KR840009092A - 벤조푸란-또는 벤조피란-카르복사미드 유도체의 제조방법 - Google Patents

벤조푸란-또는 벤조피란-카르복사미드 유도체의 제조방법 Download PDF

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Publication number
KR840009092A
KR840009092A KR1019840001850A KR840001850A KR840009092A KR 840009092 A KR840009092 A KR 840009092A KR 1019840001850 A KR1019840001850 A KR 1019840001850A KR 840001850 A KR840001850 A KR 840001850A KR 840009092 A KR840009092 A KR 840009092A
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KR
South Korea
Prior art keywords
group
lower alkyl
hydrogen atom
alkyl group
benzopyran
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KR1019840001850A
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English (en)
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KR910002883B1 (ko
Inventor
데쯔야(외3) 다하라
Original Assignee
원본미기재
요시또미세이야꾸 가부시기 가이샤
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Publication of KR840009092A publication Critical patent/KR840009092A/ko
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Publication of KR910002883B1 publication Critical patent/KR910002883B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

내용 없음

Description

벤조파란-또는 벤조피란-카르복사미드 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 하기 일반식(Ⅱ)의 카르복시산 또는 그의 반응성 유도체와 하기 일반식(Ⅲ)의 화합물을 반응시킴을 특징으로 하는 하기 일반식(I)의 벤조푸란-또는 벤조피란-카르복사미드 유도체, 그들의 생리학적으로 허용된 염 또는 그들의 광학 이성체의 제조방법.
    상기 식중, ι은 1또는 2이고, X는 수소원자, 아미조기 또는 할로겐원자이며, Y는 -S(O)mR-3(여기서 R3는 저급알킬이고 m은 , 0,1또는 2이다)또는--(여기서 R5및 R4는 동일하거나 상이하며 각각 수소원자 또는 저급알킬기이다)이고, R1은 수소원자, 저급알킬기, 아릴티오메틸기, 할로게노메틸기 또는(여기서 R6및 R7는 동일하거나 상이하며 각각 수소원자 또는 저급알킬기이거나 또는 R6및 R7은 인접한 질소원자와 함께 헤테로사이클을 형성한다)이며, R2는 수소원자 또는 저급알킬이고, Z는(여기서 p는 2 또는 3 이고, R8및 R9는 동일하거나 상이하며 각각 저급알킬기이거나 또는R8및 R9은 인접한 질소원자와 함께 헤테로사이클을 형성한다) 또는
    (여기서 q는 0 또는 1이고, n은 1또는 2이며, R10은 저급알킬기, 저급알케닐기, 저급알키닐기, 아르알킬기 또는 시클로알킬기이고, R11은 수소원자 또는 저급알킬기이다)이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840001850A 1983-04-08 1984-04-07 벤조푸란-또는 벤조피란-카르복사미드 유도체의 제조방법 KR910002883B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP58062554A JPS59186969A (ja) 1983-04-08 1983-04-08 ベンゾフラン−およびベンゾピランカルボキサミド誘導体
JP62554 1983-04-08

Publications (2)

Publication Number Publication Date
KR840009092A true KR840009092A (ko) 1984-12-24
KR910002883B1 KR910002883B1 (ko) 1991-05-09

Family

ID=13203591

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840001850A KR910002883B1 (ko) 1983-04-08 1984-04-07 벤조푸란-또는 벤조피란-카르복사미드 유도체의 제조방법

Country Status (8)

Country Link
US (1) US4617314A (ko)
EP (1) EP0124783B1 (ko)
JP (1) JPS59186969A (ko)
KR (1) KR910002883B1 (ko)
AT (1) ATE31307T1 (ko)
CA (1) CA1238906A (ko)
DE (1) DE3468024D1 (ko)
ES (1) ES531121A0 (ko)

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US5122528A (en) * 1983-12-22 1992-06-16 Erbamont, Inc. Analgesic use of benzobicyclic carboxamides
CA1297877C (en) * 1983-12-22 1992-03-24 Daniel Lednicer Benzofurancarboxamides useful as antiemetic or antipsychotic agents
US4888353A (en) * 1986-02-28 1989-12-19 Erbamont, Inc. Carboxamides useful as antiemetic or antipsychotic agents
SE8503055D0 (sv) * 1985-06-19 1985-06-19 Astra Laekemedel Ab Piperonylcarboxamido derivatives
FR2593504B1 (fr) * 1986-01-30 1988-12-09 Ile De France Nouveaux derives de dihydrobenzofuranne - et de chromane - carboxamides, leurs procedes de preparation et leur utilisation comme neuroleptiques
JPS62234083A (ja) * 1986-02-28 1987-10-14 アーバモント　インク　ディビーエイ　アドリヤ　ラボラトリーズ 鎮吐薬または精神病治療薬として有用なカルボキサミド類
US4772459A (en) * 1986-09-09 1988-09-20 Erbamont, Inc. Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein
DE3724756A1 (de) * 1987-07-25 1989-02-09 Basf Ag Basisch substituierte benzofurancarbonsaeureamide, verfahren zu ihrer herstellung und sie enthaltende therapeutische mittel
EP0314483A1 (en) * 1987-10-29 1989-05-03 Erbamont, Inc. Preparation of benzamides
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
US5122361A (en) * 1989-04-17 1992-06-16 Trustees Of The University Of Pennsylvania Dopamine receptor ligands and imaging agents
GB9005014D0 (en) 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
NZ246915A (en) * 1992-02-06 1996-05-28 Smithkline Beecham Plc Benzopyran, benzothiopyran and benzofuran derivatives, preparation and pharmaceutical compositions thereof
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US7728155B2 (en) 2003-10-24 2010-06-01 Wyeth Llc Dihydrobenzofuranyl alkanamines and methods for using same as cns agents
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NL281394A (ko) * 1961-07-25
US3342826A (en) * 1964-01-13 1967-09-19 Ile De France Heterocyclic aminoalkyl benzamides
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Also Published As

Publication number Publication date
KR910002883B1 (ko) 1991-05-09
JPS59186969A (ja) 1984-10-23
ES8507135A1 (es) 1985-09-01
EP0124783B1 (en) 1987-12-09
DE3468024D1 (de) 1988-01-21
US4617314A (en) 1986-10-14
JPS6119630B2 (ko) 1986-05-17
CA1238906A (en) 1988-07-05
ES531121A0 (es) 1985-09-01
EP0124783A1 (en) 1984-11-14
ATE31307T1 (de) 1987-12-15

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