ES8405412A1 - Procedimiento para la preparacion de cefalosporinas - Google Patents

Procedimiento para la preparacion de cefalosporinas

Info

Publication number
ES8405412A1
ES8405412A1 ES524040A ES524040A ES8405412A1 ES 8405412 A1 ES8405412 A1 ES 8405412A1 ES 524040 A ES524040 A ES 524040A ES 524040 A ES524040 A ES 524040A ES 8405412 A1 ES8405412 A1 ES 8405412A1
Authority
ES
Spain
Prior art keywords
preparation
medicaments containing
cephalosporin derivatives
alkyl
antibiotic medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES524040A
Other languages
English (en)
Other versions
ES524040A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of ES524040A0 publication Critical patent/ES524040A0/es
Publication of ES8405412A1 publication Critical patent/ES8405412A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE CEFALOSPORINAS, DE FORMULA GENERAL (I), EN LA QUE EL GRUPO ACIDO COOA SE HALLA EN FORMA ACIDA, EN FORMA DE SAL O EN FORMA DE ESTER HIDROLIZABLE; R1 REPRESENTA UN RADICAL; R2 Y R3 REPRESENTAN, INDEPENDIENTEMENTE, HIDROGENO, UN GRUPO ALQUILO O UN GRUPO ALQUENILO INFERIOR; R4 Y R5 REPRESENTAN, INDEPENDIENTEMENTE, HIDROGENO, UN GRUPO ALQUILO INFERIOR O UN GRUPO ALQUENILO INFERIOR; Y X DESIGNA EL ANION DE UN ACIDO.CONSISTE EN HACER REACCIONAR AMINO-7-BROMO-ETIL-3-C EFEMO-3-CARBOXILATO DE TERCIBUTIL-4 S-OXIDO, CON UN ACIDO DE FORMULA (II), EN LA QUETR ES UN GRUPO PROTECTOR DEL GRUPO AMINO; Y R1 ES UN ESTER LABIL DEL RADICAL R1 CUYA FUNCION ACIDA HA SIDO ACTIVADA, EN UN DISOLVENTE ADECUADO, TAL COMO LA METILFORMAMIDA. EL PRODUCTO OBTENIDO SE HACE REACCIONAR CON UNA TIOUREA DE FORMULA GENERAL (III).DE APLICACION COMO ANTIBIOTICOS EN MEDICINA HUMANA O VETERINARIA.
ES524040A 1982-07-13 1983-07-12 Procedimiento para la preparacion de cefalosporinas Expired ES8405412A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8212317A FR2530248A1 (fr) 1982-07-13 1982-07-13 Nouveaux derives des cephalosporines, leur procede de preparation et medicaments antibiotiques contenant lesdits derives

Publications (2)

Publication Number Publication Date
ES524040A0 ES524040A0 (es) 1984-06-16
ES8405412A1 true ES8405412A1 (es) 1984-06-16

Family

ID=9275967

Family Applications (1)

Application Number Title Priority Date Filing Date
ES524040A Expired ES8405412A1 (es) 1982-07-13 1983-07-12 Procedimiento para la preparacion de cefalosporinas

Country Status (28)

Country Link
US (1) US4578377A (es)
EP (1) EP0099297B1 (es)
JP (1) JPS5973590A (es)
KR (1) KR840005455A (es)
AT (1) ATE33392T1 (es)
AU (1) AU555185B2 (es)
CA (1) CA1209126A (es)
CS (1) CS236797B2 (es)
DD (1) DD210054A5 (es)
DE (1) DE3376213D1 (es)
DK (1) DK323183A (es)
EG (1) EG15964A (es)
ES (1) ES8405412A1 (es)
FI (1) FI74286C (es)
FR (1) FR2530248A1 (es)
GR (1) GR79285B (es)
HU (1) HU189712B (es)
IL (1) IL69210A (es)
MA (1) MA19841A1 (es)
NO (1) NO832515L (es)
NZ (1) NZ204873A (es)
OA (1) OA07495A (es)
PH (1) PH19298A (es)
PL (1) PL141582B1 (es)
PT (1) PT77017B (es)
SU (1) SU1194280A3 (es)
YU (1) YU149683A (es)
ZA (1) ZA835101B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8413152D0 (en) * 1983-06-03 1984-06-27 Ici Pharma Cephalosporin derivatives
US4855420A (en) * 1983-06-03 1989-08-08 Ici Pharma Cephalosporin derivatives
US4868173A (en) * 1984-11-20 1989-09-19 Ici Pharma Cephalosporin derivatives
EP0333082A3 (en) * 1988-03-15 1991-05-02 Takeda Chemical Industries, Ltd. Cephem compounds, their production and use
JPH0320265A (ja) * 1989-02-10 1991-01-29 Meiji Seika Kaisha Ltd アミノチアゾール酢酸誘導体並びにその製造法
WO2013053953A1 (en) * 2011-10-14 2013-04-18 Université de Liège Method for measuring beta-lactam antibiotics

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK128611B (da) * 1961-05-16 1974-06-04 Glaxo Lab Ltd Fremgangsmåde til fremstilling af derivater af cephalosporin C eller salte deraf.
GB1012943A (en) * 1961-05-16 1965-12-15 Glaxo Lab Ltd Improvements in or relating to antibiotics
DE2716677C2 (de) * 1977-04-15 1985-10-10 Hoechst Ag, 6230 Frankfurt Cephemderivate und Verfahren zu ihrer Herstellung
FR2442240A1 (fr) * 1978-11-27 1980-06-20 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-substitue 7-amino thiazolyl acetamido cephalosporanique comportant un groupement eliminable sur le radical amino, leur procede de preparation et leur application a la synthese de produits actifs comme medicaments

Also Published As

Publication number Publication date
HU189712B (en) 1986-07-28
FI74286B (fi) 1987-09-30
IL69210A (en) 1986-12-31
PL141582B1 (en) 1987-08-31
AU555185B2 (en) 1986-09-18
DE3376213D1 (en) 1988-05-11
GR79285B (es) 1984-10-22
FR2530248A1 (fr) 1984-01-20
EP0099297A1 (fr) 1984-01-25
PH19298A (en) 1986-03-05
JPS5973590A (ja) 1984-04-25
FI832522L (fi) 1984-01-14
KR840005455A (ko) 1984-11-12
PL242988A1 (en) 1984-08-13
DK323183A (da) 1984-01-14
MA19841A1 (fr) 1984-04-01
DK323183D0 (da) 1983-07-13
CS236797B2 (en) 1985-05-15
FR2530248B1 (es) 1985-02-15
US4578377A (en) 1986-03-25
ATE33392T1 (de) 1988-04-15
ZA835101B (en) 1984-03-28
SU1194280A3 (ru) 1985-11-23
DD210054A5 (de) 1984-05-30
PT77017B (fr) 1986-01-24
CA1209126A (en) 1986-08-05
ES524040A0 (es) 1984-06-16
NO832515L (no) 1984-01-16
AU1679583A (en) 1984-01-19
EP0099297B1 (fr) 1988-04-06
OA07495A (fr) 1985-03-31
FI832522A0 (fi) 1983-07-11
NZ204873A (en) 1985-12-13
FI74286C (fi) 1988-01-11
IL69210A0 (en) 1983-11-30
PT77017A (fr) 1983-08-01
EG15964A (en) 1986-06-30
YU149683A (en) 1985-10-31

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