ES8704469A1 - Procedimiento para preparar naftoxacinas - Google Patents

Procedimiento para preparar naftoxacinas

Info

Publication number
ES8704469A1
ES8704469A1 ES544074A ES544074A ES8704469A1 ES 8704469 A1 ES8704469 A1 ES 8704469A1 ES 544074 A ES544074 A ES 544074A ES 544074 A ES544074 A ES 544074A ES 8704469 A1 ES8704469 A1 ES 8704469A1
Authority
ES
Spain
Prior art keywords
psychostimulating
naphthoxazines
antidepressant agents
antidepressant
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544074A
Other languages
English (en)
Other versions
ES544074A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES544074A0 publication Critical patent/ES544074A0/es
Publication of ES8704469A1 publication Critical patent/ES8704469A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE NAFTOXACINAS. CONSISTENTE EN LA OBTENCION DE UN COMPUESTO DE FORMULA (I), EN LA QUE R1 Y R2 SON HIDROGENO O ALQUILO (C1-C4); R3 ES HIDROXI O ALCOXI (C1-C4); Y R4 ES ALQUILTIO (C1-C4) SULFONA, CLORO, BROMO, IODO O TRIFLUOROMETILO. MEDIANTE INTRODUCCION DE UN RESTO AMINOETILENOXI EN LA POSICION 2,3 DE UNA 1,4-DIHIDRO-NAFTALINA; O REDUCCION DE UNA 2,4,4A,5,10,10A-HEXAHIDRO-3H-NAFT(2,3-B)-1,4-OXACIN-3-ONA EN POSICION 3; O ALQUILACION DE UNA 3,4,4A,5,10,10A-HEXAHIDRO-2H-NAFT(2,3-B)-1,4-OXACINA EN POSICION 4; O TRANSFORMACION DE UNA 3,4,4A,5,10,10A-HEXAHIDRO-2H-NAFT(2,3-B)-1,4-OXACINA. DE APLICACION POR SU ACTIVIDAD PSICOESTIMULADORA Y ANTIDEPRIMENTE.
ES544074A 1984-06-12 1985-06-12 Procedimiento para preparar naftoxacinas Expired ES8704469A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3421729 1984-06-12
DE3508263 1985-03-08

Publications (2)

Publication Number Publication Date
ES544074A0 ES544074A0 (es) 1987-04-01
ES8704469A1 true ES8704469A1 (es) 1987-04-01

Family

ID=25822036

Family Applications (1)

Application Number Title Priority Date Filing Date
ES544074A Expired ES8704469A1 (es) 1984-06-12 1985-06-12 Procedimiento para preparar naftoxacinas

Country Status (28)

Country Link
US (1) US4656167A (es)
JP (1) JPS611676A (es)
AT (1) AT394717B (es)
AU (1) AU582751B2 (es)
BE (1) BE902600A (es)
CA (1) CA1285561C (es)
CH (1) CH666031A5 (es)
CY (1) CY1581A (es)
DE (1) DE3520104C2 (es)
DK (1) DK172306B1 (es)
ES (1) ES8704469A1 (es)
FI (1) FI86301C (es)
FR (1) FR2565586B1 (es)
GB (1) GB2160200B (es)
GR (1) GR851418B (es)
HK (1) HK11891A (es)
HU (1) HU193979B (es)
IE (1) IE58398B1 (es)
IL (1) IL75468A (es)
IT (1) IT1200079B (es)
LU (1) LU85941A1 (es)
MY (1) MY102059A (es)
NL (1) NL194166C (es)
NZ (1) NZ212358A (es)
PH (1) PH23666A (es)
PT (1) PT80634B (es)
SE (1) SE465428B (es)
SG (1) SG9691G (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8616669D0 (en) * 1986-07-09 1986-08-13 Merk Sharpe & Dohme Ltd Pharmaceutical compositions
US5071875A (en) * 1989-09-25 1991-12-10 Northwestern University Substituted 2-amidotetralins as melatonin agonists and antagonists
HU214591B (hu) * 1989-12-14 1998-04-28 Novartis Ag. Eljárás egy naftoxazinszármazék malonátsójának és az ilyen hatóanyagot tartalmazó gyógyszerkészítmények előállítására
DE4329776A1 (de) * 1993-09-03 1995-03-09 Sandoz Ag Naphthoxazine, ihre Herstellung und Verwendung
TW357143B (en) * 1995-07-07 1999-05-01 Novartis Ag Benzo[g]quinoline derivatives
WO2009156458A1 (en) * 2008-06-27 2009-12-30 H. Lundbeck A/S Novel phenolic and catecholic amines and prodrugs thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2194421B1 (es) * 1972-08-03 1975-10-17 Cerpha
AU521527B2 (en) * 1979-09-12 1982-04-08 Dow Chemical Company, The Dehydrohalogenation of (polyhaloalkyl) benzenes
US4368201A (en) * 1981-07-20 1983-01-11 Usv Pharmaceutical Corporation Tetrahydronaphthoxazoles
US4420480A (en) * 1981-11-20 1983-12-13 Merck & Co., Inc. Hexahydronaphth[1,2-b]-1,4-oxazines
CA1204745A (en) * 1981-11-20 1986-05-20 Merck Co. Hexahydronaphth (1,2-b) -1,4 -oxazines
DE4003262A1 (de) * 1990-02-03 1991-08-08 Sandoz Ag Neues naphthoxazin, seine herstellung und verwendung

Also Published As

Publication number Publication date
SG9691G (en) 1991-04-05
FI86301C (fi) 1992-08-10
CH666031A5 (de) 1988-06-30
PT80634A (en) 1985-07-01
ES544074A0 (es) 1987-04-01
PH23666A (en) 1989-09-27
IE58398B1 (en) 1993-09-08
FR2565586B1 (fr) 1989-09-15
AT394717B (de) 1992-06-10
GR851418B (es) 1985-11-25
JPH0576472B2 (es) 1993-10-22
GB8514636D0 (en) 1985-07-10
FI852325L (fi) 1985-12-13
DE3520104A1 (de) 1985-12-12
FI852325A0 (fi) 1985-06-11
FR2565586A1 (fr) 1985-12-13
NL194166C (nl) 2001-08-03
IL75468A (en) 1989-05-15
DK172306B1 (da) 1998-03-09
SE8502865D0 (sv) 1985-06-10
LU85941A1 (fr) 1986-01-24
HU193979B (en) 1987-12-28
HK11891A (en) 1991-02-22
DK259185A (da) 1985-12-13
FI86301B (fi) 1992-04-30
AU4345885A (en) 1985-12-19
IE851437L (en) 1985-12-12
BE902600A (fr) 1985-12-06
JPS611676A (ja) 1986-01-07
NL194166B (nl) 2001-04-02
GB2160200A (en) 1985-12-18
SE8502865L (sv) 1985-12-13
NZ212358A (en) 1989-01-27
DK259185D0 (da) 1985-06-10
CY1581A (en) 1992-04-03
IT1200079B (it) 1989-01-05
IT8548195A0 (it) 1985-06-11
NL8501526A (nl) 1986-01-02
CA1285561C (en) 1991-07-02
IL75468A0 (en) 1985-10-31
SE465428B (sv) 1991-09-09
GB2160200B (en) 1988-03-16
DE3520104C2 (de) 1997-01-23
ATA172385A (de) 1991-11-15
HUT39438A (en) 1986-09-29
PT80634B (pt) 1987-10-20
AU582751B2 (en) 1989-04-13
MY102059A (en) 1992-03-31
US4656167A (en) 1987-04-07

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Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20041004