ATE316523T1 - Benzoxazinderivate als 5-ht6-modulatoren und deren verwendungen - Google Patents

Benzoxazinderivate als 5-ht6-modulatoren und deren verwendungen

Info

Publication number
ATE316523T1
ATE316523T1 AT03727430T AT03727430T ATE316523T1 AT E316523 T1 ATE316523 T1 AT E316523T1 AT 03727430 T AT03727430 T AT 03727430T AT 03727430 T AT03727430 T AT 03727430T AT E316523 T1 ATE316523 T1 AT E316523T1
Authority
AT
Austria
Prior art keywords
modulators
benzoxazine derivatives
benzoxazine
derivatives
Prior art date
Application number
AT03727430T
Other languages
English (en)
Inventor
Jacob Berger
Robin Douglas Clark
Shu-Hai Zhao
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE316523T1 publication Critical patent/ATE316523T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT03727430T 2002-05-13 2003-05-05 Benzoxazinderivate als 5-ht6-modulatoren und deren verwendungen ATE316523T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37800302P 2002-05-13 2002-05-13

Publications (1)

Publication Number Publication Date
ATE316523T1 true ATE316523T1 (de) 2006-02-15

Family

ID=29420358

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03727430T ATE316523T1 (de) 2002-05-13 2003-05-05 Benzoxazinderivate als 5-ht6-modulatoren und deren verwendungen

Country Status (37)

Country Link
US (4) US6867204B2 (de)
EP (1) EP1506179B1 (de)
JP (1) JP4307377B2 (de)
KR (1) KR100636475B1 (de)
CN (1) CN100429206C (de)
AR (1) AR039988A1 (de)
AT (1) ATE316523T1 (de)
AU (1) AU2003233231B2 (de)
BR (1) BRPI0310032B8 (de)
CA (1) CA2485136C (de)
DE (1) DE60303376T2 (de)
DK (1) DK1506179T3 (de)
EA (1) EA009982B1 (de)
EC (1) ECSP045420A (de)
EG (1) EG25683A (de)
ES (1) ES2256744T3 (de)
GT (1) GT200300108A (de)
HK (1) HK1080846A1 (de)
HR (1) HRP20041030B1 (de)
IL (1) IL164928A0 (de)
JO (1) JO2413B1 (de)
MA (1) MA27118A1 (de)
MX (1) MXPA04011254A (de)
MY (1) MY139612A (de)
NO (1) NO329380B1 (de)
NZ (1) NZ536230A (de)
PA (1) PA8573501A1 (de)
PE (1) PE20040757A1 (de)
PL (1) PL211057B1 (de)
PT (1) PT1506179E (de)
RS (1) RS51042B (de)
TN (1) TNSN04225A1 (de)
TW (1) TWI258479B (de)
UA (1) UA76877C2 (de)
UY (1) UY27803A1 (de)
WO (1) WO2003095434A1 (de)
ZA (1) ZA200408783B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7504395B2 (en) * 2001-07-20 2009-03-17 Psychogenics, Inc. Treatment for attention-deficit hyperactivity disorder
PL209872B1 (pl) 2002-03-27 2011-10-31 Glaxo Group Ltd Pochodna chinolinowa, sposób jej wytwarzania i jej zastosowanie oraz zawierająca ją farmaceutyczna kompozycja
DE60303376T2 (de) * 2002-05-13 2006-11-16 F. Hoffmann-La Roche Ag Benzoxazinderivate als 5-ht6-modulatoren und deren verwendungen
DK1562918T3 (da) * 2002-11-08 2008-05-05 Hoffmann La Roche Substituerede benzoxazinoner og anvendelser deraf
DE602004000260T2 (de) 2003-07-22 2006-08-24 Arena Pharmaceuticals, Inc., San Diego Diaryl- und arylheteroarylharnstoffderivate als modulatoren des 5-ht2a-serotoninrezeptors, die sich zur prophylaxe und behandlung von damit im zusammenhang stehenden erkrankungen eignen
WO2005058847A1 (en) * 2003-12-09 2005-06-30 F. Hoffmann-La Roche Ag Benzoxazine derivatives and uses thereof
KR100843053B1 (ko) * 2004-01-16 2008-07-01 에프. 호프만-라 로슈 아게 중추 신경계 질환의 치료를 위한 5-하이드록시트립트아민수용체(5-ｈｔ)의 조절제로서1-벤질-5-피페라진-1-일-3,4-다이하이드로-1ｈ-퀴나졸린-2-온 유도체 및 각각의1ｈ-벤조(1,2,6)티아다이아진-2,2-다이옥사이드 및1,4-다이하이드로-벤조(ｄ)(1,3)옥사진-2-온 유도체
ATE458727T1 (de) * 2004-05-05 2010-03-15 Hoffmann La Roche Zur modulation des 5-ht6-rezeptors, des 5-ht2a- rezeptors oder beider rezeptoren geeignete arylsulfonylbenzodioxane
ES2643615T3 (es) * 2004-09-30 2017-11-23 F. Hoffmann-La Roche Ag Composiciones y métodos para el tratamiento de trastornos cognitivos
WO2006037481A1 (en) * 2004-09-30 2006-04-13 F.Hoffmann-La Roche Ag Benzoxazine and quinoxaline derivatives and uses
US7378415B2 (en) * 2004-09-30 2008-05-27 Roche Palo Alto Llc Benzoxazine and quinoxaline derivatives and uses thereof
US7713954B2 (en) * 2004-09-30 2010-05-11 Roche Palo Alto Llc Compositions and methods for treating cognitive disorders
EP2508177A1 (de) 2007-12-12 2012-10-10 Glaxo Group Limited Kombinationen mit 3-phenylsulfonyl-8-piperazinyl-1yl-chinolin
US20110021538A1 (en) 2008-04-02 2011-01-27 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
WO2010062321A1 (en) 2008-10-28 2010-06-03 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
AR078770A1 (es) * 2009-10-27 2011-11-30 Elara Pharmaceuticals Gmbh Derivados de dihidrobenzo oxacinas y tiazinas, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades inflamatorias e hiperproliferativas.
KR101293384B1 (ko) * 2010-10-13 2013-08-05 주식회사 대웅제약 신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도
US9403800B2 (en) * 2012-01-24 2016-08-02 Chemregen, Inc. Compounds for inhibition of cancer cell proliferation
JP6510539B2 (ja) 2014-01-09 2019-05-08 ザ ジェイ． デヴィッド グラッドストーン インスティテューツ， ア テスタメンタリー トラスト エスタブリッシュド アンダー ザ ウィル オブ ジェイ． デヴィッド グラッドストーン 置換ベンゾオキサジン及び関連化合物
JP2018516992A (ja) 2015-06-12 2018-06-28 アクソファント サイエンシーズ ゲーエムベーハーＡｘｏｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ レム睡眠行動障害の予防および処置のために有用なジアリールおよびアリールヘテロアリール尿素誘導体
RU2018103338A (ru) 2015-07-15 2019-08-15 Аксовант Сайенсиз Гмбх Производные диарил- и арилгетероарилмочевины для профилактики и лечения галлюцинаций, ассоциированных с нейродегенеративным заболеванием

