ECSP045420A - Derivados de benzoxazina como moduladores 5-ht6 y usos de los mismos - Google Patents
Derivados de benzoxazina como moduladores 5-ht6 y usos de los mismosInfo
- Publication number
- ECSP045420A ECSP045420A EC2004005420A ECSP045420A ECSP045420A EC SP045420 A ECSP045420 A EC SP045420A EC 2004005420 A EC2004005420 A EC 2004005420A EC SP045420 A ECSP045420 A EC SP045420A EC SP045420 A ECSP045420 A EC SP045420A
- Authority
- EC
- Ecuador
- Prior art keywords
- modulators
- same
- benzoxazine derivatives
- formula
- methods
- Prior art date
Links
- CMLFRMDBDNHMRA-UHFFFAOYSA-N 2h-1,2-benzoxazine Chemical class C1=CC=C2C=CNOC2=C1 CMLFRMDBDNHMRA-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención proporciona un compuesto de la fórmula una sal farmacéuticamente aceptable o un pro fármaco de las mismas, donde R1, R2, R3, R4, R5, R6, R7, R8, R9, Y, Z1, m, n, y p son como se define aquí. La presente invención también proporciona composiciones que comprenden, métodos para usar, y métodos para preparar Compuestos de la Fórmula I.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37800302P | 2002-05-13 | 2002-05-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP045420A true ECSP045420A (es) | 2005-01-03 |
Family
ID=29420358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2004005420A ECSP045420A (es) | 2002-05-13 | 2004-11-10 | Derivados de benzoxazina como moduladores 5-ht6 y usos de los mismos |
Country Status (36)
| Country | Link |
|---|---|
| US (4) | US6867204B2 (es) |
| EP (1) | EP1506179B1 (es) |
| JP (1) | JP4307377B2 (es) |
| KR (1) | KR100636475B1 (es) |
| CN (1) | CN100429206C (es) |
| AR (1) | AR039988A1 (es) |
| AT (1) | ATE316523T1 (es) |
| AU (1) | AU2003233231B2 (es) |
| BR (1) | BRPI0310032B8 (es) |
| CA (1) | CA2485136C (es) |
| DE (1) | DE60303376T2 (es) |
| DK (1) | DK1506179T3 (es) |
| EA (1) | EA009982B1 (es) |
| EC (1) | ECSP045420A (es) |
| EG (1) | EG25683A (es) |
| ES (1) | ES2256744T3 (es) |
| GT (1) | GT200300108A (es) |
| HR (1) | HRP20041030B1 (es) |
| IL (1) | IL164928A0 (es) |
| JO (1) | JO2413B1 (es) |
| MA (1) | MA27118A1 (es) |
| MX (1) | MXPA04011254A (es) |
| MY (1) | MY139612A (es) |
| NO (1) | NO329380B1 (es) |
| NZ (1) | NZ536230A (es) |
| PA (1) | PA8573501A1 (es) |
| PE (1) | PE20040757A1 (es) |
| PL (1) | PL211057B1 (es) |
| PT (1) | PT1506179E (es) |
| RS (1) | RS51042B (es) |
| TN (1) | TNSN04225A1 (es) |
| TW (1) | TWI258479B (es) |
| UA (1) | UA76877C2 (es) |
| UY (1) | UY27803A1 (es) |
| WO (1) | WO2003095434A1 (es) |
| ZA (1) | ZA200408783B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002322539B2 (en) | 2001-07-20 | 2007-09-27 | Psychogenics Inc. | Treatment for attention-deficit hyperactivity disorder |
| BRPI0308696B8 (pt) | 2002-03-27 | 2021-05-25 | Axovant Sciences Gmbh | composto derivado de quinolina, seu processo de preparação, sua composição farmacêutica e seus usos |
| CA2485136C (en) * | 2002-05-13 | 2011-12-20 | F. Hoffmann-La Roche Ag | Benzoxazine derivatives as 5-ht6 modulators and uses thereof |
| JP4401297B2 (ja) * | 2002-11-08 | 2010-01-20 | エフ．ホフマン−ラ ロシュ アーゲー | 置換ベンゾオキサジノン及びその使用 |
| BRPI0412263B1 (pt) | 2003-07-22 | 2019-10-15 | Arena Pharmaceuticals, Inc. | Derivados de diaril e aril heteroaril uréia, uso e composição farmacêutica contendo os mesmos, bem como processo para preparação da dita composição |
| WO2005058847A1 (en) * | 2003-12-09 | 2005-06-30 | F. Hoffmann-La Roche Ag | Benzoxazine derivatives and uses thereof |
