BE901456A - Nouvelles 8 alpha-acylaminoergolines, leur preparation et leur utilisation comme medicaments. - Google Patents

Nouvelles 8 alpha-acylaminoergolines, leur preparation et leur utilisation comme medicaments.

Info

Publication number
BE901456A
BE901456A BE1/11168A BE1011168A BE901456A BE 901456 A BE901456 A BE 901456A BE 1/11168 A BE1/11168 A BE 1/11168A BE 1011168 A BE1011168 A BE 1011168A BE 901456 A BE901456 A BE 901456A
Authority
BE
Belgium
Prior art keywords
acylaminoergolins
news
medicines
alpha
preparation
Prior art date
Application number
BE1/11168A
Other languages
English (en)
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Publication of BE901456A publication Critical patent/BE901456A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne les 8a-acylaminoergolines de formules I dans laquelle R1 représente l'hydrogène ou un alkyle, R2 représente l'hydrogène, le chlore, le brome ou méthyle, R3 représente un alkyle ou alcényle et R4CO représente un groupe acyle aliphatique, cycloaliphatique, aromatique ou hétérocyclique. Ces composés possèdent entre autres une activité clopaminergique et inhibitrice sur la sécrétion de la prolactine.
BE1/11168A 1984-01-12 1985-01-08 Nouvelles 8 alpha-acylaminoergolines, leur preparation et leur utilisation comme medicaments. BE901456A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3400853 1984-01-12

Publications (1)

Publication Number Publication Date
BE901456A true BE901456A (fr) 1985-07-08

Family

ID=6224786

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1/11168A BE901456A (fr) 1984-01-12 1985-01-08 Nouvelles 8 alpha-acylaminoergolines, leur preparation et leur utilisation comme medicaments.

Country Status (28)

Country Link
US (2) US4950672A (fr)
JP (1) JPH0655739B2 (fr)
AT (1) AT391317B (fr)
AU (3) AU583489B2 (fr)
BE (1) BE901456A (fr)
CA (1) CA1245640A (fr)
CH (1) CH664568A5 (fr)
CY (1) CY1542A (fr)
DE (1) DE3500251C2 (fr)
DK (1) DK169891B1 (fr)
ES (1) ES8605514A1 (fr)
FI (1) FI82466C (fr)
FR (1) FR2560196B1 (fr)
GB (1) GB2152507B (fr)
GR (1) GR850065B (fr)
HK (1) HK48590A (fr)
HU (1) HU197569B (fr)
IE (1) IE58228B1 (fr)
IL (1) IL74043A (fr)
IT (1) IT1214648B (fr)
LU (1) LU85725A1 (fr)
NL (1) NL193541C (fr)
NZ (1) NZ210818A (fr)
PH (1) PH23286A (fr)
PT (1) PT79818B (fr)
SE (1) SE460420B (fr)
SG (1) SG32390G (fr)
ZA (1) ZA85276B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL193541C (nl) * 1984-01-12 2000-01-04 Novartis Ag 8 Alfa-acylaminoergolinen, werkwijzen voor de bereiding daarvan en preparaten die ze bevatten.
DE3587860D1 (de) * 1984-04-09 1994-07-28 Schering Ag 2-substituierte Ergolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
HUT45248A (en) * 1986-01-24 1988-06-28 Sandoz Ag Process for producing 8alpha-(acylamino)-ergoline derivatives and pharmaceuticals comprising such compounds
US4931447A (en) * 1987-06-15 1990-06-05 Eli Lilly And Company Cycloalkylamides of (8β)-1-alkyl-6-(substituted) ergolines
US4981859A (en) * 1987-06-15 1991-01-01 Cycloalkylamides of (8 beta )-1-alkyl-6-(substituted)ergolines
IT1219652B (it) * 1987-06-23 1990-05-24 Sandoz Ag 8-acilamminoergolina,la sua preparazione e il suo impiego come medicamneto
DE3820159A1 (de) * 1987-06-23 1989-01-05 Sandoz Ag 8(alpha)-acylaminoergolin, seine herstellung und dieses enthaltende arzneimittel
DK338789A (da) * 1988-07-15 1990-01-16 Schering Ag 2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf
GB8824744D0 (en) * 1988-10-21 1988-11-30 Erba Carlo Spa Antiemesis ergoline derivatives
DE3915950A1 (de) * 1989-05-12 1990-11-15 Schering Ag 8(alpha)-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel
JP2018502889A (ja) 2015-01-20 2018-02-01 エックスオーシー ファーマシューティカルズ インコーポレイテッドＸｏｃ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ イソエルゴリン化合物およびその使用
CN107428745A (zh) 2015-01-20 2017-12-01 Xoc制药股份有限公司 麦角灵化合物及其用途
WO2018223065A1 (fr) 2017-06-01 2018-12-06 Xoc Pharmaceuticals, Inc. Dérivés d'ergoline destinés à être utilisés en médecine

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3218323A (en) * 1965-11-16 Esters of i,g-dimethyl-b-ergolenyl carbamic acid
US2864822A (en) * 1956-10-22 1958-12-16 Lilly Co Eli 9-amino-7-methyl-belta10-ergolene and derivatives thereof
CH622519A5 (en) * 1974-07-05 1981-04-15 Hoechst Ag Process for the preparation of hydroxyalkylxanthines
US4348392A (en) * 1974-07-19 1982-09-07 Sandoz Ltd. 8α-Substituted ergoline-I derivatives
GB1517973A (en) * 1974-07-19 1978-07-19 Sandoz Ltd 6-methyl-8alpha-n,n-dimethylsulphamoylaminoergoline i
US3922347A (en) * 1974-12-19 1975-11-25 Lilly Co Eli Method of inhibiting prolactin secretion with 8-acylaminoergolenes
CH615929A5 (en) * 1975-06-02 1980-02-29 Sandoz Ag Process for the preparation of novel ergoline compounds
DE2656344A1 (de) * 1975-12-23 1977-07-07 Sandoz Ag Ergolinderivate, ihre verwendung und herstellung
CH622518A5 (en) * 1976-12-14 1981-04-15 Sandoz Ag Process for the preparation of novel ergoline compounds
CH644606A5 (de) * 1980-09-23 1984-08-15 Sandoz Ag Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten.
DE3151912A1 (de) * 1981-12-23 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
NL193541C (nl) * 1984-01-12 2000-01-04 Novartis Ag 8 Alfa-acylaminoergolinen, werkwijzen voor de bereiding daarvan en preparaten die ze bevatten.
CH666035A5 (de) * 1984-12-24 1988-06-30 Sandoz Ag 8-alpha-acylaminoergolene.
IT1219652B (it) * 1987-06-23 1990-05-24 Sandoz Ag 8-acilamminoergolina,la sua preparazione e il suo impiego come medicamneto

Also Published As

Publication number Publication date
ES8605514A1 (es) 1986-03-16
FI850130A0 (fi) 1985-01-11
IE850064L (en) 1985-07-12
GR850065B (fr) 1985-05-03
AU583489B2 (en) 1989-05-04
PH23286A (en) 1989-06-30
AU3760985A (en) 1985-07-18
HU197569B (en) 1989-04-28
AU618290B2 (en) 1991-12-19
NL193541B (nl) 1999-09-01
NL193541C (nl) 2000-01-04
JPS60174783A (ja) 1985-09-09
IE58228B1 (en) 1993-08-11
JPH0655739B2 (ja) 1994-07-27
FR2560196B1 (fr) 1986-07-18
AU2506688A (en) 1989-02-23
CY1542A (en) 1991-03-22
PT79818B (en) 1987-01-07
GB8500454D0 (en) 1985-02-13
DE3500251C2 (de) 1995-01-26
HUT37148A (en) 1985-11-28
SE8500107D0 (sv) 1985-01-10
AU2506788A (en) 1989-03-02
US4950672A (en) 1990-08-21
PT79818A (en) 1985-02-01
FI82466B (fi) 1990-11-30
US5077298A (en) 1991-12-31
SG32390G (en) 1990-08-03
IL74043A (en) 1988-10-31
ATA5985A (de) 1990-03-15
DE3500251A1 (de) 1985-07-18
SE460420B (sv) 1989-10-09
LU85725A1 (fr) 1985-10-22
IT1214648B (it) 1990-01-18
GB2152507A (en) 1985-08-07
ZA85276B (en) 1986-08-27
AT391317B (de) 1990-09-25
DK12685A (da) 1985-07-13
HK48590A (en) 1990-06-29
FR2560196A1 (fr) 1985-08-30
SE8500107L (sv) 1985-07-13
ES539511A0 (es) 1986-03-16
DK169891B1 (da) 1995-03-27
FI82466C (fi) 1991-03-11
NL8500008A (nl) 1985-08-01
NZ210818A (en) 1989-02-24
CA1245640A (fr) 1988-11-29
GB2152507B (en) 1987-07-15
AU609539B2 (en) 1991-05-02
IL74043A0 (en) 1985-04-30
DK12685D0 (da) 1985-01-10
FI850130L (fi) 1985-07-13
IT8547538A0 (it) 1985-01-11
CH664568A5 (de) 1988-03-15

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: NOVARTIS A.G.

Effective date: 20000131