ES2002037A6 - Un procedimiento para la preparacioon de quinolonas -2-sustituidas. - Google Patents
Un procedimiento para la preparacioon de quinolonas -2-sustituidas.Info
- Publication number
- ES2002037A6 ES2002037A6 ES8602615A ES8602615A ES2002037A6 ES 2002037 A6 ES2002037 A6 ES 2002037A6 ES 8602615 A ES8602615 A ES 8602615A ES 8602615 A ES8602615 A ES 8602615A ES 2002037 A6 ES2002037 A6 ES 2002037A6
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- alkyl
- unsubstituted
- radical
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE QUINOLINAS-2-SUSTITUIDAS DE FORMULA I, DONDE R1 ES H, HALOGENO, ALQUILO C1-8 ALQUENILO O ALQUINILO C2-8, CF3, -OR2, -SR2, -SOR2, -SO2R2, -NR2R2, -CHO, -COOR2, -(CFO)R2, -CN, -C(OH)R2R2, -NO2, FENILO, BENCILO O FENETILO OPCIONALMENTE SUSTITUIDOS; R2 ES H, ALQUILO C1-8, ALQUENILO O ALQUINILO C2-8, -CF3, FENILO, BENCILO O FENETILO OPCIONALMENTE SUSTITUIDOS; R2K ES R2 EXCEPTO H; R4 ES H, HALOGENO, -NO2, -CN, -OR2, -SR2, NR2R2 O ALQUILO C1-8; Y ES -CR2FCR2, DONDE UNO DE R2 ES H; Y Z ES ETILO O H. SE OBTIENEN POR COPULACION DE UN COMPUESTO XXIV PROCEDENTE DE UN DIALDEHIDO VI, CON UN DERIVADO DE QUINOLINA DE FORMULA III. LOS COMPUESTOS 1 ASI OBTENIDOS SON ANTAGONISTAS DE LEUCOTRIENIOS E INHIBEN SU BIOSINTESIS. SON UTILES COMO AGENTES ANTIASMATICOS, ANTIALERGICOS, ANTI-INFLAMATORIOS Y CITO-PROTECTORES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78794285A | 1985-10-16 | 1985-10-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2002037A6 true ES2002037A6 (es) | 1988-07-01 |
Family
ID=25142975
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8602615A Expired ES2002037A6 (es) | 1985-10-16 | 1986-10-15 | Un procedimiento para la preparacioon de quinolonas -2-sustituidas. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0219308B1 (es) |
JP (1) | JPS6293277A (es) |
AT (1) | ATE68789T1 (es) |
CA (1) | CA1298838C (es) |
DE (1) | DE3682160D1 (es) |
DK (1) | DK487586A (es) |
ES (1) | ES2002037A6 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4962203A (en) * | 1985-06-18 | 1990-10-09 | Merck Frost Canada, Inc. | 2-substituted quinolines useful as leukotriene antagonists |
EP0271287A3 (en) * | 1986-12-11 | 1990-06-13 | Merck Frosst Canada Inc. | Quinoline dioic acids and amides |
DE3867401D1 (de) * | 1987-03-18 | 1992-02-13 | American Home Prod | Sulfonylcarboxamide. |
JPS63258854A (ja) * | 1987-04-16 | 1988-10-26 | Mitsubishi Kasei Corp | カルボキシスチレン誘導体およびそれを有効成分とする薬剤 |
US4920131A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
GB8728051D0 (en) * | 1987-12-01 | 1988-01-06 | Leo Pharm Prod Ltd | Chemical compounds |
DE3916663A1 (de) * | 1989-05-23 | 1990-11-29 | Bayer Ag | Substituierte (chinolin-2-yl-methoxy)phenyl-acyl-sulfonamide und -cyanamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
US5304563A (en) * | 1991-02-22 | 1994-04-19 | Bayer Aktiengesellschaft | 2-substituted quinolines, and their use in medicaments |
US5385912A (en) * | 1991-03-08 | 1995-01-31 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Multicyclic tertiary amine polyaromatic squalene synthase inhibitors |
US5157040A (en) * | 1991-04-05 | 1992-10-20 | Merck & Co., Inc. | Substituted quinolines as angiotensin ii antagonists |
US5455260A (en) * | 1993-05-21 | 1995-10-03 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aliphatic amino bis-aryl squalene synthase inhibitors |
US5508408A (en) * | 1993-09-10 | 1996-04-16 | Ciba-Geigy Corporation | Quinoline compound |
US5561143A (en) * | 1995-01-25 | 1996-10-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aliphatic amino bis-aryl squalene synthase inhibitors |
TWI311133B (en) | 2001-04-20 | 2009-06-21 | Eisai R&D Man Co Ltd | Carboxylic acid derivativeand the salt thereof |
US7371777B2 (en) | 2001-08-17 | 2008-05-13 | Eisai Co., Ltd. | Cyclic compound and PPAR agonist |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB321738A (en) * | 1928-08-21 | 1929-11-21 | Ig Farbenindustrie Ag | Process for the manufacture of phenylcarboxylic acid compounds |
DE2735919A1 (de) * | 1977-08-10 | 1979-02-22 | Boehringer Sohn Ingelheim | Neue 2-pyridyl- und 2-pyrimidylaminobenzoesaeuren |
CA1134828A (en) * | 1978-12-28 | 1982-11-02 | Tadao Tanouchi | Pyridine derivatives |