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1029479C (zh) * 1989-11-08 1995-08-09 山之内制药株式会社 新型苯并噁嗪衍生物的制备方法
US5492914A (en) * 1994-07-28 1996-02-20 Syntex (U.S.A.) Inc. 2-(1-azabicyclo[2.2.2]oct-3 s-yl)-6-hydroxy-2,4,5,6-tetrahydro-1H-benz[DE]is[2.2.2]oct-3's-yl)-6-hydroxy-2,3,3a,4,5,6-hexahydro-1h-benz [DE]isoquinolin-1-one and individual stereoisomers thereof
GB9507203D0 (en) 1995-04-07 1995-05-31 Smithkline Beecham Plc Novel compounds
DZ2376A1 (fr) * 1996-12-19 2002-12-28 Smithkline Beecham Plc Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant.
HUP0001123A3 (en) 1997-04-18 2002-04-29 Smithkline Beecham Plc Indole derivatives having combined 5ht1a, 5ht1b and 5ht1d receptor antagonist activity
WO1999002502A2 (en) 1997-07-11 1999-01-21 Smithkline Beecham Plc Sulphonamide derivatives being 5-ht6 receptor antagonists and process for their preparation
WO1999005140A1 (en) * 1997-07-25 1999-02-04 H. Lundbeck A/S Indole and 2,3-dihydroindole derivatives, their preparation and use
GB9801392D0 (en) 1998-01-22 1998-03-18 Smithkline Beecham Plc Novel compounds
AU765317C (en) * 1998-06-19 2004-05-20 H. Lundbeck A/S 4,5,6 and 7-indole and indoline derivatives, their preparation and use
GB9818916D0 (en) * 1998-08-28 1998-10-21 Smithkline Beecham Plc Use
US6380235B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Benzimidazolones and analogues
SK287018B6 (sk) * 1999-08-23 2009-09-07 Solvay Pharmaceuticals B. V. Deriváty fenylpiperazínov, spôsob ich prípravy, farmaceutická kompozícia s ich obsahom a ich použitie
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
WO2001057003A1 (en) 2000-02-01 2001-08-09 Cor Therapeutics, Inc. 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE INHIBITORS OF FACTOR Xa
DE60303376T2 (de) * 2002-05-13 2006-11-16 F. Hoffmann-La Roche Ag Benzoxazinderivate als 5-ht6-modulatoren und deren verwendungen

