ES8604601A1 - Procedimiento de preparar derivados de penicilina - Google Patents

Procedimiento de preparar derivados de penicilina

Info

Publication number
ES8604601A1
ES8604601A1 ES536964A ES536964A ES8604601A1 ES 8604601 A1 ES8604601 A1 ES 8604601A1 ES 536964 A ES536964 A ES 536964A ES 536964 A ES536964 A ES 536964A ES 8604601 A1 ES8604601 A1 ES 8604601A1
Authority
ES
Spain
Prior art keywords
hydrogen
alkoxycarbonyl
derivative
same
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES536964A
Other languages
English (en)
Other versions
ES536964A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP58192040A external-priority patent/JPS6084291A/ja
Priority claimed from JP59071499A external-priority patent/JPS60215688A/ja
Priority claimed from JP59078064A external-priority patent/JPS60222488A/ja
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of ES8604601A1 publication Critical patent/ES8604601A1/es
Publication of ES536964A0 publication Critical patent/ES536964A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO DE PREPARAR DERIVADOS DE PENICILINA. COMPRENDE: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO ELEGIDO ENTRE: R5-C F C-R6 Y R9-CR10 F CH2, PARA OBTENER UN COMPUESTO DE FORMULA (III), EN UN DISOLVENTE COMO BENCENO, XILENO, TOLUENO, ACETONA, A 50JC, DURANTE 2 HORAS A 2 SEMANAS; B) SOMETER A DESBENCILACION EL COMPUESTO DE FORMULA (III); C) SOMETER A DESETSERIFICACION; D) SOMETER A ESTERIFICACION; Y E) SOMETER A UNA REACCION DE INTERCAMBIO DE ESTERES O DE FORMACION DE SALES, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: R3 Y R4, H, GRUPO PROTECTOR DE CARBOXILO DE LA PENICILINA, Y OTROS; R5 Y R6, CADA UNO, H, ALQUILO DE C 1 A 6, ACILOXIALQUILO DE C 3 A 9 Y OTROS; R7 Y R8, CADA UNO, H, HIDROXIALQUILO DE C 1 A 6, ALCOXIALQUILO DE C 2 A 7, Y OTROS; R9, ACILOXI DE C 2 A 5 O BENCILOXI; R10, ALQUILO DE C 1 A 6. SE UTILIZAN EN FARMACOLOGIA COMO INHIBIDORES DE LA BETA-LACTAMASA Y POTENCIADORES DE ANTIBIOTICOS DEL TIPO BETA-LACTAMA.
ES536964A 1983-10-13 1984-10-11 Procedimiento de preparar derivados de penicilina Expired ES8604601A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP58192040A JPS6084291A (ja) 1983-10-13 1983-10-13 ペニシリン誘導体
JP59071499A JPS60215688A (ja) 1984-04-09 1984-04-09 ペニシリン誘導体
JP59078064A JPS60222488A (ja) 1984-04-18 1984-04-18 ペニシリン誘導体

Publications (2)

Publication Number Publication Date
ES8604601A1 true ES8604601A1 (es) 1986-02-16
ES536964A0 ES536964A0 (es) 1986-02-16

Family

ID=27300661

Family Applications (2)

Application Number Title Priority Date Filing Date
ES536964A Expired ES8604601A1 (es) 1983-10-13 1984-10-11 Procedimiento de preparar derivados de penicilina
ES548129A Expired ES8605276A1 (es) 1983-10-13 1985-10-01 Procedimiento de preparar derivados de penicilina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES548129A Expired ES8605276A1 (es) 1983-10-13 1985-10-01 Procedimiento de preparar derivados de penicilina

Country Status (7)

Country Link
US (1) US4668514A (es)
EP (1) EP0138523B1 (es)
KR (1) KR900007183B1 (es)
AU (1) AU550560B2 (es)
CA (1) CA1239392A (es)
DE (1) DE3465475D1 (es)
ES (2) ES8604601A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8624628D0 (en) * 1986-10-14 1986-11-19 Scras Soluble/splitable tablets
US4891369A (en) * 1986-12-03 1990-01-02 Taiho Pharmaceutical Company, Limited 2β-Substituted-methylpenicillanic acid derivatives, and salts and esters thereof
JP2602685B2 (ja) * 1988-03-01 1997-04-23 大鵬薬品工業株式会社 ２α−メチル−２β―（１，２，３−トリアゾール−１−イル）メチルペナム−３α−カルボン酸誘導体の製造法
JP2599610B2 (ja) * 1988-03-01 1997-04-09 大鵬薬品工業株式会社 ２β―置換メチルペニシリン誘導体の製造法
US4958020A (en) * 1989-05-12 1990-09-18 American Cyanamid Company Process for producing β-lactamase inhibitor
ES2274978T3 (es) * 2002-06-07 2007-06-01 Orchid Chemicals And Pharmaceuticals Limited Procedimiento para la reparacion de derivados de penam a partir de derivados de cefam.
US20060173177A1 (en) * 2005-01-28 2006-08-03 Gego Csaba L Process for preparation of penam derivatives
JP4579021B2 (ja) * 2005-03-23 2010-11-10 ヒロセ電機株式会社 電気コネクタ
JP2022548067A (ja) * 2019-09-11 2022-11-16 テンノア・セラピューティクス・（スージョウ）・リミテッド 細菌感染症を治療するためのペナム誘導体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58185589A (ja) * 1982-04-23 1983-10-29 Taiho Yakuhin Kogyo Kk ペニシリン誘導体
AU541028B2 (en) * 1982-06-21 1984-12-13 Taiho Pharmaceutical Co., Ltd. 6-unsubstituted penicillin derivatives
US4562073A (en) * 1982-12-24 1985-12-31 Taiho Pharmaceutical Company Limited Penicillin derivatives

Also Published As

Publication number Publication date
EP0138523A1 (en) 1985-04-24
CA1239392A (en) 1988-07-19
US4668514A (en) 1987-05-26
ES8605276A1 (es) 1986-04-01
ES548129A0 (es) 1986-04-01
KR900007183B1 (ko) 1990-09-29
AU550560B2 (en) 1986-03-27
EP0138523B1 (en) 1987-08-19
KR850002988A (ko) 1985-05-28
ES536964A0 (es) 1986-02-16
AU3378784A (en) 1985-04-18
DE3465475D1 (en) 1987-09-24

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981001