ES8308331A1 - Un procedimiento de preparacion de cefalosporinas sustituidas en la posicion 3 con un grupo heterociclo-tiometilo. - Google Patents

Un procedimiento de preparacion de cefalosporinas sustituidas en la posicion 3 con un grupo heterociclo-tiometilo.

Info

Publication number
ES8308331A1
ES8308331A1 ES517840A ES517840A ES8308331A1 ES 8308331 A1 ES8308331 A1 ES 8308331A1 ES 517840 A ES517840 A ES 517840A ES 517840 A ES517840 A ES 517840A ES 8308331 A1 ES8308331 A1 ES 8308331A1
Authority
ES
Spain
Prior art keywords
thiomethylheterocyclic
preparation
group
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES517840A
Other languages
English (en)
Other versions
ES517840A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of ES517840A0 publication Critical patent/ES517840A0/es
Publication of ES8308331A1 publication Critical patent/ES8308331A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Tunnel Furnaces (AREA)
  • Noodles (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE CEFALOSPORINAS SUBSTITUIDAS EN LA POSICION 3 CON UN GRUPO HETEROCICLO-TIOMETILO, DE FORMULA GENERAL (I), EN LA QUE R<1 Y R<2 REPRESENTAN UN GRUPO METILO O UN GRUPO 1,3-PROPILENO; R<3 REPRESENTA UN HETEROCICLO; Y A REPRESENTA HIDROGENO, UN CATION O UN ESTER. COMPRENDE LAS SIGUIENTES FASES: PRIMERA, SE ACILA EL 1-S-OXIDO DE 7-AMINO-3-BROMOMETIL-3-CEFEM-CARBOXILATO DE T-BUTILO, CON UN ACIDO DE FORMULA (II), EN LA QUE R<1 Y R<2 TIENEN LOS SIGNIFICADOS YA INDICADOS; Y TR ES UN GRUPO PROTECTOR; SEGUNDA, EL PRODUCTO OBTENIDO SE HACE REACCIONAR CON UN TIOL DE FORMULA: R<3SH; TERCERA, SE SEPARAN POR HIDROLISIS LOS GRUPOS PROTECTORES; Y POR ULTIMO, SE PUEDE TRANSFORMAR LA FUNCION ACIDA EN UNA SAL O EN UN ESTER. DE APLICACION EN FARMACIA POR SU ACTIVIDAD ANTIBACTERIANA.
ES517840A 1981-12-01 1982-11-30 Un procedimiento de preparacion de cefalosporinas sustituidas en la posicion 3 con un grupo heterociclo-tiometilo. Expired ES8308331A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8122506A FR2517309A1 (fr) 1981-12-01 1981-12-01 Nouveaux derives de cephalosporines substitues en position 3 par un groupe heterocycle thiomethyl; procede de preparation desdits composes et compositions pharmaceutiques en contenant

Publications (2)

Publication Number Publication Date
ES517840A0 ES517840A0 (es) 1983-08-16
ES8308331A1 true ES8308331A1 (es) 1983-08-16

Family

ID=9264556

Family Applications (1)

Application Number Title Priority Date Filing Date
ES517840A Expired ES8308331A1 (es) 1981-12-01 1982-11-30 Un procedimiento de preparacion de cefalosporinas sustituidas en la posicion 3 con un grupo heterociclo-tiometilo.

Country Status (30)

