KR830005157A - 페녹시-아미노프로판올 유도체의 제조방법 - Google Patents

페녹시-아미노프로판올 유도체의 제조방법 Download PDF

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Publication number
KR830005157A
KR830005157A KR1019810000622A KR810000622A KR830005157A KR 830005157 A KR830005157 A KR 830005157A KR 1019810000622 A KR1019810000622 A KR 1019810000622A KR 810000622 A KR810000622 A KR 810000622A KR 830005157 A KR830005157 A KR 830005157A
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general formula
atom
formula
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ethylene
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KR1019810000622A
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KR840002089B1 (ko
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제임스 마쉰 페러
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쿠르트 네셀보쉬, 한스 스튜크린
에프 호프만 라 롯슈 앤드 캄파니
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Publication of KR830005157A publication Critical patent/KR830005157A/ko
Priority to KR1019840005796A priority Critical patent/KR840002069B1/ko
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Publication of KR840002089B1 publication Critical patent/KR840002089B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

페녹시-아미노프로판올 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. (a) 일반식(Ⅱ)의 에폭사이드를 일반식(Ⅲ)의 아민과 반응시키거나
    (b) 일반식(Ⅳ)의 페놀의 알카리 금속유도체를 일반식(Ⅴ)의 화합물과 반응시켜
    X가 산소원자이고 n이 1의 정수이며
    Y가 메틸렌, 에틸렌 또는 프로필렌그룹인 일반식(Ⅰ)의 화합물을 제조하거나,
    (c) 필요시 일반식(Ⅰ)의 라세미체를 광학적 이성체로 용해시키거나
    (d) 필요시 일반식(Ⅰ)의 화합물을 약학적으로 무독한 그의 산부가염으로 전환시켜 일반식(Ⅰ)의 치환된 펜옥시-아미노프로판올 유도체 및 약학적으로 무독한 이의 산부가염을 제조하는 방법.
    상기 구조식에서
    R은 저급알킬그룹이고
    X는 산소 또는 유황원자이고
    n은 0 또는 1의 정수이고
    Y는 메틸렌, 에틸렌 또는 프로필렌그룹이며
    n이 0인 경우 Y는
    구조식(a)-CH=CH-(여기에서 이중결합은 트랜스이고 *표로 된 탄소원자는 Z에 연결되어 있으며 Z는 유일한 이종원자로서 1개 또는 그이상의 질소원자를 함유하는 5원인 방향족 복소환이며 이종원자는 질소원자를 통하여 Y에 연결되어 있으며 이는 할로겐 또는 저급알킬, 저급알콕시, 아릴, 시아노 또는 카복스아미도그룹 또는 인접탄소원자임)그룹을 나타내거나
    또는를
    나타내고
    R'은 이탈원자 또는 그룹을 나타내며
    Y'는 메틸렌, 에틸렌 또는 프로필렌그룹을 나타낸다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019810000622A 1980-02-25 1981-02-25 치환된 펜옥시-아미노프로판올 유도체의 제조방법 KR840002089B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019840005796A KR840002069B1 (ko) 1980-02-25 1984-09-21 치환된 펜옥시-아미노 프로판올 유도체의 제조방법

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8006261 1980-02-25
GB8006261 1980-02-25

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019840005796A Division KR840002069B1 (ko) 1980-02-25 1984-09-21 치환된 펜옥시-아미노 프로판올 유도체의 제조방법

Publications (2)

Publication Number Publication Date
KR830005157A true KR830005157A (ko) 1983-08-03
KR840002089B1 KR840002089B1 (ko) 1984-11-14

Family

ID=10511646

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019810000622A KR840002089B1 (ko) 1980-02-25 1981-02-25 치환된 펜옥시-아미노프로판올 유도체의 제조방법
KR1019840005796A KR840002069B1 (ko) 1980-02-25 1984-09-21 치환된 펜옥시-아미노 프로판올 유도체의 제조방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019840005796A KR840002069B1 (ko) 1980-02-25 1984-09-21 치환된 펜옥시-아미노 프로판올 유도체의 제조방법

Country Status (3)

Country Link
JP (1) JPS56133270A (ko)
KR (2) KR840002089B1 (ko)
ZA (1) ZA811085B (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01125372A (ja) * 1988-09-12 1989-05-17 Yamanouchi Pharmaceut Co Ltd イミダゾリルアルキルオキシベンゼン誘導体

Also Published As

Publication number Publication date
ZA811085B (en) 1982-03-31
KR840002089B1 (ko) 1984-11-14
KR840002069B1 (ko) 1984-11-09
JPS56133270A (en) 1981-10-19

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