ES8202554A1 - Procedimiento para la preparacion de 2-fenilamino-imidazoli-nas-(2)sustituidas - Google Patents

Procedimiento para la preparacion de 2-fenilamino-imidazoli-nas-(2)sustituidas

Info

Publication number
ES8202554A1
ES8202554A1 ES497948A ES497948A ES8202554A1 ES 8202554 A1 ES8202554 A1 ES 8202554A1 ES 497948 A ES497948 A ES 497948A ES 497948 A ES497948 A ES 497948A ES 8202554 A1 ES8202554 A1 ES 8202554A1
Authority
ES
Spain
Prior art keywords
addition salts
thiemyl
imidazoline
bromophenyl
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES497948A
Other languages
English (en)
Other versions
ES497948A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES497948A0 publication Critical patent/ES497948A0/es
Publication of ES8202554A1 publication Critical patent/ES8202554A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 2-FENILAMINO-IMIDAZOLINAS-(2) SUSTITUIDAS, DE FORMULA GENERAL (1), ASI COMO DE SUS SALES. CONSISTENTE EN OBTENER EL COMPUESTO DE FORMULA (I) HACIENDO REACCIONAR UNA 2-FENILIMINO-IMIDAZOLINA DE FORMULA GENERAL (II) CON UN HALOGENURO DE FORMULA GENERAL (III), EN CUYAS FORMULAS R SIGNIFICA UN ATOMO DE BROMO O UN GRUPO TRIFLUOROFENILO Y HAL SIGNIFICA UN ATOMO DE CLORO, BROMO O YODO. EL PRODUCTO OBTENIDO SE TRANSFORMA EVENTUALMENTE EN UNA SAL POR ADICION DE ACIDO. LA REACCION SE REALIZA POR CALENTAMIENTO DE LOS REACTIVOS A TEMPERATURAS DE 40 A 150 C, PREFERENTEMENTE EN PRESENCIA DE UN DISOLVENTE POLAR O NO POLAR.
ES497948A 1979-12-21 1980-12-19 Procedimiento para la preparacion de 2-fenilamino-imidazoli-nas-(2)sustituidas Expired ES8202554A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792951601 DE2951601A1 (de) 1979-12-21 1979-12-21 Neue substituierte 2-phenylaminoimidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben

Publications (2)

Publication Number Publication Date
ES497948A0 ES497948A0 (es) 1982-02-01
ES8202554A1 true ES8202554A1 (es) 1982-02-01

Family

ID=6089187

Family Applications (1)

Application Number Title Priority Date Filing Date
ES497948A Expired ES8202554A1 (es) 1979-12-21 1980-12-19 Procedimiento para la preparacion de 2-fenilamino-imidazoli-nas-(2)sustituidas

Country Status (15)

Country Link
US (1) US4478844A (es)
EP (1) EP0031429B1 (es)
JP (1) JPS5697284A (es)
AT (1) ATE8260T1 (es)
AU (1) AU538931B2 (es)
CA (1) CA1143738A (es)
DE (2) DE2951601A1 (es)
DK (1) DK544980A (es)
ES (1) ES8202554A1 (es)
FI (1) FI63940C (es)
IE (1) IE50588B1 (es)
IL (1) IL61769A (es)
NO (1) NO154091C (es)
NZ (1) NZ195897A (es)
ZA (1) ZA807905B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT376436B (de) * 1982-11-05 1984-11-26 Laevosan Gmbh & Co Kg Verfahren zur herstellung neuer thiophen-2carbons[urederivate und pharmazeutisch vertraeglicher saeure- oder basenadditionssalze davon
EP0200947B1 (de) * 1985-04-26 1990-09-12 F. Hoffmann-La Roche Ag 1,3-Disubstituierte Imidazoliumsalze
US4740230A (en) * 1985-09-13 1988-04-26 Idemitsu Kosan Company Limited Triazine derivatives, and herbicides containing the derivatives as the effective component

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2208434C2 (de) * 1972-02-23 1982-09-16 C.H. Boehringer Sohn, 6507 Ingelheim Substituierte 2-(N-Furylmethyl-N-phenyl-amino)-2-imidazoline, deren Säureadditionssalze, Verfahren zu ihrer Herstellung und diese enthaltende Mittel
US4036972A (en) * 1973-02-23 1977-07-19 Boehringer Ingelheim Gmbh 2-(N-thienylmethyl-phenylamino)-imidazolines-(2) and salts thereof
DE2308883C3 (de) * 1973-02-23 1978-05-24 C.H. Boehringer Sohn, 6507 Ingelheim 2-Phenylamino-thienylmethyl-imidazoline-(2), Verfahren zur Herstellung derselben und diese enthaltene Arzneimittel
DE2830279A1 (de) * 1978-07-10 1980-01-31 Boehringer Sohn Ingelheim 2-eckige klammer auf n-(2'-chlor-4'- methyl-thienyl-3')-n-(cyclopropylmethyl)- amino eckige klammer zu-imidazolin-(2), dessen saeureadditionssalze, dieses enthaltende arzneimittel und verfahren zu seiner herstellung
DE2831143A1 (de) * 1978-07-15 1980-01-31 Boehringer Sohn Ingelheim Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
DE2831480A1 (de) * 1978-07-18 1980-01-31 Boehringer Sohn Ingelheim Neue substituierte 2-phenylamino- imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben

Also Published As

Publication number Publication date
ATE8260T1 (de) 1984-07-15
IL61769A (en) 1984-12-31
FI803969L (fi) 1981-06-22
FI63940B (fi) 1983-05-31
AU538931B2 (en) 1984-09-06
IE50588B1 (en) 1986-05-14
DK544980A (da) 1981-06-22
EP0031429A1 (de) 1981-07-08
FI63940C (fi) 1983-09-12
DE3068456D1 (en) 1984-08-09
DE2951601A1 (de) 1981-07-02
NO154091B (no) 1986-04-07
CA1143738A (en) 1983-03-29
NO154091C (no) 1986-07-16
EP0031429B1 (de) 1984-07-04
NZ195897A (en) 1984-07-06
JPS5697284A (en) 1981-08-05
US4478844A (en) 1984-10-23
ES497948A0 (es) 1982-02-01
AU6560280A (en) 1981-06-25
IL61769A0 (en) 1981-01-30
ZA807905B (en) 1982-08-25
IE802690L (en) 1981-06-21
NO803862L (no) 1981-06-22

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