Country Link
US (1) US4609654A (es)
EP (1) EP0080944B1 (es)
JP (1) JPS58103392A (es)
KR (1) KR880001775B1 (es)
AT (1) ATE15199T1 (es)
AU (1) AU564235B2 (es)
CA (1) CA1189854A (es)
CS (1) CS232743B2 (es)
DD (1) DD204257A5 (es)
DE (1) DE3265901D1 (es)
DK (1) DK532282A (es)
EG (1) EG15644A (es)
ES (1) ES8308331A1 (es)
FI (1) FI73221C (es)
FR (1) FR2517309A1 (es)
GR (1) GR76739B (es)
HU (2) HU186999B (es)
IE (1) IE54173B1 (es)
IL (1) IL67285A (es)
MA (1) MA19659A1 (es)
NO (1) NO159857C (es)
NZ (1) NZ202658A (es)
OA (1) OA07262A (es)
PH (1) PH18949A (es)
PL (1) PL132054B1 (es)
PT (1) PT75905B (es)
SG (1) SG12188G (es)
SU (1) SU1114338A3 (es)
YU (1) YU265482A (es)
ZA (1) ZA828598B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60142987A (ja) * 1983-12-29 1985-07-29 Mochida Pharmaceut Co Ltd セフアロスポリン誘導体
DE150507T1 (de) * 1983-12-29 1987-02-26 Mochida Pharmaceutical Co., Ltd., Tokio/Tokyo Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US4812562A (en) * 1985-07-25 1989-03-14 Taisho Pharmaceutical Co., Ltd. Cephalosporin derivatives
HU196814B (en) * 1985-10-22 1989-01-30 Biogal Gyogyszergyar Process for producing new cepheme-carboxylic acid derivatives
JPS63132893A (ja) * 1986-11-25 1988-06-04 Mochida Pharmaceut Co Ltd 新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB694060A (en) * 1949-12-27 1953-07-15 Bataafsche Petroleum Process for the manufacture of ethers of glycerols
US4165430A (en) * 1976-03-19 1979-08-21 Glaxo Laboratories Limited Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group
DE2716677C2 (de) * 1977-04-15 1985-10-10 Hoechst Ag, 6230 Frankfurt Cephemderivate und Verfahren zu ihrer Herstellung
PT70995B (en) * 1979-03-22 1981-06-25 Glaxo Group Ltd Cephalosporin antibiotics
US4237128A (en) * 1979-04-12 1980-12-02 E. R. Squibb & Sons, Inc. 7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides

Also Published As

Publication number Publication date
DD204257A5 (de) 1983-11-23
PH18949A (en) 1985-11-14
HU186998B (en) 1985-10-28
ES517840A0 (es) 1983-08-16
DE3265901D1 (en) 1985-10-03
FI824043A0 (fi) 1982-11-24
IE54173B1 (en) 1989-07-05
NO159857B (no) 1988-11-07
HU186999B (en) 1985-10-28
PL239271A1 (en) 1983-06-06
FI824043L (fi) 1983-06-02
IL67285A0 (en) 1983-03-31
FR2517309A1 (fr) 1983-06-03
IL67285A (en) 1985-11-29
OA07262A (fr) 1984-04-30
MA19659A1 (fr) 1983-07-01
NZ202658A (en) 1985-07-12
EP0080944B1 (fr) 1985-08-28
PL132054B1 (en) 1985-01-31
SG12188G (en) 1989-01-27
NO159857C (no) 1989-02-15
FR2517309B1 (es) 1985-03-22
US4609654A (en) 1986-09-02
ZA828598B (en) 1983-09-28
YU265482A (en) 1985-03-20
JPS58103392A (ja) 1983-06-20
KR840002406A (ko) 1984-07-21
FI73221B (fi) 1987-05-29
CS232743B2 (en) 1985-02-14
EP0080944A1 (fr) 1983-06-08
SU1114338A3 (ru) 1984-09-15
AU564235B2 (en) 1987-08-06
FI73221C (fi) 1987-09-10
PT75905A (fr) 1982-12-01
KR880001775B1 (ko) 1988-09-15
AU9094882A (en) 1983-06-09
IE822721L (en) 1983-06-01
CA1189854A (en) 1985-07-02
GR76739B (es) 1984-08-30
PT75905B (fr) 1985-10-04
NO823930L (no) 1983-06-02
CS859582A2 (en) 1984-02-13
EG15644A (en) 1986-09-30
ATE15199T1 (de) 1985-09-15
DK532282A (da) 1983-06-02

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