HK1045843B - 製造4-2-(芳基或雜環)-1氫-咪唑-1-基苯氨磺酰的方法 - Google Patents
製造4-2-(芳基或雜環)-1氫-咪唑-1-基苯氨磺酰的方法Info
- Publication number
- HK1045843B HK1045843B HK02107266.0A HK02107266A HK1045843B HK 1045843 B HK1045843 B HK 1045843B HK 02107266 A HK02107266 A HK 02107266A HK 1045843 B HK1045843 B HK 1045843B
- Authority
- HK
- Hong Kong
- Prior art keywords
- alkyl
- protected
- halo
- aryl
- forming
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59216796A | 1996-01-26 | 1996-01-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HK1045843A1 HK1045843A1 (en) | 2002-12-13 |
| HK1045843B true HK1045843B (zh) | 2007-03-02 |
Family
ID=24369588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK02107266.0A HK1045843B (zh) | 1996-01-26 | 2002-10-03 | 製造4-2-(芳基或雜環)-1氫-咪唑-1-基苯氨磺酰的方法 |
Country Status (12)
| Country | Link |
|---|---|
| EP (2) | EP0880504B1 (zh) |
| JP (1) | JP2000503987A (zh) |
| AT (2) | ATE346849T1 (zh) |
| AU (1) | AU730642B2 (zh) |
| DE (3) | DE69720428T2 (zh) |
| DK (2) | DK1193265T3 (zh) |
| ES (2) | ES2274843T3 (zh) |
| HK (1) | HK1045843B (zh) |
| NZ (1) | NZ327022A (zh) |
| PT (2) | PT1193265E (zh) |
| WO (1) | WO1997027181A1 (zh) |
| ZA (1) | ZA97670B (zh) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6512121B2 (en) | 1998-09-14 | 2003-01-28 | G.D. Searle & Co. | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
| NZ333399A (en) | 1997-12-24 | 2000-05-26 | Sankyo Co | Cyclooxygenase-2 inhibitors (COX-2) for the prevention and treatment of tumors, cachexia and tumor-metastasis |
| CN1231440C (zh) | 1998-01-28 | 2005-12-14 | 盐野义制药株式会社 | 新的三环化合物 |
| US6294558B1 (en) | 1999-05-31 | 2001-09-25 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
| US6727238B2 (en) | 1998-06-11 | 2004-04-27 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
| US6410562B1 (en) | 1998-12-18 | 2002-06-25 | Eli Lilly And Company | Hypoglycemic imidazoline compounds |
| ES2166710B1 (es) * | 2000-04-25 | 2004-10-16 | J. URIACH & CIA, S.A. | Nuevos compuestos heterociclicos con actividad antiinflamatoria. |
| JP4759207B2 (ja) * | 2000-05-15 | 2011-08-31 | あすか製薬株式会社 | １−（ベンゾチアゾール−２−イル）ピラゾール誘導体およびそれを含有するｃｏｘ−２阻害剤 |
| US6555563B1 (en) * | 2001-11-16 | 2003-04-29 | Medinox, Inc. | Heteroaryl substituted amidinyl and imidazolyl compounds and methods employing same for the treatment of inflammation |
| US20030232813A1 (en) * | 2002-04-10 | 2003-12-18 | Orchid Chemicals & Pharmaceuticals Limited | Novel amino substituted pyrimidinone derivatives |
| US6878735B2 (en) * | 2002-05-31 | 2005-04-12 | Board Of Trustees Of Michigan State University | Multi-substituted imidazolines and method of use thereof |
| EP1539679A4 (en) | 2002-06-28 | 2007-07-04 | Nitromed Inc | OXIM- AND / OR HYDRAZO-CONTAINING, NITROSED AND / OR NITROSYLATED CYCLOOXIGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND USE METHODS |
| WO2004060367A1 (en) * | 2002-12-30 | 2004-07-22 | Fujisawa Pharmaceutical Co., Ltd. | Imidazole and triazole derivatives useful as selective cox-1 inhibitors |
