DE69425250D1 - 1-phenyl-imidazol-2-on bipehenylmethyl verbindungen zur behandlung von kreislaufstörungen - Google Patents

1-phenyl-imidazol-2-on bipehenylmethyl verbindungen zur behandlung von kreislaufstörungen

Info

Publication number
DE69425250D1
DE69425250D1 DE69425250T DE69425250T DE69425250D1 DE 69425250 D1 DE69425250 D1 DE 69425250D1 DE 69425250 T DE69425250 T DE 69425250T DE 69425250 T DE69425250 T DE 69425250T DE 69425250 D1 DE69425250 D1 DE 69425250D1
Authority
DE
Germany
Prior art keywords
compounds
hydrogen
phenyl
alkyl
imidazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69425250T
Other languages
English (en)
Inventor
B Reitz
E Manning
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of DE69425250D1 publication Critical patent/DE69425250D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69425250T 1993-03-24 1994-03-08 1-phenyl-imidazol-2-on bipehenylmethyl verbindungen zur behandlung von kreislaufstörungen Expired - Lifetime DE69425250D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3631693A 1993-03-24 1993-03-24
PCT/US1994/002156 WO1994021629A1 (en) 1993-03-24 1994-03-08 1-phenyl-imidazol-2-one biphenylmethyl compounds for treatment of circulatory disorders

Publications (1)

Publication Number Publication Date
DE69425250D1 true DE69425250D1 (de) 2000-08-17

Family

ID=21887905

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69425250T Expired - Lifetime DE69425250D1 (de) 1993-03-24 1994-03-08 1-phenyl-imidazol-2-on bipehenylmethyl verbindungen zur behandlung von kreislaufstörungen

Country Status (10)

Country Link
US (2) US6630497B2 (de)
EP (2) EP0978515A3 (de)
JP (1) JPH08508249A (de)
KR (1) KR960701041A (de)
CN (1) CN1119861A (de)
AT (1) ATE194613T1 (de)
AU (1) AU6516994A (de)
CA (1) CA2156741A1 (de)
DE (1) DE69425250D1 (de)
WO (1) WO1994021629A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2156741A1 (en) * 1993-03-24 1994-09-29 David B. Reitz 1-phenyl-imidazol-2-one biphenylmethyl compounds for treatment of circulatory disorders
US20060258691A1 (en) * 2005-05-13 2006-11-16 Joseph Barbosa Methods and compositions for improving cognition
KR20080014775A (ko) 2005-05-13 2008-02-14 렉시컨 파마슈티컬스 인코퍼레이티드 다환 화합물 및 그의 사용 방법
TW200827345A (en) * 2006-11-07 2008-07-01 Lexicon Pharmaceuticals Inc (R)-phenyl(heterocycle)methanol-based compounds, compositions comprising them and methods of their use
TW200823193A (en) * 2006-11-07 2008-06-01 Lexicon Pharmaceuticals Inc (S)-phenyl(heterocycle)methanol-based compounds, compositions comprising them and methods of their use
US7803940B2 (en) 2006-11-24 2010-09-28 Takeda Pharmaceutical Company Limited Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases
TWI448284B (zh) 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
EP2297113A1 (de) 2008-04-29 2011-03-23 Theravance, Inc. Blutdrucksenkende mittel mit dualer wirkung
EP2334651A2 (de) * 2008-07-24 2011-06-22 Theravance, Inc. Blutdrucksenkende mittel mit dualer wirkung
TW201014830A (en) * 2008-09-30 2010-04-16 Theravance Inc Crystalline form of an alkoxyimidazol-1-ylmethyl biphenyl carboxylic acid
WO2011005674A1 (en) 2009-07-07 2011-01-13 Theravance, Inc. Dual-acting pyrazole antihypertensive agents
ES2441419T3 (es) 2009-07-22 2014-02-04 Theravance, Inc. Agentes antihipertensivos de doble acción basados en oxazol
JP2013517295A (ja) 2010-01-19 2013-05-16 セラヴァンス， インコーポレーテッド 二重に作用するチオフェン、ピロール、チアゾールおよびフラン抗高血圧症薬

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5087634A (en) * 1990-10-31 1992-02-11 G. D. Searle & Co. N-substituted imidazol-2-one compounds for treatment of circulatory disorders
US5238952A (en) * 1990-10-31 1993-08-24 G. D. Searle & Co. N-substituted imidazol-2-one compounds for treatment of circulatory disorders
US5164403A (en) * 1991-04-05 1992-11-17 G. D. Searle & Co. N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders
CA2156741A1 (en) * 1993-03-24 1994-09-29 David B. Reitz 1-phenyl-imidazol-2-one biphenylmethyl compounds for treatment of circulatory disorders

Also Published As

Publication number Publication date
EP0978515A3 (de) 2000-05-17
US20040048911A1 (en) 2004-03-11
EP0690854A1 (de) 1996-01-10
US6630497B2 (en) 2003-10-07
US20020038035A1 (en) 2002-03-28
ATE194613T1 (de) 2000-07-15
AU6516994A (en) 1994-10-11
JPH08508249A (ja) 1996-09-03
EP0978515A2 (de) 2000-02-09
CN1119861A (zh) 1996-04-03
WO1994021629A1 (en) 1994-09-29
US6858636B2 (en) 2005-02-22
EP0690854B1 (de) 2000-07-12
CA2156741A1 (en) 1994-09-29
KR960701041A (ko) 1996-02-24

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Legal Events

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