BE902600A - Derives de naphtoxazine, leur preparation, leur application comme medicaments et compositions pharmaceutiques les contenant. - Google Patents

Derives de naphtoxazine, leur preparation, leur application comme medicaments et compositions pharmaceutiques les contenant.

Info

Publication number
BE902600A
BE902600A BE1/011270A BE1011270A BE902600A BE 902600 A BE902600 A BE 902600A BE 1/011270 A BE1/011270 A BE 1/011270A BE 1011270 A BE1011270 A BE 1011270A BE 902600 A BE902600 A BE 902600A
Authority
BE
Belgium
Prior art keywords
naphtoxazine
medicaments
derivatives
preparation
application
Prior art date
Application number
BE1/011270A
Other languages
English (en)
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Publication of BE902600A publication Critical patent/BE902600A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Des 3,4,4a,5,10,10a-hexahydro-2H-naphto(2,3-b)-1,4-oxazines à activité psychostimulante et/ou anti-dépressive, en particulier les composés de formule I dans laquelle R1 et R2 signifient l'hydrogène ou un groupe alkyle, R3 signifie un groupe hydroxy ou alcoxy et R4 signifie le chlore, le brome ou l'iode ou un groupe trifluorométhyle, alkylthio, alkylsulfinyle ou alkylsulfonyle. Ces composés peuvent etre utilisés comme médicaments.
BE1/011270A 1984-06-12 1985-06-06 Derives de naphtoxazine, leur preparation, leur application comme medicaments et compositions pharmaceutiques les contenant. BE902600A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3421729 1984-06-12
DE3508263 1985-03-08

Publications (1)

Publication Number Publication Date
BE902600A true BE902600A (fr) 1985-12-06

Family

ID=25822036

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1/011270A BE902600A (fr) 1984-06-12 1985-06-06 Derives de naphtoxazine, leur preparation, leur application comme medicaments et compositions pharmaceutiques les contenant.

Country Status (28)

Country Link
US (1) US4656167A (fr)
JP (1) JPS611676A (fr)
AT (1) AT394717B (fr)
AU (1) AU582751B2 (fr)
BE (1) BE902600A (fr)
CA (1) CA1285561C (fr)
CH (1) CH666031A5 (fr)
CY (1) CY1581A (fr)
DE (1) DE3520104C2 (fr)
DK (1) DK172306B1 (fr)
ES (1) ES8704469A1 (fr)
FI (1) FI86301C (fr)
FR (1) FR2565586B1 (fr)
GB (1) GB2160200B (fr)
GR (1) GR851418B (fr)
HK (1) HK11891A (fr)
HU (1) HU193979B (fr)
IE (1) IE58398B1 (fr)
IL (1) IL75468A (fr)
IT (1) IT1200079B (fr)
LU (1) LU85941A1 (fr)
MY (1) MY102059A (fr)
NL (1) NL194166C (fr)
NZ (1) NZ212358A (fr)
PH (1) PH23666A (fr)
PT (1) PT80634B (fr)
SE (1) SE465428B (fr)
SG (1) SG9691G (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8616669D0 (en) * 1986-07-09 1986-08-13 Merk Sharpe & Dohme Ltd Pharmaceutical compositions
US5071875A (en) * 1989-09-25 1991-12-10 Northwestern University Substituted 2-amidotetralins as melatonin agonists and antagonists
HU214591B (hu) * 1989-12-14 1998-04-28 Novartis Ag. Eljárás egy naftoxazinszármazék malonátsójának és az ilyen hatóanyagot tartalmazó gyógyszerkészítmények előállítására
DE4329776A1 (de) * 1993-09-03 1995-03-09 Sandoz Ag Naphthoxazine, ihre Herstellung und Verwendung
TW357143B (en) * 1995-07-07 1999-05-01 Novartis Ag Benzo[g]quinoline derivatives
CN102131790A (zh) * 2008-06-27 2011-07-20 H.隆德贝克有限公司 新型苯酚型和儿茶酚型胺及其前药

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2194421B1 (fr) * 1972-08-03 1975-10-17 Cerpha
AU521527B2 (en) * 1979-09-12 1982-04-08 Dow Chemical Company, The Dehydrohalogenation of (polyhaloalkyl) benzenes
US4368201A (en) * 1981-07-20 1983-01-11 Usv Pharmaceutical Corporation Tetrahydronaphthoxazoles
US4420480A (en) * 1981-11-20 1983-12-13 Merck & Co., Inc. Hexahydronaphth[1,2-b]-1,4-oxazines
CA1204745A (fr) * 1981-11-20 1986-05-20 Merck Co. Hexahydronapht-(1,2-b)-1,4-oxazines
DE4003262A1 (de) * 1990-02-03 1991-08-08 Sandoz Ag Neues naphthoxazin, seine herstellung und verwendung

Also Published As

Publication number Publication date
CA1285561C (fr) 1991-07-02
DE3520104A1 (de) 1985-12-12
GB2160200A (en) 1985-12-18
FR2565586B1 (fr) 1989-09-15
ES8704469A1 (es) 1987-04-01
NL194166B (nl) 2001-04-02
IL75468A0 (en) 1985-10-31
NL8501526A (nl) 1986-01-02
AT394717B (de) 1992-06-10
LU85941A1 (fr) 1986-01-24
IT8548195A0 (it) 1985-06-11
FI852325A0 (fi) 1985-06-11
PT80634A (en) 1985-07-01
HU193979B (en) 1987-12-28
IT1200079B (it) 1989-01-05
SE8502865D0 (sv) 1985-06-10
MY102059A (en) 1992-03-31
SG9691G (en) 1991-04-05
DK172306B1 (da) 1998-03-09
DE3520104C2 (de) 1997-01-23
CY1581A (en) 1992-04-03
IE851437L (en) 1985-12-12
FI852325L (fi) 1985-12-13
DK259185D0 (da) 1985-06-10
SE465428B (sv) 1991-09-09
CH666031A5 (de) 1988-06-30
IL75468A (en) 1989-05-15
DK259185A (da) 1985-12-13
FI86301C (fi) 1992-08-10
ES544074A0 (es) 1987-04-01
HK11891A (en) 1991-02-22
PH23666A (en) 1989-09-27
GB2160200B (en) 1988-03-16
PT80634B (pt) 1987-10-20
US4656167A (en) 1987-04-07
GR851418B (fr) 1985-11-25
FI86301B (fi) 1992-04-30
HUT39438A (en) 1986-09-29
NL194166C (nl) 2001-08-03
NZ212358A (en) 1989-01-27
JPS611676A (ja) 1986-01-07
SE8502865L (sv) 1985-12-13
GB8514636D0 (en) 1985-07-10
AU4345885A (en) 1985-12-19
IE58398B1 (en) 1993-09-08
JPH0576472B2 (fr) 1993-10-22
FR2565586A1 (fr) 1985-12-13
ATA172385A (de) 1991-11-15
AU582751B2 (en) 1989-04-13

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Legal Events

Date Code Title Description
RE Patent lapsed

Effective date: 20030630