ES8802610A1 - Un metodo para preparar un compuesto quimico, inhibidor de las 5-lipoxigenasas,util para la terapia humana y veterinaria - Google Patents
Un metodo para preparar un compuesto quimico, inhibidor de las 5-lipoxigenasas,util para la terapia humana y veterinariaInfo
- Publication number
- ES8802610A1 ES8802610A1 ES552805A ES552805A ES8802610A1 ES 8802610 A1 ES8802610 A1 ES 8802610A1 ES 552805 A ES552805 A ES 552805A ES 552805 A ES552805 A ES 552805A ES 8802610 A1 ES8802610 A1 ES 8802610A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- alkyl
- formula
- compounds
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
- C07D213/34—Sulfur atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
Abstract
LOS DERIVADOS ARIL SUSTITUIDOS DE PRIRIDINA O QUINOLINA (I), DONDE NO EXCLUSIVAMENTE, X ES OXIGENO O AZUFRE, R1 Y R2 SON ALQUILO C1-8, R3, R4, R5 Y R6, HALOGENO, CIANO O NITRO, PUDIENDO R5 Y R6 FORMAR UN ANILLO AROMATICO FUSIONADO CON EL PIRIDILO; SE OBTIENEN HACIENDO REACCIONAR UN COMPUESTO (II) CON OTRO R2Y, SIENDO Y <<UN GRUPO DE BUENA SALIDA>> TAL COMO HALOGENO O ALQUIL-, Y POSTERIORMENTE CON OTRO COMPUESTO R1Y, EN UN DISOLVENTE INERTE COMO LA DIMETILFROMAMIDA, EN PRESENCIA DE UNA BASE OPCIONAL EL CARBONATO POTASICO Y ENTRE TEMPERATURA AMBIENTE Y LA DE REFLUJO. INHIBEN LA 5-LIPOXIGENASA, POR LO QUE ES APLICABLE A LA TERAPIA DE ASMA, ALERGIA, ARTRITIS REUMATICA, ARTEROESCLEROSIS, PSORIASIS Y OTRAS SITUACIONES INFLAMATORIAS. *FORMULA*
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB858506094A GB8506094D0 (en) | 1985-03-08 | 1985-03-08 | Chemical products |
GB858525153A GB8525153D0 (en) | 1985-10-11 | 1985-10-11 | Chemical compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
ES552805A0 ES552805A0 (es) | 1988-09-16 |
ES8802610A1 true ES8802610A1 (es) | 1988-09-16 |
Family
ID=26288945
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES552805A Expired ES8802610A1 (es) | 1985-03-08 | 1986-03-07 | Un metodo para preparar un compuesto quimico, inhibidor de las 5-lipoxigenasas,util para la terapia humana y veterinaria |
Country Status (18)
Country | Link |
---|---|
US (2) | US4826987A (es) |
JP (1) | JPH0764813B2 (es) |
AU (1) | AU585586B2 (es) |
BE (1) | BE904368A (es) |
CA (1) | CA1276640C (es) |
DE (1) | DE3607382A1 (es) |
DK (1) | DK166582B1 (es) |
ES (1) | ES8802610A1 (es) |
FR (1) | FR2578540B1 (es) |
GB (1) | GB2173788B (es) |
GR (1) | GR860628B (es) |
IE (1) | IE58870B1 (es) |
IT (1) | IT1221079B (es) |
LU (1) | LU86349A1 (es) |
NL (1) | NL8600596A (es) |
NZ (1) | NZ215347A (es) |
PT (1) | PT82147B (es) |
SE (1) | SE463819B (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE68789T1 (de) * | 1985-10-16 | 1991-11-15 | Merck Frosst Canada Inc | 2-substituierte chinoline. |
DK196688A (da) * | 1987-04-28 | 1988-10-29 | Fujisawa Pharmaceutical Co | Bicykliske forbindelser og fremgangsmaade til fremstilling deraf |
US4826990A (en) * | 1987-09-30 | 1989-05-02 | American Home Products Corporation | 2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents |
GB8728051D0 (en) * | 1987-12-01 | 1988-01-06 | Leo Pharm Prod Ltd | Chemical compounds |
US4889935A (en) * | 1987-12-18 | 1989-12-26 | American Home Products Corporation | Aminoguanidine derivatives |
US5248685A (en) * | 1989-04-07 | 1993-09-28 | Pfizer Inc. | Substituted 1-[3-(heteroarylmethoxy)phenyl]alkanols and related compounds in the treatment of asthma |
DE3927369A1 (de) * | 1989-08-19 | 1991-02-21 | Bayer Ag | Substituierte n-(chinolin-2-yl-methoxy)benzyl-sulfonyl-harnstoffe |
DE3935139A1 (de) * | 1989-10-21 | 1991-04-25 | Bayer Ag | Substituierte (chinolin-2-yl-methoxy)phenyl-thioharnstoffe |
US5021576A (en) * | 1989-10-27 | 1991-06-04 | American Home Products Corporation | 2-Anilino phenylacetic acid derivatives |
US5324747A (en) * | 1992-07-15 | 1994-06-28 | Hoffmann-La Roche Inc. | N-substituted anilines, inhibitors of phospholipases A2 |
US7189834B2 (en) * | 1993-05-11 | 2007-03-13 | Marshall William E | Oligoribonucleotides alert the immune system of animals to the imminence of microbial infection |
US5840318A (en) * | 1993-05-11 | 1998-11-24 | Immunom Technologies, Inc. | Methods and compositions for modulating immune systems of animals |
US5508408A (en) * | 1993-09-10 | 1996-04-16 | Ciba-Geigy Corporation | Quinoline compound |
US5795900A (en) * | 1995-10-03 | 1998-08-18 | Abbott Laboratories | Symmetrical bis-heteroaryl-methoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis |
US5668150A (en) * | 1996-07-26 | 1997-09-16 | Abbott Laboratories | Non-symmetrical bis-heteroarylmethoxyphenylalkyl carboxylates as inhibitors of leukotriene biosynthesis |
ATE261730T1 (de) * | 1997-12-31 | 2004-04-15 | Univ Kansas | Wasserlösliche medikamentenvorstufen tertiärer amine enthaltender medikamente und verfahren zu ihrer herstellung |
HN2001000008A (es) | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
GB2431927B (en) * | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
US8399666B2 (en) * | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
TW200920369A (en) * | 2007-10-26 | 2009-05-16 | Amira Pharmaceuticals Inc | 5-lipoxygenase activating protein (flap) inhibitor |
CN102137858B (zh) * | 2008-05-23 | 2014-07-23 | 潘米拉制药有限责任公司 | 5-脂氧合酶-活化蛋白抑制剂 |
US8546431B2 (en) | 2008-10-01 | 2013-10-01 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
TW201215607A (en) | 2010-07-02 | 2012-04-16 | Lundbeck & Co As H | Aryl-and heteroarylamid derivatives as PDE10A enzyme inhibitor |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US31624A (en) * | 1861-03-05 | Tatting-frame | ||
US2761865A (en) * | 1954-07-07 | 1956-09-04 | Hoffmann La Roche | Pyridylalkyl sulfones |
US4003906A (en) * | 1974-01-22 | 1977-01-18 | The Dow Chemical Company | Substituted pyridinyl methylthio or (methylsulfonyl)benzeneamines |
GB2069492B (en) * | 1980-02-20 | 1984-02-29 | Wyeth John & Brother Ltd | Sulphur compounds |
GB2069493B (en) * | 1980-02-20 | 1984-02-29 | Wyeth John & Brother Ltd | Pyridine derivatives |
US4567184A (en) * | 1982-12-01 | 1986-01-28 | Usv Pharmaceutical Corporation | Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies |
IE56702B1 (en) * | 1982-12-01 | 1991-11-06 | Usv Pharma Corp | Antiinflammatory antiallergic compounds |
JPS5988835U (ja) * | 1982-12-06 | 1984-06-15 | ホシデン株式会社 | スイツチ |
US4486593A (en) * | 1983-01-19 | 1984-12-04 | The Upjohn Company | 2-,3-, or 4-Pyridinylmethylamino arylic acids as thromboxane A2 synthetase and 5-lipoxygenase inhibitors |
US4563463A (en) * | 1983-03-18 | 1986-01-07 | Usv Pharmaceutical Corp. | 2-Oxo-1,3-oxazolo[4,5-h] quinolines useful as anti-allergy agents |
US4554355A (en) * | 1984-07-19 | 1985-11-19 | American Home Products Corporation | Heterocyclic compounds as antiallergic agents |
US5109009A (en) * | 1985-03-08 | 1992-04-28 | Leo Pharmaceutical Products Ltd. | Quinoline and pyridine compounds and inhibition of 5-lipoxygenases therewith |
-
1986
- 1986-02-10 IE IE37086A patent/IE58870B1/en not_active IP Right Cessation
- 1986-02-20 GB GB08604183A patent/GB2173788B/en not_active Expired
- 1986-02-28 SE SE8600913A patent/SE463819B/sv not_active IP Right Cessation
- 1986-02-28 US US06/834,542 patent/US4826987A/en not_active Expired - Fee Related
- 1986-03-03 NZ NZ215347A patent/NZ215347A/xx unknown
- 1986-03-04 DK DK096986A patent/DK166582B1/da not_active IP Right Cessation
- 1986-03-06 PT PT82147A patent/PT82147B/pt not_active IP Right Cessation
- 1986-03-06 GR GR860628A patent/GR860628B/el unknown
- 1986-03-06 IT IT67183/86A patent/IT1221079B/it active
- 1986-03-06 CA CA000503464A patent/CA1276640C/en not_active Expired - Fee Related
- 1986-03-06 DE DE19863607382 patent/DE3607382A1/de not_active Ceased
- 1986-03-07 LU LU86349A patent/LU86349A1/fr unknown
- 1986-03-07 BE BE0/216378A patent/BE904368A/fr not_active IP Right Cessation
- 1986-03-07 AU AU54444/86A patent/AU585586B2/en not_active Ceased
- 1986-03-07 NL NL8600596A patent/NL8600596A/nl not_active Application Discontinuation
- 1986-03-07 ES ES552805A patent/ES8802610A1/es not_active Expired
- 1986-03-07 FR FR868603268A patent/FR2578540B1/fr not_active Expired - Fee Related
- 1986-03-08 JP JP61051286A patent/JPH0764813B2/ja not_active Expired - Lifetime
-
1990
- 1990-12-31 US US07/633,390 patent/US5157039A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IT1221079B (it) | 1990-06-21 |
BE904368A (fr) | 1986-09-08 |
GB2173788B (en) | 1988-08-10 |
AU5444486A (en) | 1986-09-18 |
DE3607382A1 (de) | 1986-09-11 |
NL8600596A (nl) | 1986-10-01 |
US5157039A (en) | 1992-10-20 |
DK96986A (da) | 1986-09-09 |
GB2173788A (en) | 1986-10-22 |
SE8600913D0 (sv) | 1986-02-28 |
GR860628B (en) | 1986-06-26 |
PT82147B (pt) | 1988-07-29 |
FR2578540B1 (fr) | 1990-11-16 |
IE860370L (en) | 1986-09-08 |
AU585586B2 (en) | 1989-06-22 |
US4826987A (en) | 1989-05-02 |
FR2578540A1 (fr) | 1986-09-12 |
GB8604183D0 (en) | 1986-03-26 |
IT8667183A0 (it) | 1986-03-06 |
JPS61207374A (ja) | 1986-09-13 |
IE58870B1 (en) | 1993-11-17 |
JPH0764813B2 (ja) | 1995-07-12 |
DK166582B1 (da) | 1993-06-14 |
LU86349A1 (fr) | 1987-04-02 |
PT82147A (en) | 1986-04-01 |
NZ215347A (en) | 1990-02-26 |
ES552805A0 (es) | 1988-09-16 |
SE463819B (sv) | 1991-01-28 |
CA1276640C (en) | 1990-11-20 |
DK96986D0 (da) | 1986-03-04 |
SE8600913L (sv) | 1986-09-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19990405 |