BE900718A - Nouveaux derives du carbapeneme, leur preparation et leur utilisation comme medicaments. - Google Patents

Nouveaux derives du carbapeneme, leur preparation et leur utilisation comme medicaments.

Info

Publication number
BE900718A
BE900718A BE1/11108A BE1011108A BE900718A BE 900718 A BE900718 A BE 900718A BE 1/11108 A BE1/11108 A BE 1/11108A BE 1011108 A BE1011108 A BE 1011108A BE 900718 A BE900718 A BE 900718A
Authority
BE
Belgium
Prior art keywords
medicaments
carbapenemic
derivatives
preparation
new
Prior art date
Application number
BE1/11108A
Other languages
English (en)
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Publication of BE900718A publication Critical patent/BE900718A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Les composés de formule (I) dans laquelle R1 représente l'hydrogène ou un groupe méthyle, R2 représente l'hydrogène ou un reste hydrocarboné éventuellement substitué, R3 représente l'hydrogène ou un groupe alkyle et R4 représente un groupe alkyle. Ces composés sont indiqués pour une utilisation comme médicaments, en particulier comme antibiotiques à activité antibactérienne.
BE1/11108A 1983-10-03 1984-10-01 Nouveaux derives du carbapeneme, leur preparation et leur utilisation comme medicaments. BE900718A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH5363/83A CH660736A5 (de) 1983-10-03 1983-10-03 Carbapenemderivate.

Publications (1)

Publication Number Publication Date
BE900718A true BE900718A (fr) 1985-04-01

Family

ID=4292307

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1/11108A BE900718A (fr) 1983-10-03 1984-10-01 Nouveaux derives du carbapeneme, leur preparation et leur utilisation comme medicaments.

Country Status (24)

Country Link
US (1) US4720491A (fr)
JP (2) JPS60105676A (fr)
KR (1) KR910009290B1 (fr)
AT (1) AT386204B (fr)
AU (1) AU3376084A (fr)
BE (1) BE900718A (fr)
CA (1) CA1241656A (fr)
CH (2) CH662117A5 (fr)
DE (1) DE3434504A1 (fr)
DK (1) DK470684A (fr)
ES (1) ES8706680A1 (fr)
FI (1) FI843847L (fr)
FR (1) FR2552763B1 (fr)
GB (1) GB2147298B (fr)
GR (1) GR80515B (fr)
HU (1) HUT36478A (fr)
IL (1) IL73127A0 (fr)
IT (1) IT1199203B (fr)
LU (1) LU85570A1 (fr)
NL (1) NL8402936A (fr)
PL (1) PL249834A1 (fr)
PT (1) PT79293B (fr)
SE (1) SE462493B (fr)
ZA (1) ZA847781B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0464900A2 (fr) 1990-06-26 1992-01-08 Merck & Co. Inc. 2-Biphényl-carbapénèmes
EP0480712A1 (fr) 1990-10-11 1992-04-15 Merck & Co. Inc. 2-(Substitué-dibenzofuranyl- et dibenzothiényl)-carbapénèmes comme agents antibactériens

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60202886A (ja) * 1984-03-27 1985-10-14 Sankyo Co Ltd １―置換カルバペネム―３―カルボン酸誘導体
EP0234484B1 (fr) * 1986-02-19 1993-10-20 Sanraku Incorporated Dérivés de l'azétidinone

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4312871A (en) * 1979-12-03 1982-01-26 Merck & Co., Inc. 6-, 1- And 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids
PT73791B (en) * 1980-10-17 1983-10-14 Merck & Co Inc Process for preparing 2-carbamimidoyl-6-substituted-1- -carbadethiapen-2-em-3-carboxylic acids
ES514240A0 (es) * 1981-08-03 1984-04-16 Merck & Co Inc Un procedimiento para la prepracion de nuevos derivados de acidos 2-carbamimidoil-1-,carbadestiapen-2-en-3-carboxilados.
FI832619A (fi) * 1982-07-26 1984-01-27 Sandoz Ag Fluoralkylerade karbapenemderivat

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0464900A2 (fr) 1990-06-26 1992-01-08 Merck & Co. Inc. 2-Biphényl-carbapénèmes
EP0480712A1 (fr) 1990-10-11 1992-04-15 Merck & Co. Inc. 2-(Substitué-dibenzofuranyl- et dibenzothiényl)-carbapénèmes comme agents antibactériens

Also Published As

Publication number Publication date
ATA311584A (de) 1987-12-15
HUT36478A (en) 1985-09-30
GB2147298B (en) 1988-01-13
GB2147298A (en) 1985-05-09
IT8448934A1 (it) 1986-04-02
DE3434504A1 (de) 1985-04-18
JPH04364183A (ja) 1992-12-16
IL73127A0 (en) 1984-12-31
DK470684A (da) 1985-04-04
SE8404906L (sv) 1985-04-04
JPH0670059B2 (ja) 1994-09-07
FI843847A0 (fi) 1984-10-01
NL8402936A (nl) 1985-05-01
GB8424708D0 (en) 1984-11-07
CH662117A5 (de) 1987-09-15
PT79293A (en) 1984-11-01
SE8404906D0 (sv) 1984-10-01
IT1199203B (it) 1988-12-30
ES536443A0 (es) 1987-07-01
AT386204B (de) 1988-07-25
KR850002983A (ko) 1985-05-28
CH660736A5 (de) 1987-06-15
GR80515B (en) 1985-01-28
JPS60105676A (ja) 1985-06-11
US4720491A (en) 1988-01-19
JPH0564153B2 (fr) 1993-09-14
FI843847L (fi) 1985-04-04
PT79293B (en) 1986-09-10
IT8448934A0 (it) 1984-10-02
PL249834A1 (en) 1985-12-03
SE462493B (sv) 1990-07-02
ES8706680A1 (es) 1987-07-01
FR2552763B1 (fr) 1987-01-09
DK470684D0 (da) 1984-10-01
FR2552763A1 (fr) 1985-04-05
LU85570A1 (fr) 1985-06-19
ZA847781B (en) 1986-05-28
AU3376084A (en) 1985-04-18
CA1241656A (fr) 1988-09-06
KR910009290B1 (ko) 1991-11-09

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Legal Events

Date Code Title Description
CH Change of patent owner

Owner name: *SANKARU INC.

Effective date: 19840901

RE Patent lapsed

Owner name: MERCIAN CORP.

Effective date: 19921031