PE20040757A1 - Derivados de benzoxazina - Google Patents

Derivados de benzoxazina

Info

Publication number
PE20040757A1
PE20040757A1 PE2003000452A PE2003000452A PE20040757A1 PE 20040757 A1 PE20040757 A1 PE 20040757A1 PE 2003000452 A PE2003000452 A PE 2003000452A PE 2003000452 A PE2003000452 A PE 2003000452A PE 20040757 A1 PE20040757 A1 PE 20040757A1
Authority
PE
Peru
Prior art keywords
alkyl
benzo
piperazin
chloro
oxazine
Prior art date
Application number
PE2003000452A
Other languages
English (en)
Inventor
Jacob Berger
Shu-Hai Zhao
Robin Douglas Clark
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20040757A1 publication Critical patent/PE20040757A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/341,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/361,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D267/00Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02Seven-membered rings
    • C07D267/08Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE m ES DE 0 A 3; n Y p SON CADA UNO DE 2 A 3; Y ES -S(O2)-, -S(O2)-N(R10)-; R10 ES H O ALQUILO INFERIOR; Z1 ES CH, N; R1 Y R2 SON CADA UNO H O ALQUILO; R3 ES ALQUILO, ARILO, HALOALQUILO, ENTRE OTROS; LOS R4 SON CADA UNO HALO, ALQUILO, HALOALQUILO, CIANO, ENTRE OTROS; R5, R6, R7 Y R8 SON CADA UNO H O ALQUILO; R9 ES H, ALQUILO, CICLOALQUILO, BENCILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 6-CLORO-4-(4-METANOSULFONIL-BENCENOSULFONIL)-8-PIPERAZIN-1-IL-3,4-DIHIDRO-2H-BENZO[1,4]OXAZINA; 6-CLORO-4-(3-FLUORO-BENCENOSULFONIL)-8-PIPERAZIN-1-IL-3,4-DIHIDRO-2H-BENZO[1,4]OXAZINA Y 4-(BENZO[1,2,5] TIADIAZOL-4-SULFONIL)-6-CLORO-8-PIPERAZIN-1-IL-3,4-DIHIDRO-2H-BENZO[1,4]OXAZINA; ENTRE OTROS. SE REFIERE TAMBIEN A COMPOSICIONES ASOCIADAS. DICHOS COMPUESTOS SON AGONISTAS 5HT6 UTILES EN EL TRATAMIENTO DE CIERTOS TRASTORNOS DEL SNC
PE2003000452A 2002-05-13 2003-05-09 Derivados de benzoxazina PE20040757A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37800302P 2002-05-13 2002-05-13

Publications (1)

Publication Number Publication Date
PE20040757A1 true PE20040757A1 (es) 2004-11-06

Family

ID=29420358

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000452A PE20040757A1 (es) 2002-05-13 2003-05-09 Derivados de benzoxazina

Country Status (37)

Country Link
US (4) US6867204B2 (es)
EP (1) EP1506179B1 (es)
JP (1) JP4307377B2 (es)
KR (1) KR100636475B1 (es)
CN (1) CN100429206C (es)
AR (1) AR039988A1 (es)
AT (1) ATE316523T1 (es)
AU (1) AU2003233231B2 (es)
BR (1) BRPI0310032B8 (es)
CA (1) CA2485136C (es)
DE (1) DE60303376T2 (es)
DK (1) DK1506179T3 (es)
EA (1) EA009982B1 (es)
EC (1) ECSP045420A (es)
EG (1) EG25683A (es)
ES (1) ES2256744T3 (es)
GT (1) GT200300108A (es)
HK (1) HK1080846A1 (es)
HR (1) HRP20041030B1 (es)
IL (1) IL164928A0 (es)
JO (1) JO2413B1 (es)
MA (1) MA27118A1 (es)
MX (1) MXPA04011254A (es)
MY (1) MY139612A (es)
NO (1) NO329380B1 (es)
NZ (1) NZ536230A (es)
PA (1) PA8573501A1 (es)
PE (1) PE20040757A1 (es)
PL (1) PL211057B1 (es)
PT (1) PT1506179E (es)
RS (1) RS51042B (es)
TN (1) TNSN04225A1 (es)
TW (1) TWI258479B (es)
UA (1) UA76877C2 (es)
UY (1) UY27803A1 (es)
WO (1) WO2003095434A1 (es)
ZA (1) ZA200408783B (es)