US4325959A (en) * | 1979-08-09 | 1982-04-20 | The Dow Chemical Company | Hypoglycemic 4-(((1,3,4, thiadiazolyl)thio)methyl)benzoic acids, ester and amides |
US4464533A (en) * | 1982-11-08 | 1984-08-07 | Ppg Industries, Inc. | Herbicidally active quinoline or quinoxaline benzoate derivatives |
IE56702B1 (en) * | 1982-12-01 | 1991-11-06 | Usv Pharma Corp | Antiinflammatory antiallergic compounds |
NO174506B (no) * | 1984-10-30 | 1994-02-07 | Usv Pharma Corp | Analogifremgangsmaate ved fremstilling av terapeutisk aktive forbindelser |
IE58870B1 (en) * | 1985-03-08 | 1993-11-17 | Leo Pharm Prod Ltd | Pyridine derivatives |
US4839369A (en) * | 1985-04-16 | 1989-06-13 | Rorer Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
JPH06752B2 (ja) * | 1985-04-24 | 1994-01-05 | 正木 長谷川 | 非対称ジオレフイン化合物 |
-
1986
- 1986-10-08 AT AT86307785T patent/ATE68789T1/de active
- 1986-10-08 EP EP86307785A patent/EP0219308B1/en not_active Expired - Lifetime
- 1986-10-08 DE DE8686307785T patent/DE3682160D1/de not_active Expired - Lifetime
- 1986-10-13 DK DK487586A patent/DK487586A/da not_active Application Discontinuation
- 1986-10-15 CA CA000520525A patent/CA1298838C/en not_active Expired - Lifetime
- 1986-10-15 ES ES8602615A patent/ES2002037A6/es not_active Expired
- 1986-10-16 JP JP61244299A patent/JPS6293277A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DE3682160D1 (de) | 1991-11-28 |
ATE68789T1 (de) | 1991-11-15 |
EP0219308A2 (en) | 1987-04-22 |
JPS6293277A (ja) | 1987-04-28 |
CA1298838C (en) | 1992-04-14 |
DK487586D0 (da) | 1986-10-13 |
EP0219308B1 (en) | 1991-10-23 |
DK487586A (da) | 1987-04-17 |
EP0219308A3 (en) | 1987-10-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2002037A6 (es) | Un procedimiento para la preparacioon de quinolonas -2-sustituidas. | |
ES8801209A1 (es) | Un procedimiento para la preparacion de quinolinas 2-sustituidas. | |
ES2062395T3 (es) | Nuevos compuestos de bencimidazol y su uso. | |
ES8801787A1 (es) | Procedimiento para la obtencion de amidas de acidos benzoheterociclilalcanoicos | |
AU8194891A (en) | Substituted bicyclic bis-aryl compounds exhibiting selective leukotriene b4 antagonist activity, their preparation and use in pharmaceutical compositions | |
ES8503339A1 (es) | Procedimiento para la obtencion de tetrahidropiridazinonas | |
JPS5519267A (en) | 3,7-disubstituted-3-cephem-4-carboxylic acid, its salts, their preparation, and preventive and remedy for microbism comprising them as active constituents | |
Schmelkes et al. | Substituted p-aminobenzoic acids | |
JPS5653656A (en) | Quinoline derivative and its preparation | |
GB2184121B (en) | Phenethyl sulphides and their use as leukotriene antagonists | |
KR920008005A (ko) | 류코트리엔 길항제로서의 하이드록시 알킬퀴놀린 에테르 산 | |
ES8301219A1 (es) | Procedimiento para la preparacion de 2-fenilamino-imidazoli-nas-(2) sustituidas | |
ES8504182A1 (es) | Procedimiento para preparar nuevos derivados de piperidina | |
ES8202554A1 (es) | Procedimiento para la preparacion de 2-fenilamino-imidazoli-nas-(2)sustituidas | |
GR3002958T3 (en) | Thiophene derivatives | |
AU535927B2 (en) | 2-phenylamino-imidazolines | |
ZA811149B (en) | Cyclohepitindolol derivatives and their salts with the acids, their preparation, their use as medicaments and the compositions containing them | |
MX5687E (es) | Procedimiento para la preparacion de derivados imidazo(1,2-alpha)-imidazol substituidos | |
IE40528B1 (en) | Cephalosporin derivatives and the preparation thereof | |
CH610877A5 (en) | Process for the preparation of o-(2,6-dichloroanilino)phenylacetic acid and of the addition salts of this acid | |
JPS55151555A (en) | Proline derivatives and their production | |
ES8307812A1 (es) | Un procedimiento para la preparacion de nuevos amidin derivados del acido clavulawilo. | |
ES8105325A1 (es) | Un procedimiento para la preparacion de una composicion far-maceutica de derivados del acido penicilanico. | |
ATE41663T1 (de) | Verfahren zur herstellung von oxazolinen. | |
JPS5572186A (en) | Dibenzothiepin derivative and its preparation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
SA6 | Expiration date (snapshot 920101) |
Free format text: 2006-10-15 |