ATE68789T1 - 2-substituierte chinoline. - Google Patents

2-substituierte chinoline.

Info

Publication number
ATE68789T1
ATE68789T1 AT86307785T AT86307785T ATE68789T1 AT E68789 T1 ATE68789 T1 AT E68789T1 AT 86307785 T AT86307785 T AT 86307785T AT 86307785 T AT86307785 T AT 86307785T AT E68789 T1 ATE68789 T1 AT E68789T1
Authority
AT
Austria
Prior art keywords
substituted
alkyl
unsubstituted
radical
benzyl
Prior art date
Application number
AT86307785T
Other languages
English (en)
Inventor
Robert N Young
Robert Zamboni
Serge Leger
Original Assignee
Merck Frosst Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc
Application granted granted Critical
Publication of ATE68789T1 publication Critical patent/ATE68789T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
AT86307785T 1985-10-16 1986-10-08 2-substituierte chinoline. ATE68789T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78794285A 1985-10-16 1985-10-16
EP86307785A EP0219308B1 (de) 1985-10-16 1986-10-08 2-Substituierte Chinoline

Publications (1)

Publication Number Publication Date
ATE68789T1 true ATE68789T1 (de) 1991-11-15

Family

ID=25142975

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86307785T ATE68789T1 (de) 1985-10-16 1986-10-08 2-substituierte chinoline.

Country Status (7)

Country Link
EP (1) EP0219308B1 (de)
JP (1) JPS6293277A (de)
AT (1) ATE68789T1 (de)
CA (1) CA1298838C (de)
DE (1) DE3682160D1 (de)
DK (1) DK487586A (de)
ES (1) ES2002037A6 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962203A (en) * 1985-06-18 1990-10-09 Merck Frost Canada, Inc. 2-substituted quinolines useful as leukotriene antagonists
EP0271287A3 (de) * 1986-12-11 1990-06-13 Merck Frosst Canada Inc. Chinolindicarbonsäuren und ihre Amide
ATE70976T1 (de) * 1987-03-18 1992-01-15 American Home Prod Sulfonylcarboxamide.
JPS63258854A (ja) * 1987-04-16 1988-10-26 Mitsubishi Kasei Corp カルボキシスチレン誘導体およびそれを有効成分とする薬剤
US4920131A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
GB8728051D0 (en) * 1987-12-01 1988-01-06 Leo Pharm Prod Ltd Chemical compounds
DE3916663A1 (de) * 1989-05-23 1990-11-29 Bayer Ag Substituierte (chinolin-2-yl-methoxy)phenyl-acyl-sulfonamide und -cyanamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US5304563A (en) * 1991-02-22 1994-04-19 Bayer Aktiengesellschaft 2-substituted quinolines, and their use in medicaments
US5385912A (en) * 1991-03-08 1995-01-31 Rhone-Poulenc Rorer Pharmaceuticals Inc. Multicyclic tertiary amine polyaromatic squalene synthase inhibitors
US5157040A (en) * 1991-04-05 1992-10-20 Merck & Co., Inc. Substituted quinolines as angiotensin ii antagonists
US5455260A (en) * 1993-05-21 1995-10-03 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aliphatic amino bis-aryl squalene synthase inhibitors
US5508408A (en) * 1993-09-10 1996-04-16 Ciba-Geigy Corporation Quinoline compound
US5561143A (en) * 1995-01-25 1996-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aliphatic amino bis-aryl squalene synthase inhibitors
TWI311133B (en) * 2001-04-20 2009-06-21 Eisai R&D Man Co Ltd Carboxylic acid derivativeand the salt thereof
JPWO2003016265A1 (ja) 2001-08-17 2004-12-02 エーザイ株式会社 環状化合物およびｐｐａｒアゴニスト

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB321738A (en) * 1928-08-21 1929-11-21 Ig Farbenindustrie Ag Process for the manufacture of phenylcarboxylic acid compounds
DE2735919A1 (de) * 1977-08-10 1979-02-22 Boehringer Sohn Ingelheim Neue 2-pyridyl- und 2-pyrimidylaminobenzoesaeuren
CA1134828A (en) * 1978-12-28 1982-11-02 Tadao Tanouchi Pyridine derivatives
US4325959A (en) * 1979-08-09 1982-04-20 The Dow Chemical Company Hypoglycemic 4-(((1,3,4, thiadiazolyl)thio)methyl)benzoic acids, ester and amides
US4464533A (en) * 1982-11-08 1984-08-07 Ppg Industries, Inc. Herbicidally active quinoline or quinoxaline benzoate derivatives
IE56702B1 (en) * 1982-12-01 1991-11-06 Usv Pharma Corp Antiinflammatory antiallergic compounds
NZ213986A (en) * 1984-10-30 1989-07-27 Usv Pharma Corp Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such
IE58870B1 (en) * 1985-03-08 1993-11-17 Leo Pharm Prod Ltd Pyridine derivatives
US4839369A (en) * 1985-04-16 1989-06-13 Rorer Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
JPH06752B2 (ja) * 1985-04-24 1994-01-05 正木 長谷川 非対称ジオレフイン化合物

Also Published As

Publication number Publication date
DK487586D0 (da) 1986-10-13
DK487586A (da) 1987-04-17
EP0219308A2 (de) 1987-04-22
DE3682160D1 (de) 1991-11-28
JPS6293277A (ja) 1987-04-28
EP0219308A3 (en) 1987-10-14
EP0219308B1 (de) 1991-10-23
CA1298838C (en) 1992-04-14
ES2002037A6 (es) 1988-07-01

Similar Documents

Publication Publication Date Title
ATE68789T1 (de) 2-substituierte chinoline.
ES8801209A1 (es) Un procedimiento para la preparacion de quinolinas 2-sustituidas.
ES2062395T3 (es) Nuevos compuestos de bencimidazol y su uso.
WO1992001675A2 (en) Substituted bicyclic bis-aryl compounds exhibiting selective leukotriene b4 antagonist activity, their preparation and use in pharmaceutical compositions
NO820264L (no) Fremgangsmaate for fremstilling av 2-penemforbindelser
MX5680E (es) Procedimiento para la preparacion de 2-(2-alcoxietil)-2'-hidroxi-6,7-benzomorfanos
ES467154A1 (es) Procedimiento para la preparacion de materiales organicos aclarados opticamente
SE8703886L (sv) Nya mellanprodukter anvendbara for framstellning av 4-hydroxi-3-kinolinkarboxylsyraderivat
EP0007605A1 (de) Verfahren zur Umkehrung der Konfiguration in optisch aktiven Verbindungen und dazu benötigte neue optisch aktive Zwischenprodukte und deren Salze
FI803654L (fi) Nya substituerade 2-fenylaminoimidazoliner-(2) deras syraadditionssalter dessa foereningar innehaollande laekemedel och deras framstaellningsfoerfarande
DE3068456D1 (en) 2-(n-(2-fluoro-6-bromophenyl)-n-(thiemyl-2-methyl)-amino)-2-imidazoline, its addition salts, pharmaceutical compositions containing them and processes for their preparation
FI803887L (fi) Nya substituerade 2-fenylamino-imidazoliner-(2) deras syraadditionssalter dessa innehaollande laekemedel och deras framstaellningsfoerfarande
MX5687E (es) Procedimiento para la preparacion de derivados imidazo(1,2-alpha)-imidazol substituidos
ATE66919T1 (de) Thiophen-derivate.
CH610877A5 (en) Process for the preparation of o-(2,6-dichloroanilino)phenylacetic acid and of the addition salts of this acid
ES8307812A1 (es) Un procedimiento para la preparacion de nuevos amidin derivados del acido clavulawilo.
JPS5572186A (en) Dibenzothiepin derivative and its preparation
TH2974A (th) อนุพันธ์ควิโนโลนคาร์บอกซิลิคแอซิด
FI922482A (fi) Foerfarande foer framstaellning av kinolinfoerening.
JPS5581869A (en) Substituted benzoic acid amide
TH4042B (th) อนุพันธ์ควิโนโลนคาร์บอกซิลิคแอซิด