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TWI268928B (en) 2002-03-27 2006-12-21 Glaxo Group Ltd Novel quinoline compounds, the processes for their preparation, the compositions containing them and their uses as medicaments
ES2256744T3 (es) * 2002-05-13 2006-07-16 F. Hoffmann-La Roche Ag Derivados de benzoxazina como moduladores de 5-ht6 y usos de los mismos.
NZ539508A (en) 2002-11-08 2007-05-31 Hoffmann La Roche Substituted benzoxazinones and uses thereof
DE602004000260T2 (de) 2003-07-22 2006-08-24 Arena Pharmaceuticals, Inc., San Diego Diaryl- und arylheteroarylharnstoffderivate als modulatoren des 5-ht2a-serotoninrezeptors, die sich zur prophylaxe und behandlung von damit im zusammenhang stehenden erkrankungen eignen
EP1694656B1 (en) 2003-12-09 2007-08-29 F.Hoffmann-La Roche Ag Benzoxazine derivatives and uses thereof
EP1708713B1 (en) * 2004-01-16 2008-03-12 F. Hoffmann-la Roche AG 1-benzyl-5-piperazin-1-yl-3,4 dihydro-1h-quinazolin-2-one derivatives and the respective 1h-benzo(1,2,6)thiadiazine-2,2-dioxide and 1,4-dihydro-benzo(d)(1,3)oxazin-2-one derivatives as modulators of the 5-hydroxytryptamine receptor (5-ht) for the treatment of diseases of the central nervous system
ES2338668T3 (es) * 2004-05-05 2010-05-11 F. Hoffmann-La Roche Ag Arilsulfonil benzodioxanos utiles para la modulacion del receptor 5-ht6 y del receptor 5-ht2a o ambos.
AU2005291541B2 (en) * 2004-09-30 2011-03-10 F. Hoffmann-La Roche Ag Benzoxazine and quinoxaline derivatives and uses
ES2643615T3 (es) * 2004-09-30 2017-11-23 F. Hoffmann-La Roche Ag Composiciones y métodos para el tratamiento de trastornos cognitivos
US7713954B2 (en) * 2004-09-30 2010-05-11 Roche Palo Alto Llc Compositions and methods for treating cognitive disorders
US7378415B2 (en) * 2004-09-30 2008-05-27 Roche Palo Alto Llc Benzoxazine and quinoxaline derivatives and uses thereof
EP2254564A1 (en) 2007-12-12 2010-12-01 Glaxo Group Limited Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline
US20110021538A1 (en) 2008-04-02 2011-01-27 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
WO2010062321A1 (en) 2008-10-28 2010-06-03 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
AR078770A1 (es) * 2009-10-27 2011-11-30 Elara Pharmaceuticals Gmbh Derivados de dihidrobenzo oxacinas y tiazinas, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades inflamatorias e hiperproliferativas.
KR101293384B1 (ko) * 2010-10-13 2013-08-05 주식회사 대웅제약 신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도
US9403800B2 (en) * 2012-01-24 2016-08-02 Chemregen, Inc. Compounds for inhibition of cancer cell proliferation
CA2935944A1 (en) * 2014-01-09 2015-07-16 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Substituted benzoxazine and related compounds
CA2989343A1 (en) 2015-06-12 2016-12-15 Yandong Wen Diaryl and arylheteroaryl urea derivatives useful for the prophylaxis and treatment of rem sleep behavior disorder
BR112018000728A2 (pt) 2015-07-15 2018-09-04 Axovant Sciences Gmbh resumo método para a profilaxia e/ou tratamento de alucinações visuais em um sujeito com necessidade do mesmo

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Also Published As

Publication number Publication date
GT200300108A (es) 2004-03-15
MA27118A1 (fr) 2004-12-20
AU2003233231B2 (en) 2009-02-26
EA200401455A1 (ru) 2005-06-30
TWI258479B (en) 2006-07-21
PL211057B1 (pl) 2012-04-30
ES2256744T3 (es) 2006-07-16
DK1506179T3 (da) 2006-06-06
CN1653054A (zh) 2005-08-10
PL374019A1 (en) 2005-09-19
US6867204B2 (en) 2005-03-15
CN100429206C (zh) 2008-10-29
AR039988A1 (es) 2005-03-09
DE60303376D1 (de) 2006-04-13
BRPI0310032B8 (pt) 2021-05-25
US20030232825A1 (en) 2003-12-18
ECSP045420A (es) 2005-01-03
HK1080846A1 (en) 2006-05-04
NO329380B1 (no) 2010-10-04
HRP20041030A2 (en) 2005-06-30
IL164928A0 (en) 2005-12-18
MY139612A (en) 2009-10-30
NO20044665L (no) 2004-12-03
ZA200408783B (en) 2005-12-28
TW200400188A (en) 2004-01-01
EP1506179B1 (en) 2006-01-25
DE60303376T2 (de) 2006-11-16
TNSN04225A1 (fr) 2007-03-12
EA009982B1 (ru) 2008-04-28
US20050130962A1 (en) 2005-06-16
JP4307377B2 (ja) 2009-08-05
US8377931B2 (en) 2013-02-19
US20130123251A1 (en) 2013-05-16
KR100636475B1 (ko) 2006-10-18
PT1506179E (pt) 2006-06-30
WO2003095434A1 (en) 2003-11-20
BRPI0310032B1 (pt) 2019-01-08
EG25683A (en) 2012-05-16
JO2413B1 (en) 2007-11-11
RS97004A (en) 2006-10-27
CA2485136A1 (en) 2003-11-20
AU2003233231A1 (en) 2003-11-11
UY27803A1 (es) 2003-11-28
PA8573501A1 (es) 2003-12-10
UA76877C2 (uk) 2006-09-15
HRP20041030B1 (hr) 2013-03-31
BR0310032A (pt) 2005-02-15
KR20040106538A (ko) 2004-12-17
RS51042B (sr) 2010-10-31
CA2485136C (en) 2011-12-20
MXPA04011254A (es) 2005-01-25
EP1506179A1 (en) 2005-02-16
US20090325950A1 (en) 2009-12-31
JP2005530774A (ja) 2005-10-13
NZ536230A (en) 2007-05-31
ATE316523T1 (de) 2006-02-15

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