ATE275132T1 - 4-acylamino(halogen)alkyl-chinolin derivate, deren herstellung und deren verwendung als melatonin-agonisten - Google Patents

4-acylamino(halogen)alkyl-chinolin derivate, deren herstellung und deren verwendung als melatonin-agonisten

Info

Publication number
ATE275132T1
ATE275132T1 AT96921083T AT96921083T ATE275132T1 AT E275132 T1 ATE275132 T1 AT E275132T1 AT 96921083 T AT96921083 T AT 96921083T AT 96921083 T AT96921083 T AT 96921083T AT E275132 T1 ATE275132 T1 AT E275132T1
Authority
AT
Austria
Prior art keywords
pct
acylamino
halogen
alkyl
preparation
Prior art date
Application number
AT96921083T
Other languages
English (en)
Inventor
Shigenori Ohkawa
Osamu Uchikawa
Masaomi Miyamoto
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE275132T1 publication Critical patent/ATE275132T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT96921083T 1995-06-27 1996-06-26 4-acylamino(halogen)alkyl-chinolin derivate, deren herstellung und deren verwendung als melatonin-agonisten ATE275132T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP16111495 1995-06-27
PCT/JP1996/001759 WO1997001539A1 (en) 1995-06-27 1996-06-26 4-acylamino(halogeno) alkyl-quinoline derivatives, their preparation and their use as melatonin agonists

Publications (1)

Publication Number Publication Date
ATE275132T1 true ATE275132T1 (de) 2004-09-15

Family

ID=15728878

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96921083T ATE275132T1 (de) 1995-06-27 1996-06-26 4-acylamino(halogen)alkyl-chinolin derivate, deren herstellung und deren verwendung als melatonin-agonisten

Country Status (7)

Country Link
US (1) US5708005A (de)
EP (1) EP0837850B1 (de)
AT (1) ATE275132T1 (de)
AU (1) AU6241796A (de)
CA (1) CA2215178A1 (de)
DE (1) DE69633289T2 (de)
WO (1) WO1997001539A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2853649B1 (fr) * 2003-04-09 2006-07-14 Servier Lab Nouveaux derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20050137247A1 (en) * 2003-12-22 2005-06-23 The Brigham And Women's Hospital, Inc. Methods and compositions for treatment of hypertension
US8134004B2 (en) 2006-07-11 2012-03-13 Pfizer Inc. Substituted N-bicyclicalkyl bicycliccarboxyamide compounds
RU2011107443A (ru) * 2008-07-30 2012-09-10 Феррер Интернасионал С.А. (ES) Индаценовые соединения, фармацевтическая композиция и лекарственное средство на их основе, способ их получения и способ лечения или профилактики состояний, связанных с нарушением функционирования систем, регулируемых мелатонином, с их помощью
KR20180100627A (ko) 2016-01-08 2018-09-11 다케다 야쿠힌 고교 가부시키가이샤 섬망의 예방 또는 치료제
WO2017119455A1 (ja) 2016-01-08 2017-07-13 武田薬品工業株式会社 自閉症スペクトラム障害の予防または治療剤
TW202214558A (zh) * 2020-07-28 2022-04-16 大陸商上海翰森生物醫藥科技有限公司 雙環類衍生物調節劑、其製備方法和應用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3615889A (en) * 1969-09-04 1971-10-26 American Cyanamid Co Chemical treatment of metal
FI80022C (fi) * 1982-07-05 1990-04-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av ett nytt, terapeutiskt anvaendbart karbostyrilderivat.
JPS60142959A (ja) * 1983-12-28 1985-07-29 Otsuka Pharmaceut Co Ltd キノリン誘導体
GB8829296D0 (en) * 1988-12-15 1989-01-25 Ici Plc Anti-tumour compounds
FR2658818B1 (fr) * 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
AU7440691A (en) * 1990-03-12 1991-10-10 Yamanouchi Pharmaceutical Co., Ltd. Monourea derivative and its salt
EP0555347A4 (en) * 1990-10-31 1995-01-11 Smithkline Beecham Corp Substituted indolizino 1,2-b)quinolinones
DK0540099T3 (da) * 1991-10-29 1996-06-17 Glaxo Wellcome Inc Vandopløselige camptothecinderivater
EP0556585A3 (de) * 1992-01-24 1993-09-01 Takeda Chemical Industries, Ltd. Kondensierte Camptotherinderivate, ihre Herstellung und ihre Verwendung als Antitumormittel
US5432172A (en) * 1992-08-03 1995-07-11 The Research Foundation Of State University Of New York Biological applications of alkaloids derived from the tunicate Eudistoma sp.
US5449683A (en) * 1992-10-01 1995-09-12 Massachussetts Institute Of Technology Methods of inducing sleep using melatonin
FR2696453B1 (fr) * 1992-10-02 1994-12-23 Adir Nouveaux arylalkyl(thio)amides, leur procédé de préparation, et les compositions pharmaceutiques qui les contiennent.
US5342947A (en) * 1992-10-09 1994-08-30 Glaxo Inc. Preparation of water soluble camptothecin derivatives
FR2713636B1 (fr) * 1993-12-07 1996-01-05 Adir Nouveaux dérivés naphtaléniques, leur procédé de préparation, et les compositions pharmaceutiques qui les contiennent.
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
AU3399895A (en) * 1994-09-12 1996-03-29 Takeda Chemical Industries Ltd. Benzocycloalkene compounds, their production and use
KR960029336A (ko) * 1995-01-09 1996-08-17 김충환 캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제
FR2729147A1 (fr) * 1995-01-11 1996-07-12 Adir Nouveaux composes (hetero) cycliques alkyles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
CA2215178A1 (en) 1997-01-16
EP0837850B1 (de) 2004-09-01
DE69633289D1 (de) 2004-10-07
DE69633289T2 (de) 2006-01-12
WO1997001539A1 (en) 1997-01-16
US5708005A (en) 1998-01-13
EP0837850A1 (de) 1998-04-29
AU6241796A (en) 1997-01-30

