ES8203375A1 - Procedimiento de preparar triazoloquinoxalin-4-onas substi- tuidas antihipertensoras - Google Patents
Procedimiento de preparar triazoloquinoxalin-4-onas substi- tuidas antihipertensorasInfo
- Publication number
- ES8203375A1 ES8203375A1 ES502747A ES502747A ES8203375A1 ES 8203375 A1 ES8203375 A1 ES 8203375A1 ES 502747 A ES502747 A ES 502747A ES 502747 A ES502747 A ES 502747A ES 8203375 A1 ES8203375 A1 ES 8203375A1
- Authority
- ES
- Spain
- Prior art keywords
- triazoloquinoxalin
- ones
- oxaline
- thiones
- well
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
Abstract
PROCEDIMENTO PARA LA OBTENCION DE TRIAZOLOQUINOXALIN-4-ONAS-SUSTITUIDAS. CONSISTE EN SOMETER EN CIERRE DE ANILLO O CICLACION LA CORRESPONDIENTE 3-(2''-ACILDIAZANIL) QUINOXALINONA. SE OBTIENE EL COMPUESTO (I), EN EL QUE CUANDO R1 Y-O R2 SON HIDROGENO SE AÑADEN SUSTITUYENTES R1 Y-O R2 DISTINTOS DEL HIDROGENO POR MEDIO DE REACCIONES DE REDUCCION O HIDROLISIS O BIEN PUEDEN FORMARSE SALES DE ADICION DE ACIDO DE LOS PRODUCTOS OBTENIDOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/151,220 US4354027A (en) | 1980-05-19 | 1980-05-19 | Triazoloquinoxalin-4-ones |
Publications (2)
Publication Number | Publication Date |
---|---|
ES502747A0 ES502747A0 (es) | 1982-04-01 |
ES8203375A1 true ES8203375A1 (es) | 1982-04-01 |
Family
ID=22537818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES502747A Expired ES8203375A1 (es) | 1980-05-19 | 1981-05-14 | Procedimiento de preparar triazoloquinoxalin-4-onas substi- tuidas antihipertensoras |
Country Status (12)
Country | Link |
---|---|
US (1) | US4354027A (es) |
EP (1) | EP0040401B1 (es) |
JP (1) | JPS5718681A (es) |
AU (1) | AU538782B2 (es) |
CA (1) | CA1176634A (es) |
DE (1) | DE3162761D1 (es) |
DK (1) | DK214981A (es) |
ES (1) | ES8203375A1 (es) |
FI (1) | FI71148C (es) |
NO (1) | NO811646L (es) |
NZ (1) | NZ197101A (es) |
ZA (1) | ZA813255B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3141304A (en) * | 1960-11-14 | 1964-07-21 | Jefferson Chem Co Inc | Soil stabilization by atactic polypropylene coating |
US4400382A (en) * | 1980-05-09 | 1983-08-23 | Usv Pharmaceutical Corporation | Thiazoloquinoxalin-1,4-diones for treating allergy |
US4507300A (en) * | 1980-05-09 | 1985-03-26 | Usv Pharmaceutical Corporation | Pyridotriazolopyrazine-diones for treating allergy |
US5196421A (en) * | 1991-06-05 | 1993-03-23 | Eli Lilly And Company | Excitatory amino acid receptor antagonists in methods for the use thereof |
US5153196A (en) * | 1991-06-05 | 1992-10-06 | Eli Lilly And Company | Excitatory amino acid receptor antagonists and methods for the use thereof |
DK162491D0 (da) * | 1991-09-20 | 1991-09-20 | Novo Nordisk As | Heterocycliske forbindelser, deres fremstilling og farmaceutiske praeparater indeholdende forbindelserne |
FR2696466B1 (fr) * | 1992-10-02 | 1994-11-25 | Rhone Poulenc Rorer Sa | Dérivés de 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant. |
DK31093D0 (es) * | 1993-03-19 | 1993-03-19 | Novo Nordisk As | |
FR2717805B1 (fr) * | 1994-03-28 | 1996-05-10 | Rhone Poulenc Rorer Sa | Dérivés de 5H-indeno[1,2-b]pyrazine-2,3-dione, leur préparation et les médicaments les contenant . |
FR2717814B1 (fr) * | 1994-03-28 | 1996-04-26 | Rhone Poulenc Rorer Sa | Dérivés de 1,2,4-triazolo(4,3-a)pyrazine-4-one, leur préparation et les médicaments les contenant. |
FR2717813B1 (fr) * | 1994-03-28 | 1996-05-10 | Rhone Poulenc Rorer Sa | Dérivés d'imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant . |
FR2717812B1 (fr) * | 1994-03-28 | 1996-05-10 | Rhone Poulenc Rorer Sa | Indeno[1,2-e]pyrazine-4-ones, leur préparation et les médicaments les contenant. |
HUT76810A (en) * | 1994-09-16 | 1997-11-28 | Novo Nordisk As | [1,2,4]triazolo[4,3-a]quinoxalinone derivatives, process for their preparation and pharmaceutical compositions containing them |
EP0781282B1 (en) * | 1994-09-16 | 1999-08-11 | Novo Nordisk A/S | [1,2,4]TRIAZOLO[4,3-a]QUINOXALINONE DERIVATIVES, THEIR PREPARATION AND USE |
FR2726275B1 (fr) * | 1994-11-02 | 1996-12-06 | Rhone Poulenc Rorer Sa | Spiro heterocycle-imidazo(1,2-a)indeno(1,2-e)pyrazine)-4'- ones, leur preparation et les medicaments les contenants |
US5679680A (en) * | 1995-02-16 | 1997-10-21 | Warner-Lambert Company | α-substituted hydrazides having calpain inhibitory activity |
US8299080B2 (en) * | 2006-12-13 | 2012-10-30 | Aska Pharmaceutical Co., Ltd. | Substituted imidazo[1,5-A] quinoxalines as a PDE9 inhibitor |
AR107456A1 (es) | 2016-02-12 | 2018-05-02 | Lilly Co Eli | Inhibidor de pde1 |
JOP20170164A1 (ar) | 2016-08-25 | 2019-01-30 | Lilly Co Eli | مشتق ترايازولو بيرازينون مفيد كمثبط لـ pde1 بشري |
AR112457A1 (es) | 2017-08-02 | 2019-10-30 | Lilly Co Eli | Derivados de [1,2,4]triazolo[4,3-a]pirazin-6(5h)-ona |
AR112346A1 (es) * | 2017-08-10 | 2019-10-16 | Lilly Co Eli | Derivados de [1,2,4]triazolo |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1301228A (es) * | 1971-03-04 | 1972-12-29 | Ici Ltd | |
JPS50116498A (es) * | 1974-02-27 | 1975-09-11 | ||
US3979387A (en) * | 1975-06-10 | 1976-09-07 | Eli Lilly And Company | 4,5-Dihydrotetrazolo(1,5-A)quinoxalines |
-
1980
- 1980-05-19 US US06/151,220 patent/US4354027A/en not_active Expired - Lifetime
-
1981
- 1981-05-12 CA CA000377439A patent/CA1176634A/en not_active Expired
- 1981-05-13 EP EP81103695A patent/EP0040401B1/en not_active Expired
- 1981-05-13 AU AU70544/81A patent/AU538782B2/en not_active Ceased
- 1981-05-13 DE DE8181103695T patent/DE3162761D1/de not_active Expired
- 1981-05-14 NZ NZ197101A patent/NZ197101A/en unknown
- 1981-05-14 NO NO811646A patent/NO811646L/no unknown
- 1981-05-14 ES ES502747A patent/ES8203375A1/es not_active Expired
- 1981-05-14 DK DK214981A patent/DK214981A/da not_active Application Discontinuation
- 1981-05-15 ZA ZA00813255A patent/ZA813255B/xx unknown
- 1981-05-15 FI FI811504A patent/FI71148C/fi not_active IP Right Cessation
- 1981-05-15 JP JP7239281A patent/JPS5718681A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ES502747A0 (es) | 1982-04-01 |
JPS5718681A (en) | 1982-01-30 |
NZ197101A (en) | 1984-03-16 |
AU538782B2 (en) | 1984-08-30 |
FI71148B (fi) | 1986-08-14 |
DK214981A (da) | 1981-11-20 |
NO811646L (no) | 1981-11-20 |
FI71148C (fi) | 1986-11-24 |
FI811504L (fi) | 1981-11-20 |
EP0040401A1 (en) | 1981-11-25 |
EP0040401B1 (en) | 1984-03-21 |
AU7054481A (en) | 1981-11-19 |
US4354027A (en) | 1982-10-12 |
CA1176634A (en) | 1984-10-23 |
ZA813255B (en) | 1982-06-30 |
DE3162761D1 (en) | 1984-04-26 |
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