BE904368A - Nouveaux derives de pyridylmethoxy- et methylmercaptoanilines, utiles notamment comme antiasthmatiques, leur fabrication et medicaments les contenant. - Google Patents

Nouveaux derives de pyridylmethoxy- et methylmercaptoanilines, utiles notamment comme antiasthmatiques, leur fabrication et medicaments les contenant.

Info

Publication number
BE904368A
BE904368A BE0/216378A BE216378A BE904368A BE 904368 A BE904368 A BE 904368A BE 0/216378 A BE0/216378 A BE 0/216378A BE 216378 A BE216378 A BE 216378A BE 904368 A BE904368 A BE 904368A
Authority
BE
Belgium
Prior art keywords
methylmercaptoaniline
antiasthmatics
pyridylmethoxy
novel
manufacture
Prior art date
Application number
BE0/216378A
Other languages
English (en)
Inventor
Ole Bent Tvaermose Nielsen
Ian Ahnfelt-Ronne
Original Assignee
Leo Pharm Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858506094A external-priority patent/GB8506094D0/en
Priority claimed from GB858525153A external-priority patent/GB8525153D0/en
Application filed by Leo Pharm Prod Ltd filed Critical Leo Pharm Prod Ltd
Publication of BE904368A publication Critical patent/BE904368A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C07D213/34—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Les composés de l'invention répondent à la formule générale, dans laquelle X représente O, S, SO ou SO2. Applications : médicaments antiallergiques et anti-asthmatiques, notamment en unités de dosage pour l'administration en quantité de 0,5 à 100 mg par kg de poids corporel en une ou plusieurs fois par jour.
BE0/216378A 1985-03-08 1986-03-07 Nouveaux derives de pyridylmethoxy- et methylmercaptoanilines, utiles notamment comme antiasthmatiques, leur fabrication et medicaments les contenant. BE904368A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858506094A GB8506094D0 (en) 1985-03-08 1985-03-08 Chemical products
GB858525153A GB8525153D0 (en) 1985-10-11 1985-10-11 Chemical compounds

Publications (1)

Publication Number Publication Date
BE904368A true BE904368A (fr) 1986-09-08

Family

ID=26288945

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/216378A BE904368A (fr) 1985-03-08 1986-03-07 Nouveaux derives de pyridylmethoxy- et methylmercaptoanilines, utiles notamment comme antiasthmatiques, leur fabrication et medicaments les contenant.

Country Status (18)

