted imidazolines and method of use thereof |
| AU2003279622A1 (en) | 2002-06-28 | 2004-01-19 | Nitromed, Inc. | Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use |
| WO2004060367A1 (en) * | 2002-12-30 | 2004-07-22 | Fujisawa Pharmaceutical Co., Ltd. | Imidazole and triazole derivatives useful as selective cox-1 inhibitors |
| CA2519189C (en) | 2003-05-07 | 2012-07-17 | Osteologix A/S | Water-soluble strontium salts for use in treatment of cartilage and/or bone conditions |
| CA2558214A1 (en) * | 2004-03-08 | 2005-09-22 | Wyeth | Ion channel modulators |
| CN102584695B (zh) * | 2012-01-13 | 2014-02-19 | 江苏中邦制药有限公司 | 一种5-甲基烟酸的制备方法 |
| IL305573A (en) | 2021-03-15 | 2023-10-01 | Saul Yedgar | Hyaluronic acid conjugated with dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment or suppression of inflammatory diseases |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69322254T2 (de) * | 1992-01-13 | 1999-04-29 | Smithkline Beecham Corp., Philadelphia, Pa. 19101 | Pyridyl-substituierte imidazole |
| US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5475018A (en) * | 1993-11-30 | 1995-12-12 | G. D. Searle & Co. | 1,5-diphenyl pyrazole compounds for treatment of inflammation |
| US5616601A (en) * | 1994-07-28 | 1997-04-01 | Gd Searle & Co | 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation |
-
1997
- 1997-01-24 DK DK97901952T patent/DK0880504T3/da active
- 1997-01-24 ES ES97901952T patent/ES2197983T3/es not_active Expired - Lifetime
- 1997-01-24 AU AU15739/97A patent/AU730642B2/en not_active Ceased
- 1997-01-24 DE DE69737042T patent/DE69737042T8/de active Active
- 1997-01-24 NZ NZ327022A patent/NZ327022A/xx unknown
- 1997-01-24 DK DK01123289T patent/DK1193265T3/da active
- 1997-01-24 PT PT01123289T patent/PT1193265E/pt unknown
- 1997-01-24 AT AT97901952T patent/ATE236130T1/de not_active IP Right Cessation
- 1997-01-24 PT PT97901952T patent/PT880504E/pt unknown
- 1997-01-24 DE DE69720428T patent/DE69720428T2/de not_active Expired - Fee Related
- 1997-01-24 DE DE69737042A patent/DE69737042D1/de not_active Expired - Fee Related
- 1997-01-24 AT AT01123289T patent/ATE346849T1/de not_active IP Right Cessation
- 1997-01-24 EP EP01123289A patent/EP1193265B1/de not_active Expired - Lifetime
- 1997-01-24 EP EP97901952A patent/EP0880504B1/de not_active Expired - Lifetime
- 1997-01-24 WO PCT/US1997/000300 patent/WO1997027181A1/en active IP Right Grant
- 1997-01-24 ES ES01123289T patent/ES2274843T3/es not_active Expired - Lifetime
- 1997-01-24 JP JP9526876A patent/JP2000503987A/ja not_active Abandoned
- 1997-01-27 ZA ZA9700670A patent/ZA97670B/xx unknown
-
2002
- 2002-10-03 HK HK02107266.0A patent/HK1045843B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE346849T1 (de) | 2006-12-15 |
| DK1193265T3 (da) | 2007-02-19 |
| EP1193265B1 (de) | 2006-11-29 |
| HK1045843A1 (en) | 2002-12-13 |
| EP0880504A1 (de) | 1998-12-02 |
| DE69720428D1 (de) | 2003-05-08 |
| ES2274843T3 (es) | 2007-06-01 |
| WO1997027181A1 (en) | 1997-07-31 |
| EP1193265A2 (de) | 2002-04-03 |
| ES2197983T3 (es) | 2004-01-16 |
| EP0880504B1 (de) | 2003-04-02 |
| PT1193265E (pt) | 2007-03-30 |
| DE69737042T8 (de) | 2007-11-22 |
| DE69720428T2 (de) | 2004-02-12 |
| DE69737042D1 (de) | 2007-01-11 |
| PT880504E (pt) | 2003-08-29 |
| JP2000503987A (ja) | 2000-04-04 |
| AU1573997A (en) | 1997-08-20 |
| DK0880504T3 (da) | 2003-07-21 |
| HK1045843B (zh) | 2007-03-02 |
| EP1193265A3 (de) | 2002-04-10 |
| NZ327022A (en) | 1999-06-29 |
| AU730642B2 (en) | 2001-03-08 |
| ZA97670B (en) | 1998-04-16 |
| DE69737042T2 (de) | 2007-07-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0880504 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |