IL132409A0 - Indole derivatives having combined 5ht1a 5ht1b and 5ht1d receptor antagonist activity - Google Patents
Indole derivatives having combined 5ht1a 5ht1b and 5ht1d receptor antagonist activityInfo
- Publication number
- IL132409A0 IL132409A0 IL13240998A IL13240998A IL132409A0 IL 132409 A0 IL132409 A0 IL 132409A0 IL 13240998 A IL13240998 A IL 13240998A IL 13240998 A IL13240998 A IL 13240998A IL 132409 A0 IL132409 A0 IL 132409A0
- Authority
- IL
- Israel
- Prior art keywords
- 5ht1b
- 5ht1a
- combined
- receptor antagonist
- antagonist activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9707829.9A GB9707829D0 (en) | 1997-04-18 | 1997-04-18 | Novel compounds |
| GBGB9801882.3A GB9801882D0 (en) | 1998-01-29 | 1998-01-29 | Novel compounds |
| PCT/EP1998/002262 WO1998050358A1 (en) | 1997-04-18 | 1998-04-14 | Indole derivatives having combined 5ht1a, 5ht1b and 5ht1d receptor antagonist activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL132409A0 true IL132409A0 (en) | 2001-03-19 |
Family
ID=26311401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13240998A IL132409A0 (en) | 1997-04-18 | 1998-04-14 | Indole derivatives having combined 5ht1a 5ht1b and 5ht1d receptor antagonist activity |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0975593A1 (en) |
| JP (1) | JP2001524116A (en) |
| KR (1) | KR20010006487A (en) |
| CN (1) | CN1260781A (en) |
| AR (1) | AR013076A1 (en) |
| AU (1) | AU732863B2 (en) |
| BR (1) | BR9809092A (en) |
| CA (1) | CA2288662A1 (en) |
| CO (1) | CO4950608A1 (en) |
| HU (1) | HUP0001123A3 (en) |
| IL (1) | IL132409A0 (en) |
| NO (1) | NO995065L (en) |
| NZ (1) | NZ500252A (en) |
| PL (1) | PL336317A1 (en) |
| TR (1) | TR199902590T2 (en) |
| TW (1) | TW509687B (en) |
| WO (1) | WO1998050358A1 (en) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9725931D0 (en) * | 1997-12-05 | 1998-02-04 | Smithkline Beecham Plc | Novel compounds |
| AU753360B2 (en) | 1998-07-31 | 2002-10-17 | Nippon Soda Co., Ltd. | Phenylazole compounds, process for producing the same and drugs for hyperlipemia |
| GB9827882D0 (en) * | 1998-12-17 | 1999-02-10 | Smithkline Beecham Plc | Novel compounds |
| UA62015C2 (en) | 1998-12-28 | 2003-12-15 | Pfizer Prod Inc | Benzoizoxazol derivatives, a pharmaceutical composition (variants) based thereon (variants) and a method for treatment (variants) |
| GB9912417D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912413D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| CA2378047A1 (en) * | 1999-07-15 | 2001-01-25 | Methvin Isaac | Heterocyclic compounds for the treatment of migraine |
| BR0014279A (en) * | 1999-09-25 | 2002-05-21 | Smithkline Beecham Plc | Piperazine derivatives as 5-ht1b antagonists |
| ES2234683T3 (en) * | 1999-11-05 | 2005-07-01 | Smithkline Beecham Plc | ISOQUINOLINE AND QUINAZOLINE DERIVATIVES WITH COMBINED ACTIVITY ON THE 5HT1A, 5HT1B AND 5HT1D RECEPTORS. |
| GB9926303D0 (en) * | 1999-11-05 | 2000-01-12 | Smithkline Beecham Plc | Novel compounds |
| DE10051981A1 (en) | 2000-10-20 | 2002-05-02 | Bayer Ag | Substituted phenyluracile |
| GB0106419D0 (en) * | 2001-03-15 | 2001-05-02 | Smithkline Beecham Plc | Novel compounds |
| GB0106586D0 (en) * | 2001-03-16 | 2001-05-09 | Smithkline Beecham Plc | Novel compounds |
| SK16052003A3 (en) * | 2001-06-07 | 2004-10-05 | Hoffmann La Roche | New indole derivatives with 5-HT6 receptor affinity |
| TW200403223A (en) | 2002-02-15 | 2004-03-01 | Glaxo Group Ltd | Novel compounds |
| ATE316523T1 (en) | 2002-05-13 | 2006-02-15 | Hoffmann La Roche | BENZOXAZINE DERIVATIVES AS 5-HT6 MODULATORS AND USES THEREOF |
| CA2547764A1 (en) | 2003-12-09 | 2005-06-30 | F.Hoffmann-La Roche Ag | Benzoxazine derivatives and uses thereof |
| JP2011506445A (en) * | 2007-12-13 | 2011-03-03 | アムジエン・インコーポレーテツド | γ-secretase modulator |
| BR112012024380A2 (en) | 2010-03-25 | 2015-09-15 | Glaxosmithkline Llc | chemical compounds |
| GB201106817D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compound |
| CN102924330A (en) * | 2012-09-03 | 2013-02-13 | 华东理工大学 | Method for large-scale preparation of 5-amino-1-naphthyl nitrile |
| GB201218850D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218864D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| US9980973B2 (en) | 2012-10-19 | 2018-05-29 | Astex Therapeutics Limited | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218862D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| CN103467374A (en) * | 2013-08-30 | 2013-12-25 | 江苏弘和药物研发有限公司 | Synthesis method of 8-bromine-4-carboxyl quinoline |
| WO2015092420A1 (en) | 2013-12-20 | 2015-06-25 | Astex Therapeutics Limited | Bicyclic heterocycle compounds and their uses in therapy |
| CN115197099A (en) * | 2022-05-30 | 2022-10-18 | 安徽昊帆生物有限公司 | Preparation method of N-Boc-1,4-phenylenediamine |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9119920D0 (en) * | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
| DE69232003T2 (en) * | 1991-09-18 | 2002-04-25 | Glaxo Group Ltd., Greenford | Benzanilide derivatives as 5-HT1D antagonists |
| GB9119932D0 (en) * | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
| WO1995004729A1 (en) * | 1993-08-06 | 1995-02-16 | Smithkline Beecham Plc | Amide derivatives as 5ht1d receptor antagonists |
| DE69411176T2 (en) * | 1993-08-20 | 1998-11-12 | Smithkline Beecham Plc | AMIDES AND UREA DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS |
| WO1995006637A1 (en) * | 1993-09-03 | 1995-03-09 | Smithkline Beecham Plc | Indole and indoline derivatives as 5ht1d receptor antagonists |
-
1998
- 1998-04-14 BR BR9809092-5A patent/BR9809092A/en not_active IP Right Cessation
- 1998-04-14 JP JP54766098A patent/JP2001524116A/en active Pending
- 1998-04-14 WO PCT/EP1998/002262 patent/WO1998050358A1/en not_active Application Discontinuation
- 1998-04-14 KR KR1019997009577A patent/KR20010006487A/en not_active Application Discontinuation
- 1998-04-14 TR TR1999/02590T patent/TR199902590T2/en unknown
- 1998-04-14 NZ NZ500252A patent/NZ500252A/en unknown
- 1998-04-14 HU HU0001123A patent/HUP0001123A3/en unknown
- 1998-04-14 EP EP98921462A patent/EP0975593A1/en not_active Withdrawn
- 1998-04-14 PL PL98336317A patent/PL336317A1/en unknown
- 1998-04-14 CN CN98806185A patent/CN1260781A/en active Pending
- 1998-04-14 AU AU74310/98A patent/AU732863B2/en not_active Ceased
- 1998-04-14 IL IL13240998A patent/IL132409A0/en unknown
- 1998-04-14 CA CA002288662A patent/CA2288662A1/en not_active Abandoned
- 1998-04-16 AR ARP980101760A patent/AR013076A1/en not_active Application Discontinuation
- 1998-04-17 TW TW087105843A patent/TW509687B/en active
- 1998-04-17 CO CO98021149A patent/CO4950608A1/en unknown
-
1999
- 1999-10-15 NO NO995065A patent/NO995065L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO995065D0 (en) | 1999-10-15 |
| CA2288662A1 (en) | 1998-11-12 |
| PL336317A1 (en) | 2000-06-19 |
| HUP0001123A2 (en) | 2001-04-28 |
| WO1998050358A1 (en) | 1998-11-12 |
| BR9809092A (en) | 2002-01-22 |
| HUP0001123A3 (en) | 2002-04-29 |
| NZ500252A (en) | 2001-07-27 |
| KR20010006487A (en) | 2001-01-26 |
| TR199902590T2 (en) | 2000-06-21 |
| AU7431098A (en) | 1998-11-27 |
| CN1260781A (en) | 2000-07-19 |
| AR013076A1 (en) | 2000-12-13 |
| NO995065L (en) | 1999-10-15 |
| AU732863B2 (en) | 2001-05-03 |
| EP0975593A1 (en) | 2000-02-02 |
| JP2001524116A (en) | 2001-11-27 |
| CO4950608A1 (en) | 2000-09-01 |
| TW509687B (en) | 2002-11-11 |
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