IL69210A - 7-(2-(2-amino 4-thiazolyl)-2-carboxyalkyloxyimino)acetamido)-3-(uronium thiomethyl)3-cephem 4-carboxylic acid derivatives,their preparation and antibiotic pharmaceutical compositions containing them - Google Patents
7-(2-(2-amino 4-thiazolyl)-2-carboxyalkyloxyimino)acetamido)-3-(uronium thiomethyl)3-cephem 4-carboxylic acid derivatives,their preparation and antibiotic pharmaceutical compositions containing themInfo
- Publication number
- IL69210A IL69210A IL69210A IL6921083A IL69210A IL 69210 A IL69210 A IL 69210A IL 69210 A IL69210 A IL 69210A IL 6921083 A IL6921083 A IL 6921083A IL 69210 A IL69210 A IL 69210A
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- carboxyalkyloxyimino
- cephem
- uronium
- thiomethyl
- Prior art date
Links
- IKWLIQXIPRUIDU-ZCFIWIBFSA-N (6r)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical class OC(=O)C1=CCS[C@@H]2CC(=O)N12 IKWLIQXIPRUIDU-ZCFIWIBFSA-N 0.000 title 1
- 230000003115 biocidal effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- -1 R4 and R5 are H Chemical group 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- General Preparation And Processing Of Foods (AREA)
- Bakery Products And Manufacturing Methods Therefor (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
The present invention relates to cephalosporins having the formula: <IMAGE> (1) in which COOA is an acidic radical, salt or ester, and R1 represents a group: <IMAGE> in which RA and RB are H or alkyl or together form a cycloalkyl with the carbon to which they are bonded, R2 and R3 are H, alkyl or alkenyl, R4 and R5 are H, alkyl or alkenyl or together form a ring to the nitrogen atom with which they are bonded. This invention also relates to a process for the preparation of these compounds and to drugs containing them.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8212317A FR2530248A1 (en) | 1982-07-13 | 1982-07-13 | NOVEL DERIVATIVES OF CEPHALOSPORINS, PROCESS FOR THEIR PREPARATION AND ANTIBIOTIC DRUGS CONTAINING SAID DERIVATIVES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL69210A0 IL69210A0 (en) | 1983-11-30 |
| IL69210A true IL69210A (en) | 1986-12-31 |
Family
ID=9275967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL69210A IL69210A (en) | 1982-07-13 | 1983-07-12 | 7-(2-(2-amino 4-thiazolyl)-2-carboxyalkyloxyimino)acetamido)-3-(uronium thiomethyl)3-cephem 4-carboxylic acid derivatives,their preparation and antibiotic pharmaceutical compositions containing them |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US4578377A (en) |
| EP (1) | EP0099297B1 (en) |
| JP (1) | JPS5973590A (en) |
| KR (1) | KR840005455A (en) |
| AT (1) | ATE33392T1 (en) |
| AU (1) | AU555185B2 (en) |
| CA (1) | CA1209126A (en) |
| CS (1) | CS236797B2 (en) |
| DD (1) | DD210054A5 (en) |
| DE (1) | DE3376213D1 (en) |
| DK (1) | DK323183A (en) |
| EG (1) | EG15964A (en) |
| ES (1) | ES8405412A1 (en) |
| FI (1) | FI74286C (en) |
| FR (1) | FR2530248A1 (en) |
| GR (1) | GR79285B (en) |
| HU (1) | HU189712B (en) |
| IL (1) | IL69210A (en) |
| MA (1) | MA19841A1 (en) |
| NO (1) | NO832515L (en) |
| NZ (1) | NZ204873A (en) |
| OA (1) | OA07495A (en) |
| PH (1) | PH19298A (en) |
| PL (1) | PL141582B1 (en) |
| PT (1) | PT77017B (en) |
| SU (1) | SU1194280A3 (en) |
| YU (1) | YU149683A (en) |
| ZA (1) | ZA835101B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4855420A (en) * | 1983-06-03 | 1989-08-08 | Ici Pharma | Cephalosporin derivatives |
| GB8413152D0 (en) * | 1983-06-03 | 1984-06-27 | Ici Pharma | Cephalosporin derivatives |
| EP0182633A3 (en) * | 1984-11-20 | 1987-09-02 | Ici Pharma | Cephalosporin derivatives |
| EP0333082A3 (en) * | 1988-03-15 | 1991-05-02 | Takeda Chemical Industries, Ltd. | Cephem compounds, their production and use |
| JPH0320265A (en) * | 1989-02-10 | 1991-01-29 | Meiji Seika Kaisha Ltd | Aminothiazoleacetic acid derivative and its production |
| WO2013053953A1 (en) * | 2011-10-14 | 2013-04-18 | Université de Liège | Method for measuring beta-lactam antibiotics |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1012943A (en) * | 1961-05-16 | 1965-12-15 | Glaxo Lab Ltd | Improvements in or relating to antibiotics |
| DK128611B (en) * | 1961-05-16 | 1974-06-04 | Glaxo Lab Ltd | Process for the preparation of derivatives of cephalosporin C or salts thereof. |
| DE2716677C2 (en) * | 1977-04-15 | 1985-10-10 | Hoechst Ag, 6230 Frankfurt | Cephem derivatives and processes for their preparation |
| FR2442240A1 (en) * | 1978-11-27 | 1980-06-20 | Roussel Uclaf | 2-Thiazolyl-2-hydroxy-imino-acetamido cephalosporin derivs. - useful as antibacterials (BE 5.6.79) |
-
1982
- 1982-07-13 FR FR8212317A patent/FR2530248A1/en active Granted
-
1983
- 1983-07-07 MA MA20061A patent/MA19841A1/en unknown
- 1983-07-08 EP EP83401413A patent/EP0099297B1/en not_active Expired
- 1983-07-08 AT AT83401413T patent/ATE33392T1/en active
- 1983-07-08 DE DE8383401413T patent/DE3376213D1/en not_active Expired
- 1983-07-11 FI FI832522A patent/FI74286C/en not_active IP Right Cessation
- 1983-07-11 NO NO832515A patent/NO832515L/en unknown
- 1983-07-12 IL IL69210A patent/IL69210A/en unknown
- 1983-07-12 YU YU01496/83A patent/YU149683A/en unknown
- 1983-07-12 SU SU833622788A patent/SU1194280A3/en active
- 1983-07-12 ES ES524040A patent/ES8405412A1/en not_active Expired
- 1983-07-12 PH PH29214A patent/PH19298A/en unknown
- 1983-07-12 GR GR71918A patent/GR79285B/el unknown
- 1983-07-12 HU HU832485A patent/HU189712B/en unknown
- 1983-07-12 CA CA000432224A patent/CA1209126A/en not_active Expired
- 1983-07-12 PT PT77017A patent/PT77017B/en unknown
- 1983-07-12 NZ NZ204873A patent/NZ204873A/en unknown
- 1983-07-13 DD DD83253036A patent/DD210054A5/en unknown
- 1983-07-13 OA OA58062A patent/OA07495A/en unknown
- 1983-07-13 PL PL1983242988A patent/PL141582B1/en unknown
- 1983-07-13 AU AU16795/83A patent/AU555185B2/en not_active Ceased
- 1983-07-13 DK DK323183A patent/DK323183A/en not_active Application Discontinuation
- 1983-07-13 ZA ZA835101A patent/ZA835101B/en unknown
- 1983-07-13 JP JP58127512A patent/JPS5973590A/en active Pending
- 1983-07-13 KR KR1019830003186A patent/KR840005455A/en not_active Abandoned
- 1983-07-13 CS CS835304A patent/CS236797B2/en unknown
- 1983-07-16 EG EG83429A patent/EG15964A/en active
-
1985
- 1985-04-16 US US06/723,709 patent/US4578377A/en not_active Expired - Fee Related
Also Published As
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