| RU2006129464A (ru) * | 2004-01-16 | 2008-02-27 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные 1-бензил-5-пиперазин-1-ил-3, 4-дигидро-1н-хиназолин-2-она и соответствующие производные 1н-бензо (1, 2, 6) тиадиазин-2, 2-диоксида и 1, 4-дигидробензо (1, 3)оксазин-2-она в качестве модуляторов рецептора 5-гидрокситриптамина (5нт) для лечения заболевания центральной нервной системы |
| WO2005105776A1 (en) * | 2004-05-05 | 2005-11-10 | F. Hoffmann-La Roche Ag | Arylsulfonyl benzodioxanes useful for modulation the 5-ht6 receptor, the 5-ht2areceptor or both |
| CA2581921A1 (en) * | 2004-09-30 | 2006-04-13 | F. Hoffmann-La Roche Ag | Benzoxazine and quinoxaline derivatives and uses |
| US7378415B2 (en) * | 2004-09-30 | 2008-05-27 | Roche Palo Alto Llc | Benzoxazine and quinoxaline derivatives and uses thereof |
| US7713954B2 (en) * | 2004-09-30 | 2010-05-11 | Roche Palo Alto Llc | Compositions and methods for treating cognitive disorders |
| WO2006037482A2 (en) * | 2004-09-30 | 2006-04-13 | F. Hoffmann-La Roche Ag | Compositions and methods for treating cognitive disorders |
| WO2009074607A1 (en) | 2007-12-12 | 2009-06-18 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
| WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
| AR078770A1 (es) * | 2009-10-27 | 2011-11-30 | Elara Pharmaceuticals Gmbh | Derivados de dihidrobenzo oxacinas y tiazinas, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades inflamatorias e hiperproliferativas. |
| KR101293384B1 (ko) * | 2010-10-13 | 2013-08-05 | 주식회사 대웅제약 | 신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도 |
| US9403800B2 (en) * | 2012-01-24 | 2016-08-02 | Chemregen, Inc. | Compounds for inhibition of cancer cell proliferation |
| CA2935944A1 (en) | 2014-01-09 | 2015-07-16 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Substituted benzoxazine and related compounds |
| EP4119141A1 (en) | 2015-06-12 | 2023-01-18 | Axovant Sciences GmbH | Nelotanserin for the prophylaxis and treatment of rem sleep behavior disorder |
| EP3322415A4 (en) | 2015-07-15 | 2019-03-13 | Axovant Sciences GmbH | DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR FOR PROPHYLAXIS AND TREATMENT OF HALLUCINATIONS RELATED TO A NEUROGENERATIVE DISEASE |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1029479C (zh) * | 1989-11-08 | 1995-08-09 | 山之内制药株式会社 | 新型苯并噁嗪衍生物的制备方法 |
| US5492914A (en) * | 1994-07-28 | 1996-02-20 | Syntex (U.S.A.) Inc. | 2-(1-azabicyclo[2.2.2]oct-3 s-yl)-6-hydroxy-2,4,5,6-tetrahydro-1H-benz[DE]is[2.2.2]oct-3's-yl)-6-hydroxy-2,3,3a,4,5,6-hexahydro-1h-benz [DE]isoquinolin-1-one and individual stereoisomers thereof |
| GB9507203D0 (en) | 1995-04-07 | 1995-05-31 | Smithkline Beecham Plc | Novel compounds |
| DZ2376A1 (fr) * | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
| AU732863B2 (en) | 1997-04-18 | 2001-05-03 | Smithkline Beecham Plc | Indole derivatives having combined 5HT1A, 5HT1B and 5HT1D receptor antagonist activity |
| WO1999002502A2 (en) | 1997-07-11 | 1999-01-21 | Smithkline Beecham Plc | Sulphonamide derivatives being 5-ht6 receptor antagonists and process for their preparation |
| PT1007523E (pt) * | 1997-07-25 | 2004-02-27 | Lundbeck & Co As H | Derivados indole e 2,3-di-ridroindole, sua preparacao e utilizacao |
| GB9801392D0 (en) | 1998-01-22 | 1998-03-18 | Smithkline Beecham Plc | Novel compounds |
| JP2003521443A (ja) * | 1998-06-19 | 2003-07-15 | ハー・ルンドベック・アクチエゼルスカベット | ４，５，６及び７−インドール及びインドリン誘導体、その製造方法及びその使用方法 |
