ES8106147A1 - Procedimiento para preparar un 1,2,4-triazol-3-tiol - Google Patents

Procedimiento para preparar un 1,2,4-triazol-3-tiol

Info

Publication number
ES8106147A1
ES8106147A1 ES494226A ES494226A ES8106147A1 ES 8106147 A1 ES8106147 A1 ES 8106147A1 ES 494226 A ES494226 A ES 494226A ES 494226 A ES494226 A ES 494226A ES 8106147 A1 ES8106147 A1 ES 8106147A1
Authority
ES
Spain
Prior art keywords
thiols
triazole
antisecretory agents
compounds
antisecretory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES494226A
Other languages
English (en)
Other versions
ES494226A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richardson Vicks Inc
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of ES494226A0 publication Critical patent/ES494226A0/es
Publication of ES8106147A1 publication Critical patent/ES8106147A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms

Abstract

PROCEDIMIENTO PARA PREPARAR UN 1,2,4-TRIAZOL-3-TIOL, DE FORMULA (I), DONDE R1 ES NH2 Y R2 ES CH2OH O -(CH2)NNH2. CONSISTE EN HACER REACCIONAR TIOCARBOHIDRACIDA CON UN ACIDO CARBOXILICO DE FORMULA R2COOH. CUANDO EL RADICAL R2 REPRESENTA UN GRUPO AMINO ALQUILO EL GRUPO AMINO DEL AMINO ACIDO TIENE QUE PROTEGERSE ADECUADAMENTE, POR LO QUE SE LE HACE REACCIONAR PRIMERO CON ANHIDRIDO FTALICO PARA FORMAR EL AMINO-ACIDO PROTEGIDO DE FORMULA (II), Y POSTERIORMENTE CON TIOCARBOHIDRAZIDA; DEL COMPUESTO OBTENIDO SE SEPARA EL GRUPO PROTECTOR POR REACCION CON HIDRAZINA. LOS COMPUESTOS OBTENIDOS SON APLICABLES COMO AGENTES ANTISECRETORIOS. *FORMULA*
ES494226A 1979-09-04 1980-08-13 Procedimiento para preparar un 1,2,4-triazol-3-tiol Expired ES8106147A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/071,814 US4230715A (en) 1979-09-04 1979-09-04 1,2,4-Triazole-3-thiols as antisecretory agents

Publications (2)

Publication Number Publication Date
ES494226A0 ES494226A0 (es) 1981-08-01
ES8106147A1 true ES8106147A1 (es) 1981-08-01

Family

ID=22103760

Family Applications (1)

Application Number Title Priority Date Filing Date
ES494226A Expired ES8106147A1 (es) 1979-09-04 1980-08-13 Procedimiento para preparar un 1,2,4-triazol-3-tiol

Country Status (15)

Country Link
US (1) US4230715A (es)
JP (1) JPS5640672A (es)
AU (1) AU6108980A (es)
BE (1) BE885015A (es)
DE (1) DE3031320A1 (es)
DK (1) DK375480A (es)
ES (1) ES8106147A1 (es)
FR (1) FR2464257A1 (es)
GB (1) GB2057446A (es)
IL (1) IL60763A0 (es)
IT (1) IT1145443B (es)
NL (1) NL8004630A (es)
NO (1) NO802592L (es)
SE (1) SE8006142L (es)
ZA (1) ZA804668B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0232382U (es) * 1988-08-22 1990-02-28
US5489598A (en) * 1994-06-08 1996-02-06 Warner-Lambert Company Cytoprotection utilizing aryltriazol-3-thiones
ATE194334T1 (de) * 1995-04-20 2000-07-15 Aventis Pharma Inc 3-phenyl-1,4-dialkyl-1,2,4-triazolium salze und ihre verwendung als antidepressiva
US20030125562A1 (en) * 1999-08-21 2003-07-03 Heindel Ned H. Methods of producing 4-amino-3-mercapto-triazoles

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB928919A (en) * 1960-08-16 1963-06-19 Bellon Labor Sa Roger Triazole derivatives and a process for their preparation
DE1620506A1 (de) * 1965-07-07 1970-01-02 Thomae Gmbh Dr K Verfahren zur Herstellung von neuen 1,2,4-Triazolin-Thionen-(5)
US3701784A (en) * 1968-09-04 1972-10-31 Rohm & Haas 1,2,4-4h-triazole derivatives
US3818097A (en) * 1969-10-29 1974-06-18 Smith Kline French Lab Method of inhibiting histamine activity with isothioureas
IL49200A0 (en) * 1975-03-27 1976-05-31 Pfizer Novel heterocyclic thiols and their preparation

Also Published As

Publication number Publication date
DE3031320A1 (de) 1981-03-26
JPS5640672A (en) 1981-04-16
IT8049543A0 (it) 1980-08-22
AU6108980A (en) 1981-03-12
IT1145443B (it) 1986-11-05
SE8006142L (sv) 1981-03-05
ZA804668B (en) 1981-07-29
BE885015A (fr) 1980-12-31
FR2464257A1 (fr) 1981-03-06
NO802592L (no) 1981-03-05
GB2057446A (en) 1981-04-01
ES494226A0 (es) 1981-08-01
DK375480A (da) 1981-03-05
IL60763A0 (en) 1980-10-26
US4230715A (en) 1980-10-28
NL8004630A (nl) 1981-03-06

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