Also Published As

Publication number Publication date
PL211057B1 (pl) 2012-04-30
KR100636475B1 (ko) 2006-10-18
ECSP045420A (es) 2005-01-03
US20130123251A1 (en) 2013-05-16
KR20040106538A (ko) 2004-12-17
BR0310032A (pt) 2005-02-15
JP2005530774A (ja) 2005-10-13
AU2003233231A1 (en) 2003-11-11
PE20040757A1 (es) 2004-11-06
UA76877C2 (uk) 2006-09-15
NZ536230A (en) 2007-05-31
EP1506179B1 (de) 2006-01-25
CN1653054A (zh) 2005-08-10
EG25683A (en) 2012-05-16
GT200300108A (es) 2004-03-15
EA200401455A1 (ru) 2005-06-30
CA2485136A1 (en) 2003-11-20
MA27118A1 (fr) 2004-12-20
DK1506179T3 (da) 2006-06-06
TNSN04225A1 (fr) 2007-03-12
HRP20041030A2 (en) 2005-06-30
IL164928A0 (en) 2005-12-18
HRP20041030B1 (hr) 2013-03-31
US20050130962A1 (en) 2005-06-16
DE60303376D1 (de) 2006-04-13
PL374019A1 (en) 2005-09-19
EP1506179A1 (de) 2005-02-16
PT1506179E (pt) 2006-06-30
US20090325950A1 (en) 2009-12-31
BRPI0310032B8 (pt) 2021-05-25
MXPA04011254A (es) 2005-01-25
ES2256744T3 (es) 2006-07-16
TW200400188A (en) 2004-01-01
US6867204B2 (en) 2005-03-15
AU2003233231B2 (en) 2009-02-26
CN100429206C (zh) 2008-10-29
ZA200408783B (en) 2005-12-28
AR039988A1 (es) 2005-03-09
WO2003095434A1 (en) 2003-11-20
JO2413B1 (en) 2007-11-11
MY139612A (en) 2009-10-30
NO20044665L (no) 2004-12-03
UY27803A1 (es) 2003-11-28
RS51042B (sr) 2010-10-31
NO329380B1 (no) 2010-10-04
CA2485136C (en) 2011-12-20
DE60303376T2 (de) 2006-11-16
BRPI0310032B1 (pt) 2019-01-08
US8377931B2 (en) 2013-02-19
JP4307377B2 (ja) 2009-08-05
PA8573501A1 (es) 2003-12-10
HK1080846A1 (en) 2006-05-04
RS97004A (en) 2006-10-27
TWI258479B (en) 2006-07-21
EA009982B1 (ru) 2008-04-28
US20030232825A1 (en) 2003-12-18

Similar Documents

Publication Publication Date Title
ATE316523T1 (de) Benzoxazinderivate als 5-ht6-modulatoren und deren verwendungen
DE602005013491D1 (de) Benzamidderivate und deren verwendung als glucokinaseaktivierende mittel
ATE398108T1 (de) Chinolinderivate und deren verwendung als 5-ht6 liganden
DE602004021904D1 (de) Gyraseinhibitoren und deren verwendungen
DE60308998D1 (de) N-aryl-2-oxazolidinon-5-carbonsäureamide und deren derivate und deren verwendung als antibakterielle mittel
ATE395339T1 (de) Biphenylderivate und deren verwendung als fungizide
DE60335151D1 (de) Pyrimidinderivate und deren Verwendung als CB2-Modulatoren
DE60006580D1 (de) Benzazolderivate und ihre verwendung als jnk modulatoren
DE60326611D1 (de) N und dergleichen
NO20054135D0 (no) Kipolinon/benzoksazin derivater og anvendelser derav
DE60235492D1 (de) Beta-amino-alpha-cyanoacrylate und deren verwendung als herbizide
ATE321050T1 (de) (1,4)diazocino(7,8,1-hi)indolderivate als antipsychotische mittel und mittel gegen obesität
DE60322551D1 (de) 2,4-substituierte indole und deren verwendung als 5-ht6 modulatoren
ATE362469T1 (de) 2,7-disubstituierteindole und ihre verwendung als 5-ht6 modulatoren
DE602004008668D1 (de) Benzoxazinderivate und deren verwendungen
ATE555097T1 (de) 4-cycloalkyl-substituierte tetrahydrochinolinderivate und deren verwendung als medikamente
DE50206476D1 (de) Cyanoanthranylamid-derivate und deren verwendung als arzneimittel
ATE382040T1 (de) Acylaminothiazolderivate und ihre vewrendung als beta-amyloid inhibitoren
DE602005007866D1 (de) 1-phenyl- und 1-pyridylpyrazolderivate und deren verwendung als pestizide
DE50313185D1 (de) 2-pyrrolidin-2-yl-ä1,3,4ü -oxadiazol-derivate und ihre verwendung als antidepressiva
ATE372342T1 (de) Substituierte aminoisoxazolinderivate und ihre verwendung als antidepressiva
DE60331160D1 (de) Kondensierte heterocyclische isoxazolinderivate und deren verwendung als antidepressiva
DE602004024538D1 (de) Sulphonamid benzoxazinonderivate. ihre herstellung und verwendung als medikamente
ATE368669T1 (de) C-substituierte trizyklische isoxazolin derivate und deren verwendung als anti-depressiva
SI1506179T1 (sl) Derivati benzoksazina kot modulatorji 5-ht6 in njihova uporaba

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1506179

Country of ref document: EP