DE69715188T2 - Verfahren und zwischenprodukte zur herstellung von 4-trifluoromethylbiphenyl-2-carbonsaüre,(2-(2h-(1,2,4) triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide - Google Patents
Verfahren und zwischenprodukte zur herstellung von 4-trifluoromethylbiphenyl-2-carbonsaüre,(2-(2h-(1,2,4) triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amideInfo
- Publication number
- DE69715188T2 DE69715188T2 DE69715188T DE69715188T DE69715188T2 DE 69715188 T2 DE69715188 T2 DE 69715188T2 DE 69715188 T DE69715188 T DE 69715188T DE 69715188 T DE69715188 T DE 69715188T DE 69715188 T2 DE69715188 T2 DE 69715188T2
- Authority
- DE
- Germany
- Prior art keywords
- trifluoromethylbiphenyl
- isoquinolin
- triazol
- ylmethyl
- tetrahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1649596P | 1996-04-30 | 1996-04-30 | |
| PCT/IB1997/000254 WO1997041111A1 (en) | 1996-04-30 | 1997-03-13 | Processes and intermediates for preparing 4'-trifluoromethylbiphenyl-2-carboxylic acid [2-(2h-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl]-amide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69715188D1 DE69715188D1 (de) | 2002-10-10 |
| DE69715188T2 true DE69715188T2 (de) | 2003-01-02 |
Family
ID=21777423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69715188T Expired - Fee Related DE69715188T2 (de) | 1996-04-30 | 1997-03-13 | Verfahren und zwischenprodukte zur herstellung von 4-trifluoromethylbiphenyl-2-carbonsaüre,(2-(2h-(1,2,4) triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5998623A (de) |
| EP (1) | EP0902785B1 (de) |
| JP (1) | JPH11507959A (de) |
| KR (1) | KR20000065152A (de) |
| CN (1) | CN1216988A (de) |
| AR (1) | AR006876A1 (de) |
| AT (1) | ATE223400T1 (de) |
| AU (1) | AU711279B2 (de) |
| BR (1) | BR9709137A (de) |
| CA (1) | CA2252621C (de) |
| CZ (1) | CZ346498A3 (de) |
| DE (1) | DE69715188T2 (de) |
| DK (1) | DK0902785T3 (de) |
| ES (1) | ES2180935T3 (de) |
| HU (1) | HUP9902157A3 (de) |
| ID (1) | ID17294A (de) |
| IL (1) | IL126202A0 (de) |
| PL (1) | PL329739A1 (de) |
| PT (1) | PT902785E (de) |
| TR (1) | TR199802163T2 (de) |
| WO (1) | WO1997041111A1 (de) |
| YU (1) | YU16297A (de) |
| ZA (1) | ZA973696B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197798B1 (en) | 1998-07-21 | 2001-03-06 | Novartis Ag | Amino-benzocycloalkane derivatives |
| IL139450A0 (en) * | 1999-11-10 | 2001-11-25 | Pfizer Prod Inc | Methods of administering apo b-secretion/mtp inhibitors |
| CA2324801A1 (en) * | 1999-11-10 | 2001-05-10 | Andrew Gordon Swick | Use of apo b secretion/mtp inhibitors and anti-obesity agents |
| IL139449A0 (en) * | 1999-11-10 | 2001-11-25 | Pfizer Prod Inc | Use of apo b secretion/mtp inhibitors |
| CA2324800A1 (en) * | 1999-11-10 | 2001-05-10 | Mary Anne Hickman | Use of apo b secretion/mtp inhibitors |
| PT1259484E (pt) * | 2000-01-18 | 2005-09-30 | Novartis Ag | Carboxamidas uteis como inibidores de proteina de transferencia de triglicerido microsomal e de secrecao de apolipoproteina b |
| AU2001277728A1 (en) * | 2000-08-10 | 2002-02-25 | Tanabe Seiyaku Co., Ltd. | Biphenylcarboxamidoisoindoline compounds, processes for the preparation of the same and intermediates for the synthesis thereof |
| AU2001277727A1 (en) * | 2000-08-10 | 2002-02-25 | Tanabe Seiyaku Co., Ltd. | Benzoylaminoisoindoline compounds, processes for the preparation of the same andintermediates for the synthesis thereof |
| ES2399721T5 (es) | 2004-03-05 | 2016-05-25 | Univ Pennsylvania | Métodos para tratar trastornos o enfermedades asociados a la hiperlipidemia e hipercolesterolemia minimizando los efectos adversos |
| WO2008075949A1 (en) * | 2006-12-20 | 2008-06-26 | Friesland Brands B.V. | Modulation of human microsomal triglyceride transfer protein (mtp or mttp) gene expression by food-grade/ingested dietary microorganisms |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU218419B (hu) * | 1992-03-06 | 2000-08-28 | E.R. Squibb And Sons, Inc. | Mikroszomális triglicerid transzfer protein (MTP) nagy molekulatömegű alegységének rekombináns úton történő előállítására és a protein és inhibitorainak kimutatására szolgáló eljárások |
| US5595872A (en) * | 1992-03-06 | 1997-01-21 | Bristol-Myers Squibb Company | Nucleic acids encoding microsomal trigyceride transfer protein |
| IL110172A (en) * | 1993-07-22 | 2001-10-31 | Lilly Co Eli | Bicycle compounds and pharmaceuticals containing them |
| DK0832069T3 (da) * | 1995-06-07 | 2003-04-22 | Pfizer | Biphenyl-2-carboxylsyre-tetrahydroisoquinolin-6-ylamidderivater, deres fremstilling og deres anvendelse som inhibitorer af sekretion af mikrosomalt triglyceridoverførselsprotein og/eller apolipoprotein B (Apo B) |
| EP0832069B1 (de) * | 1995-06-07 | 2003-03-05 | Pfizer Inc. | Biphenyl-2-carbonsäure-tetrahydro-isochinolin-6-yl amid derivate, deren hestellung und deren verwendung als inhibitoren des mikrosomalen triglycerid-transfer-proteins und/oder der apolipoprotein b (apo b) sekretion |
-
1997
- 1997-03-13 EP EP97905354A patent/EP0902785B1/de not_active Expired - Lifetime
- 1997-03-13 ES ES97905354T patent/ES2180935T3/es not_active Expired - Lifetime
- 1997-03-13 CZ CZ983464A patent/CZ346498A3/cs unknown
- 1997-03-13 PT PT97905354T patent/PT902785E/pt unknown
- 1997-03-13 WO PCT/IB1997/000254 patent/WO1997041111A1/en active IP Right Grant
- 1997-03-13 US US09/147,197 patent/US5998623A/en not_active Expired - Fee Related
- 1997-03-13 AT AT97905354T patent/ATE223400T1/de not_active IP Right Cessation
- 1997-03-13 HU HU9902157A patent/HUP9902157A3/hu unknown
- 1997-03-13 AU AU22266/97A patent/AU711279B2/en not_active Ceased
- 1997-03-13 JP JP9538686A patent/JPH11507959A/ja active Pending
- 1997-03-13 BR BR9709137A patent/BR9709137A/pt not_active Application Discontinuation
- 1997-03-13 KR KR1019980708760A patent/KR20000065152A/ko not_active Application Discontinuation
- 1997-03-13 CN CN97194209A patent/CN1216988A/zh active Pending
- 1997-03-13 DE DE69715188T patent/DE69715188T2/de not_active Expired - Fee Related
- 1997-03-13 IL IL12620297A patent/IL126202A0/xx unknown
- 1997-03-13 PL PL97329739A patent/PL329739A1/xx unknown
- 1997-03-13 DK DK97905354T patent/DK0902785T3/da active
- 1997-03-13 TR TR1998/02163T patent/TR199802163T2/xx unknown
- 1997-03-13 CA CA002252621A patent/CA2252621C/en not_active Expired - Fee Related
- 1997-04-25 AR ARP970101731A patent/AR006876A1/es unknown
- 1997-04-28 ID IDP971403A patent/ID17294A/id unknown
- 1997-04-29 YU YU16297A patent/YU16297A/sh unknown
- 1997-04-29 ZA ZA973696A patent/ZA973696B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT902785E (pt) | 2002-12-31 |
| IL126202A0 (en) | 1999-05-09 |
| JPH11507959A (ja) | 1999-07-13 |
| AR006876A1 (es) | 1999-09-29 |
| ID17294A (id) | 1997-12-18 |
| EP0902785A1 (de) | 1999-03-24 |
| DK0902785T3 (da) | 2002-10-07 |
| YU16297A (sh) | 1999-09-27 |
| HUP9902157A2 (hu) | 2000-04-28 |
| HUP9902157A3 (en) | 2000-07-28 |
| BR9709137A (pt) | 1999-08-03 |
| ES2180935T3 (es) | 2003-02-16 |
| CN1216988A (zh) | 1999-05-19 |
| CZ346498A3 (cs) | 1999-09-15 |
| KR20000065152A (ko) | 2000-11-06 |
| ZA973696B (en) | 1998-10-29 |
| PL329739A1 (en) | 1999-04-12 |
| CA2252621A1 (en) | 1997-11-06 |
| TR199802163T2 (xx) | 1999-02-22 |
| DE69715188D1 (de) | 2002-10-10 |
| US5998623A (en) | 1999-12-07 |
| AU2226697A (en) | 1997-11-19 |
| AU711279B2 (en) | 1999-10-07 |
| CA2252621C (en) | 2002-09-03 |
| EP0902785B1 (de) | 2002-09-04 |
| ATE223400T1 (de) | 2002-09-15 |
| WO1997041111A1 (en) | 1997-11-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |