ES8506018A1 - Procedimiento para la obtencion de derivados carbapenem fluoralquilados - Google Patents

Procedimiento para la obtencion de derivados carbapenem fluoralquilados

Info

Publication number
ES8506018A1
ES8506018A1 ES524424A ES524424A ES8506018A1 ES 8506018 A1 ES8506018 A1 ES 8506018A1 ES 524424 A ES524424 A ES 524424A ES 524424 A ES524424 A ES 524424A ES 8506018 A1 ES8506018 A1 ES 8506018A1
Authority
ES
Spain
Prior art keywords
mono
formula
alkylamino
unsubstituted
represents hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES524424A
Other languages
English (en)
Other versions
ES524424A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES8506018A1 publication Critical patent/ES8506018A1/es
Publication of ES524424A0 publication Critical patent/ES524424A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN COMPUESTO DE FORMULA (I), EN LA QUE R1 SIGNIFICA HIDROGENO O METILO; Y R2 SIGNIFICA HIDROGENO O ALQUILO INFERIOR.CONSISTE EN INTRODUCIR UN GRUPO -S-R2 EN UN COMPUESTO DE FORMULA (II), EN LA QUE R1 Y R2 TIENEN LOS SIGNIFICADOS YA INDICADOS; R8 SIGNIFICA UN GRUPO SUSCEPTIBLE DE SER ELIMINADO; Y R3 SIGNIFICA UN GRUPO PROTECTOR O UN GRUPO ESTER FISIOLOGICAMENTE HIDROLIZABLE Y FISIOLOGICAMENTE ACEPTABLE, EN UN DISOLVENTE INERTE Y A TEMPERATURAS REDUCIDAS.DE APLICACION EN MEDICINA COMO AGENTES QUIMIOTERAPEUTICOS.
ES524424A 1982-07-26 1983-07-26 Procedimiento para la obtencion de derivados carbapenem fluoralquilados Granted ES524424A0 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH453982 1982-07-26
CH565482 1982-09-24
CH764882 1982-12-31

Publications (2)

Publication Number Publication Date
ES8506018A1 true ES8506018A1 (es) 1985-06-16
ES524424A0 ES524424A0 (es) 1985-06-16

Family

ID=27174888

Family Applications (1)

Application Number Title Priority Date Filing Date
ES524424A Granted ES524424A0 (es) 1982-07-26 1983-07-26 Procedimiento para la obtencion de derivados carbapenem fluoralquilados

Country Status (18)

Country Link
US (1) US4720490A (es)
AT (1) AT386600B (es)
AU (1) AU1724183A (es)
CA (1) CA1250839A (es)
CH (1) CH661729A5 (es)
DE (1) DE3390137T1 (es)
DK (1) DK340483A (es)
ES (1) ES524424A0 (es)
FI (1) FI832619A (es)
FR (1) FR2530634B1 (es)
GB (1) GB2124625B (es)
HU (1) HUT34029A (es)
IL (1) IL69324A0 (es)
IT (1) IT1194339B (es)
NL (1) NL8302619A (es)
PT (1) PT77094B (es)
SE (1) SE462492B (es)
WO (1) WO1984000547A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4997936A (en) * 1977-10-19 1991-03-05 Merck & Co., Inc. 2-carbamimidoyl-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids
CH660736A5 (de) * 1983-10-03 1987-06-15 Sanraku Inc Carbapenemderivate.
US4665169A (en) * 1985-09-11 1987-05-12 Bristol-Myers Company Carbapenem antibiotics
EP0234484B1 (en) * 1986-02-19 1993-10-20 Sanraku Incorporated Novel azetidinone derivatives
US4948165A (en) * 1988-01-26 1990-08-14 Nissan Motor Company, Limited Proportioning valve assembly for an actively controlled suspension system
JPH09202789A (ja) * 1995-11-20 1997-08-05 Suntory Ltd ペネム誘導体およびこれを含有する抗菌剤
US7932381B2 (en) * 2005-02-15 2011-04-26 Shionogi & Co., Ltd. Process for producing carbapenem derivative and intermediate crystal therefor
CN116987278B (zh) * 2023-08-04 2024-07-26 青岛江达金塑制品有限公司 一种低温可自愈合聚硅氧烷超分子弹性体及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55147284A (en) * 1979-04-17 1980-11-17 Sanraku Inc Novel beta-lactam derivative and its preparation
EP0082133A3 (en) * 1979-04-19 1983-07-20 Merck & Co. Inc. A process for preparing intermediates useful for preparing 2-substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids
US4235922A (en) * 1979-06-15 1980-11-25 Merck & Co., Inc. 3-(2-Aminoethylthio)-6-ethyl-7-oxo-1-azabicyclo [3.2.0]hept-2-ene-2-carboxylic acid
US4372965A (en) * 1979-10-15 1983-02-08 Merck & Co., Inc. 6-, 1- And 2-substituted-thio-1-carbadethiapen-2-em-3-carboxylic acid S-oxides
DE3169321D1 (en) * 1980-03-27 1985-04-25 Merck & Co Inc Process for the preparation of 1-carbapenems and intermediates via silyl-substituted dithioacetals
US4309346A (en) * 1980-03-27 1982-01-05 Merck & Co., Inc. Process for the preparation of 1-carbapenems and intermediates via trithioorthoacetates
IE52147B1 (en) * 1980-03-27 1987-07-08 Merck & Co Inc 4-(3-carboxy-2-oxopropyl)-azetidin-2-ones and process for their preparation
EP0038869A1 (en) * 1980-04-30 1981-11-04 Merck & Co. Inc. Process for the preparation of 1-carbapenems, and intermediates for their preparation
EP0044170A1 (en) * 1980-07-11 1982-01-20 Beecham Group Plc Beta-lactam antibiotics, their preparation and use
PT73791B (en) * 1980-10-17 1983-10-14 Merck & Co Inc Process for preparing 2-carbamimidoyl-6-substituted-1- -carbadethiapen-2-em-3-carboxylic acids
EP0060612A1 (en) * 1981-02-04 1982-09-22 Beecham Group Plc Process for the preparation of azabicyclo(3.2.0)-hept-2-ene derivatives
ES8404184A1 (es) * 1981-08-03 1984-04-16 Merck & Co Inc Un procedimiento para la prepracion de nuevos derivados de acidos 2-carbamimidoil-1-,carbadestiapen-2-en-3-carboxilados.

Also Published As

Publication number Publication date
FR2530634A1 (fr) 1984-01-27
AU1724183A (en) 1984-02-02
IT8322230A0 (it) 1983-07-26
SE462492B (sv) 1990-07-02
PT77094A (en) 1983-08-01
GB2124625A (en) 1984-02-22
IT1194339B (it) 1988-09-14
NL8302619A (nl) 1984-02-16
HUT34029A (en) 1985-01-28
SE8304124L (sv) 1984-01-27
US4720490A (en) 1988-01-19
GB8319761D0 (en) 1983-08-24
PT77094B (en) 1986-02-26
WO1984000547A1 (en) 1984-02-16
ATA903783A (de) 1988-02-15
FR2530634B1 (fr) 1986-11-14
IL69324A0 (en) 1983-11-30
GB2124625B (en) 1986-03-19
FI832619A (fi) 1984-01-27
SE8304124D0 (sv) 1983-07-25
DE3390137T1 (de) 1984-09-20
DK340483A (da) 1984-01-27
ES524424A0 (es) 1985-06-16
DK340483D0 (da) 1983-07-25
FI832619A0 (fi) 1983-07-19
IT8322230A1 (it) 1985-01-26
CA1250839A (en) 1989-03-07
CH661729A5 (de) 1987-08-14
AT386600B (de) 1988-09-12

Similar Documents

Publication Publication Date Title
IL102703A (en) N-sulfonyl indoline derivatives carrying an amide functional group, their preparation and pharmaceutical compositions containing them
ES439172A1 (es) Procedimiento para la obtencion de agentes herbicidas.
GB1348428A (en) Herbicidal compositions
ES8506018A1 (es) Procedimiento para la obtencion de derivados carbapenem fluoralquilados
ES429234A1 (es) Procedimiento para la preparacion de nuevas amidas de aci- dos n-(1-(omega-fenilalcohil)-piperidil-4)-n-(alfa-piridil)-carboxilicos.
GB1496767A (en) 5-substituted alkyl-8-hydroxycarbostyril derivatives and production thereof
ES8307218A1 (es) Proceso de fabricacion de los nuevos derivados de la amidinopiperadina.
ES433148A1 (es) Procedimiento para preparar derivados de pirazol.
GB1354571A (en) Amides and their use as insecticides
GB1125872A (en) Isothiazole derivatives and compositions containing them
GB1434830A (en) 5-6-benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity
ES453162A1 (es) Un procedimiento para la obtencion de compuestos heteroci- clicos.
GB1323119A (en) Arylimino-oxazolidines and their use as acaricides
ES8706680A1 (es) Procedimiento para preparar derivados de carbapenem
GB1471615A (en) Morpholinothiooxamide derivatives and their use in vulcani zable rubber compositions
GB1455474A (en) Haloacetanilides for influencing plant growth
ES425939A1 (es) Metodo para controlar las malezas del campo mediante el em-pleo de un herbicida de tiocarmabato.
ES424204A1 (es) Un procedimiento para la preparacion del acido 6 beta-aci- lamido-1-oxadestiapenicilanico y derivados del mismo.
SE7412147L (es)
GB1434854A (en) Thiophene derivatives
ES433186A1 (es) Procedimiento para preparar una composicion de alanina di- sustituida en n con propiedades herbicidas.
ES8106147A1 (es) Procedimiento para preparar un 1,2,4-triazol-3-tiol
ES443752A1 (es) Procedimiento para preparar derivados de piridazina.
IE39639B1 (en) N-substituted cycloserine compounds
US4010175A (en) Thio-{62 -lactam penicillins

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203