ES2002037A6 - Un procedimiento para la preparacioon de quinolonas -2-sustituidas. - Google Patents

Un procedimiento para la preparacioon de quinolonas -2-sustituidas.

Info

Publication number
ES2002037A6
ES2002037A6 ES8602615A ES8602615A ES2002037A6 ES 2002037 A6 ES2002037 A6 ES 2002037A6 ES 8602615 A ES8602615 A ES 8602615A ES 8602615 A ES8602615 A ES 8602615A ES 2002037 A6 ES2002037 A6 ES 2002037A6
Authority
ES
Spain
Prior art keywords
substituted
alkyl
unsubstituted
radical
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8602615A
Other languages
English (en)
Inventor
Robert N Young
Robert Zamboni
Serge Leger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Frosst Canada and Co
Original Assignee
Merck Frosst Canada and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada and Co filed Critical Merck Frosst Canada and Co
Publication of ES2002037A6 publication Critical patent/ES2002037A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE QUINOLINAS-2-SUSTITUIDAS DE FORMULA I, DONDE R1 ES H, HALOGENO, ALQUILO C1-8 ALQUENILO O ALQUINILO C2-8, CF3, -OR2, -SR2, -SOR2, -SO2R2, -NR2R2, -CHO, -COOR2, -(CFO)R2, -CN, -C(OH)R2R2, -NO2, FENILO, BENCILO O FENETILO OPCIONALMENTE SUSTITUIDOS; R2 ES H, ALQUILO C1-8, ALQUENILO O ALQUINILO C2-8, -CF3, FENILO, BENCILO O FENETILO OPCIONALMENTE SUSTITUIDOS; R2K ES R2 EXCEPTO H; R4 ES H, HALOGENO, -NO2, -CN, -OR2, -SR2, NR2R2 O ALQUILO C1-8; Y ES -CR2FCR2, DONDE UNO DE R2 ES H; Y Z ES ETILO O H. SE OBTIENEN POR COPULACION DE UN COMPUESTO XXIV PROCEDENTE DE UN DIALDEHIDO VI, CON UN DERIVADO DE QUINOLINA DE FORMULA III. LOS COMPUESTOS 1 ASI OBTENIDOS SON ANTAGONISTAS DE LEUCOTRIENIOS E INHIBEN SU BIOSINTESIS. SON UTILES COMO AGENTES ANTIASMATICOS, ANTIALERGICOS, ANTI-INFLAMATORIOS Y CITO-PROTECTORES.
ES8602615A 1985-10-16 1986-10-15 Un procedimiento para la preparacioon de quinolonas -2-sustituidas. Expired ES2002037A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78794285A 1985-10-16 1985-10-16

Publications (1)

Publication Number Publication Date
ES2002037A6 true ES2002037A6 (es) 1988-07-01

Family

ID=25142975

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8602615A Expired ES2002037A6 (es) 1985-10-16 1986-10-15 Un procedimiento para la preparacioon de quinolonas -2-sustituidas.

Country Status (7)

Country Link
EP (1) EP0219308B1 (es)
JP (1) JPS6293277A (es)
AT (1) ATE68789T1 (es)
CA (1) CA1298838C (es)
DE (1) DE3682160D1 (es)
DK (1) DK487586A (es)
ES (1) ES2002037A6 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962203A (en) * 1985-06-18 1990-10-09 Merck Frost Canada, Inc. 2-substituted quinolines useful as leukotriene antagonists
EP0271287A3 (en) * 1986-12-11 1990-06-13 Merck Frosst Canada Inc. Quinoline dioic acids and amides
DE3867401D1 (de) * 1987-03-18 1992-02-13 American Home Prod Sulfonylcarboxamide.
JPS63258854A (ja) * 1987-04-16 1988-10-26 Mitsubishi Kasei Corp カルボキシスチレン誘導体およびそれを有効成分とする薬剤
US4920131A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
GB8728051D0 (en) * 1987-12-01 1988-01-06 Leo Pharm Prod Ltd Chemical compounds
DE3916663A1 (de) * 1989-05-23 1990-11-29 Bayer Ag Substituierte (chinolin-2-yl-methoxy)phenyl-acyl-sulfonamide und -cyanamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US5304563A (en) * 1991-02-22 1994-04-19 Bayer Aktiengesellschaft 2-substituted quinolines, and their use in medicaments
US5385912A (en) * 1991-03-08 1995-01-31 Rhone-Poulenc Rorer Pharmaceuticals Inc. Multicyclic tertiary amine polyaromatic squalene synthase inhibitors
US5157040A (en) * 1991-04-05 1992-10-20 Merck & Co., Inc. Substituted quinolines as angiotensin ii antagonists
US5455260A (en) * 1993-05-21 1995-10-03 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aliphatic amino bis-aryl squalene synthase inhibitors
US5508408A (en) * 1993-09-10 1996-04-16 Ciba-Geigy Corporation Quinoline compound
US5561143A (en) * 1995-01-25 1996-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aliphatic amino bis-aryl squalene synthase inhibitors
TWI311133B (en) 2001-04-20 2009-06-21 Eisai R&D Man Co Ltd Carboxylic acid derivativeand the salt thereof
US7371777B2 (en) 2001-08-17 2008-05-13 Eisai Co., Ltd. Cyclic compound and PPAR agonist

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB321738A (en) * 1928-08-21 1929-11-21 Ig Farbenindustrie Ag Process for the manufacture of phenylcarboxylic acid compounds
DE2735919A1 (de) * 1977-08-10 1979-02-22 Boehringer Sohn Ingelheim Neue 2-pyridyl- und 2-pyrimidylaminobenzoesaeuren
CA1134828A (en) * 1978-12-28 1982-11-02 Tadao Tanouchi Pyridine derivatives
US4325959A (en) * 1979-08-09 1982-04-20 The Dow Chemical Company Hypoglycemic 4-(((1,3,4, thiadiazolyl)thio)methyl)benzoic acids, ester and amides
US4464533A (en) * 1982-11-08 1984-08-07 Ppg Industries, Inc. Herbicidally active quinoline or quinoxaline benzoate derivatives
IE56702B1 (en) * 1982-12-01 1991-11-06 Usv Pharma Corp Antiinflammatory antiallergic compounds
NO174506B (no) * 1984-10-30 1994-02-07 Usv Pharma Corp Analogifremgangsmaate ved fremstilling av terapeutisk aktive forbindelser
IE58870B1 (en) * 1985-03-08 1993-11-17 Leo Pharm Prod Ltd Pyridine derivatives
US4839369A (en) * 1985-04-16 1989-06-13 Rorer Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
JPH06752B2 (ja) * 1985-04-24 1994-01-05 正木 長谷川 非対称ジオレフイン化合物

Also Published As

Publication number Publication date
DE3682160D1 (de) 1991-11-28
ATE68789T1 (de) 1991-11-15
EP0219308A2 (en) 1987-04-22
JPS6293277A (ja) 1987-04-28
CA1298838C (en) 1992-04-14
DK487586D0 (da) 1986-10-13
EP0219308B1 (en) 1991-10-23
DK487586A (da) 1987-04-17
EP0219308A3 (en) 1987-10-14

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