Country Link
US (2) US4826987A (fr)
JP (1) JPH0764813B2 (fr)
AU (1) AU585586B2 (fr)
BE (1) BE904368A (fr)
CA (1) CA1276640C (fr)
DE (1) DE3607382A1 (fr)
DK (1) DK166582B1 (fr)
ES (1) ES8802610A1 (fr)
FR (1) FR2578540B1 (fr)
GB (1) GB2173788B (fr)
GR (1) GR860628B (fr)
IE (1) IE58870B1 (fr)
IT (1) IT1221079B (fr)
LU (1) LU86349A1 (fr)
NL (1) NL8600596A (fr)
NZ (1) NZ215347A (fr)
PT (1) PT82147B (fr)
SE (1) SE463819B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE68789T1 (de) * 1985-10-16 1991-11-15 Merck Frosst Canada Inc 2-substituierte chinoline.
DK196688A (da) * 1987-04-28 1988-10-29 Fujisawa Pharmaceutical Co Bicykliske forbindelser og fremgangsmaade til fremstilling deraf
US4826990A (en) * 1987-09-30 1989-05-02 American Home Products Corporation 2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents
GB8728051D0 (en) * 1987-12-01 1988-01-06 Leo Pharm Prod Ltd Chemical compounds
US4889935A (en) * 1987-12-18 1989-12-26 American Home Products Corporation Aminoguanidine derivatives
US5248685A (en) * 1989-04-07 1993-09-28 Pfizer Inc. Substituted 1-[3-(heteroarylmethoxy)phenyl]alkanols and related compounds in the treatment of asthma
DE3927369A1 (de) * 1989-08-19 1991-02-21 Bayer Ag Substituierte n-(chinolin-2-yl-methoxy)benzyl-sulfonyl-harnstoffe
DE3935139A1 (de) * 1989-10-21 1991-04-25 Bayer Ag Substituierte (chinolin-2-yl-methoxy)phenyl-thioharnstoffe
US5021576A (en) * 1989-10-27 1991-06-04 American Home Products Corporation 2-Anilino phenylacetic acid derivatives
US5324747A (en) * 1992-07-15 1994-06-28 Hoffmann-La Roche Inc. N-substituted anilines, inhibitors of phospholipases A2
US7189834B2 (en) * 1993-05-11 2007-03-13 Marshall William E Oligoribonucleotides alert the immune system of animals to the imminence of microbial infection
US5840318A (en) * 1993-05-11 1998-11-24 Immunom Technologies, Inc. Methods and compositions for modulating immune systems of animals
US5508408A (en) * 1993-09-10 1996-04-16 Ciba-Geigy Corporation Quinoline compound
US5795900A (en) * 1995-10-03 1998-08-18 Abbott Laboratories Symmetrical bis-heteroaryl-methoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis
US5668150A (en) * 1996-07-26 1997-09-16 Abbott Laboratories Non-symmetrical bis-heteroarylmethoxyphenylalkyl carboxylates as inhibitors of leukotriene biosynthesis
DE69822514T2 (de) * 1997-12-31 2005-03-24 The University Of Kansas, Lawrence Wasserlösliche pro-pharmaka von arzneistoffen, die ein tertiäres amin enthalten, und verfahren zu ihrer herstellung
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) * 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) * 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
TW200920369A (en) * 2007-10-26 2009-05-16 Amira Pharmaceuticals Inc 5-lipoxygenase activating protein (flap) inhibitor
US20110160249A1 (en) * 2008-05-23 2011-06-30 Schaab Kevin Murray 5-lipoxygenase-activating protein inhibitor
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
TW201215607A (en) 2010-07-02 2012-04-16 Lundbeck & Co As H Aryl-and heteroarylamid derivatives as PDE10A enzyme inhibitor

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US31624A (en) * 1861-03-05 Tatting-frame
US2761865A (en) * 1954-07-07 1956-09-04 Hoffmann La Roche Pyridylalkyl sulfones
US4003906A (en) * 1974-01-22 1977-01-18 The Dow Chemical Company Substituted pyridinyl methylthio or (methylsulfonyl)benzeneamines
GB2069493B (en) * 1980-02-20 1984-02-29 Wyeth John & Brother Ltd Pyridine derivatives
GB2069492B (en) * 1980-02-20 1984-02-29 Wyeth John & Brother Ltd Sulphur compounds
US4567184A (en) * 1982-12-01 1986-01-28 Usv Pharmaceutical Corporation Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies
IE56702B1 (en) * 1982-12-01 1991-11-06 Usv Pharma Corp Antiinflammatory antiallergic compounds
JPS5988835U (ja) * 1982-12-06 1984-06-15 ホシデン株式会社 スイツチ
US4486593A (en) * 1983-01-19 1984-12-04 The Upjohn Company 2-,3-, or 4-Pyridinylmethylamino arylic acids as thromboxane A2 synthetase and 5-lipoxygenase inhibitors
US4563463A (en) * 1983-03-18 1986-01-07 Usv Pharmaceutical Corp. 2-Oxo-1,3-oxazolo[4,5-h] quinolines useful as anti-allergy agents
US4554355A (en) * 1984-07-19 1985-11-19 American Home Products Corporation Heterocyclic compounds as antiallergic agents
US5109009A (en) * 1985-03-08 1992-04-28 Leo Pharmaceutical Products Ltd. Quinoline and pyridine compounds and inhibition of 5-lipoxygenases therewith

Also Published As

Publication number Publication date
NL8600596A (nl) 1986-10-01
PT82147A (en) 1986-04-01
SE8600913L (sv) 1986-09-09
IE860370L (en) 1986-09-08
PT82147B (pt) 1988-07-29
DK96986D0 (da) 1986-03-04
AU5444486A (en) 1986-09-18
IT1221079B (it) 1990-06-21
SE463819B (sv) 1991-01-28
GB2173788B (en) 1988-08-10
GR860628B (en) 1986-06-26
DK166582B1 (da) 1993-06-14
US5157039A (en) 1992-10-20
CA1276640C (fr) 1990-11-20
ES8802610A1 (es) 1988-09-16
JPH0764813B2 (ja) 1995-07-12
US4826987A (en) 1989-05-02
GB8604183D0 (en) 1986-03-26
LU86349A1 (fr) 1987-04-02
FR2578540A1 (fr) 1986-09-12
FR2578540B1 (fr) 1990-11-16
ES552805A0 (es) 1988-09-16
JPS61207374A (ja) 1986-09-13
AU585586B2 (en) 1989-06-22
DK96986A (da) 1986-09-09
GB2173788A (en) 1986-10-22
DE3607382A1 (de) 1986-09-11
IE58870B1 (en) 1993-11-17
IT8667183A0 (it) 1986-03-06
SE8600913D0 (sv) 1986-02-28
NZ215347A (en) 1990-02-26

Similar Documents

Publication Publication Date Title
BE904368A (fr) Nouveaux derives de pyridylmethoxy- et methylmercaptoanilines, utiles notamment comme antiasthmatiques, leur fabrication et medicaments les contenant.
FR2367053A1 (fr) Nouveaux derives de phenoxy-amino-propanol, leur preparation et leur application en tant que medicaments
FR2429593A1 (fr) Medicaments contenant des derives d'imidazole
FR2392971A1 (fr) Derives de l'acide prostanoique, leur preparation et medicament contenant ces substances
FR2422643A1 (fr) Nouveaux derives d'imidazolidine, leur preparation et leur application comme medicaments
FR2604090B1 (fr) Forme de dosage pharmaceutique solide comprenant au moins une unite a liberation controlee
DE3876877D1 (de) Verwendung von indolon-derivaten zur herstellung von arzneimitteln zur behandlung des parkinsonismus.
EP0254067A3 (fr) Composition pour la prévention de la métastase
BE904796A (fr) Nouveaux derives du morphinane et de la morphine, leur preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant.
FR2370744A1 (fr) Nouveaux derives d'aminopropanol, procede pour leur preparation et medicaments contenant ces composes
FR2423485A1 (fr) Nouvelles 1,3-diaryl-2-imino-imidazolidines et 1,3-diaryl-2-imino-hexahydro-pyrimidines substituees, procedes de preparation de ces composes et medicaments les contenant
FR2415636A1 (fr) Nouveaux derives de la guanidine, leur preparation et leur application comme medicaments
FR2415103A1 (fr) Acides et derives d'acides 4-pyridone-3-carboxyliques, leur preparation et leur application en tant que medicaments
OA08957A (fr) Dérivés d'alcadiènes, leurs préparations, les médicaments les contenant et produits intermédiaires
FR2422405A1 (fr) Nouveaux medicaments constitues de derives de l'acide p-aminobenzoique
FR2370745A1 (fr) Nouveaux derives de la morphanthridine, leur preparation et leur application comme medicaments
FR2419928A1 (fr) Nouveaux derives de la n-phenylalanine, leur preparation et leur application comme medicaments
BE1002121A4 (fr) Derives de la 2,3,4,5,6,7-hexahydro-2,7-methano-1,5-benzoxazonine (ou -1,4-benzoxazonine), procede pour leur preparation et medicaments les contenant.
FR2375211A1 (fr) Nouveaux acides sulfamoylbenzoiques, leur preparation et leur application en tant que medicaments
FR2367061A1 (fr) Nouveaux derives de l'acide 13-thiaprostanoique, leur preparation et leur application en tant que medicaments
FR2366289A1 (fr) Nouveaux derives de l'imidazo(5,1-a)isoquinoleine, leur preparation et leur application comme medicaments
FR2426052A1 (fr) Composes nitrofuryl-vinyleniques, nouveaux medicaments antitumoraux
FR2701952B1 (fr) Nouveaux dérivés cyclopeptidiques de l'angiopeptine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2432316A1 (fr) Nouveaux medicaments contenant, a titre de substance active, des composes de type benzenesulfone, nouveaux composes de ce type et procede pour leur preparation
FR2365557A1 (fr) Nouveaux perhydro-indolinols, leur preparation et leur application comme medicaments

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMI

Effective date: 19970331