| GB9818916D0 (en) | 1998-08-28 | 1998-10-21 | Smithkline Beecham Plc | Use |
| US6380235B1 (en) | 1999-05-04 | 2002-04-30 | American Home Products Corporation | Benzimidazolones and analogues |
| ES2244469T3 (es) * | 1999-08-23 | 2005-12-16 | Solvay Pharmaceuticals B.V. | Fenilpiperazinas como inhibidores de la recaptacion de serotonina. |
| US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| US20020013314A1 (en) | 2000-02-01 | 2002-01-31 | Bing-Yan Zhu | 3,4-dihydro-2H-benzo[1,4]oxazine inhibitors of factor Xa |
| CA2485136C (en) * | 2002-05-13 | 2011-12-20 | F. Hoffmann-La Roche Ag | Benzoxazine derivatives as 5-ht6 modulators and uses thereof |
-
2003
- 2003-05-05 CA CA2485136A patent/CA2485136C/en not_active Expired - Lifetime
- 2003-05-05 PL PL374019A patent/PL211057B1/pl unknown
- 2003-05-05 EA EA200401455A patent/EA009982B1/ru not_active IP Right Cessation
- 2003-05-05 AU AU2003233231A patent/AU2003233231B2/en not_active Expired
- 2003-05-05 HR HRP20041030AA patent/HRP20041030B1/hr not_active IP Right Cessation
- 2003-05-05 MX MXPA04011254A patent/MXPA04011254A/es active IP Right Grant
- 2003-05-05 PT PT03727430T patent/PT1506179E/pt unknown
- 2003-05-05 EP EP03727430A patent/EP1506179B1/en not_active Expired - Lifetime
- 2003-05-05 NZ NZ536230A patent/NZ536230A/en not_active IP Right Cessation
- 2003-05-05 AT AT03727430T patent/ATE316523T1/de active
- 2003-05-05 UA UA20041210144A patent/UA76877C2/uk unknown
- 2003-05-05 WO PCT/EP2003/004671 patent/WO2003095434A1/en not_active Ceased
- 2003-05-05 KR KR1020047018299A patent/KR100636475B1/ko not_active Expired - Fee Related
- 2003-05-05 DE DE60303376T patent/DE60303376T2/de not_active Expired - Lifetime
- 2003-05-05 RS YUP-970/04A patent/RS51042B/sr unknown
- 2003-05-05 BR BRPI0310032A patent/BRPI0310032B8/pt not_active IP Right Cessation
- 2003-05-05 DK DK03727430T patent/DK1506179T3/da active
- 2003-05-05 CN CNB038109972A patent/CN100429206C/zh not_active Expired - Lifetime
- 2003-05-05 ES ES03727430T patent/ES2256744T3/es not_active Expired - Lifetime
- 2003-05-05 JP JP2004503451A patent/JP4307377B2/ja not_active Expired - Lifetime
- 2003-05-08 JO JO200352A patent/JO2413B1/en active
- 2003-05-08 TW TW092112575A patent/TWI258479B/zh not_active IP Right Cessation
- 2003-05-09 GT GT200300108A patent/GT200300108A/es unknown
- 2003-05-09 PA PA20038573501A patent/PA8573501A1/es unknown
- 2003-05-09 US US10/435,732 patent/US6867204B2/en not_active Expired - Lifetime
- 2003-05-09 AR ARP030101624A patent/AR039988A1/es active IP Right Grant
- 2003-05-09 PE PE2003000452A patent/PE20040757A1/es active IP Right Grant
- 2003-05-10 EG EG2003050432A patent/EG25683A/xx active
- 2003-05-12 UY UY27803A patent/UY27803A1/es not_active IP Right Cessation
- 2003-05-12 MY MYPI20031765A patent/MY139612A/en unknown
-
2004
- 2004-10-28 NO NO20044665A patent/NO329380B1/no not_active IP Right Cessation
- 2004-10-28 IL IL16492804A patent/IL164928A0/xx unknown
- 2004-10-29 ZA ZA2004/08783A patent/ZA200408783B/en unknown
- 2004-11-10 EC EC2004005420A patent/ECSP045420A/es unknown
- 2004-11-11 TN TNP2004000225A patent/TNSN04225A1/fr unknown
- 2004-11-12 MA MA27944A patent/MA27118A1/fr unknown
-
2005
- 2005-01-31 US US11/047,284 patent/US20050130962A1/en not_active Abandoned
-
2009
- 2009-09-04 US US12/584,373 patent/US8377931B2/en not_active Expired - Fee Related
-
2012
- 2012-12-13 US US13/713,484 patent/US20130123251A1/en not_active Abandoned
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