| PL1745791T3 (pl) | 2003-05-07 | 2013-11-29 | Osteologix As | Leczenie chorób chrząstki/kości za pomocą rozpuszczalnych w wodzie soli strontu |
| CN1938281A (zh) * | 2004-03-08 | 2007-03-28 | 惠氏公司 | 离子通道调节剂 |
| CN102584695B (zh) * | 2012-01-13 | 2014-02-19 | 江苏中邦制药有限公司 | 一种5-甲基烟酸的制备方法 |
| CA3209491A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3592493A (en) * | 1992-01-13 | 1993-08-03 | Smithkline Beecham Corporation | Pyridyl substituted imidazoles |
| US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5475018A (en) * | 1993-11-30 | 1995-12-12 | G. D. Searle & Co. | 1,5-diphenyl pyrazole compounds for treatment of inflammation |
| US5616601A (en) * | 1994-07-28 | 1997-04-01 | Gd Searle & Co | 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation |
-
1997
- 1997-01-24 AT AT01123289T patent/ATE346849T1/de not_active IP Right Cessation
- 1997-01-24 ES ES01123289T patent/ES2274843T3/es not_active Expired - Lifetime
- 1997-01-24 EP EP97901952A patent/EP0880504B1/en not_active Expired - Lifetime
- 1997-01-24 DE DE69720428T patent/DE69720428T2/de not_active Expired - Fee Related
- 1997-01-24 DK DK01123289T patent/DK1193265T3/da active
- 1997-01-24 WO PCT/US1997/000300 patent/WO1997027181A1/en active IP Right Grant
- 1997-01-24 DK DK97901952T patent/DK0880504T3/da active
- 1997-01-24 DE DE69737042A patent/DE69737042D1/de not_active Expired - Fee Related
- 1997-01-24 JP JP9526876A patent/JP2000503987A/ja not_active Abandoned
- 1997-01-24 DE DE69737042T patent/DE69737042T8/de active Active
- 1997-01-24 PT PT01123289T patent/PT1193265E/pt unknown
- 1997-01-24 ES ES97901952T patent/ES2197983T3/es not_active Expired - Lifetime
- 1997-01-24 AT AT97901952T patent/ATE236130T1/de not_active IP Right Cessation
- 1997-01-24 PT PT97901952T patent/PT880504E/pt unknown
- 1997-01-24 EP EP01123289A patent/EP1193265B1/en not_active Expired - Lifetime
- 1997-01-24 AU AU15739/97A patent/AU730642B2/en not_active Ceased
- 1997-01-24 NZ NZ327022A patent/NZ327022A/xx unknown
- 1997-01-27 ZA ZA9700670A patent/ZA97670B/xx unknown
-
2002
- 2002-10-03 HK HK02107266.0A patent/HK1045843B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000503987A (ja) | 2000-04-04 |
| ZA97670B (en) | 1998-04-16 |
| ATE236130T1 (de) | 2003-04-15 |
| PT880504E (pt) | 2003-08-29 |
| DK1193265T3 (da) | 2007-02-19 |
| HK1045843A1 (en) | 2002-12-13 |
| ES2197983T3 (es) | 2004-01-16 |
| NZ327022A (en) | 1999-06-29 |
| DE69720428D1 (de) | 2003-05-08 |
| PT1193265E (pt) | 2007-03-30 |
| DK0880504T3 (da) | 2003-07-21 |
| EP1193265B1 (en) | 2006-11-29 |
| DE69720428T2 (de) | 2004-02-12 |
| AU730642B2 (en) | 2001-03-08 |
| DE69737042T8 (de) | 2007-11-22 |
| EP1193265A3 (en) | 2002-04-10 |
| ATE346849T1 (de) | 2006-12-15 |
| AU1573997A (en) | 1997-08-20 |
| ES2274843T3 (es) | 2007-06-01 |
| DE69737042D1 (de) | 2007-01-11 |
| WO1997027181A1 (en) | 1997-07-31 |
| EP1193265A2 (en) | 2002-04-03 |
| EP0880504B1 (en) | 2003-04-02 |
| EP0880504A1 (en) | 1998-12-02 |
| DE69737042T2 (de) | 2007-07-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20110124 |