Similar Documents

Publication Publication Date Title
DE69413542T2 (de) Perhydroisoindolderivate als substanz p antagonisten
IL124537A0 (en) Naphthyl-substituted benzimidazole derivatives and pharmaceutical compositions containing the same
DE69828445D1 (de) Heterozyklische verbindungen,und deren verwendung in arzneimittel,verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen
DE69637097D1 (de) 8-azabicyclo(3.2.1)oct-2en-derivate, deren herstellung und anwendung
DE69433984D1 (de) Arylpiperazinderivate von indol als liganden der rezeptoren 5 ht1-like, 5 ht1b und 5 ht1d
HUT75865A (en) Tropane-2-aldoxime derivatives pharmaceutical compositions containing them, process for producing them and their use
ATE73790T1 (de) Amino 5,6,7,8tetrahydronaphtho(2,3b>furanderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
FI894061A0 (fi) Menetelmä lääkeaineina käyttökelpoisten , -disubstituoitujen N-sykloalkyylialkyylibentsyyliamiinien valmistamiseksi ja niiden synteesivälituotteita
ATE275132T1 (de) 4-acylamino(halogen)alkyl-chinolin derivate, deren herstellung und deren verwendung als melatonin-agonisten
DE69330601T2 (de) Serotoninergische ergolin derivate
FI970434A0 (fi) Uudet 3-substituoidut 3H-2,3-bentsodiatsepiinijohdannaiset, niiden valmistus ja käyttö lääkkeenä
BR9610175A (pt) Composto processo de preparação do composto composição farmacêutica e utilização do composto
HRP950437A2 (en) N-substituted azabicycloheptane derivatives, their production and use
ATE193705T1 (de) 4-p-fluorbenzoyl-1-piperidinyl-propoxy-chromen- - on derivate, deren herstellung und deren verwendung zur behandlung von psychosen und schizophrenie
AU4304596A (en) A process for the preparation of substituted 4-ethyl-piperidines and an intermediate for the preparation of same
ZA9480B (en) Pyrrolidine derivatives their preparation and medicaments containing them
ATE155791T1 (de) Etoposid-derivate, ihre herstellung, ihre verwendung als medikament und ihre verwendung zur herstellung eines antikrebsmittels
ES8501382A1 (es) Procedimiento para la preparacion de derivados de acido fenilacetico.
ATE203533T1 (de) INDOLDERIVATE ALS PRODRUGS VON ß5-HT1-LIKEß REZEPTOR AGONISTEN
DE69943259D1 (de) Neue 2-Halogen-Derivate von 5-O-Desosaminylerythronolid A, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
ATE79752T1 (de) Verwendung von chromanderivaten zur herstellung eines medikamentes zur behandlung von depressiven zustaenden.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties